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Review

Novel screening techniques for ion channel targeting drugs

, , , , &
Pages 367-375 | Received 29 Jul 2015, Accepted 30 Jul 2015, Published online: 10 Nov 2015

References

  • Kaczorowski GJ, McManus OB, Priest BT, Garcia ML. Ion channels as drug targets: the next GPCRs. J Gen Physiol 2008; 131:399-405; PMID:18411331; http://dx.doi.org/10.1085/jgp.200709946
  • Cavero I, Holzgrefe H. CiPA: Ongoing testing, future qualification procedures, and pending issues. J Pharmacol Toxicol Methods 2015; 76:27-37; PMID:26159293; http://dx.doi.org/10.1016/j.vascn.2015.06.004
  • Möller C, Slack M. Impact of new technologies for cellular screening along the drug value chain. Drug Discov Today 2010; 15:384-90; http://dx.doi.org/10.1016/j.drudis.2010.02.010
  • Neher E, Sakmann B. Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature 1976; 260:799-802
  • Fertig N, Blick RH, Behrends JC. Whole cell patch clamp recording performed on a planar glass chip. Biophys J 2002; 82:3056-62; http://dx.doi.org/10.1016/S0006-3495(02)75646-4
  • Bébarová M. Advances in patch clamp technique: towards higher quality and quantity. Gen Physiol Biophys 2012; 31:131-40; PMID:22781816; http://dx.doi.org/10.4149/gpb_2012_016
  • Dunlop J, Bowlby M, Peri R, Vasilyev D, Arias R. High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology. Nat Rev Drug Discov 2008; 7:358-68; http://dx.doi.org/10.1038/nrd2552
  • Farre C, Haythornthwaite A, Haarmann C, Stoelzle S, Kreir M, George M, Brüggemann A, Fertig N. Port-a-patch and patchliner: high fidelity electrophysiology for secondary screening and safety pharmacology. Comb Chem High Throughput Screen 2009; 12:24-37; PMID:19149489
  • Mergler S, Garreis F, Sahlmüller M, Reinach PS, Paulsen F, Pleyer U. Thermosensitive transient receptor potential channels in human corneal epithelial cells. J Cell Physiol 2011; 226:1828-42; PMID:21506114; http://dx.doi.org/10.1002/jcp.22514
  • Stoelzle S, Haythornthwaite A, Kettenhofen R, Kolossov E, Bohlen H, George M, Brüggemann A, Fertig N. Automated patch clamp on mESC-derived cardiomyocytes for cardiotoxicity prediction. J Biomol Screen 2011; 16:910-16; PMID:21775699; http://dx.doi.org/10.1177/1087057111413924
  • Schieder M, Rötzer K, Brüggemann A, Biel M, Wahl-Schott C. Planar patch clamp approach to characterize ionic currents from intact lysosomes. Sci Signal 2010; 3:pl3; PMID:21139138; http://dx.doi.org/10.1126/scisignal.3151pl3
  • Shaya D, Kreir M, Robbins RA, Wong S, Hammon J, Brüggemann A, Minor DL. Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins. Proc Natl Acad Sci USA 2011; 108:12313-18; PMID:21746903; http://dx.doi.org/10.1073/pnas.1106811108
  • Mahendran KR, Kreir M, Weingart H, Fertig N, Winterhalter M. Permeation of antibiotics through Escherichia coli OmpF and OmpC porins: screening for influx on a single-molecule level. J Biomol Screen 2010; 15:302-07; PMID:20086208; http://dx.doi.org/10.1177/1087057109357791
  • Stoelzle S, Obergrussberger A, Brüggemann A, Haarmann C, George M, Kettenhofen R, Fertig N. State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials, and High Throughput in Ion Channel Screening. Front Pharmacol 2011; 2:76; PMID:22131976; http://dx.doi.org/10.3389/fphar.2011.00076
  • Milligan CJ, Möller C. Automated planar patch-clamp. Methods Mol Biol 2013; 998:171-87; PMID:23529429; http://dx.doi.org/10.1007/978-1-62703-351-0_13
  • Hao Y, Tang J, Wang K. Development of Automated Patch Clamp Assay for Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists in Automated QPatch-16. Assay Drug Dev Technol 2015; 13:174-84; PMID:25880723; http://dx.doi.org/10.1089/adt.2014.622
  • Obergrussberger A, Haarmann C, Rinke I, Becker N, Guinot D, Brueggemann A, Stoelzle-Feix S, George M, Fertig N. Automated Patch Clamp Analysis of nAChα7 and NaV 1.7 Channels. Curr Protoc Pharmacol 2014; 65:11.13.1-11.13.48; PMID:24934604; http://dx.doi.org/10.1002/0471141755.ph1113s65
  • Kauthale RR, Dadarkar SS, Husain R, Karande VV, Gatne MM. Assessment of temperature-induced hERG channel blockade variation by drugs. J Appl Toxicol 2015; 35:799-805; PMID:25348819; http://dx.doi.org/10.1002/jat.3074
  • Papakosta M, Dalle C, Haythornthwaite A, Cao L, Stevens EB, Burgess G, Russell R, Cox PJ, Phillips SC, Grimm C. The chimeric approach reveals that differences in the TRPV1 pore domain determine species-specific sensitivity to block of heat activation. J Biol Chem 2011; 286:39663-72; PMID:21911503; http://dx.doi.org/10.1074/jbc.M111.273581
  • Milligan CJ, Li J, Sukumar P, Majeed Y, Dallas ML, English A, Emery P, Porter KE, Smith AM, McFadzean I, et al. Robotic multiwell planar patch-clamp for native and primary mammalian cells. Nat Protoc 2009; 4:244-55; PMID:19197268; http://dx.doi.org/10.1038/nprot.2008.230
  • Minetti G, Egée S, Mörsdorf D, Steffen P, Makhro A, Achilli C, Ciana A, Wang J, Bouyer G, Bernhardt I, et al. Red cell investigations: art and artefacts. Blood Rev 2013; 27:91-101; PMID:23425684; http://dx.doi.org/10.1016/j.blre.2013.02.002
  • Li J, Sukumar P, Milligan CJ, Kumar B, Ma Z, Munsch CM, Jiang L, Porter KE, Beech DJ. Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells. Circ Res 2008; 103:e97-104; PMID:18802022; http://dx.doi.org/10.1161/CIRCRESAHA.108.182931
  • Kettenhofen R, Bohlen H. Preclinical assessment of cardiac toxicity. Drug Discov Today 2008; 13:702-07; http://dx.doi.org/10.1016/j.drudis.2008.06.011
  • Möller C, Witchel H. Automated electrophysiology makes the pace for cardiac ion channel safety screening. Front Pharmacol 2011; 2:73; PMID:22131974; http://dx.doi.org/10.3389/fphar.2011.00073
  • Pierson JB, Berridge BR, Brooks MB, Dreher K, Koerner J, Schultze AE, Sarazan RD, Valentin J, Vargas HM, Pettit SD. A public-private consortium advances cardiac safety evaluation: achievements of the HESI Cardiac Safety Technical Committee. J Pharmacol Toxicol Methods 2013; 68:7-12; PMID:23567075; http://dx.doi.org/10.1016/j.vascn.2013.03.008
  • Becker N, Stoelzle S, Göpel S, Guinot D, Mumm P, Haarmann C, Malan D, Bohlen H, Kossolov E, Kettenhofen R, et al. Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system. J Pharmacol Toxicol Methods 2013; 68:82-87; PMID:23567076; http://dx.doi.org/10.1016/j.vascn.2013.03.009
  • Okada J, Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T. Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator. Science Advances 2015; 1:e1400142-e1400142; http://dx.doi.org/10.1126/sciadv.1400142
  • Haythornthwaite A, Stoelzle S, Hasler A, Kiss A, Mosbacher J, George M, Brüggemann A, Fertig N. Characterizing human ion channels in induced pluripotent stem cell-derived neurons. J Biomol Screen 2012; 17:1264-72; PMID:22923790; http://dx.doi.org/10.1177/1087057112457821
  • Slack M, Kirchhoff C, Moller C, Winkler D, Netzer R. Identification of novel Kv1.3 blockers using a fluorescent cell-based ion channel assay. J Biomol Screen 2006; 11:57-64; http://dx.doi.org/10.1177/1087057105282712
  • Solly K, Klein R, Rudd M, Holloway MK, Johnson EN, Henze D, Finley MFA. High-Throughput Screen of GluK1 Receptor Identifies Selective Inhibitors with a Variety of Kinetic Profiles Using Fluorescence and Electrophysiology Assays. J Biomol Screen 2015; 20:708-19; PMID:25700884; http://dx.doi.org/10.1177/1087057115570580
  • Xi B, Wang T, Li N, Ouyang W, Zhang W, Wu J, Xu X, Wang X, Abassi YA. Functional cardiotoxicity profiling and screening using the xCELLigence RTCA Cardio System. J Lab Autom 2011; 16:415-21; PMID:22093298; http://dx.doi.org/10.1016/j.jala.2011.09.002
  • Doerr L, Thomas U, Guinot DR, Bot CT, Stoelzle-Feix S, Beckler M, George M, Fertig N. New easy-to-use hybrid system for extracellular potential and impedance recordings. J Lab Autom 2015; 20:175-88; PMID:25532527; http://dx.doi.org/10.1177/2211068214562832
  • Abassi YA, Xi B, Li N, Ouyang W, Seiler A, Watzele M, Kettenhofen R, Bohlen H, Ehlich A, Kolossov E, et al. Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment. Br J Pharmacol 2012; 165:1424-41; PMID:21838757; http://dx.doi.org/10.1111/j.1476-5381.2011.01623.x
  • Ebersohn K, Coetzee P, Venter EH. An improved method for determining virucidal efficacy of a chemical disinfectant using an electrical impedance assay. J Virol Methods 2014; 199:25-8; PMID:24389126; http://dx.doi.org/10.1016/j.jviromet.2013.12.023
  • Hou X, Yan R, Yang C, Zhang L, Su R, Liu S, Zhang S, He W, Fang S, Cheng S, et al. A novel assay for high-throughput screening of anti-Alzheimer's disease drugs to determine their efficacy by real-time monitoring of changes in PC12 cell proliferation. Int J Mol Med 2013; 33(3):543-9; PMID:24378397; http://dx.doi.org/10.3892/ijmm.2013.1608
  • O'Carroll SJ, Kho DT, Wiltshire R, Nelson V, Rotimi O, Johnson R, Angel CE, Graham ES. Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells. J Neuroinflammation 2015; 12:131; PMID:26152369; http://dx.doi.org/10.1186/s12974-015-0346-0
  • Uesugi M, Ojima A, Taniguchi T, Miyamoto N, Sawada K. Low-density plating is sufficient to induce cardiac hypertrophy and electrical remodeling in highly purified human iPS cell-derived cardiomyocytes. J Pharmacol Toxicol Methods 2013; 69(2):177-88; PMID:24296355; http://dx.doi.org/10.1016/j.vascn.2013.11.002
  • Wagenaar DA, Pine J, Potter SM. Effective parameters for stimulation of dissociated cultures using multi-electrode arrays. J. Neurosci. Methods 2004; 138:27-37; PMID:15325108; http://dx.doi.org/10.1016/j.jneumeth.2004.03.005
  • Heidemann M, Streit J, Tscherter A. Functional regeneration of intraspinal connections in a new in vitro model. Neuroscience 2014; 262:40-52; PMID:24394955; http://dx.doi.org/10.1016/j.neuroscience.2013.12.051
  • Heuschkel MO, Fejtl M, Raggenbass M, Bertrand D, Renaud P. A three-dimensional multi-electrode array for multi-site stimulation and recording in acute brain slices. J Neurosci Methods 2002; 114:135-48; PMID:11856564
  • Spira ME, Hai A. Multi-electrode array technologies for neuroscience and cardiology. Nat Nanotechnol 2013; 8:83-94; PMID:23380931; http://dx.doi.org/10.1038/nnano.2012.265
  • Brüggemann A, Stoelzle S, George M, Behrends JC, Fertig N. Microchip technology for automated and parallel patch-clamp recording. Small 2006; 2:840-46; PMID:17193131; http://dx.doi.org/10.1002/smll.200600083