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Research Paper

Anticonvulsant mechanisms of piperine, a piperidine alkaloid

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Pages 317-323 | Received 13 Aug 2015, Accepted 05 Sep 2015, Published online: 05 Nov 2015

References

  • Ngugi AK, Bottomley C, Kleinschmidt I, Sander JW, Newton CR. Estimation of the burden of active and life-time epilepsy: a metaanalytic approach. Epilepsia 2010; 51:883-90; PMID:20067507; http://dx.doi.org/10.1111/j.1528-1167.2009.02481.x
  • Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000; 342:314-9; PMID:10660394; http://dx.doi.org/10.1056/NEJM200002033420503
  • Marson AG, Appleton R, Baker GA, Chadwick DW, Doughty J, Eaton B, Gamble C, Jacoby A, Shackley P, Smith DF, et al. A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial. Health Technol Assess 2007; 11:1-134; http://dx.doi.org/10.3310/hta11370
  • Carlini EA. Plants and the central nervous system. Pharmacol Biochem Behav 2003; 3:501-12; http://dx.doi.org/10.1016/S0091-3057(03)00112-6
  • Kumar S, Madaan R, Bansal G, Jamwal A, Sharma A. Plants and plant products with potential anticonvulsant activity – a review. Pharmacog Comm 2012; 2:3-99; http://dx.doi.org/10.5530/pc.2012.suppl1.2
  • Juvekar MR, Kulkarni MP, Juvekar AR, “Anti-stress, nootropic and anticonvulsant potential of fruit extracts of Piper longum L.” Planta Medica 2008; 74:PA244
  • Bukhari IA, Pivac N, Alhumayyd MS, Mahesar AL, Gilani AH. The analgesic and anticonvulsant effects of piperine in mice. J Physiol Pharmacol 2013 Dec; 64(6):789-94; PMID:24388894
  • da Cruz GM, Felipe CF, Scorza FA, da Costa MA, Tavares AF, Menezes ML, de Andrade GM, Leal LK, Brito GA, da Graça Naffah-Mazzacoratti M, et al. Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms. Pharmacol Biochem Behav 2013; 104:144-53; PMID:23313550; http://dx.doi.org/10.1016/j.pbb.2013.01.002
  • D'Hooge R, Pei YQ, Raes A, Lebrun P, van Bogaert PP, de Deyn PP. Anticonvulsant activity of piperine on seizures induced by excitatory amino acid receptor agonists. Arzneimittelforschung 1996; 46:557-60; PMID:8767343
  • Zaugg J, Baburin I, Strommer B, Kim HJ, Hering S, Hamburger M. HPLC-based activity profiling: discovery of piperine as a positive GABA(A) receptor modulator targeting a benzodiazepine-independent binding site. J Nat Prod 2010; 73:185-91; PMID:20085307; http://dx.doi.org/10.1021/np900656g
  • Browning RA, Smith JK, Brandon MT. Comparison of regional brain 5-HT and 5-HIAA content in flexor and extensor rats. Pharmacol Biochem Behav 1983; 18:525-8; PMID:6191344; http://dx.doi.org/10.1016/0091-3057(83)90275-7
  • Li S, Wang C, Li W, Koike K, Nikaido T. Antidepressant-like effects of piperine and its derivative, antiepilepsirine. J Asian Nat Prod Res 2007; 9:435-44
  • Pei YQ. A review of pharmacology and clinical use of piperine and its derivatives. Epilepsia 1983; 24:177-82; PMID:6832079; http://dx.doi.org/10.1111/j.1528-1157.1983.tb04877.x
  • Gasior M, Kleinrok Z, Czuczwar SJ. Influence of BAY k-8644, a calcium channel agonist, on the anticonvulsant activity of conventional anti-epileptics against electroconvulsions in mice. Neuropharmacology 1995; 34:433-8; PMID:7566475; http://dx.doi.org/10.1016/0028-3908(95)00004-P
  • Fu M, Sun ZH, Zuo HC. Neuroprotective effect of piperine on primarily cultured hippocampal neurons. Biol Pharm Bull 2010; 33:598-603; PMID:20410592; http://dx.doi.org/10.1248/bpb.33.598
  • Fozzard HA, Lee PJ, Lipkind GM. Mechanism of local anesthetic drug action on voltage-gated sodium channels. Curr Pharm Des 2005; 11:2671-86; PMID:16101448; http://dx.doi.org/10.2174/1381612054546833
  • Kauer JA, Gibson HE. Hot flash: TRPV channels in the brain. Trends Neurosci 2009; 32:215-24; PMID:19285736; http://dx.doi.org/10.1016/j.tins.2008.12.006
  • Schobel N, Radtke D, Lubbert M, Gisselmann G, Lehmann R, Cichy A, Schreiner BS, Altmuller J, Spector AC, Spehr J, et al. Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses. PLoS One 2012; 7:e48005; PMID:23144843; http://dx.doi.org/10.1371/journal.pone.0048005
  • Chavez AE, Chiu CQ, Castillo PE. TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus. Nat Neurosci 2010; 13:1511-8; PMID:21076423; http://dx.doi.org/10.1038/nn.2684
  • Gibson HE, Edwards JG, Page RS, Van Hook MJ, Kauer JA. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron 2008; 57:746-59; PMID:18341994; http://dx.doi.org/10.1016/j.neuron.2007.12.027
  • Zsombok A, Bhaskaran MD, Gao H, Derbenev AV, Smith BN. Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice. J Neurosci 2011; 31:14024-31; PMID:21957263; http://dx.doi.org/10.1523/JNEUROSCI.2081-11.2011
  • Chen CY, Li W, Qu KP, Chen CR. Piperine exerts anti-seizure effects via the TRPV1 receptor in mice. Eur J Pharmacol. 2013; 714:288-94; PMID:23911889; http://dx.doi.org/10.1016/j.ejphar.2013.07.041
  • McNamara FN, Randall A, Gunthorpe MJ. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol 2005; 144:781-90; PMID:15685214; http://dx.doi.org/10.1038/sj.bjp.0706040
  • Goel RK, Singh D, Lagunin A, Poroikov V. PASS-assisted exploration of new therapeutic potential of natural products. Med Chem Res 2011; 20: 1509-14; http://dx.doi.org/10.1007/s00044-010-9398-y
  • Chaudhary A, Das P, Mishra A, Kaur P, Singh B, Goel RK. Naturally occurring himachalenes to benzocycloheptene amino vinyl bromide derivatives: as antidepressant molecules. Mol Divers 2012; 16:357-66; PMID:22584731; http://dx.doi.org/10.1007/s11030-012-9372-3
  • Singh D, Singh B, Goel RK. Role of saponins for the anticonvulsant effect of adventitious roots of Ficusreligiosa. Pharm Biol 2012; 50:816-22; PMID:22471888; http://dx.doi.org/10.3109/13880209.2011.636057
  • Amabeoku G, Chandomba R. Strychnine-induced seizures in mice: the role of noradrenaline. Prog. Neuropsychopharmacol. Biol Psychiatry 1994; 18:753-63
  • Singh D, Goel RK. Anticonvulsant effect of Ficus religiosa: Role of serotonergic pathways. J Ethnopharmacol 2009; 123:330-4; PMID:19429380; http://dx.doi.org/10.1016/j.jep.2009.02.042
  • Kaur M, Goel RK. Anticonvulsant activity of Boerhaavia diffusa: Plausible role of calcium channel antagonism. Evid Based Complement Alternat Med 2011:310420(1-7).
  • Mishra A, Goel RK. Psychoneurochemical Investigations to Reveal Neurobiology of Memory Deficit in Epilepsy. Neurochem Res 2013; 38:2503-15; PMID:24100926; http://dx.doi.org/10.1007/s11064-013-1163-4
  • Singh D, Mishra A, Goel RK. Effect of saponin fraction from Ficus religiosa on memory deficit, and behavioral and biochemical impairments in pentylenetetrazol kindled mice. Epilepsy Behav 2013; 27:206-11; PMID:23332444; http://dx.doi.org/10.1016/j.yebeh.2012.11.004
  • Mishra A, Goel RK. Adjuvant anticholinesterase therapy for the management of epilepsy induced memory deficit: A critical preclinical study. Basic Clin Pharmacol Toxicol 2014; 115:512-7; PMID:24890882; http://dx.doi.org/10.1111/bcpt.12275
  • Beedle AM, Hamid J, Zamponi GW. Inhibition of transiently expressed low- and high-voltage-activated calcium channels by trivalent metal cations. J Membr Bio 2002; 187:225-38; http://dx.doi.org/10.1007/s00232-001-0166-2
  • Altier C, Khosravani H, Evans RM, Hameed S, Peloquin JB, Vartian BA, Chen L, Beedle AM, Ferguson SS, Mezghrani A, et al. ORL1 receptor-mediated internalization of N-type calciumchannels. Nat Neurosci 2006; 9:31-40; PMID:16311589; http://dx.doi.org/10.1038/nn1605
  • Feng ZP, Doering CJ, Winkfein RJ, Beedle AM, Spafford JD, Zamponi GW. Determinants of inhibition of transiently expressed voltage-gated calcium channels by ω-conotoxins GVIA and MVIIA. J Biol Chem 2003; 278:20171-8; PMID:12654924; http://dx.doi.org/10.1074/jbc.M300581200

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