Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4

References

• Bulbring E, Lin RC. The effect of intraluminal application of 5-hydroxytryptamine and 5-hydroxytryptophan on peristalsis; the local production of 5-HT and its release in relation to intraluminal pressure and propulsive activity. J Physiol. 1958; 140(3):381-407; PMID: 13514713
   PubMed Web of Science ®Google Scholar
• Bulbring E, Crema A. Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. Br J Pharmacol. 1958; 13(4):444-57
   PubMed Web of Science ®Google Scholar
• Bulbring E, Crema A. The release of 5-hydroxytryptamine in relation to pressure exerted on the intestinal mucosa. J Physiol. 1959; 146(1):18-28; PMID: 13655213; https://doi.org/10.1113/jphysiol.1959.sp006175
   PubMed Web of Science ®Google Scholar
• Cote F, Thevenot E, Fligny C, Fromes Y, Darmon M, Ripoche MA, Bayard E, Hanoun N, Saurini F, Lechat P, et al. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc Natl Acad Sci U S A. 2003; 100(23):13525-30; PMID: 14597720; https://doi.org/10.1073/pnas.2233056100
   PubMed Web of Science ®Google Scholar
• Kim M, Javed NH, Yu JG, Christofi F, Cooke HJ. Mechanical stimulation activates Galphaq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells. J Clin Invest. 2001; 108(7):1051-9; PMID: 11581306; https://doi.org/10.1172/JCI12467
   PubMed Web of Science ®Google Scholar
• Christofi FL. Purinergic receptors and gastrointestinal secretomotor function. Purinergic signalling. 2008; 4(3):213-36; PMID: 18604596; https://doi.org/10.1007/s11302-008-9104-4
   PubMed Web of Science ®Google Scholar
• Chin A, Svejda B, Gustafsson BI, Granlund AB, Sandvik AK, Timberlake A, Sumpio B, Pfragner R, Modlin IM, Kidd M. The role of mechanical forces and adenosine in the regulation of intestinal enterochromaffin cell serotonin secretion. American journal of physiology Gastrointestinal and liver physiology. 2012; 302(3):G397-405; PMID: 22038827; https://doi.org/10.1152/ajpgi.00087.2011
   PubMed Web of Science ®Google Scholar
• Linan-Rico A, Wunderlich JE, Grants IS, Frankel WL, Xue J, Williams KC, Harzman AE, Enneking JT, Cooke HJ, Christofi FL. Purinergic Autocrine Regulation of Mechanosensitivity and Serotonin Release in a HumanEC Model: ATP-gated P2×3 Channels inEC are Downregulated in Ulcerative Colitis. Inflamm Bowel Dis. 2013; 19(11):2366-79; PMID: 23917247; https://doi.org/10.1097/MIB.0b013e31829ecf4d
   PubMed Web of Science ®Google Scholar
• Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap PK, Grover M, Oeckler R, Gottlieb PA, Li HJ, et al. Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. J Physiol. 2016; 595(1):79-91; Epub ahead of print. https://doi.org/10.1113/JP272718
   PubMed Web of Science ®Google Scholar
• Bowman CL, Gottlieb PA, Suchyna TM, Murphy YK, Sachs F. Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon. 2007; 49(2):249-70; https://doi.org/10.1016/j.toxicon.2006.09.030
   PubMed Web of Science ®Google Scholar
• Bae C, Sachs F, Gottlieb PA. The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4. Biochemistry (Mosc). 2011; 50(29):6295-300; https://doi.org/10.1021/bi200770q
   Web of Science ®Google Scholar
• Ranade SS, Woo SH, Dubin AE, Moshourab RA, Wetzel C, Petrus M, Mathur J, Begay V, Coste B, Mainquist J, et al. Piezo2 is the major transducer of mechanical forces for touch sensation in mice. Nature. 2014; 516(7529):121-5; PMID: 25471886; https://doi.org/10.1038/nature13980
   PubMed Web of Science ®Google Scholar
• Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y, Qiu Z, Petrus M, Miyamoto T, Reddy K, Lumpkin EA, et al. Piezo2 is required for Merkel-cell mechanotransduction. Nature. 2014; 509(7502):622-6; PMID: 24717433; https://doi.org/10.1038/nature13251
   PubMed Web of Science ®Google Scholar
• Ranade SS, Qiu Z, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, et al. Piezo1, a mechanically activated ion channel, is required for vascular development in mice. Proc Natl Acad Sci U S A. 2014; 111(28):10347-52; PMID: 24958852; https://doi.org/10.1073/pnas.1409233111
   PubMed Web of Science ®Google Scholar
• Cox CD, Bae C, Ziegler L, Hartley S, Nikolova-Krstevski V, Rohde PR, Ng CA, Sachs F, Gottlieb PA, Martinac B. Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension. Nat Commun. 2016; 7:10366; PMID: 26785635; https://doi.org/10.1038/ncomms10366
   PubMed Web of Science ®Google Scholar
• Lewis AH, Grandl J. Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension. Elife. 2015; 4:e12088; https://doi.org/10.7554/eLife.12088
   PubMed Web of Science ®Google Scholar
• Syeda R, Florendo MN, Cox CD, Kefauver JM, Santos JS, Martinac B, Patapoutian A. Piezo1 Channels Are Inherently Mechanosensitive. Cell Rep. 2016; 17(7):1739-46; https://doi.org/10.1016/j.celrep.2016.10.033
   PubMed Web of Science ®Google Scholar
• Retailleau K, Duprat F, Arhatte M, Ranade SS, Peyronnet R, Martins JR, Jodar M, Moro C, Offermanns S, Feng Y, et al. Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling. Cell reports. 2015; 13(6):1161-71; https://doi.org/10.1016/j.celrep.2015.09.072
   PubMed Web of Science ®Google Scholar
• Faucherre A, Kissa K, Nargeot J, Mangoni ME, Jopling C. Piezo1 plays a role in erythrocyte volume homeostasis. Haematologica. 2014; 99(1):70-5; PMID: 23872304; https://doi.org/10.3324/haematol.2013.086090
   PubMed Web of Science ®Google Scholar
• Miyamoto T, Mochizuki T, Nakagomi H, Kira S, Watanabe M, Takayama Y, Suzuki Y, Koizumi S, Takeda M, Tominaga M. Functional Role for Piezo1 in Stretch-evoked Ca2+ Influx and ATP Release in Urothelial Cell Cultures. J Biol Chem. 2014; 289(23):16565-75; PMID: 24759099; https://doi.org/10.1074/jbc.M113.528638
   PubMed Web of Science ®Google Scholar
• Cinar E, Zhou S, DeCourcey J, Wang Y, Waugh RE, Wan J. Piezo1 regulates mechanotransductive release of ATP from human RBCs. Proc Natl Acad Sci U S A. 2015; 112(38):11783-8; PMID: 26351678
   PubMed Web of Science ®Google Scholar
• Martins P, Fakhry J, de Oliveira EC, Hunne B, Fothergill LJ, Ringuet M, Reis DD, Rehfeld JF, Callaghan B, Furness JB. Analysis of enteroendocrine cell populations in the human colon. Cell Tissue Res. 2016; [Epub ahead of print] PMID: 27844204; https://doi.org/10.1007/s00441-016-2530-7
   PubMed Web of Science ®Google Scholar
• Peyronnet R, Martins JR, Duprat F, Demolombe S, Arhatte M, Jodar M, Tauc M, Duranton C, Paulais M, Teulon J, et al. Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells. EMBO reports. 2013; 14(12):1143-8; PMID: 24157948; https://doi.org/10.1038/embor.2013.170
   PubMed Web of Science ®Google Scholar
• Slattum GM, Rosenblatt J. Tumour cell invasion: an emerging role for basal epithelial cell extrusion. Nat Rev Cancer. 2014; 14(7):495-501; PMID: 24943812; https://doi.org/10.1038/nrc3767
   PubMed Web of Science ®Google Scholar
• Bae C, Gnanasambandam R, Nicolai C, Sachs F, Gottlieb PA. Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1. Proc Natl Acad Sci U S A. 2013;110(12):E1162-8; PMID: 23487776; https://doi.org/10.1073/pnas.1219777110
   PubMed Web of Science ®Google Scholar
• Zarychanski R, Schulz VP, Houston BL, Maksimova Y, Houston DS, Smith B, Rinehart J, Gallagher PG. Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood. 2012;120(9):1908-15; PMID: 22529292; https://doi.org/10.1182/blood-2012-04-422253
   PubMed Web of Science ®Google Scholar
• Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, Dubin AE, Patapoutian A. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science. 2010;330(6000):55-60; PMID: 20813920; https://doi.org/10.1126/science.1193270
   PubMed Web of Science ®Google Scholar
• Ikeda R, Gu JG. Piezo2 channel conductance and localization domains in Merkel cells of rat whisker hair follicles. Neurosci Lett. 2014;583:210-5; PMID: 24911969; https://doi.org/10.1016/j.neulet.2014.05.055
   PubMed Web of Science ®Google Scholar
• Woo SH, Lukacs V, de Nooij JC, Zaytseva D, Criddle CR, Francisco A, Jessell TM, Wilkinson KA, Patapoutian A. Piezo2 is the principal mechanotransduction channel for proprioception. Nat Neurosci. 2015;18(12):1756-62; PMID: 26551544; https://doi.org/10.1038/nn.4162
   PubMed Web of Science ®Google Scholar
• Yang J, Zhang J, Yang H, Li K, Lei X, Xu C. The potential role of Piezo2 in the mediation of visceral sensation. Neurosci Lett. 2016;630:158-63; https://doi.org/10.1016/j.neulet.2016.07.058
   PubMed Web of Science ®Google Scholar
• Coste B, Houge G, Murray MF, Stitziel N, Bandell M, Giovanni MA, Philippakis A, Hoischen A, Riemer G, Steen U, et al. Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis. Proc Natl Acad Sci U S A. 2013;110(12):4667-72; PMID: 23487782; https://doi.org/10.1073/pnas.1221400110
   PubMed Web of Science ®Google Scholar
• Okubo M, Fujita A, Saito Y, Komaki H, Ishiyama A, Takeshita E, Kojima E, Koichihara R, Saito T, Nakagawa E, et al. A family of distal arthrogryposis type 5 due to a novel PIEZO2 mutation. Am J Med Genet A. 2015; 167A(5):1100-6. PMID: 25712306; https://doi.org/10.1002/ajmg.a.36881
   PubMed Web of Science ®Google Scholar
• Chesler AT, Szczot M, Bharucha-Goebel D, Ceko M, Donkervoort S, Laubacher C, Hayes LH, Alter K, Zampieri C, Stanley C, et al. The Role of PIEZO2 in Human Mechanosensation. The New England journal of medicine. 2016; 375(14):1355-1364; PMID: 27653382; https://doi.org/10.1056/NEJMoa1602812
   PubMed Web of Science ®Google Scholar
• Suchyna TM, Johnson JH, Hamer K, Leykam JF, Gage DA, Clemo HF, Baumgarten CM, Sachs F. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol. 2000;115(5):583-98; PMID: 10779316; https://doi.org/10.1085/jgp.115.5.583
   PubMed Web of Science ®Google Scholar
• Suchyna TM, Tape SE, Koeppe RE, Andersen OS, Sachs F, Gottlieb PA. Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature. 2004; 430(6996):235-40; PMID: 15241420; https://doi.org/10.1038/nature02743
   PubMed Web of Science ®Google Scholar
• Gottlieb PA, Sachs F. Piezo1: properties of a cation selective mechanical channel. Channels. 2012; 6(4):214-9; PMID: 22790400; https://doi.org/10.4161/chan.21050
   PubMed Web of Science ®Google Scholar
• Strege P, Beyder A, Bernard C, Crespo-Diaz R, Behfar A, Terzic A, Ackerman M, Farrugia G. Ranolazine inhibits shear sensitivity of endogenous Na (+) current and spontaneous action potentials in HL-1 cells. Channels (Austin). 2012; 6(6):457-62; PMID: 23018927; https://doi.org/10.4161/chan.22017
   PubMed Web of Science ®Google Scholar
• Saito YA, Strege PR, Tester DJ, Locke GR, 3rd, Talley NJ, Bernard CE, Rae JL, Makielski JC, Ackerman MJ, Farrugia G. Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy. Am J Physiol Gastrointest Liver Physiol. 2009; 296(2):G211-8; PMID: 19056759; https://doi.org/10.1152/ajpgi.90571.2008
   PubMed Web of Science ®Google Scholar
• Strege PR, Ou Y, Sha L, Rich A, Gibbons SJ, Szurszewski JH, Sarr MG, Farrugia G. Sodium current in human intestinal interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol. 2003; 285(6):G1111-21; PMID: 12893628; https://doi.org/10.1152/ajpgi.00152.2003
   PubMed Web of Science ®Google Scholar
• Maksimovic S, Nakatani M, Baba Y, Nelson AM, Marshall KL, Wellnitz SA, Firozi P, Woo SH, Ranade S, Patapoutian A, et al. Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors. Nature. 2014; 509(7502):617-21; PMID: 24717432; https://doi.org/10.1038/nature13250
   PubMed Web of Science ®Google Scholar
• Doihara H, Nozawa K, Kojima R, Kawabata-Shoda E, Yokoyama T, Ito H. QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells. Mol Cell Biochem. 2009; 331(1-2):239-45; PMID: 19507004; https://doi.org/10.1007/s11010-009-0165-7
   PubMed Web of Science ®Google Scholar
• Kojima R, Nozawa K, Doihara H, Keto Y, Kaku H, Yokoyama T, Itou H. Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur J Pharmacol. 2014; 723:288-93; https://doi.org/10.1016/j.ejphar.2013.11.020
   PubMed Web of Science ®Google Scholar
• Schulze A, Hartung P, Schaefer M, Hill K. Transient receptor potential ankyrin 1 (TRPA1) channel activation by the thienopyridine-type drugs ticlopidine, clopidogrel, and prasugrel. Cell Calcium. 2014; 55(4):200-7; https://doi.org/10.1016/j.ceca.2014.02.014
   PubMed Web of Science ®Google Scholar
• Bae C, Sachs F, Gottlieb PA. The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry. 2011;50(29):6295-300; PMID: 21696149; https://doi.org/10.1021/bi200770q
   PubMed Web of Science ®Google Scholar
• Wang F, Knutson K, Alcaino C, Linden DR, Gibbons SJ, Kashyap P, Grover M, Oeckler R, Gottlieb PA, Li HJ, et al. Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. J Physiol. 2016; 595(1):79-91. https://doi.org/10.1113/JP272718
   PubMed Web of Science ®Google Scholar
• Lee W, Leddy HA, Chen Y, Lee SH, Zelenski NA, McNulty AL, Wu J, Beicker KN, Coles J, Zauscher S, et al. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proc Natl Acad Sci U S A. 2014; 111(47):E5114-22. https://doi.org10.1073/pnas.1414298111
   PubMed Web of Science ®Google Scholar