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Channels Volume 11, 2017 - Issue 6
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Autocommentary

KIR channels mediate vasodilation but not sympatholysis

Christopher M. Hearon, Jr.Institute for Exercise and Environmental Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
&
Frank A. DinennoHuman Cardiovascular Physiology Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA;Center for Cardiovascular Research, Colorado State University, Fort Collins, CO, USACorrespondence[email protected]
Pages 495-496 | Received 03 Aug 2017, Accepted 04 Aug 2017, Published online: 25 Aug 2017

References

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  • Crecelius AR, Kirby BS, Hearon CM, Luckasen GJ, Larson DG, Dinenno FA. Contracting human skeletal muscle maintains the ability to blunt α1 -adrenergic vasoconstriction during KIR channel and Na(+)/K(+) -ATPase inhibition. J Physiol. 2015;593(12):2735-51. doi:10.1113/JP270461. PMID:25893955
  • Hearon CM, Kirby BS, Luckasen G, Larson D, Dinenno FA. Endothelium-dependent vasodilatory signalling modulates α1 -adrenergic vasoconstriction in contracting skeletal muscle of humans. J Physiol. 2016;594(24):7435-53. doi:10.1113/JP272829. PMID:27561916
  • Hearon CM, Richards JC, Racine ML, Luckasen GJ, Larson DG, Joyner MJ, Dinenno FA. Sympatholytic effect of intravascular ATP is independent of nitric oxide, prostaglandins, Na +/K + -ATPase and K IR channels in humans. J Physiol. 2017; 595(15):5175–5190; doi:10.1113/JP274532
  • Sonkusare SK, Dalsgaard T, Bonev AD, Nelson MT. Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators. J Physiol. 2016;594(12):3271-85. doi:10.1113/JP271652. PMID:26840527
  • Smith PD, Brett SE, Luykenaar KD, Sandow SL, Marrelli SP, Vigmond EJ, Welsh DG. KIR channels function as electrical amplifiers in rat vascular smooth muscle. J Physiol. 2008;586(4):1147-60. doi:10.1113/jphysiol.2007.145474. PMID:18063660
  • Kurjiaka DT, Segal SS. Interaction Between Conducted Vasodilation and Sympathetic Nerve Activation in Arterioles of Hamster Striated Muscle. Circ Res. 1995;76(5):885–91. doi:10.1161/01.RES.76.5.885. PMID:7729006
  • Tran CHT, Taylor MS, Plane F, Nagaraja S, Tsoukias NM, Solodushko V, Vigmond EJ, Furstenhaupt T, Brigdan M, Welsh DG. Endothelial Ca2+ wavelets and the induction of myoendothelial feedback. Am J Physiol Cell Physiol. 2012;302(8):C1226–42. doi:10.1152/ajpcell.00418.2011. PMID:22277756

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