Specific protein kinase C isoform exerts chronic inhibition on the slowly activating delayed-rectifier potassium current by affecting channel trafficking

References

• Moss AJ, Kass RS. Long QT syndrome: from channels to cardiac arrhythmias. J Clin Invest. 2005 Aug;115(8):2018–2024.
   PubMed Web of Science ®Google Scholar
• Splawski I, Shen J, Timothy KW, et al. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation. 2000 Sep 5;102(10):1178–1185.
   PubMed Web of Science ®Google Scholar
• Hegyi B, Bossuyt J, Ginsburg KS, et al. Altered repolarization reserve in failing rabbit ventricular myocytes: calcium and beta-adrenergic effects on delayed- and inward-rectifier potassium currents. Circ Arrhythm Electrophysiol. 2018 Feb;11(2):e005852.
   PubMed Web of Science ®Google Scholar
• Schwartz PJ, Priori SG, Spazzolini C, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation. 2001 Jan 2;103(1):89–95.
   PubMed Web of Science ®Google Scholar
• Wu J, Naiki N, Ding WG, et al. A molecular mechanism for adrenergic-induced long QT syndrome. J Am Coll Cardiol. 2014 Mar 4;63(8):819–827.
   PubMed Web of Science ®Google Scholar
• Fischer R, Dechend R, Gapelyuk A, et al. Angiotensin II-induced sudden arrhythmic death and electrical remodeling. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1242–53.
   PubMed Web of Science ®Google Scholar
• Yasuno S, Kuwahara K, Kinoshita H, et al. Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy. Br J Pharmacol. 2013 Dec;170(7):1384–1395.
   PubMed Web of Science ®Google Scholar
• Gou X, Wang W, Zou S, et al. Protein kinase C epsilon mediates the inhibition of angiotensin II on the slowly activating delayed-rectifier potassium current through channel phosphorylation. J Mol Cell Cardiol. 2018 Mar;116:165–174.
   PubMed Web of Science ®Google Scholar
• Dai S, Hall DD, Hell JW. Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev. 2009 Apr;89(2):411–452.
   PubMed Web of Science ®Google Scholar
• Mochly-Rosen D, Das K, Grimes KV. Protein kinase C, an elusive therapeutic target? Nat Rev Drug Discov. 2012 Dec;11(12):937–957.
   PubMed Web of Science ®Google Scholar
• Li J, Gobe G. Protein kinase C activation and its role in kidney disease. Nephrology. 2006 Oct;11(5):428–434.
   PubMed Web of Science ®Google Scholar
• Arimoto T, Takeishi Y, Takahashi H, et al. Cardiac-specific overexpression of diacylglycerol kinase zeta prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice. Circulation. 2006 Jan 3;113(1):60–66.
   PubMed Web of Science ®Google Scholar
• Parks XX, Ronzier E, OU J, et al. Fluvastatin inhibits Rab5-mediated IKs internalization caused by chronic Ca(2+)-dependent PKC activation. J Mol Cell Cardiol. 2019 Apr;129:314–325.
   PubMed Web of Science ®Google Scholar
• Liu X, Wang Y, Zhang H, et al. Different protein kinase C isoenzymes mediate inhibition of cardiac rapidly activating delayed rectifier K(+) current by different G-protein coupled receptors. Br J Pharmacol. 2017 Dec;174(23):4464–4477.
   PubMed Web of Science ®Google Scholar
• Singh RM, Cummings E, Pantos C, et al. Protein kinase C and cardiac dysfunction: a review. Heart Fail Rev. 2017 Nov;22(6):843–859.
   PubMed Web of Science ®Google Scholar
• Chen L, Wright LR, Chen CH, et al. Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7). Chem Biol. 2001 Dec;8(12):1123–1129.
   PubMedGoogle Scholar
• Harmati G, Banyasz T, Barandi L, et al. Effects of beta-adrenoceptor stimulation on delayed rectifier K(+) currents in canine ventricular cardiomyocytes. Br J Pharmacol. 2011 Feb;162(4):890–896.
   PubMed Web of Science ®Google Scholar
• Port JD, Bristow MR. Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure. J Mol Cell Cardiol. 2001 May;33(5):887–905.
   PubMed Web of Science ®Google Scholar
• Matavel A, Lopes CM. PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors. J Mol Cell Cardiol. 2009 May;46(5):704–712.
   PubMed Web of Science ®Google Scholar
• Shirai Y, Saito N. Activation mechanisms of protein kinase C: maturation, catalytic activation, and targeting. J Biochem. 2002 Nov;132(5):663–668.
   PubMed Web of Science ®Google Scholar
• OU J, Sorenson J, Jhun BS, et al. Isoform-specific dynamic translocation of PKC by alpha1-adrenoceptor stimulation in live cells. Biochem Biophys Res Commun. 2015 Sep 25;465(3):464–470.
   PubMed Web of Science ®Google Scholar
• Konopatskaya O, Poole AW. Protein kinase Calpha: disease regulator and therapeutic target. Trends Pharmacol Sci. 2010 Jan;31(1):8–14.
   PubMed Web of Science ®Google Scholar
• Ferreira JC, Brum PC, Mochly-Rosen D. betaIIPKC and epsilonPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure. J Mol Cell Cardiol. 2011 Oct;51(4):479–484.
   PubMed Web of Science ®Google Scholar
• de Git KC, de Boer TP, Vos MA, et al. Cardiac ion channel trafficking defects and drugs. Pharmacol Ther. 2013 Jul;139(1):24–31.
   PubMed Web of Science ®Google Scholar
• Seebohm G, Strutz-Seebohm N, Birkin R, et al. Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels. Circ Res. 2007 Mar 16;100(5):686–692.
   PubMed Web of Science ®Google Scholar
• Hutagalung AH, Novick PJ. Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev. 2011 Jan;91(1):119–149.
   PubMed Web of Science ®Google Scholar
• Wang T, Cheng Y, Dou Y, et al. Trafficking of an endogenous potassium channel in adult ventricular myocytes. Am J Physiol Cell Physiol. 2012 Nov 1;303(9):C963–76.
   PubMed Web of Science ®Google Scholar
• Piccini I, Fehrmann E, Frank S, et al. Adrenergic stress protection of human iPS cell-derived cardiomyocytes by Fast Kv7.1 recycling. Front physiol. 2017;8:705.
   PubMed Web of Science ®Google Scholar