1,519
Views
3
CrossRef citations to date
0
Altmetric
Research Paper

Fast desensitization of acetylcholine receptors induced by a spider toxin

ORCID Icon, , , &
Pages 507-515 | Received 01 Jun 2021, Accepted 23 Jul 2021, Published online: 10 Aug 2021

References

  • Changeux JP, Devillers-Thiery A, Galzi JL, et al. The acetylcholine receptor: a model of an allosteric membrane protein mediating intercellular communication. Ciba Found Symp. 1992;164:66–89, discussion 87-97
  • Fertuck HC, Salpeter MM. Localization of acetylcholine receptor by 125I-labeled alpha-bungarotoxin binding at mouse motor endplates. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1376–1378.
  • Wu H, Xiong WC, Mei L. To build a synapse: signaling pathways in neuromuscular junction assembly. Development. 2010 Apr;137(7):1017–1033.
  • Koneczny I, Herbst R. Myasthenia gravis: pathogenic effects of autoantibodies on neuromuscular architecture. Cells. 2019 Jul 2;8(7):671.
  • Engel AG, Sine SM. Current understanding of congenital myasthenic syndromes. Curr Opin Pharmacol. 2005 Jun;5(3):308–321.
  • Engel AG, Shen XM, Selcen D, et al. Further observations in congenital myasthenic syndromes. Ann N Y Acad Sci. 2008;1132:104–113.
  • Katz B, Thesleff S. A study of the desensitization produced by acetylcholine at the motor end-plate. J Physiol. 1957 Aug 29;138(1):63–80.
  • Elenes S, Auerbach A. Desensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels. J Physiol. 2002 Jun 1;541(Pt 2):367–383.
  • Gielen M, Corringer PJ. The dual-gate model for pentameric ligand-gated ion channels activation and desensitization. J Physiol. 2018 May 15;596(10):1873–1902.
  • Dilger JP, Brett RS. Direct measurement of the concentration- and time-dependent open probability of the nicotinic acetylcholine receptor channel. Biophys J. 1990 Apr;57(4):723–731.
  • Feltz A, Trautmann A. Desensitization at the frog neuromuscular junction: a biphasic process. J Physiol. 1982 Jan;322:257–272.
  • Naranjo D, Brehm P. Modal shifts in acetylcholine receptor channel gating confer subunit-dependent desensitization. Science. 1993 Jun 18;260(5115):1811–1814.
  • Papke D, Gonzalez-Gutierrez G, Grosman C. Desensitization of neurotransmitter-gated ion channels during high-frequency stimulation: a comparative study of Cys-loop, AMPA and purinergic receptors. J Physiol. 2011 Apr 1;589(Pt 7):1571–1585.
  • Reitstetter R, Lukas RJ, Gruener R. Dependence of nicotinic acetylcholine receptor recovery from desensitization on the duration of agonist exposure. J Pharmacol Exp Ther. 1999 May;289(2):656–660.
  • Suchyna TM, Johnson JH, Hamer K, et al. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol. 2000 May;115(5):583–598.
  • Suchyna TM, Tape SE, Koeppe RE 2nd, et al. Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature. 2004 Jul 8;430(6996):235–240.
  • Zhu S, Darbon H, Dyason K, et al. Evolutionary origin of inhibitor cystine knot peptides. FASEB J. 2003 Sep;17(12):1765–1767.
  • Posokhov YO, Gottlieb PA, Morales MJ, et al. Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers? Biophys J. 2007 Aug 15;93(4):L20–2.
  • Jung HJ, Kim PI, Lee SK, et al. Lipid membrane interaction and antimicrobial activity of GsMTx-4, an inhibitor of mechanosensitive channel. Biochem Biophys Res Commun. 2006 Feb 10;340(2):633–638.
  • Park SP, Kim BM, Koo JY, et al. A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Pain. 2008 Jul;137(1):208–217.
  • Bowman CL, Gottlieb PA, Suchyna TM, et al. Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon. 2007 Feb;49(2):249–270.
  • Fang J, Iwasa KH. Effects of tarantula toxin GsMTx4 on the membrane motor of outer hair cells. Neurosci Lett. 2006 Aug 14;404(1–2):213–216.
  • Bae C, Sachs F, Gottlieb PA. The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry. 2011 Jul 26;50(29):6295–6300.
  • Li H, Xu J, Shen ZS, et al. The neuropeptide GsMTx4 inhibits a mechanosensitive BK channel through the voltage-dependent modification specific to mechano-gating. J Biol Chem. 2019 Aug 2;294(31):11892–11909.
  • Pan NC, Ma JJ, Peng HB. Mechanosensitivity of nicotinic receptors. Pflugers Arch. 2012 Aug;464(2):193–203.
  • Anwyl R, Narahashi T. Desensitization of the acetylcholine receptor of denervated rat soleus muscle and the effect of calcium. Br J Pharmacol. 1980 May;69(1):91–98.
  • Edelstein SJ, Schaad O, Henry E, et al. A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions. Biol Cybern. 1996 Nov;75(5):361–379.
  • Jahn K, Mohammadi B, Krampfl K, et al. Deactivation and desensitization of mouse embryonic- and adult-type nicotinic receptor channel currents. Neurosci Lett. 2001 Jul 13;307(2):89–92.
  • Boyd ND. Two distinct kinetic phases of desensitization of acetylcholine receptors of clonal rat PC12 cells. J Physiol. 1987 Aug;389:45–67.
  • Sakmann B, Patlak J, Neher E. Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist. Nature. 1980 Jul 3;286(5768):71–73.
  • Shelley C, Cull-Candy SG. Desensitization and models of receptor-channel activation. J Physiol. 2010 May 1;588(Pt 9):1395–1397.
  • Bufler J, Franke C, Witzemann V, et al. Desensitization of embryonic nicotinic acetylcholine receptors expressed in xenopus oocytes. Neurosci Lett. 1993 Apr 2;152(1–2):77–80.
  • Nishizawa M, Nishizawa K. Molecular dynamics simulations of a stretch-activated channel inhibitor GsMTx4 with lipid membranes: two binding modes and effects of lipid structure. Biophys J. 2007 Jun 15;92(12):4233–4243.
  • Gnanasambandam R, Ghatak C, Yasmann A, et al. GsMTx4: mechanism of inhibiting mechanosensitive ion channels. Biophys J. 2017 Jan 10;112(1):31–45.
  • Yao J, Qin F. Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor. PLoS Biol. 2009 Feb 24;7(2):e46.