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Research Paper

Integrated analysis of Solute carrier family-2 members reveals SLC2A4 as an independent favorable prognostic biomarker for breast cancer

, , & ORCID Icon
Pages 555-568 | Received 19 Apr 2021, Accepted 24 Aug 2021, Published online: 07 Sep 2021

References

  • Schwartz L,Supuran CT,Alfarouk KO.The Warburg effect and the Hallmarks ofcancer.Anticancer Agents Med Chem.2017;17(2):164–170.
  • Tekade RK,Sun X.The Warburg effect andglucose-derived cancertheranostics.Drug Discov Today.2017;22(11):1637–1653.
  • Augustin R.The protein family of glucose transport facilitators: it’s not only about glucose after all.IUBMB Life.2010;62:315–333.
  • Thorens B,Mueckler M.Glucose transporters in the 21stCentury.Am J Physiol Endocrinol Metab.2010;298(2):E141–145.
  • Mueckler M,Thorens B.The SLC2 (GLUT) family of membranetransporters.Mol Aspects Med.2013;34(2–3):121–138.
  • Fan H,Zhou Y,Wen H,et al.Genome-wideidentification and characterization of glucose transporter (glut) genes in spotted sea bass (Lateolabrax maculatus) and their regulated hepatic expression duringshort-termstarvation.Comp Biochem Physiol Part D Genomics Proteomics.2019;30:217–229.
  • Wieman HL,Wofford JA,Rathmell JC.Cytokine stimulation promotes glucose uptake viaphosphatidylinositol-3 kinase/Akt regulation of Glut1 activity andtrafficking.Mol Biol Cell.2007;18(4):1437–1446.
  • Yuan G,Zhao Y,Wu D, et al.Mir-150up-Regulates Glut1 and increases glycolysis in osteosarcomacells.Asian Pac J Cancer Prev.2017;18:1127–1131.
  • Wei S,Fan Q,Yang L,et al.Promotion of glycolysis by HOTAIR through GLUT1 upregulation via mTORsignaling.Oncol Rep.2017;38(3):1902–1908.
  • Wu CH,Ho Y-S,Tsai C-Y,et al.In vitro and in vivo study ofphloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucosetransporter.Int J Cancer.2009;124(9):2210–2219.
  • Barron CC,Bilan PJ,Tsakiridis T, et al.Facilitative glucose transporters: implications for cancer detection, prognosis andtreatment.Metabolism.2016;65(2):124–139.
  • Van den Abbeele AD,Gatsonis C,De Vries DJ,et al.ACRIN 6665/RTOG 0132 Phase II trial of Neoadjuvant Imatinib Mesylate for operable malignant gastrointestinal stromal tumor: monitoring with18F-FDG PET and correlation with genotype and GLUT4expression.J Nucl Med.2012;53(4):567–574.
  • Zamora-León SP,Golde DW,Concha II,et al.Expression of the fructose transporter GLUT5 in human breastcancer.Proc Natl Acad Sci U S A.1996;93(5):1847–1852.
  • Rhodes DR,Yu J,Shanker K,et al.ONCOMINE: a cancer microarray database and integrateddata-miningplatform.Neoplasia.2004;6(1):1–6.
  • Chandrashekar DS,Bashel B,Balasubramanya SAH,et al.UALCAN: a portal for facilitating tumor subgroup gene expression and survivalanalyses.Neoplasia.2017;19(8):649–658.
  • Lánczky A,Nagy Á,Bottai G,et al.miRpower: aweb-tool to validatesurvival-associated miRNAs utilizing expression data from 2178 breast cancerpatients.Breast Cancer Res Treat.2016;160(3):439–446.
  • Cerami E,Gao J,Dogrusoz U,et al.The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomicsdata.Cancer Discov.2012;2(5):401–404.
  • Koch A,De Meyer T,Jeschke J, et al.MEXPRESS: visualizing expression, DNA methylation and clinical TCGAdata.BMC Genomics.2015;16(1):636.
  • Huang WY,Hsu S-D,Huang H-Y,et al.MethHC: a database of DNA methylation and gene expression in humancancer.Nucleic Acids Res.2015;43(D1):D856–861.
  • Szklarczyk D,Franceschini A,Wyder S,et al.STRING v10:protein-protein interaction networks, integrated over the tree oflife.Nucleic Acids Res.2015;43(D1):D447–452.
  • Tripathi S,Pohl M,Zhou Y,et al.Meta- and orthogonal integration of Influenza “OMICs” data defines a role for UBR4 in virus budding.Cell Host Microbe.2015;18(6):723–735.
  • Curtis C,Shah SP,Chin S-F,et al.The genomic and transcriptomic architecture of 2,000 breast tumours reveals novelsubgroups.Nature.2012;486(7403):346–352.
  • Zhao H,Langerød A,Ji Y,et al.Different gene expression patterns in invasive lobular and ductal carcinomas of thebreast.Mol Biol Cell.2004;15(6):2523–2536.
  • Finak G,Bertos N,Pepin F,et al.Stromal gene expression predicts clinical outcome in breastcancer.Nat Med.2008;14(5):518–527.
  • Wei W,Zeng H,Zheng R,et al.Cancer registration in China and its role in cancer prevention andcontrol.Lancet Oncol.2020;21(7):e342–e349.
  • Sharma S,Kelly TK,Jones PA.Epigenetics incancer.Carcinogenesis.2010;31(1):27–36.
  • Joost HG,Thorens B.The extendedGLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members(review).Mol Membr Biol.2001;18(4):247–256.
  • Wood IS,Trayhurn P.Glucose transporters (GLUT and SGLT): expanded families of sugar transportproteins.Br J Nutr.2003;89(1):3–9.
  • Huang S,Czech MP.The GLUT4 glucosetransporter.Cell Metab.2007;5(4):237–252.
  • Tozzo E,Shepherd PR,Gnudi L, et al.TransgenicGLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acidsynthesis.A J Physiol.1995;268:E956–964.
  • Tsao TS,Li J,Chang KS,et al.Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physicalactivity.FASEB J.2001;15(6):958–969.
  • Aruleba RT,Adekiya TA.Structural studies of predicted ligand binding sites and molecular docking analysis of SLC2A4 as a therapeutic target for the treatment ofcancer. Int J Mol Sci. 2018;19.https://doi.org/10.3390/ijms19020386.
  • Garrido P,Osorio FG,Morán J,et al.Loss of GLUT4 induces metabolic reprogramming and impairs viability of breast cancercells.J Cell Physiol.2015;230(1):191–198.
  • Gu CJ,Xie F,Zhang B,et al.High glucose promotesEpithelial-Mesenchymal transition of uterus endometrial cancer cells by increasingER/GLUT4-Mediated VEGFsecretion.Cell Physiol Biochem.2018;50(2):706–720.
  • Mao A,Zhou X,Liu Y, et al.KLF8 is associated with poor prognosis and regulates glycolysis by targeting GLUT4 in gastriccancer. J Cell Mol Med. 2019;23:5087–5097.
  • Kim YA,Keogh JB,Clifton PM.Probiotics, prebiotics, synbiotics and insulinsensitivity.Nutr Res Rev.2018;31(1):35–51.
  • Sadler JB,Bryant NJ,Gould GW, et al.Posttranslational modifications of GLUT4 affect its subcellular localization andtranslocation.Int J Mol Sci.2013;14(5):9963–9978.
  • Able AA,Richard AJ,Stephens JM.Loss of DBC1 (CCAR2) affects TNFα-inducedlipolysis and Glut4 gene expression in murine adipocytes.J Mol Endocrinol.2018;61(4):195–205.
  • Moraes-Vieira PM,Saghatelian A,Kahn BB.GLUT4 expression in adipocytes regulates de Novo lipogenesis and levels of a novel class of lipids with antidiabetic andanti-inflammatoryeffects.Diabetes.2016;65(7):1808–1815.
  • Kondo T,Nakamura M,Kitano S,et al.The clinical course and pathophysiological investigation of adolescent gestational diabetes insipidus: a casereport.BMC Endocr Disord.2018;18(1):4.
  • Holloszy JO.Regulation of mitochondrial biogenesis and GLUT4 expression byexercise.Compr Physiol.2011;1:921–940.
  • Koh JH,Hancock CR.AMPK and PPARβ positive feedback loop regulates endurance exercise training-mediatedGLUT4 expression in skeletal muscle. Am J Physiol Endocrinol Metab. 2019;316:E931–e939.
  • Flores-Opazo M,McGee SL,Hargreaves M.Exercise and GLUT4. Exerc Sport Sci Rev. 2020;48:110–118.
  • Balakrishnan BB,Krishnasamy K,Mayakrishnan V, et al.Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediatedoxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamideinduced diabetic rats.Biomed Pharmacothe.2019;112:108688.
  • Neisy A,Zal F,Seghatoleslam A, et al.Amelioration by quercetin of insulin resistance and uterine GLUT4 and ERα gene expression in rats with polycystic ovary syndrome (PCOS).Reprod Fertil Dev.2019;31(2):315–323.
  • Vigneri R,Goldfine ID,Frittitta L.Insulin, insulin receptors, andcancer.J Endocrinol Invest.2016;39(12):1365–1376.
  • Djiogue S,Nwabo Kamdje AH,Vecchio L,et al.Insulin resistance and cancer: the role of insulin andIGFs.Endocr Relat Cancer.2013;20(1):R1–r17.
  • Argilés JM,López-Soriano FJ.Insulin and cancer(Review).Int J Oncol.2001;18:683–687.
  • Pan K,Chlebowski RT.Insulin resistance and breast cancer incidence and mortality in postmenopausal women in the Women’s health initiative. Cancer. 2020;126:3638–3647.
  • Yee LD,Mortimer JE,Natarajan R, et al.Metabolic health, Insulin, and breast cancer: Why oncologists should care aboutInsulin.Front Endocrinol (Lausanne).2020;11:58.
  • Jeon SM,Hay N.Thedouble-edged sword of AMPK signaling in cancer and its therapeuticimplications.Arch Pharm Res.2015;38(3):346–357.
  • Hardie DG,Schaffer BE,Brunet A.AMPK: anEnergy-Sensing Pathway with Multiple Inputs andOutputs.Trends Cell Biol.2016;26(3):190–201.
  • Wang Z,Wang N,Liu P, et al.AMPK andCancer.Experientia supplementum (2012).2016;107:203–226.
  • Tang M,Zhou J,You L, et al.LIN28B/IRS1 axis is targeted bymiR-30a-5p and promotes tumor growth in colorectalcancer. J Cell Biochem. 2020; 121: 3720–3729.
  • Li R,Peng C,Zhang X,et al.Roles of Arf6 in cancer cell invasion, metastasis andproliferation.Life Sci.2017;182:80–84.
  • Riggio M,Perrone MC,Polo ML,et al.AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstreamproteins.Sci Rep.2017;7(1):44244.
  • Wang G,Fang X,Han M, et al.MicroRNA-493-5p promotes apoptosis and suppresses proliferation and invasion in liver cancer cells by targetingVAMP2.Int J Mol Med.2018;41:1740–1748.
  • Du Y,Chen Y,Wang F, et al.miR-137 plays tumor suppressor roles in gastric cancer cell lines by targeting KLF12 andMYO1C.Tumour Biol.2016;37(10):13557–13569.
  • Zhang Y,Jiang X,Deng Q,et al.Downregulation of MYO1C mediated by cepharanthine inhibitsautophagosome-lysosome fusion through blockade of theF-actinnetwork.J Exp Clin Cancer Res.2019;38(1):457.
  • Yang H,Jin L,Sun X.A thirteen‑gene set efficiently predicts the prognosis of glioblastoma.Mol Med Rep.2019;19:1613–1621.
  • Huang K, ChenS, XieR, et al.Identification of three predictors of gastric cancer progression andprognosis. FEBS Open Bio. 2020;10:1891–1899.
  • Li H,Ou L,Fan J,et al.Rab8A regulatesinsulin-stimulated GLUT4 translocation in C2C12myoblasts.FEBS Lett.2017;591(3):491–499.