DNA Damage, Glutathione, and Total Antioxidant Capacity in Anesthesia Nurses

References

• Hoerauf , K , Funk , W , Harth , M and Hobbhahn , J . 1997 . Occupational exposure to sevoflurane, halothane and nitrous oxide during paediatric anaesthesia. Waste gas exposure during paediatric anaesthesia . Anaesthesia. , 52 : 215 – 219 .
   PubMed Web of Science ®Google Scholar
• Bilban , M , Jakopin , C B and Ogrinc , D . 2005 . Cytogenetic tests performed on operating room personnel (the use of anaesthetic gases) . Int Arch Occup Environ Health. , 78 : 60 – 64 .
   PubMed Web of Science ®Google Scholar
• Chandrasekhar , M , Rekhadevi , P V and Sailaja , N . 2006 . Evaluation of genetic damage in operating room personnel exposed to anaesthetic gases . Mutagenesis. , 21 : 249 – 254 .
   PubMed Web of Science ®Google Scholar
• Sardas , S , Cuhruk , H , Karakaya , A E and Atakurt , Y . 1992 . Sister chromatid exchanges in operating room personnel . Mutat Res. , 279 : 117 – 120 .
   PubMed Web of Science ®Google Scholar
• Sardas , S , Aygün , N and Gamli , M . 1998 . Use of alkaline comet assay (single cell gel electrophoresis technique) to detect DNA damages in lymphocytes of operating room personnel occupationally exposed to anaesthetic gases . Mutat Res. , 418 : 93 – 100 .
   PubMed Web of Science ®Google Scholar
• Duthie , S J , Ma , A , Ross , M A and Collins , A R . 1996 . Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes . Cancer Res. , 56 : 1291 – 1295 .
   PubMed Web of Science ®Google Scholar
• Halliwell , B and Gutteridge , J MC . 1999 . Free Radicals in Biology and Medicine , New York : Oxford University Press .
   Google Scholar
• Koracevic , D , Koracevic , G , Djordjevic , V , Andrejevic , S and Cosic , V . 2001 . Method for the measurement of antioxidant activity in human fluids . J Clin Pathol. , 54 : 356 – 361 .
   PubMed Web of Science ®Google Scholar
• Naziroglu , M . 1999 . Protective role of intraperitoneally administered vitamin E and selenium in rats anesthetized with enflurane . Biol Trace Elem Res. , 69 : 199 – 209 .
   PubMed Web of Science ®Google Scholar
• Karakilcik , A Z , Hayat , A , Zerin , M and Cay , M . 2003 . Effects of intraperitoneally injected selenium and vitamin E in rats anaesthetized with halothane . J Trace Elem Med Biol. , 17 : 33 – 38 .
   PubMed Web of Science ®Google Scholar
• Sardas , S , Izdes , S , Ozcagli , E and Kanbak , O . 2006 . The role of antioxidant supplementation in occupational exposure to waste anaesthetic gases . Int Arch Occup Environ Health. , 80 : 154 – 159 .
   PubMed Web of Science ®Google Scholar
• Kidd , P M . 1997 . Glutathione: systemic protectant against oxidative and free radical damage . Altern Med Rev. , 2 : 155 – 176 .
   Google Scholar
• Chasseaud , L F . 1979 . The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents . Adv Cancer Res. , 29 : 175 – 274 .
   PubMedGoogle Scholar
• Altuntas , T G and Kharasch , E D . 2001 . Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro . Toxicol Appl Pharmacol. , 177 : 85 – 93 .
   PubMed Web of Science ®Google Scholar
• Singh , N P , McCoy , M T , Tice , R R and Schneider , E L . 1988 . A simple technique for quantitation of low levels of DNA damage in individual cells . Exp Cell Res. , 175 : 184 – 191 .
   PubMed Web of Science ®Google Scholar
• Beutler , E , Duron , O and Kelly , B M . 1963 . Improved method for the determination of blood glutathione . J Lab Clin Med. , 51 : 882 – 888 .
   Google Scholar
• Rozgaj , R , Kasuba , V and Perić , M . 1999 . Chromosome aberrations in operating room personnel . Am J Ind Med. , 35 : 642 – 646 .
   PubMed Web of Science ®Google Scholar
• Rozgaj , R and Kasuba , V . 2000 . Chromosome aberrations and micronucleus frequency in anaesthesiology personnel . Arh Hig Rada Toksikol. , 51 : 361 – 368 .
   PubMedGoogle Scholar
• Rozgaj , R , Kasuba , V and Jazbec , A . 2001 . Preliminary study of cytogenetic damage in personnel exposed to anaesthetic gases . Mutagenesis. , 16 : 139 – 143 .
   PubMed Web of Science ®Google Scholar
• Chang , W P , Lee , S R , Tu , J and Hseu , S . 1996 . Increased micronucleus formation in nurses with occupational nitrous oxide exposure in operating theatres . Environ Mol Mutagen. , 27 : 93 – 97 .
   PubMed Web of Science ®Google Scholar
• Lewińska , D , Stepnik , M , Krajewski , W , Arkusz , J , Stańczyk , M and Wrońska-Nofer , T . 2005 . Increased incidence of micronuclei assessed with the micronucleus assay and the fluorescence in situ hybridization (FISH) technique in peripheral blood lymphocytes of nurses exposed to nitrous oxide . Mutat Res. , 581 : 1 – 9 .
   PubMed Web of Science ®Google Scholar
• Rozgaj , R , Kasuba , V , Brozovic , G and Jazbec , A . 2009 . Genotoxic effects of anaesthetics in operating theatre personnel evaluated by the comet assay and micronucleus test . Int J Hyg Environ Health. , 212 : 11 – 17 .
   PubMed Web of Science ®Google Scholar
• Wiesner , G , Hoerauf , K , Schroegendorfer , K , Sobczynski , P , Harth , M and Ruediger , H W . 2001 . High-level, but not low-level, occupational exposure to inhaled anesthetics is associated with genotoxicity in the micronucleus assay . Anesth Analg. , 92 : 118 – 122 .
   PubMed Web of Science ®Google Scholar
• Hoerauf , K , Lierz , M and Wiesner , G . 1999 . Genetic damage in operating room personnel exposed to isoflurane and nitrous oxide . Occup Environ Med. , 56 : 433 – 437 .
   PubMed Web of Science ®Google Scholar
• Akın , A , Ugur , F , Ozkul , Y , Esmaoglu , A and Ergul , H . 2005 . Desflurane anaesthesia increases sister chromatid exchanges in human lymphocytes . Acta Anaesth Scand. , 49 : 1559 – 1561 .
   PubMed Web of Science ®Google Scholar
• Eroglu , A , Celep , F and Erciyes , N . 2006 . A comparison of sister chromatid exchanges in lymphocytes of anesthesiologists to nonanesthesiologists in the same hospital . Anesth Analg. , 102 : 1573 – 1577 .
   PubMed Web of Science ®Google Scholar
• Husum , B , Wulf , H C and Niebuhr , E . 1985 . Monitoring of sister chromatid exchanges in lymphocytes of nurse-anesthetists . Anesthesiology. , 62 : 475 – 479 .
   PubMed Web of Science ®Google Scholar
• Bozkurt , G , Memis , D and Karabogaz , G . 2002 . Genotoxicity of waste anaesthetic gases . Anaesth Intensive Care. , 30 : 597 – 602 .
   PubMed Web of Science ®Google Scholar
• Szyfter , K , Szulc , R , Mikstacki , A , Stachecki , I , Rydzanicz , M and Jałoszyński , P . 2004 . Genotoxicity of inhalation anaesthetics: DNA lesions generated by sevoflurane in vitro and in vivo . J Appl Genet. , 45 : 369 – 374 .
   PubMedGoogle Scholar
• Moller , P , Knudsen , L E , Loft , S and Wallin , H . 2000 . The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors . Cancer Epidemiol Biomarkers Prev. , 9 : 1005 – 1015 .
   PubMed Web of Science ®Google Scholar
• Hoffmann , H , Hogel , J and Speit , G . 2005 . The effect of smoking on DNA effects in the comet assay: a meta-analysis . Mutagenesis. , 20 : 455 – 466 .
   PubMed Web of Science ®Google Scholar
• Speit , G , Witton-Davies , T , Heepchantree , W , Trenz , K and Hoffmann , H . 2003 . Investigations on the effect of cigarette smoking in the comet assay . Mutat Res. , 542 : 33 – 42 .
   PubMed Web of Science ®Google Scholar
• Speit , G and Hartmann , A . 1995 . The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay) . Mutagenesis. , 10 : 555 – 559 .
   PubMed Web of Science ®Google Scholar
• Hoffmann , H , Isner , C , Hogel , J and Speit , G . 2005 . Genetic polymorphisms and the effect of cigarette smoking in the comet assay . Mutagenesis. , 20 : 359 – 364 .
   PubMed Web of Science ®Google Scholar
• Hoffmann , H and Speit , G . 2005 . Assessment of DNA damage in peripheral blood of heavy smokers with the comet assay and the micronucleus test . Mutat Res. , 581 : 105 – 114 .
   PubMed Web of Science ®Google Scholar
• Stahl , W and Sies , H . 1997 . Antioxidant defense: vitamins E and C and carotenoids . Diabetes. , 46 ( Suppl 2 ) : 14 – 18 .
   Google Scholar
• Turkan , H , Bukan , N , Sayal , A , Aydin , A and Bukan , M H . 2004 . Effects of halothane, enflurane, and isoflurane on plasma and erythrocyte antioxidant enzymes and trace elements . Biol Trace Elem Res. , 102 : 105 – 112 .
   PubMed Web of Science ®Google Scholar
• Kaymak , C , Kadioglu , E , Basar , H and Sardas , S . 2004 . Genoprotective role of vitamin E and selenium in rabbits anaesthetized with sevoflurane . Hum Exp Toxicol. , 23 : 413 – 419 .
   PubMed Web of Science ®Google Scholar
• Alleva , R , Tomasetti , M and Solenghi , M D . 2003 . Lymphocyte DNA damage precedes DNA repair or cell death after orthopaedic surgery under general anaesthesia . Mutagenesis. , 18 : 423 – 428 .
   PubMed Web of Science ®Google Scholar
• Turkan , H , Aydin , A and Sayal , A . 2005 . Effect of volatile anesthetics on oxidative stress due to occupational exposure . World J Surg. , 29 : 540 – 542 .
   PubMed Web of Science ®Google Scholar
• Wong , C H , Liu , T Z and Chye , S M . 2006 . Sevoflurane-induced oxidative stress and cellular injury in human peripheral polymorphonuclear neutrophils . Food Chem Toxicol. , 44 : 1399 – 1407 .
   PubMed Web of Science ®Google Scholar
• Dale , O and Nilsen , O G . 1984 . Glutathione and glutathione S-transferases in rat liver after inhalation of halothane and enflurane . Toxicol Lett. , 23 : 61 – 66 .
   PubMed Web of Science ®Google Scholar
• Jones , D P , Brown , L A and Sternberg , P . 1995 . Variability in glutathione-dependent detoxication in vivo and its relevance to detoxication of chemical mixtures . Toxicology. , 105 : 267 – 274 .
   PubMed Web of Science ®Google Scholar