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Research Paper

Regional variation of human pancreatic islets dimension and its impact on beta cells in Indian population

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Pages 141-151 | Received 03 Aug 2019, Accepted 21 Oct 2019, Published online: 19 Nov 2019

References

  • Nanditha A, Ma RCW, Ramachandran A, Snehalatha C, Chan JCN, Chia KS, Shaw JE, Zimmet PZ. Diabetes in asia and the pacific: implications for the global epidemic. Diabetes Care. 2016;39:472–485. doi:10.2337/dc15-1536.
  • Westermark P, Wernstedtt C, Wilander E, Hayden DW, O’brient TD, Johnsont KH. Amyloid fibrils in human insulinoma and islets of langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Nati Acad Sci USA. 1987;84:3881–3885. doi:10.1073/pnas.84.11.3881.
  • Kamata K, Mizukami H, Inaba W, Tsuboi K, Tateishi Y, Yoshida T, Yagihashi S. Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients. Amyloid. 2014;21:191–201. doi:10.3109/13506129.2014.937857.
  • Yagihashi S, Inaba W, Mizukami H. Dynamic pathology of islet endocrine cells in type 2 diabetes: β-cell growth, death, regeneration and their clinical implications. J Diabetes Investig. 2016;7:155–165. doi:10.1111/jdi.2016.7.issue-2.
  • Ehses JA, Perren A, Eppler E, Ribaux P, Pospisilik JA, Maor-Cahn R, Gueripel X, Ellingsgaard H, Schneider MKJ, Biollaz G, et al. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes. 2007;56:2356–2370. doi:10.2337/db06-1650.
  • Saito K, Nobuhisa Y, Tohbu T. Differential volumetry of A, B and D cell in the pancreatic islets of diabetic and nondiabetic subjects. Tohoku J Exp Med. 1979;129:273–283. doi:10.1620/tjem.129.273.
  • Gepts W. Pathologic anatomy of the islet cell system in juvenile diabetes mellitus. Diabetes. 1965;14:619–633. doi:10.2337/diab.14.10.619.
  • Yoon KH, Ko SH, Cho JH, Lee JM, Ahn YB, Song KH, Yoo SJ, Kang M Il, Cha BY, Lee KW, et al. Selective β-cell loss and α-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab. 2003;88:2300–2308. doi:10.1210/jc.2002-020735.
  • Rahier J, Goebbels RM, Sempoux C, Henquin JC. Pancreatic b-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab. 2008;10:32–42. doi:10.1111/j.1463-1326.2008.00969.x.
  • Henquin JC, Rahier J. Pancreatic alpha cell mass in European subjects with type 2 diabetes. Diabetologia. 2011;54:1720–1725. doi:10.1007/s00125-011-2118-4.
  • Poudel A, Fowler JL, Zielinski MC, Kilimnik G, Hara M. Stereological analyses of the whole human pancreas. Sci Rep. 2016;6:1–13. doi:10.1038/srep34049.
  • Wang X, Zielinski MC, Misawa R, Wen P, Wang TY, Wang CZ, Witkowski P, Hara M. Quantitative analysis of pancreatic polypeptide cell distribution in the human pancreas. PLoS One. 2013;8:1–7.
  • Sagar S, Rajendran K. Genetic markers in type ii diabetes mellitus among indian population-a review. Int J Curr Adv Res. 2017;6:3229–3232. doi:10.24327/IJCAR.
  • Unnikrishnan R, Anjana RM, Mohan V. Diabetes in South Asians: is the phenotype different? Diabetes. 2014;63:53–55. doi:10.2337/db13-1592.
  • Unnikrishnan R, Anjana RM, Mohan V. Diabetes mellitus and its complications in India. Nat Rev Endocrinol. 2016;12:357–370. doi:10.1038/nrendo.2016.53.
  • Sakuraba H, Mizukami H, Yagihashi N, Wada R, Hanyu C, Yagihashi S. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients. Diabetologia. 2002;45:85–96. doi:10.1007/s125-002-8248-z.
  • Campbell-Thompson ML, Montgomery EL, Foss RM, Kolheffer KM, Phipps G, Schneider L, Atkinson MA. Collection protocol for human pancreas. J Vis Exp. 2012;63:1–5.
  • Kilimnik G, Jo J, Periwal V, Zielinski MC, Hara M. Quantification of islet size and architecture. Islets. 2012;4:167–172. doi:10.4161/isl.19256.
  • Kim A, Kilimnik G, Guo C, Sung J, Jo J, Periwal V, Witkowski P, Dilorio P, Hara M. Computer-assisted large-scale visualization and quantification of pancreatic islet mass, size distribution and architecture. J Vis Exp. 2011;49:1–7.
  • Jones LC, Clark A. β-cell neogenesis in type 2 diabetes. Diabetes. 2001;50:14–15. doi:10.2337/diabetes.50.2007.S186.
  • Saisho Y, Butler AE, Manesso E, Elashoff D, Rizza RA, Butler PC. β-cell mass and turnover in humans: effects of obesity and aging. Diabetes Care. 2013;36:111–117. doi:10.2337/dc12-0421.
  • Ionescu-Tirgoviste C, Gagniuc PA, Gubceac E, Mardare L, Popescu I, Dima S, Militaru M. A 3D map of the islet routes throughout the healthy human pancreas. Sci Rep. 2015;5:1–14. doi:10.1038/srep14634.
  • Olehnik SK, Fowler JL, Avramovich G, Hara M. Quantitative analysis of intra-and inter-individual variability of human beta-cell mass. Sci Rep. 2017;7:1–7. doi:10.1038/s41598-017-16300-w.
  • Wang X, Misawa R, Zielinski MC, Cowen P, Jo J, Periwal V, Ricordi C, Khan A, Szust J, Shen J, et al. Regional differences in islet distribution in the human pancreas - preferential beta-cell loss in the head region in patients with type 2 diabetes. PLoS One. 2013;8:1–9.
  • Redecker P, Jörns A, Jahn R, Grube D. Synaptophysin immunoreactivity in the mammalian endocrine pancreas. Cell Tissue Res. 1991;264:461–467. doi:10.1007/BF00319036.
  • Kim A, Miller K, Jo J, Kilimnik G, Wojcik P, Hara M. Islet architecture: a comparative study. Islets. 2009;1:129–136. doi:10.4161/isl.1.2.9480.
  • Inaishi J, Saisho Y. Ethnic similarities and differences in the relationship between beta cell mass and diabetes. J Clin Med. 2017;6:113. doi:10.3390/jcm6120113.
  • Trimble ER, Halban PA, Wollheim CB, Renold AE. Functional differences between rat islets of ventral and dorsal pancreatic origin. J Clin Invest. 1982;69:405–413. doi:10.1172/JCI110464.
  • Trimble ER, Renold AE. Ventral and dorsal areas of rat pancreas: islet hormone content and secretion. Am J Physiol Metab. 2017;240:E422–427.
  • Leclercq-Meyer V, Marchand J, Malaisse WJ. Insulin and glucagon release from the ventral and dorsal parts of the perfused pancreas of the rat. Horm Res Paediatr. 1985;21:19–32. doi:10.1159/000180021.
  • Kilimnik G, Zhao B, Jo J, Periwal V, Witkowski P, Misawa R, Hara M. Altered islet composition and disproportionate loss of large islets in patients with type 2 diabetes. PLoS One. 2011;6:e27445. doi:10.1371/journal.pone.0027445.
  • Unger RH, Orci L. Paracrinology of islets and the paracrinopathy of diabetes. Proc Natl Acad Sci. 2010;107:16009–16012. doi:10.1073/pnas.1006639107.
  • Leahy JL, Hirsch IB, Peterson KA, Schneider D. Targeting β-cell function early in the course of therapy for type 2 diabetes mellitus. J Clin Endocrinol Metab. 2010;95:4206–4216. doi:10.1210/jc.2010-0668.
  • Inaishi J, Saisho Y, Sato S, Kou K, Murakami R, Watanabe Y, Kitago M, Kitagawa Y, Yamada T, Itoh H. Effects of obesity and diabetes on α-and β-cell mass in surgically resected human pancreas. J Clin Endocrinol Metab. 2016;101:2863–2873. doi:10.1210/jc.2016-1374.
  • Saisho Y. Obesity, type 2 diabetes and beta cell failure: an Asian perspective. J Mol Genet Med. 2014;s1. doi:10.4172/1747-0862.S1-008.

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