Curcumin protects islet cells from glucolipotoxicity by inhibiting oxidative stress and NADPH oxidase activity both in vitro and in vivo

References

• Donath MY, Storling J, Maedler K, Mandrup-Poulsen T. Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med. 2003;81:455–470.
   Google Scholar
• Sudhahar V, Okur MN, Bagi Z, O’Bryan JP, Hay N, Makino A, Patel VS, Phillips SA, Stepp D, Ushio-Fukai M, et al. Akt2 stabilizes ATP7A, a Cu transporter for SOD3, in vascular smooth muscles: novel mechanism to limit endothelial dysfunction in type2 diabetes. Arterioscler Thromb Vasc Biol. 2018;38:529–541.
   Google Scholar
• Gizaw M, Anandakumar P, Debela T. A review on the role of irisin in insulin resistance and type 2 diabetes mellitus. J Pharmacopuncture. 2017;20:235–242.
   Google Scholar
• Li YY, Wang H, Yang XX, Wu JJ, Geng HY, Kim HJ, Yang ZJ, Wang LS. LEPR gene Gln223Arg polymorphism and type 2 diabetes mellitus: a meta-analysis of 3,367 subjects. Oncotarget. 2017;8:61927–61934.
   Google Scholar
• Momin AA, Bankar MP, Bhoite GM. Association of single nucleotide polymorphisms of adiponectin gene with type 2 diabetes mellitus, and their influence on cardiovascular risk markers. Indian J Clin Biochem. 2017;32:53–60.
   Google Scholar
• Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocrinol Rev. 2008;29:351–366.
   Google Scholar
• El-Assaad W, Joly E, Barbeau A, Sladek R, Buteau J, Maestre I, Pepin E, Zhao SG, Iglesias J, Roche E, et al. Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 b-cells. Endocrinology. 2010;151:3061–3073.
   Google Scholar
• Lupi R, Dotta F, Marselli L, DelGuerra S, Masini M, Santangelo C, Patane G, Boggi U, Piro S, Anello M, et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that b-cell dea this caspase mediated, partially dependent on ceramide pathway and Bcl-2 regulated. Diabetes. 2002;51:1437–1442.
   Google Scholar
• El-Assaad W, Buteau J, Peyot ML, Nolan C, Roduit R, Hardy S, Joly E, Dbaibo G, Rosenberg L, Prentki M. Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology. 2003;144:4154–4163.
   Google Scholar
• Wang X, Elksnis A, Wikström P, Walum E, Welsh N, Carlsson PO. The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro. PLoS One. 2018;13:e0204271.
   Google Scholar
• Daiber A, Di Lisa F, Oelze M, Kröller‐Schön S, Steven S, Schulz E, Münzel T. Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function. Br J Pharmacol. 2017;174:1670–1689.
   Google Scholar
• Parascandolo A, Laukkanen MO. Carcinogenesis and reactive oxygen species signaling: interaction of the NADPH oxidase NOX1-5 and superoxide dismutase 1-3 signal transduction pathways. Antioxid Redox Sign. 2019;30:443–486.
   Google Scholar
• Skonieczna M, Hejmo T, Poterala-Hejmo A, Cieslar-Pobuda A, Buldak RJ. NADPH oxidases: insights into selected functions and mechanisms of action in cancer and stem cells. Oxid Med Cell Longev. 2017;2017:9420539.
   Google Scholar
• Zielonka J, Hardy M, Michalski R, Sikora A, Zielonka M, Cheng G, Ouari O, Podsiadły R, Kalyanaraman B. Recent developments in the probes and assays for measurement of the activity of NADPH oxidases. Cell Biochem Biophys. 2017;75:335–349.
   Google Scholar
• Salazar G. NADPH oxidases and mitochondria in vascular senescence. Int J Mol Sci. 2018;19:1327.
   Google Scholar
• Li WY, Chen BX, Chen ZJ, Gao YT, Chen Z, Liu J. Reactive oxygen species generated by NADPH oxidases promote radicle protrusion and root elongation during rice seed germination. Int J Mol Sci. 2017;18:110.
   Google Scholar
• Sun QA, Runge MS, Madamanchi NR. Oxidative stress, NADPH oxidases, and arteries. Hamostaseologie. 2016;36:77–88.
   Google Scholar
• Choi DH, Lee J. A mini-review of the NADPH oxidases in vascular dementia: correlation with NOXs and risk factors for VaD. Int J Mol Sci. 2017;18:2500.
   Google Scholar
• Li Y, Pagano PJ. Microvascular NADPH oxidase in health and disease. Free Radic Biol Med. 2017;109:33–47.
   Google Scholar
• Miyata Y, Matsuo T, Sagara Y, Ohba K, Ohyama K, Sakai H. A mini-review of reactive oxygen species in urological cancer: correlation with NADPH oxidases, angiogenesis, and apoptosis. Int J Mol Sci. 2017;18:2214.
   Google Scholar
• Fang GH, Chen SQ, Huang QY, Chen LW, Liao DS. Curcumin suppresses cardiac fibroblasts activities by regulating the proliferation and cell cycle via the inhibition of the p38 MAPK/ERK signaling pathway. Mol Med Rep. 2018;18:1433–1438.
   Google Scholar
• Zhao NJ, Liao MJ, Wu JJ, Chu KX. Curcumin suppresses Notch-1 signaling: improvements in fatty liver and insulin resistance in rats. Mol Med Rep. 2018;17:819–826.
   Google Scholar
• Zhang C, He LJ, Ye HZ, Liu DF, Zhu YB, Miao DD, Zhang SP, Chen YY, Jia YW, Shen J, et al. Nrf2 is a key factor in the reversal effect of curcumin on multidrug resistance in the HCT-8/5-Fu human colorectal cancer cell line. Mol Med Rep. 2018;18:5409–5416.
   Google Scholar
• Shang W, Zhao LJ, Dong XL, Zhao ZM, Li J, Zhang BB, Cai H. Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways. Mol Med Rep. 2016;14:3620–3626.
   Google Scholar
• Zhang LZ, Xue H, Zhao G, Qiao CX, Sun XM, Pang CJ, Zhang DL. Curcumin and resveratrol suppress dextran sulfate sodium-induced colitis in mice. Mol Med Rep. 2019;19:3053–3060.
   Google Scholar
• He Y, Yue Y, Zheng X, Zhang K, Chen SH, Du ZY. Curcumin, inflammation, and chronic diseases: how are they linked? Molecules. 2015;20:9183–9213.
   Google Scholar
• Sarkar A, De R, Mukhopadhyay AK. Curcumin as a potential therapeutic candidate for helicobacter pylori associated diseases. World J Gastroenterol. 2016;22:2736–2748.
   Google Scholar
• Swatson WS, Katoh-Kurasawa M, Shaulsky G, Alexander S. Curcumin affects gene expression and reactive oxygen species via a PKA dependent mechanism in dictyostelium discoideum. PLoS One. 2017;12:e0187562.
   Google Scholar
• Furlan V, Konc J, Bren U. Inverse molecular docking as a novel approach to study anticarcinogenic and anti-neuroinflammatory effects of curcumin. Molecules. 2018;23:3351.
   Google Scholar
• Wang LH, Chen XW, Du ZY, Li GF, Chen MY, Chen X, Liang G, Chen TK. Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics. J Exp Clin Cancer Res. 2017;36:47.
   Google Scholar
• Maiti P, Dunbar GL. Use of curcumin, a natural polyphenol for targeting molecular pathways in treating age-related neurodegenerative diseases. Int J Mol Sci. 2018;19:1637.
   Google Scholar
• Mohajeri M, Sahebkar A. Protective effects of curcumin against doxorubicin-induced toxicity and resistance: a review. Crit Rev Oncol Hematol. 2018;122:30–51.
   Google Scholar
• Santezi C, Reina BD, Dovigo LN. Curcumin-mediated photodynamic therapy for the treatment of oral infections-a review. Photodiagnosis Photodyn Ther. 2018;21:409–415.
   Google Scholar
• Hosseini A, Hosseinzadeh H. Antidotal or protective effects of curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: a review. Biomed Pharmacother. 2018;99:411–421.
   Google Scholar
• Gawde KA, Sau S, Tatiparti K, Kashaw SK, Mehrmohammadi M, Azmi AS, Iyer AK. Paclitaxel and di-fluorinated curcumin loaded in albumin nanoparticles for targeted synergistic combination therapy of ovarian and cervical cancers. Colloid Surface B. 2018;167:8–19.
   Google Scholar
• Jiang S, Han J, Li T, Xin Z, Ma Z, Di W, Hu W, Gong B, Di SY, Wang DJ, et al. Curcumin as a potential protective compound against cardiac diseases. Pharmacol Res. 2017;119:373–383.
   Google Scholar
• Zhao G, Liu Y, Yi X, Wang Y, Qiao S, Li Z, Ni J, Song ZQ. Curcumin inhibiting Th17 cell differentiation by regulating the metabotropic glutamate receptor-4 expression on dendritic cells. Int Immunopharmacol. 2017;46:80–86.
   Google Scholar
• Assis RP, Arcaro CA, Gutierres VO, Oliveira JO, Costa PI, Baviera AM, Brunetti IL. Combined effects of curcumin and lycopene or bixin in yoghurt on inhibition of LDL oxidation and increases in HDL and paraoxonase levels in streptozotocin-diabetic rats. Int J Mol Sci. 2017;18:332.
   Google Scholar
• Prasad S, Gupta SC, Tyagi AK, Aggarwal BB. Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv. 2014;32:1053–1064.
   Google Scholar
• Nguyen GT, Green ER, Mecsas J. Neutrophils to the ROScue: mechanisms of NADPH oxidase activation and bacterial resistance. Front Cell Infect Microbiol. 2017;7:373.
   Google Scholar
• Oh YS. Mechanistic insights into pancreatic beta-cell mass regulation by glucose and free fatty acids. Anat Cell Biol. 2015;48:16–24.
   Google Scholar
• Kornelius E, Li HH, Peng CH, Yang YS, Chen WJ, Chang YZ, Bai YC, Liu S, Huang CN, Lin CL. Liraglutide protects against glucolipotoxicity‐induced RIN‐m5F β‐cell apoptosis through restoration of PDX1 expression. J Cell Mol Med. 2019;23:619–629.
   Google Scholar
• Bhatti JS, Bhatti GK, Reddy PH. Mitochondrial dysfunction and oxidative stress in metabolic disorders-a step towards mitochondria based therapeutic strategies. Biochim Biophys Acta. 2017;1863:1066–1077.
   Google Scholar
• Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest. 2006;116:1802–1812.
   Google Scholar
• Robertson RP. Oxidative stress and impaired insulin secretionin type 2 diabetes. Curr Opin Pharmacol. 2006;6:615–619.
   Google Scholar
• Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H. Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes. 2003;52:581–587.
   Google Scholar
• Poitout V, Robertson RP. Mini review: secondary beta-cell failure in type 2 diabetes-a convergence of glucotoxicity and lipotoxicity. Endocrinology. 2002;143:339–342.
   Google Scholar
• Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med. 1996;20:463–466.
   Google Scholar
• Tiedge M, Lortz S, Drinkgern J, Lenzen S. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes. 1997;46:1733–1742.
   Google Scholar
• Pickering RJ, Rosado CJ, Sharma A, Buksh S, Tate M, de Haan JB. Recent novel approaches to limit oxidative stress and inflammation in diabetic complications. Clin Transl Immunology. 2018;7:e1016.
   Google Scholar
• Hadzi-Petrushev N, Bogdanov J, Krajoska J, Ilievska J, Bogdanova-Popov B, Gjorgievska E, Mitrokhin V, Sopi R, Gagov H, Kamkin A, et al. Comparative study of the antioxidant properties of monocarbonyl curcumin analogues C66 and B2BrBC in isoproteranol induced cardiac damage. Life Sci. 2018;197:10–18.
   Google Scholar
• Hayashi M, Tojo A, Shimosawa T, Fujita T. The role of adrenomedullin in the renal NADPH oxidase and (pro)renin in diabetic mice. J Diabetes Res. 2013;2013:134395.
   Google Scholar
• Holthoff JH, Woodling KA, Doerge DR, Burns ST, Hinson JA, Mayeux PR. Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite. Biochem Pharmacol. 2010;80:1260–1265.
   Google Scholar
• Kovacic P, Somanathan R. Multifaceted approach to resveratrol bioactivity: focus on antioxidant action, cell signaling and safety. Oxid Med Cell Longev. 2010;3:86–100.
   Google Scholar
• Ko HM, Joo SH, Jo JH, Park WS, Jung WY, Shin JH, Ahn HJ. Liver-wrapping, nitric oxide-releasing nanofiber downregulates cleaved caspase-3 and Bax expression on rat hepatic ischemia-reperfusion injury. Transplant Proc. 2017;49:1170–1174.
   Google Scholar