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Articles

Impact of Zinc Supplementation on the Clinical Outcomes of Patients with Severe Head Trauma: A Double-Blind Randomized Clinical Trial

, MSc, , MSc, , MD, , MD, DSc, , PhD & , MD, PhD

References

  • Adamo AM, Oteiza PI. Zinc deficiency and neurodevelopment: the case of neurons. Biofactors. 2010;36(2):117–124.
  • Agarwal A, Khanna P, Baidya DK, Arora MK. Trace elements in critical illness. J Endocrinol Metab. 2011;1(2):57–63.
  • Bao B, Prasad AS, Beck FW, Fitzgerald JT, Snell D, Bao GW, et al. Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. Am J clin nutr. 2010;91(6):1634–1641.
  • Bonaventura P, Benedetti G, Albarède F, Miossec P. Zinc and its role in immunity and inflammation. Autoimmunity Rev. 2015;14(4):277–285.
  • Cander B, Dundar ZD, Gul M, Girisgin S. Prognostic value of serum zinc levels in critically ill patients. J Crit Care. 2011;26(1):42–46.
  • Chasapis CT, Loutsidou AC, Spiliopoulou CA, Stefanidou ME. Zinc and human health: an update. Arch Toxicol. 2011:1–14. Epub ahead of print. doi: 10.1007/s00204-011-0775-1.
  • Cope EC, Morris DR, Levenson CW. Improving treatments and outcomes: an emerging role for zinc in traumatic brain injury. Nutrit Rev. 2012;70(7):410–413.
  • Cope EC, Morris DR, Scrimgeour AG, Levenson CW. Use of zinc as a treatment for traumatic brain injury in the rat effects on cognitive and behavioral outcomes. Neurorehabil Neural Repair. 2012;26(7):907–913.
  • Corniola RS, Tassabehji NM, Hare J, Sharma G, Levenson CW. Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms. Brain Res. 2008;1237:52–61.
  • Dardenne M. Zinc and immune function. European J Clin Nutr. 2002;56(3):S20–2S3.
  • Foster M, Samman S. Zinc and regulation of inflammatory cytokines: implications for cardiometabolic disease. Nutrients. 2012;4(7):676–694.
  • Gerber LM, Chiu Y-L, Carney N, Härtl R, Ghajar J. Marked reduction in mortality in patients with severe traumatic brain injury: clinical article. J Neurosurg. 2013;119(6):1583–1590.
  • Ghashut RA, McMillan DC, Kinsella J, Vasilaki AT, Talwar D, Duncan A. The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin. Clin Nutr. 2016;35(2):381–387.
  • Gülcher SS, Bruins NA, Kingma WP, Boerma EC. Elevated C-reactive protein levels at ICU discharge as a predictor of ICU outcome: a retrospective cohort study. Ann Intensive Care. 2016;6(1):1–8.
  • Haase H, Rink L. Zinc signals and immune function. Biofactors. 2014;40(1):27–40.
  • Hancock SM, Bush AI, Adlard PA. The clinical implications of impaired zinc signaling in the brain. In: T. Fukada and T. Kambe (Eds.), Zinc signals in cellular functions and disorders. Tokyo, Japan: Springer Japan, 2014.
  • Hennig B, Wang Y, Ramasamy S, McClain CJ. Zinc protects against tumor necrosis factor-induced disruption of porcine endothelial cell monolayer integrity. J Nutr. 1993;123(6):1003–1009.
  • Heyland DK, Jones N, Cvijanovich NZ, Wong H. Zinc supplementation in critically ill patients: a key pharmaconutrient? J Parenteral Enteral Nutr. 2008;32(5):509–519.
  • Knoell DL, Julian MW, Bao S, Besecker B, Macre JE, Leikauf GD, et al. Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis. Crit Care Med. 2009;37(4):1380–1388.
  • Levenson CW. Zinc supplementation: neuroprotective or neurotoxic? Nutr Rev. 2005;63(4):122–125.
  • Livingstone C. Zinc: physiology, deficiency, and parenteral nutrition. Nutr Clin Pract. 2015;30(3):371–382.
  • Lobo SM, Lobo FR, Bota DP, Lopes-Ferreira F, Soliman HM, Mélot C, et al. C-reactive protein levels correlate with mortality and organ failure in critically ill patients. CHEST J. 2003;123(6):2043–2049.
  • MacDonald RS. The role of zinc in growth and cell proliferation. J Nutr. 2000;130(5):1500S–1508S.
  • Mahan LK, Escott-Stump S, Raymond JL. Krause's food & the nutrition care process. St. Louis, MO: Elsevier, 2013.
  • Marshall LF, Gautille T, Klauber MR, Eisenberg HM, Jane JA, Luerssen TG, et al. The outcome of severe closed head injury. Special Supplements. 1991;75(1S):S28–S36.
  • McClain CJ, Boosalis M, Hennig B. Zinc and the stress response. Scand J Work Environ Health. 1993;19(132).
  • McClain CJ, Twyman DL, Ott LG, Rapp RP, Tibbs PA, Norton JA, et al. Serum and urine zinc response in head-injured patients. J Neurosurg. 1986;64(2):224–230.
  • Ostad Rahimi A. Effect of zinc supplementation on the recovery of patients with head trauma. Tabriz Medical University. 2009;1(31):61–65.
  • Prasad AS. Zinc in human health: effect of zinc on immune cells. Mol Med. 2008;14(5/6):353–357.
  • Rau B, Steinbach G, Baumgart K, Gansauge F, Grünert A, Beger HG. Serum amyloid A versus C-reactive protein in acute pancreatitis: clinical value of an alternative acute-phase reactant. Crit Care Med. 2000;28(3):736–742.
  • Song Y, Leonard SW, Traber MG, Ho E. Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats. J Nutr. 2009;139(9):1626–1631.
  • Xu G Hu B, Chen G, Yu X, Luo J, Lv J, et al. Analysis of blood trace elements and biochemical indexes levels in severe craniocerebral trauma adults with Glasgow Coma Scale and Injury Severity Score. Biol Trace Elem Res. 2015;164(2):192—197.
  • Yamasaki S, Sakata-Sogawa K, Hasegawa A, Suzuki T, Kabu K, Sato E, et al. Zinc is a novel intracellular second messenger. J Cell Biol. 2007;177(4):637–645.
  • Yeiser EC, Vanlandingham JW, Levenson CW. Moderate zinc deficiency increases cell death after brain injury in the rat. Nutr Neurosci. 2002;5(5):345–352.
  • Young B, Ott L, Kasarskis E, Rapp R, Moles K, Dempsey RJ, et al. Zinc supplementation is associated with improved neurologic recovery rate and visceral protein levels of patients with severe closed head injury. J Neurotrauma. 1996;13(1):25–34.

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