969
Views
47
CrossRef citations to date
0
Altmetric
Review

New Findings on Biological Actions and Clinical Applications of Royal Jelly: A Review

, PhD, , MD & , MSc

References

  • Abdelatif M, Yakoot M, Etmaan M. 2008. Safety and efficacy of a new honey ointment on diabetic foot ulcers: a prospective pilot study. J Wound Care. 17(3):108–110.
  • Abdel-Hafez SMN, Rifaai RA, Abdelzaher WY. 2017. Possible protective effect of royal jelly against cyclophosphamide induced prostatic damage in male albino rats; a biochemical, histological and immuno-histo-chemical study. Biomed Pharmacother. 90:15–23.
  • Abdelhafiz AT, Muhamad JA. 2008. Midcycle pericoital intravaginal bee honey and royal jelly for male factor infertility. Int J Gynecol Obstet. 101(2):146–149.
  • Amirshahi T, Najafi G, Nejati V. 2014. Protective effect of royal jelly on fertility and biochemical parameters in bleomycin-induced male rats. Iran J Reprod Med. 12(3):209–216.
  • Bachanová K, Klaudiny J, Kopernicky J, Simúth J. 2002. Identification of honeybee peptide active against Paenibacillus larvae larvae through bacterial growth-inhibition assay on polyacrylamide gel. Apidologie. 33:259–69.
  • Bărnuţiu LI, Mărghitaş LA, Dezmirean DS, Mihai CM, Bobiş O. 2011. Chemical composition and antimicrobial activity of royal jelly-review. Anim Sci Biotechnol. 44(2):67–72.
  • Bilikova K, Hanes J, Nordhoff E, Saenger W, Klaudiny J, Simuth J. 2002. Apisimin, a new serine-valine-rich peptide from honeybee (Apis mellifera L.) Royal jelly: purification and molecular characterization. FEBS Lett. 528:125–129.
  • Bílikova K, Huang SC, Lin IP, Šimuth J, Peng CC. 2015. Structure and antimicrobial activity relationship of royalisin, an antimicrobial peptide from royal jelly of Apis mellifera. Peptides. 68:190–196.
  • Bíliková K, Wu G, Šimúth J. 2001. Isolation of a peptide fraction from honeybee royal jelly as a potential antifoulbrood factor. Apidologie. 32:275–283.
  • Bincoletto C, Eberlin S, Figueiredo CA, Luengo MB, Queiroz ML. 2005. Effects produced by royal jelly on haematopoiesis: relation with host resistance against Ehrlich ascites tumour challenge. Int immunopharmacol. 5:679–688.
  • Boukraâ L, Niar A, Benbarek H, Benhanifia M. 2008. Additive action of royal jelly and honey against Staphylococcus aureus. J Med Food. 11:190–192.
  • Çavuşoğlu K, Yapar K, Yalçin E. 2009. Royal jelly (honey bee) is a potential antioxidant against cadmium-induced genotoxicity and oxidative stress in albino mice. J Med Food. 12:1286–1292.
  • Cemek M, Aymelek F, Büyükokuroğlu ME, Karaca T, Büyükben A, Yilmaz F. 2010. Protective potential of royal jelly against carbon tetrachloride induced-toxicity and changes in the serum sialic acid levels. Food Chem Toxicol. 48:2827–2832.
  • Chan QW, Melathopoulos AP, Pernal SF, Foster LJ. 2009. The innate immune and systemic response in honey bees to a bacterial pathogen, Paenibacillus larvae. BMC Genomics. 10:387.
  • Chiu HF, Chen BK, Lu YY, Han YC, Shen YC, Venkatakrishnan K, Golovinskaia O, Wang CK. 2017. Hypocholesterolemic efficacy of royal jelly in healthy mild hypercholesterolemic adults. Pharm Biol. 55:497–502.
  • Chu X, Filali M, Stanic B, Takapoo M, Sheehan A, Bhalla R, Lamb FS, Miller FJ Jr. 2011. A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. Arterioscler Thromb Vasc Biol. 31:345–351.
  • Cihan YB, Ozturk A, Gokalp SS. 2013. Protective role of royal jelly against radiation-induced oxidative stress in rats. Int J Hematol Oncol. 26:79–87.
  • Daemen M, Lombardi D, Bosman F, Schwartz SM. 1991. Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall. Circ Res. 68:450–456.
  • Devlin AM, Clark JS, Reid JL, Dominiczak AF. 2000. DNA synthesis and apoptosis in smooth muscle cells from a model of genetic hypertension. Hypertension. 36:110–115.
  • Dzopalic T, Vucevic D, Tomic S, Djokic J, Chinou I, Colic M. 2011. 3, 10-Dihydroxy-decanoic acid, isolated from royal jelly, stimulates Th1 polarising capability of human monocyte-derived dendritic cells. Food Chem. 126:1211–1217.
  • El-Gayar MH, Aboshanab KM, Aboulwafa MM, Hassouna NA. 2016. Antivirulence and wound healing effects of royal jelly and garlic extract for the control of MRSA skin infections. Wound Med. 13;18–27.
  • Elnagar SA. 2010. Royal jelly counteracts bucks' “summer infertility”. Anim Reprod Sci. 121:174–180.
  • El-Nekeety AA, El-Kholy W, Abbas NF, Ebaid A, Amra HA, Abdel-Wahhab MA. 2007. Efficacy of royal jelly against the oxidative stress of fumonisin in rats. Toxicon. 50:256–269.
  • Erem C, Deger O, Ovali E, Barlak Y. 2006. The effects of royal jelly on autoimmunity in Graves' disease. Endocrine. 30:175–183.
  • Eshraghi S, Seifollahi F. 2003. Antibacterial effects of royal jelly on different strains of bacteria. Iran J Publ Health. 32:25–30.
  • Eshtiyaghi M, Deldar H, Pirsaraei ZA, Shohreh B. 2016. Royal jelly may improve the metabolism of glucose and redox state of ovine oocytes matured in vitro and embryonic development following in vitro fertilization. Theriogenology. 86:2210–2221.
  • Feng M, Fang Y, Han B, Xu X, Fan P, Hao Y, Qi Y, Hu H, Huo X, Meng L, et al. 2015. In-depth N-Glycosylation reveals species-specific modifications and functions of the royal jelly protein from western (Apis mellifera) and eastern honeybees (Apis cerana). J Proteome Res. 14:5327–5340.
  • Fontana R, Mendes MA, De Souza BM, Konno K, César LMM, Malaspina O, Palma MS. 2004. Jelleines: a family of antimicrobial peptides from the royal jelly of honeybees (Apis mellifera). Peptides. 25:919–928.
  • Fratini F, Cilia G, Mancini S, Felicioli A. 2016. Royal jelly: an ancient remedy with remarkable antibacterial properties. Microbiol Res. 192:130–141.
  • Fujii A, Kobayashi S, Kuboyama N, Furukawa Y, Kaneko Y, Ishihama S, Yamamoto H, Tamura T. 1990. Augmentation of wound healing by royal jelly (RJ) in streptozotocin-diabetic rats. Japan J Pharmacol. 53:331–337.
  • Fujita T, Kozuka-Hata H, Ao-Kondo H, Kunieda T, Oyama M, Kubo T. 2012. Proteomic analysis of the royal jelly and characterization of the functions of its derivation glands in the honeybee. J Proteome Res. 12(1):404–411.
  • Fujiwara S, Imai J, Fujiwara M, Yaeshima T, Kawashima T, Kobayashi K. 1990. A potent antibacterial protein in royal jelly. Purification and determination of the primary structure of royalisin. J Bio Chem. 265:11333–11337.
  • García M, Finola M, Marioli J. 2010. Antibacterial activity of royal jelly against bacteria capable of infecting cutaneous wounds. J Api Prod Api Med Sci. 2:93–99.
  • Genç M, Aslan A. 1999. Determination of trans-10-hydroxy-2-decenoic acid content in pure royal jelly and royal jelly products by column liquid chromatography. J Chromatogr A. 839:265–268.
  • Ghanbari E, Nejati V, Azadbakht M. 2015. Protective effect of royal jelly against renal damage in streptozotocin induced diabetic rats. Iran J Toxicol. 9:1258–1263.
  • Ghanbari E, Nejati V, Khazaei M. 2016a. Antioxidant and protective effects of royal jelly on histopathological changes in testis of diabetic rats. Int J Reprod Biomed. 14:519.
  • Ghanbari E, Nejati V, Khazaei M. 2016b. Improvement in serum biochemical alterations and oxidative stress of liver and pancreas following use of royal jelly in streptozotocin-induced diabetic rats. Cell J (Yakhteh). 18:362.
  • Ghanbari E, Nejati V, Najafi G, Khazaei M, Babaei M. 2015. Study on the effect of royal jelly on reproductive parameters in streptozotocin-induced diabetic rats. Int J Fertil Steril. 9:113–120.
  • Gimenez-Diaz C, Emsen B, Emsen E, Kutluca M, Koycegiz F. 2012. Improved reproductive response of sheep in intrauterine insemination program with the use of royal jelly. Afri J Biotechnol. 11:12518–12521.
  • Guo H, Kouzuma Y, Yonekura M. 2009. Structures and properties of antioxidative peptides derived from royal jelly protein. Food Chem. 113:238–245.
  • Han B, Fang Y, Feng M, Lu X, Huo X, Meng L, Wu B, Li J. 2014. In-depth phosphoproteomic analysis of royal jelly derived from western and eastern honeybee species. J Proteome Res. 13:5928–5943.
  • Hang G, Ekusa A, Koji I, Yonekura M, Takahata Y, Morimatsu F. 2008. Royal jelly peptides inhibit lipid peroxidation in vitro and in vivo. J Nutr Sci Vitaminol. 54:191–195.
  • Hang G, Saiga A, Miyazawa I, Shibata M, Takahata Y, Morimatsu F. 2007. Royal jelly supplementation improves lipoprotein metabolism in humans. J Nutr Sci Vitaminol. 53:345–348.
  • Hattori N, Nomoto H, Fukumitsu H, Mishima S, Furukawa S. 2007a. AMP N1-oxide potentiates astrogenesis by cultured neural stem/progenitor cells through STAT3 activation. Biomed Res. 28:295–299.
  • Hattori N, Nomoto H, Fukumitsu H, Mishima S, Furukawa S. 2007b. Royal jelly-induced neurite outgrowth from rat pheochromocytoma PC12 cells requires integrin signal independent of activation of extracellular signalregulated kinases. Biomed Res. 28:139–146.
  • Hattori N, Nomoto H, Fukumitsu H, Mishima S, Furukawa S. 2007c. Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro. Biomed Res 28:261–266.
  • Hattori N, Nomoto H, Fukumitsu H, Mishima S, Furukawa S. 2010. AMP N1-oxide, a unique compound of royal jelly, induces neurite outgrowth from pc12 vells via signaling by protein kinase A independent of that by mitogen-activated protein kinase. Evid Based Complement Alternat Med. 7:63–68.
  • Hattori N, Nomoto H, Mishima S, Inagaki S, Furukawa S. 2006. Identification of AMP N1-oxide in royal jelly as a component neurotrophic toward cultured rat pheochromocytoma PC12 cells. Biosci Biotechnol Biochem. 70:897–906.
  • Hattori N, Ohta S, Sakamoto T, Mishima S, Furukawa S. 2010. Royal jelly facilitates restoration of the cognitive ability in trimethyltin-intoxicated mice. Evid Based Complement Alternat Med. 2011.165968. doi:10.1093/ecam/nep029.
  • Hidaka S, Okamoto Y, Uchiyama S, Nakatsuma A, Hashimoto K, Ohnishi ST, Yamaguchi M. 2006. Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model. Evid Based Complement Alternat Med. 3:339–348.
  • Inoue S-i, Koya-Miyata S, Ushio S, Iwaki K, Ikeda M, Kurimoto M. 2003. Royal jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage. Exp Gerontol. 38:965–969.
  • Isidorov V, Bakier S, Grzech I. 2012. Gas chromatographic–mass spectrometric investigation of volatile and extractable compounds of crude royal jelly. J Chromatogr B. 885:109–116.
  • Izuta H, Chikaraishi Y, Shimazawa M, Mishima S, Hara H. 2009. 10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells. Evid Based Complement Alternat Med. 6:489–494.
  • Kajimoto O, Maruyama H, Yoshida C, Araki Y, Mishima S, Sakamoto A, Kajimoto Y. 2005. Antihypertensive effects and safety of drink containing protease-treated royal jelly in subjects with high-normal or mild hypertension. Health Sci. 21:229.
  • Kaku M, Rocabado JMR, Kitami M, Ida T, Uoshima K. 2014. Royal jelly affects collagen crosslinking in bone of ovariectomized rats. J Funct Foods. 7:398–406.
  • Kamakura M. 2011. Royalactin induces queen differentiation in honeybees. Nature. 473:478–483.
  • Kanbur M, Eraslan G, Beyaz L, Silici S, Liman BC, Altınordulu Ş, Atasever A. 2009. The effects of royal jelly on liver damage induced by paracetamol in mice. Exp Toxicol Pathol. 61:123–132.
  • Karaca T, Bayiroglu F, Yoruk M, Kaya S, Uslu S, Comba B, Mis L. 2010. Effect of royal jelly on experimental colitis induced by acetic acid and alteration of mast cell distribution in the colon of rats. Eur J Histochem. 54:35.
  • Karaca T, Demirtaş S, Karaboğa İ, Ayvaz S. 2015. Protective effects of royal jelly against testicular damage in streptozotocin-induced diabetic rats. Turk J Med Sci. 45:27–32.
  • Karaca T, Şimşek N, Uslu S, Kalkan Y, Can I, Kara A, Yörük M. 2012. The effect of royal jelly on CD3+, CD5+, CD45+ T-cell and CD68+ cell distribution in the colon of rats with acetic acid-induced colitis. Allergol Immunopathol. 40:357–361.
  • Karadeniz A, Simsek N, Karakus E, Yildirim S, Kara A, Can I, Kisa F, Emre H, Turkeli M. 2011. Royal jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treated with cisplatin. Oxid Med Cell Longev. 2011:981793. doi:10.1155/2011/981793.
  • Kashima Y, Kanematsu S, Asai S, Kusada M, Watanabe S, Kawashima T, Nakamura T, Shimada M, Goto T, Nagaoka S. 2014. Identification of a novel hypocholesterolemic protein, major royal jelly protein 1, derived from royal jelly. PloS One. 9(8):e105073. doi:10.1371/journal.pone.0105073.
  • Khoshpey B, Djazayeri S, Amiri F, Malek M, Hosseini AF, Hosseini S, Shidfar S, Shidfar F. 2016. Effect of royal jelly intake on serum glucose, apolipoprotein AI (ApoA-I), apolipoprotein B (ApoB) and ApoB/ApoA-I ratios in patients with type 2 diabetes: a randomized, double-blind clinical trial study. Can J Diabetes. 40(4):324–328.
  • Kim BY, Jin BR. 2015. Apolipophorin III from honeybees (Apis cerana) exhibits antibacterial activity. Comparative biochemistry and physiology part B. Biochem Mol Biol. 182:6–13.
  • Kim J, Kim Y, Yun H, Park H, Kim SY, Lee KG, Han SM, Cho Y. 2010. Royal jelly enhances migration of human dermal fibroblasts and alters the levels of cholesterol and sphinganine in an in vitro wound healing model. Nutr Res Pract. 4:362–368.
  • Kim J, Zhang L, Peppel K, Wu J-H, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ. 2008. β-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. Circ Res. 103:70–79.
  • Kimura Y. 2008. Antitumor and antimetastatic actions of various natural products. Stud Nat Prod Chem. 34:35–76.
  • Kitahara T, Sato N, Ohya Y, Shinta H, Hori K. 1995. The inhibitory effect of ω-hydroxy acids in royal jelly extract on sebaceous gland lipogenesis. J Dermatol Sci. 10:75.
  • Kohguchi M, Inoue SI, Ushio S, Iwaki K, Ikeda M, Kurimoto M. 2007. Effect of royal jelly diet on the testicular function of hamsters. Food Sci Technol Res. 10:420–423.
  • Kohno K, Okamoto I, Norie A, Iwaki K, Ikeda M, Kurimoto M. 2004. Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages. Biosci Biotechnol Biochem. 68:138–145.
  • Kotha J, Zhang C, Longhurst CM, Lu Y, Jacobs J, Cheng Y, Jennings LK. 2009. Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia. Atherosclerosis. 203:377–386.
  • Kridli R, Al-Khetib S. 2006. Reproductive responses in ewes treated with eCG or increasing doses of royal jelly. Anim Reprod Sci. 92:75–85.
  • Kumashiro N, Tamura Y, Uchida T, Ogihara T, Fujitani Y, Hirose T, Mochizuki, H., Kawamori, R., Watada, H. 2008. Impact of oxidative stress and peroxisome proliferator–activated receptor γ coactivator-1α in hepatic insulin resistance. Diabetes. 57:2083–2091.
  • Lambrinoudaki I, Augoulea A, Rizos D, Politi M, Tsoltos N, Moros M, Chinou I, Graikou K, Kouskouni E, Kambani S, et al. 2016. Greek-origin royal jelly improves the lipid profile of postmenopausal women. Gynecol Endocrinol. 32(10):835–839.
  • Lees P, Aliabadi FS. 2002. Rational dosing of antimicrobial drugs: animals versus humans. Int J Antimicrob Agents. 19:269–284.
  • Leung R, Ho A, Chan J, Choy D, Lai C. 1997. Royal jelly consumption and hypersensitivity in the community. Clin Exp Allergy. 27:333–336.
  • Manfredi R, Chiodo F. 2000. The effects of alternative treatments for HIV disease on recommended pharmacological regimens. Int J Antimicrob Agents. 13:281–285.
  • Mannoor M, Shimabukuro I, Tsukamotoa M, Watanabe H, Yamaguchi K, Sato Y. 2009. Honeybee royal jelly inhibits autoimmunity in SLE-prone NZB×NZW F1 mice. Lupus. 18:44–52.
  • Mihajlovic D, Vucevic D, Chinou I, Colic M. 2014. Royal jelly fatty acids modulate proliferation and cytokine production by human peripheral blood mononuclear cells. Eur Food Res Technol. 238:881–887.
  • Minami A, Matsushita H, Ieno D, Matsuda Y, Horii Y, Ishii A, Takahashi T, Kanazawa H, Wakatsuki A, Suzuki T. 2016. Improvement of neurological disorders in postmenopausal model rats by administration of royal jelly. Climacteric. 19(6): 568–573.
  • Mishima S, Miyata T, Suzuki KM, Araki Y, Akao YYI. 2005. Estrogenic effects of royal jelly. J Tradit Med. 22:171–175.
  • Mishima S, Suzuki KM, Isohama Y, Kuratsu N, Araki Y, Inoue M, Miyata T. 2005. Royal jelly has estrogenic effects in vitro and in vivo. J Ethnopharmacol. 101:215–220.
  • Moselhy W, Fawzy A, Kamel A. 2013. An evaluation of the potent antimicrobial effects and unsaponifiable matter analysis of the royal jelly. Life Sci J. 2:290–296.
  • Münstedt K, Bargello M, Hauenschild A. 2009. Royal jelly reduces the serum glucose levels in healthy subjects. J Med Food. 12:1170–1172.
  • Nagai T, Inoue R. 2004. Preparation and the functional properties of water extract and alkaline extract of royal jelly. Food chem. 84:181–186.
  • Nakajima Y, Tsuruma K, Shimazawa M, Mishima S, Hara H. 2009. Comparison of bee products based on assays of antioxidant capacities. BMC Complement Altern Med. 26:9(4). doi: 10.1186/1472-6882-9-4.
  • Nakaya M, Sasaki K, Yukiyoshi A, Tachibana H, Yamada K. 2007. Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells. Biosci Biotechnol Biochem. 71:253–255.
  • Nieto N, Torres MI, Ríos A, Gil A. 2002. Dietary polyunsaturated fatty acids improve histological and biochemical alterations in rats with experimental ulcerative colitis. J Nutr. 132:11–19.
  • Oka H, Emori Y, Kobayashi N, Hayashi Y, Nomoto K. 2001. Suppression of allergic reactions by royal jelly in association with the restoration of macrophage function and the improvement of Th1/Th2 cell responses. Int Immunopharmacol. 1:521–532.
  • Okamoto I, Taniguchi Y, Kunikata T, Kohno K, Iwaki K, Ikeda M, Kurimoto M. 2003. Major royal jelly protein 3 modulates immune responses in vitro and in vivo. Life Sci. 73:2029–2045.
  • Orsolic N, Terzic S, Sver L, Basic I. 2005. Honey-bee products in prevention and/or therapy of murine transplantable tumours. J Sci Food Agric. 85:363–370.
  • Pan Q, Pan H, Lou H, Xu Y, Tian L. 2013. Inhibition of the angiogenesis and growth of aloin in human colorectal cancer in vitro and in vivo. Cancer Cell Int. 13:69.
  • Park HM, Cho MH, Cho Y, Kim SY. 2012. Royal jelly increases collagen production in rat skin after ovariectomy. J Med Food. 15:568–575.
  • Pourmoradian S, Mahdavi R, Mobasseri M, Faramarzi E, Mobasseri M. 2014. Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: a randomized clinical trial. Chin J Integr Med. 20:347–352.
  • Premratanachai P, Chanchao C. 2014. Review of the anticancer activities of bee products. Asian Pac J Trop Biomed. 4:337–344.
  • Ramadan MF, Al-Ghamdi A. 2012. Bioactive compounds and health-promoting properties of royal jelly: a review. J Funct Foods. 4:39–52.
  • Rösen P, Osmers A. 2006. Oxidative stress in young Zucker rats with impaired glucose tolerance is diminished by acarbose. Horm Metab Res. 38:575–586.
  • Rosmilah M, Shahnaz M, Patel G, Lock J, Rahman D, Masita A, Noormalin A. 2008. Characterization of major allergens of royal jelly Apis mellifera. Trop Biomed. 25(3):243–251.
  • Sagona S, Turchi B, Fratini F, Giusti M, Torracca B, Nuvoloni R, Cerri, D., Felicioli, A. 2015. Preliminary evaluation of glucose oxidase and its products in vitro antimicrobial activities on Paenibacillus larvae ATCC9545 vegetative form. Bull Insect. 68 (2):233–237.
  • Satomi KM, Okamoto I, Ushio S, Iwaki K, Ikeda M, Kurimoto M. 2004. Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism. Biosci Biotechnol Biochem. 68:767–773.
  • Shahzad Q, Mehmood MU, Khan H, ul Husna A, Qadeer S, Azam A, Naseer Z, Ahmad E, Safdar M, Ahmad M. 2016. Royal jelly supplementation in semen extender enhances post-thaw quality and fertility of Nili-Ravi buffalo bull sperm. Anim Reprod Sci. 167:83–88.
  • Sheridan R, Tompkins R, Burke J. 1993. Prophylactic antibiotics and their role in the prevention of surgical wound infection. Adv Surg. 27:43–65.
  • Shirzad M, Kordyazdi R, Shahinfard N, Nikokar M. 2013. Does royal jelly affect tumor cells. J Herb Med Pharmacol. 2:45–48.
  • Siavash M, Shokri S, Haghighi S, Mohammadi M, Shahtalebi MA, Farajzadehgan Z. 2011. The efficacy of topical royal jelly on diabetic foot ulcers healing: a case series. J Res Med Sci. 16(7):904–909.
  • Silici S, Ekmekcioglu O, Eraslan G, Demirtas A. 2009. Antioxidative effect of royal jelly in cisplatin-induced testes damage. Urology. 74:545–551.
  • Silici S, Ekmekcioglu O, Kanbur M, Deniz K. 2011. The protective effect of royal jelly against cisplatin-induced renal oxidative stress in rats. World J Urol. 29:127–132.
  • Suemaru K, Cui R, Li B, Watanabe S, Okihara K, Hashimoto K, et al. 2008. Topical application of royal jelly has a healing effect for 5-fluorouracil-induced experimental oral mucositis in hamsters. Methods Find Exp Clin Pharmacol. 30(2):103–106.
  • Suzuki KM, Isohama Y, Maruyama H, Yamada Y, Narita Y, Ohta S, Araki Y, Miyata T, Mishima S. 2008. Estrogenic activities of fatty acids and a sterol isolated from royal jelly. Evid Based Complement Alternat Med. 5:295–302.
  • Šver L, Oršolić N, Tadić Z, Njari B, Valpotic I, Bašic I. 1996. A royal jelly as a new potential immunomodulator in rats and mice. Comp Immunol Microbiol Infect Dis. 19:31–38.
  • Takaki-Doi S, Hashimoto K, Yamamura M, Kamei C. 2009. Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats. Acta Med Okayama. 63:57–64.
  • Tokunaga KH, Yoshida C, Suzuki KM, Maruyama H, Futamura Y, Araki Y, et al. 2004. Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats. Biol Pharm Bull. 27:189–192.
  • Tseng JM, Huang JR, Huang HC, Tzen JT, Chou WM, Peng CC. 2011. Facilitative production of an antimicrobial peptide royalisin and its antibody via an artificial oil‐body system. Biotechnol Prog. 27:153–161.
  • Vittek J. 1995. Effect of royal jelly on serum lipids in experimental animals and humans with atherosclerosis. Cell Mol Life Sci. 51:927–935.
  • Viuda‐Martos M, Ruiz‐Navajas Y, Fernández‐López J, Pérez‐Álvarez J. 2008. Functional properties of honey, propolis, and royal jelly. J Food Sci. 73:117–124.
  • Watanabe S, Suemaru K, Takechi K, Kaji H, Imai K, Araki H. 2013. Oral mucosal adhesive films containing royal jelly accelerate recovery from 5-fluorouracil–induced oral mucositis. J Pharmacol Sci. 121:110–118.
  • Yang XY, Yang DS, Wang JM, Li CY, Lei KF, Chen XF, Shen NH, Jin LQ, Wang JG. 2010. 10-Hydroxy-2-decenoic acid from royal jelly: a potential medicine for RA. J Ethnopharmacol. 128:314–321.
  • Yildirim S, Karadeniz A, Karakoc A, Yildirim A, Kalkan Y, Şimşek N. 2012. Effects of royal jelly on liver paraoxonase activity in rats treated with cisplatin. Turk J Med Sci. 42:367–375.
  • Yoneshiro T, Kaede R, Nagaya K, Aoyama J, Saito M, Okamatsu-Ogura Y, et al. 2017. Royal jelly ameliorates diet-induced obesity and glucose intolerance by promoting brown adipose tissue thermogenesis in mice. Obesity Res Clin Pract. doi:10.1016/j.orcp.2016.12.006.
  • Zahmatkesh E, Najafi G, Nejati V. 2015. Protective effect of royal jelly on in vitro fertilization (IVF) in male mice treated with oxymetholone. Cell Journal (Yakhteh). 17(3):569–575.
  • Zahran AM, Elsayh KI, Saad K, Eloseily EM, Osman NS, Alblihed MA, Badr G, Mahmoud MH. 2016. Effects of royal jelly supplementation on regulatory T cells in children with SLE. Food Nutr Res. 60(1):32963.
  • Zamani Z, Reisi P, Alaei H, Pilehvarian A. 2012. Effect of royal jelly on improving passive avoidance learning and spatial learning and memory in rats. J Shahid Sadoughi Univ Med Sci. 20(2):211–19.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.