Effect of Probiotic Supplementation on CD4 Cell Count in HIV-Infected Patients: A Systematic Review and Meta-analysis

References

• Anukam KC, Osazuwa E, Osemene GI, Ehigiagbe F, Bruce AW, Reid G. 2006. Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis. Microbes Infect. 8(1213):2772–2776. doi:10.1016/j.micinf.2006.08.008. PMID: 17045832
   Google Scholar
• Anukam KC, Osazuwa EO, Osadolor HB, Bruce AW, Reid G. 2008. Yogurt containing probiotic Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 helps resolve moderate diarrhea and increases CD4 count in HIV/AIDS patients. J Clin Gastroenterol. 42(3):239–243. PMID: 18223503
   Google Scholar
• Botros D, Somarriba G, Neri D, Miller TL. 2012. Interventions to address chronic disease and HIV: strategies to promote exercise and nutrition among HIV-infected individuals. Curr HIV/AIDS Rep. 9(4):351–363. doi:10.1007/s11904-012-0135-7. PMID: 22933247
   Google Scholar
• Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D. 2006. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 12(12):1365. doi:10.1038/nm1511. PMID: 17115046
   Google Scholar
• Collazos J, Asensi V, Cartón JA and G. E. p. e. E. M. d. l. Adherencia. 2007. Sex differences in the clinical, immunological and virological parameters of HIV-infected patients treated with HAART. Aids. 21(7):835–843. doi:10.1097/QAD.0b013e3280b0774a. PMID: 17415038
   Google Scholar
• Cunningham-Rundles S, Ahrne S, Johann-Liang R, Abuav R, Dunn-Navarra AM, Grassey C, Bengmark S, Cervia JS. 2011. Effect of probiotic bacteria on microbial host defense, growth, and immune function in human immunodeficiency virus type-1 infection. Nutrients. 3(12):1042–1070. doi:10.3390/nu3121042. PMID: 22292110
   Google Scholar
• D'Angelo C, Reale M, Costantini E. 2017. Microbiota and Probiotics in Health and HIV Infection. Nutrients. 9(6):615. doi:10.3390/nu9060615.
   Google Scholar
• De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P. 2010. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci. 107(33):14691–14696. doi:10.1073/pnas.1005963107.
   Google Scholar
• Egger M, Davey-Smith G, Altman D. 2001. Systematic reviews in health care: meta-analysis in context. 2nd ed. London: BMJ Books.
   Google Scholar
• Elmer GW, Moyer KA, Vega R, Surawicz CM, Collier AC, Hooton TM, McFarland LV. 1995. Evaluation of Saccharomyces boulardii for patients with HIV-related chronic diarrhoea and in healthy volunteers receiving antifungals. Microb Ther. 25:23–31.
   Google Scholar
• González-Hernández LA, Jave-Suarez LF, Fafutis-Morris M, Montes-Salcedo KE, Valle-Gutierrez LG, Campos-Loza AE, Enciso-Gómez LF, Andrade-Villanueva JF. 2012. Synbiotic therapy decreases microbial translocation and inflammation and improves immunological status in HIV-infected patients: A double-blind randomized controlled pilot trial. Nutr J. 11(1):90. doi:10.1186/1475-2891-11-90.
   Google Scholar
• Gori A, Rizzardini G, Van'T Land B, Amor KB, Van Schaik J, Torti C, Quirino T, Tincati C, Bandera A, Knol J, et al. 2011. Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: Results of the “cOPA” pilot randomized trial. Mucosal Immunol. 4(5):554–563.
   Google Scholar
• Heiser CR, Ernst JA, Barrett JT, French N, Schutz M, Dube MP. 2004. Probiotics, soluble fiber, and L-glutamine (GLN) reduce nelfinavir (NFV)or lopinavir/ritonavir (LPV/r)-related diarrhea. J Int Assoc Physicians AIDS Care. 3(4):121–129. doi:10.1177/154510970400300403. PMID: 15768732
   Google Scholar
• Higgins JP, Thompson SG, Deeks JJ, Altman DG. 2003. Measuring inconsistency in meta-analyses. Br Med J. 327(7414):557. doi:10.1136/bmj.327.7414.557.
   Google Scholar
• Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S. 2014. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 11(8):506–514. doi:10.1038/nrgastro.2014.66.
   Google Scholar
• Hummelen R, Changalucha J, Butamanya NL, Koyama TE, Habbema JDF, Reid G. 2011a. Efect of 25 weeks probiotic supplementation on immune function of HIV patients. Gut Microbes. 2(2):80–85. doi:10.4161/gmic.2.2.15787.
   Google Scholar
• Hummelen R, Hemsworth J, Changalucha J, Butamanya NL, Hekmat S, Habbema JDF, Reid G. 2011b. Effect of micronutrient and probiotic fortified yogurt on immune-function of anti-retroviral therapy naive HIV patients. Nutrients. 3(10):897–909. doi:10.3390/nu3100897.
   Google Scholar
• Karunasena E, McMahon KW, Chang D, Brashears MM. 2014. Host responses to the pathogen Mycobacterium avium subsp. paratuberculosis and beneficial microbes exhibit host sex specificity. Appl Environ Microbiol. 80(15):4481–4490. doi:10.1128/AEM.01229-14. PMID: 24814797
   Google Scholar
• Lozupone CA, Li M, Campbell TB, Flores SC, Linderman D, Gebert MJ, Knight R, Fontenot AP, Palmer BE. 2013. Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe. 14(3):329–339. doi:10.1016/j.chom.2013.08.006.
   Google Scholar
• McFarland LV. 2010. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World journal of gastroenterology (WJG). 16(18):2202.
   Google Scholar
• Masco L, Huys G, De Brandt E, Temmerman R, Swings J. 2015. Culture-dependent and culture-independent qualitative analysis of probiotic products claimed to contain bifidobacteria. Inter journal food microbio. 102(2):221–230. [PubMed] PMID: 15992621. Epub 2005/07/05. eng.
   Google Scholar
• Marchetti G, Bellistrì GM, Borghi E, Tincati C, Ferramosca S, La Francesca M, Morace G, Gori A, Monforte ADA. 2008. Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy. Aids. 22(15):2035–2038. doi:10.1097/QAD.0b013e3283112d29.
   Google Scholar
• Marcobal A, Underwood MA, Mills DA. 2008. Rapid determination of the bacterial composition of commercial probiotic products by terminal restriction fragment length polymorphism analysis. J pediatric gastroenterology nutrition. 46(5):608–611. [PubMed] PMID: 18493222. Epub 2008/05/22. eng.
   Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. 2009. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 6(7):e1000097. doi:10.1371/journal.pmed.1000097.
   Google Scholar
• Moore D, Hogg R, Yip B, Craib K, Wood E, Montaner J. 2006. CD4 percentage is an independent predictor of survival in patients starting antiretroviral therapy with absolute CD4 cell counts between 200 and 350 cells/µL. HIV Med. 7(6):383–388. doi:10.1111/j.1468-1293.2006.00397.x. PMID: 16903983
   Google Scholar
• Nicastri E, Leone S, Angeletti C, Palmisano L, Sarmati L, Chiesi A, Geraci A, Vella S, Narciso P, Corpolongo A. 2007. Sex issues in HIV-1-infected persons during highly active antiretroviral therapy: a systematic review. J Antimicrob Chemother. 60(4):724–732. doi:10.1093/jac/dkm302. PMID: 17715125
   Google Scholar
• Oertelt-Prigione S. 2012. The influence of sex and gender on the immune response. Autoimmun Rev. 11(6):A479–A485. doi:10.1016/j.autrev.2011.11.022. PMID: 22155201
   Google Scholar
• Saint-Marc T, Blehaut H, Musial C, Touraine JL. 1995. AIDS-related diarrhea: a double-blind trial of Saccharomyces boulardii. Semaine des Hopitaux de Paris. 71(23):735–741.
   Google Scholar
• Schrezenmeir J, de Vrese M. 2001. Probiotics, prebiotics, and synbiotics—approaching a definition. Am J Clin Nutrit. 73(2):361s–364s. PMID: 11157342
   Google Scholar
• Schunter M, Chu H, Hayes TL, McConnell D, Crawford SS, Luciw PA, Bengmark S, Asmuth DM, Brown J, Bevins CL, Shacklett BL, Critchfield JW. 2012. Randomized pilot trial of a synbiotic dietary supplement in chronic HIV-1 infection. BMC Complement Alternat Med. 12(1):84. doi:10.1186/1472-6882-12-84. PMID: 22747752
   Google Scholar
• Sinha B, Rubens M. 2014. Systemic immune activation in HIV and potential therapeutic options. Immunopharmacol Immunotoxicol. 36(2):89–95. doi:10.3109/08923973.2014.890217. PMID: 24552614
   Google Scholar
• Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre M-L. 2015. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy. Science. 350(6264):1084–1089. doi:10.1126/science.aac4255. PMID: 26541606
   Google Scholar
• Stiksrud B, Nowak P, Nwosu FC, Kvale D, Thalme A, Sonnerborg A, Ueland PM, Holm K, Birkeland SE, Dahm AE, et al. 2015. Reduced Levels of D-dimer and Changes in Gut Microbiota Composition after Probiotic Intervention in HIV-infected Individuals on Stable ART. J Acquir Immune Defic Syndr. doi:10.1097/QAI.0000000000000784.
   Google Scholar
• Swain SL, McKinstry KK, Strutt TM. 2012. Expanding roles for CD4+ T cells in immunity to viruses. Nat Rev Immunol. 12(2):136. PMID: 22266691
   Google Scholar
• Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CP. 2015. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 350(6264):1079–1084. doi:10.1126/science.aad1329. PMID: 26541610
   Google Scholar
• Villar-García J, Hernàndez JJ, Güerri-Fernàndez R, Gonzàlez A, Lerma E, Guelar A, Saenz D, Sorlí L, Montero M, Horcajada JP, Freud HK. 2015. Effect of probiotics (Saccharomyces boulardii) on microbial translocation and inflammation in HIV-treated patients: A double-blind, randomized, placebo-controlled trial. J Acquired Immun Defic Syndromes. 68(3):256–263. doi:10.1097/QAI.0000000000000468. PMID: 25469528
   Google Scholar
• Wilson NL, Moneyham LD, Alexandrov AW. 2013. A systematic review of probiotics as a potential intervention to restore gut health in HIV infection. J Assoc Nurses AIDS Care. 24(2):98–111. doi:10.1016/j.jana.2012.04.004. PMID: 22853885
   Google Scholar
• Wolf BW, Wheeler KB, Ataya DG, Garleb KA. 1998. Safety and tolerance of Lactobacillus reuteri supplementation to a population infected with the human immunodeficiency virus. Food Chem Toxicol. 36(12):1085–1094. doi:10.1016/S0278-6915(98)00090-8. PMID: 9862651
   Google Scholar
• Wu GD, Chen J, Hoffmann C, Bittinger K, Chen Y-Y, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R. 2011. Linking long-term dietary patterns with gut microbial enterotypes. Science. 334(6052):105–108. doi:10.1126/science.1208344. PMID: 21885731
   Google Scholar
• Yang OO, Kelesidis T, Cordova R, Khanlou H. 2014. Immunomodulation of antiretroviral drug-suppressed chronic HIV-1 infection in an oral probiotic double-blind placebo-controlled trial. AIDS Res Human Retroviruses. 30(10):988–995. doi:10.1089/aid.2014.0181. PMID: 25127924
   Google Scholar
• Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP. 2012. Human gut microbiome viewed across age and geography. Nature. 486(7402):222. PMID: 22699611
   Google Scholar