Oral Supplementation with Beta-Hydroxy-Beta-Methylbutyrate, Arginine, and Glutamine Improves Lean Body Mass in Healthy Older Adults

References

• Alpers DH. 2006. Glutamine: do the data support the cause for glutamine supplementation in humans?. Gastroenterology. 130:S106–S116. doi:10.1053/j.gastro.2005.11.049. PMID: 16473057.
   PubMed Web of Science ®Google Scholar
• Appleton J. 2002. Arginine: Clinical potential of a semi-essential amino. Altern Med Rev. 7:512–522. PMID: 12495375.
   PubMedGoogle Scholar
• Baier S, Johannsen D, Abumrad N, Rathmacher JA, Nissen S, Flakoll P. 2009. Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), L-arginine, and L-lysine. JPEN J Parenter Enteral Nutr. 33:71–82. doi:10.1177/0148607108322403. PMID: 19164608.
   PubMed Web of Science ®Google Scholar
• Ban H, Shigemitsu K, Yamatsuji T, Haisa M, Nakajo T, Takaoka M, Nobuhisa T, Gunduz M, Tanaka N, Naomoto Y. 2004. Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells. Int J Mol Med. 13:537–543. PMID: 15010853.
   PubMed Web of Science ®Google Scholar
• Baumgartner RN, Heymsfield SB, Lichtman S, Wang J, Pierson RN. 1991. Body composition in elderly people: effect of criterion estimates on predictive equations. Am J Clin Nutr. 53:1345–1353. doi:10.1093/ajcn/53.6.1345. PMID: 2035461.
   PubMed Web of Science ®Google Scholar
• Berk L, James J, Schwartz A, Hug E, Mahadevan A, Samuels M, Kachnic L. 2008. A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122). Support Care Cancer. 16:1179–1188. doi:10.1007/s00520-008-0403-7. PMID: 18293016.
   PubMed Web of Science ®Google Scholar
• Bischoff-Ferrari H, Stähelin HB, Walter P. 2011. Vitamin D effects on bone and muscle. Int J Vitam Nutr Res. 81:264–272. doi:10.1024/0300-9831/a000072. PMID: 22237776.
   PubMed Web of Science ®Google Scholar
• Burton LA, Sumukadas D. 2010. Optimal management of sarcopenia. Clin Interv Aging. 5:217–228. PMID: 20852669.
   PubMed Web of Science ®Google Scholar
• Ceglia L. 2009. Vitamin D and its role in skeletal muscle. Curr Opin Clin Nutr Metab Care. 12:628–633. doi:10.1097/MCO.0b013e328331c707. PMID: 19770647.
   PubMed Web of Science ®Google Scholar
• Chiu M, Tardito S, Barilli A, Bianchi MG, Dall'Asta V, Bussolati O. 2012. Glutamine stimulates mTORC1 independent of the cell content of essential amino acids. Amino Acids. 43:2561–2567. doi:10.1007/s00726-012-1312-0. PMID: 22566039.
   PubMed Web of Science ®Google Scholar
• Clark RH, Feleke G, Din M, Yasmin T, Singh G, Khan FA, Rathmacher JA. 2000. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. JPEN J Parenter Enteral Nutr. 24:133–139. doi:10.1177/0148607100024003133. PMID: 10850936.
   PubMed Web of Science ®Google Scholar
• Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, Wackerhage H, Taylor PM, and Rennie MJ. 2005. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 19:422–424. doi:10.1096/fj.04-2640fje. PMID: 15596483.
   PubMed Web of Science ®Google Scholar
• Eley HL, Russell ST, Baxter JH, Mukerji P, Tisdale MJ. 2007. Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. Am J Physiol Endocrinol Metab. 293:E923–31. doi:10.1152/ajpendo.00314.2007. PMID: 17609254.
   PubMed Web of Science ®Google Scholar
• Eley HL, Russell ST, Tisdale MJ. 2008a. Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by beta-hydroxy-beta-methylbutyrate. Am J Physiol Endocrinol Metab. 295:E1409–16. doi:10.1152/ajpendo.90530.2008.
   PubMed Web of Science ®Google Scholar
• Fitschen PJ, Wilson GJ, Wilson JM, Wilund KR. 2013. Efficacy of β-hydroxy-β-methylbutyrate supplementation in elderly and clinical populations. Nutrition. 29:29–36. doi:10.1016/j.nut.2012.05.005. PMID: 23085015.
   PubMed Web of Science ®Google Scholar
• Flakoll P, Sharp R, Baier S, Levenhagen D, Carr C, Nissen S. 2004. ‘Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women.’ Nutrition. 20:445–451. doi:10.1016/j.nut.2004.01.009. PMID: 15105032.
   PubMed Web of Science ®Google Scholar
• Fuller JC, Baier S, Flakoll P, Nissen SL, Abumrad NN, Rathmacher JA. 2011. Vitamin D status affects strength gains in older adults supplemented with a combination of β-hydroxy-β-methylbutyrate, arginine, and lysine: a cohort study. JPEN J Parenter Enteral Nutr. 35:757–762. doi:10.1177/0148607111413903. PMID: 21807930.
   PubMed Web of Science ®Google Scholar
• Holick MF. 2008. The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Mol Aspects Med. 29:361–368. doi:10.1016/j.mam.2008.08.008. PMID: 18801384.
   PubMed Web of Science ®Google Scholar
• Hsieh LC, Chien SL, Huang MS, Tseng HF, Chang CK. 2006. Anti-inflammatory and anticatabolic effects of short-term beta-hydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive care unit. Asia Pac J Clin Nutr. 15:544–550. PMID: 17077073.
   PubMed Web of Science ®Google Scholar
• Hunter GR, McCarthy JP, Bamman MM. 2004. Effects of resistance training on older adults. Sports Medicine. 34:329–348. doi:10.2165/00007256-200434050-00005. PMID: 15107011.
   PubMed Web of Science ®Google Scholar
• Hunter GR, Treuth MS, Weinsier RL, Kekes-Szabo T, Kell SH, Roth DL, Nicholson C. 1995. The effects of strength conditioning on older women's ability to perform daily tasks. J Am Geriatr Soc. 43:756–760. doi:10.1111/j.1532-5415.1995.tb07045.x. PMID: 7602026.
   PubMed Web of Science ®Google Scholar
• Jensen GL. 2008. Inflammation: roles in aging and sarcopenia. JPEN J Parenter Enteral Nutr. 32:656–659. doi:10.1177/0148607108324585. PMID: 18974248.
   PubMed Web of Science ®Google Scholar
• Jones TE, Stephenson KW, King JG, Knight KR, Marshall TL, Scott WB. 2009. Sarcopenia–mechanisms and treatments. J Geriatr Phys Ther. 32:39–45. doi:10.1519/00139143-200932020-00008. PMID: 19856635.
   PubMed Web of Science ®Google Scholar
• Kanaley JA. 2008. Growth hormone, arginine and exercise. Curr Opin Clin Nutr Metab Care. 11:50–54. doi:10.1097/MCO.0b013e3282f2b0ad. PMID: 18090659.
   PubMed Web of Science ®Google Scholar
• Kim H. 2007. Glutamine as an immunonutrient. Yonsei Med J. 52:892–897. doi:10.3349/ymj.2011.52.6.892.
   Google Scholar
• Malina RM. 2007. Body composition in athletes: assessment and estimated fatness. Clin Sports Med. 26:37–68. doi:10.1016/j.csm.2006.11.004. PMID: 17241914.
   PubMed Web of Science ®Google Scholar
• Mattsson S, Thomas BJ. 2006. Development of methods for body composition studies. Phys Med Biol. 51:R203–R228. doi:10.1088/0031-9155/51/13/R13. PMID: 16790904.
   PubMed Web of Science ®Google Scholar
• May PE, Barber A, D'Olimpio JT, Hourihane A, Abumrad NN. 2002. Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine. Am J Surg. 183:471–479. doi:10.1016/S0002-9610(02)00823-1. PMID: 11975938.
   PubMed Web of Science ®Google Scholar
• Melis GC, Wengel t N, Boelens PG, van Leeuwen PA. 2004. Glutamine: Recent developments in research on the clinical significance of glutamine. Curr Opin Clin Nutr Metab Care. 7:59–70. doi:10.1097/00075197-200401000-00011. PMID: 15090905.
   PubMed Web of Science ®Google Scholar
• Meng SJ, Yu LJ. 2010. Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci. 11:1509–1526. doi:10.3390/ijms11041509. PMID: 20480032.
   PubMed Web of Science ®Google Scholar
• Minderico CS, Silva AM, Keller K, Branco TL, Martins SS, Palmeira AL, Barata JT, Carnero EA, Rocha PM, Teixeira PJ, Sardinha LB. 2008. Usefulness of different techniques for measuring body composition changes during weight loss in overweight and obese women. Br J Nutr. 99:432–441. doi:10.1017/S0007114507815789. PMID: 17894918.
   PubMed Web of Science ®Google Scholar
• Moreno LA, Valtueña J, Pérez-López F, González-Gross M. 2011. Health effects related to low vitamin D concentrations: beyond bone metabolism. Ann Nutr Metab. 59:22–27. doi:10.1159/000332070. PMID: 22123633.
   PubMed Web of Science ®Google Scholar
• Morley JE. 2009. Vitamin D redux. J Am Med Dir Assoc. 10:591–592. doi:10.1016/j.jamda.2009.08.013. PMID: 19883878.
   PubMed Web of Science ®Google Scholar
• Morley JE, Argiles JM, Evans WJ, Bhasin S, Cella D, Deutz NE, Doehner W, Fearon KC, Ferrucci L, Hellerstein MK, Kalantar-Zadeh K, Lochs H, MacDonald N, Mulligan K, Muscaritoli M, Ponikowski P, Posthauer ME, Rossi Fanelli F, Schambelan M, Schols AM, Schuster MW, Anker SD, Cachexia Society for Sarcopenia, and Wasting Disease. 2010. Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc. 11:391–396. doi:10.1016/j.jamda.2010.04.014. PMID: 20627179.
   PubMed Web of Science ®Google Scholar
• Pimentel GD, Rosa JC, Lira FS, Zanchi NE, Ropelle ER, Oyama LM, Oller do Nascimento CM, de Mello MT, Tufik S, Santos RV. 2011. β-Hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway. Nutr Metab (Lond). 8:11. doi:10.1186/1743-7075-8-11. PMID: 21345206.
   PubMed Web of Science ®Google Scholar
• Podsiadlo D, Richardson S. 1991. The timed “Up & Go”: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 39:142–148. doi:10.1111/j.1532-5415.1991.tb01616.x. PMID: 1991946.
   PubMed Web of Science ®Google Scholar
• Portal S, Eliakim A, Nemet D, Halevy O, Zadik Z. 2010. Effect of HMB supplementation on body composition, fitness, hormonal profile and muscle damage indices. J Pediatr Endocrinol Metab. 23:641–650. doi:10.1515/JPEM.2010.23.7.641. PMID: 20857835.
   PubMed Web of Science ®Google Scholar
• Potenza MA, Nacci C, Mitolo-Chieppa D. 2001. Immunoregulatory effects of L-arginine and therapeutical implications. Curr Drug Targets Immune Endocr Metabol Disord. 1:67–77. doi:10.2174/1568008013341811. PMID: 12476782.
   PubMedGoogle Scholar
• Preli RB, Klein KP, Herrington DM. 2002. Vascular effects of dietary L-arginine supplementation. Atherosclerosis. 162:1–15. doi:10.1016/S0021-9150(01)00717-1. PMID: 11947892.
   PubMed Web of Science ®Google Scholar
• Roth E. 2008. Nonnutritive effects of glutamine. J Nutr. 138:2025S–2031S. doi:10.1093/jn/138.10.2025S. PMID: 18806119.
   PubMed Web of Science ®Google Scholar
• Roubenoff R. 2007. Physical activity, inflammation, and muscle loss. Nutr Rev. 65:S208–S212. doi:10.1301/nr.2007.dec.S208-S212. PMID: 18240550.
   PubMed Web of Science ®Google Scholar
• Schaap LA, Pluijm SM, Deeg DJ, Visser M. 2006. Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med. 119:526.e9–17. doi:10.1016/j.amjmed.2005.10.049.
   PubMed Web of Science ®Google Scholar
• Schoeller DA, van Santen E, Peterson DW, Dietz W, Jaspan J, Klein PD. 1980. Total body water measurement in humans with 18O and 2H labeled water. Am J Clin Nutr. 33:2686–2693. doi:10.1093/ajcn/33.12.2686. PMID: 6776801.
   PubMed Web of Science ®Google Scholar
• Singh T, Newman AB. 2011. Inflammatory markers in population studies of aging. Ageing Res Rev. 10:319–329. doi:10.1016/j.arr.2010.11.002. PMID: 21145432.
   PubMed Web of Science ®Google Scholar
• Skelton DA, Young A, Greig CA, Malbut KE. 1995. Effects of resistance training on strength, power, and selected functional abilities of women aged 75 and older. J Am Geriatr Soc. 43:1081–1087. doi:10.1111/j.1532-5415.1995.tb07004.x. PMID: 7560695.
   PubMed Web of Science ®Google Scholar
• Smith DN. 1993. Bioelectrical impedance and body composition. Lancet. 341:569. doi:10.1016/0140-6736(93)90342-E. PMID: 8094818.
   PubMedGoogle Scholar
• Stout JR, Smith-Ryan AE, Fukuda DH, Kendall KL, Moon JR, Hoffman JR, Wilson JM, Oliver JS, Mustad VA. 2013. Effect of calcium β-hydroxy-β-methylbutyrate (CaHMB) with and without resistance training in men and women 65+yrs: A randomized, double-blind pilot trial. Exp Gerontol. 48:1303–1310. doi:10.1016/j.exger.2013.08.007. PMID: 23981904.
   PubMed Web of Science ®Google Scholar
• Tong BC, Barbul A. 2004. Cellular and physiological effects of arginine. Mini Rev Med Chem. 4:823–832. doi:10.2174/1389557043403305. PMID: 15544543.
   PubMed Web of Science ®Google Scholar
• Townsend JR, Fragala MS, Jajtner AR, Gonzalez AM, Wells AJ, Mangine GT, Robinson EH, McCormack WP, Beyer KS, Pruna GJ, Boone CH, Scanlon TM, Bohner JD, Stout JR, Hoffman JR. 2013. β-Hydroxy-β-methylbutyrate (HMB)-free acid attenuates circulating TNF-α and TNFR1 expression postresistance exercise. J Appl Physiol. 115:1173–1182. doi:10.1152/japplphysiol.00738.2013. PMID: 23908318.
   PubMed Web of Science ®Google Scholar
• Vukovich MD, Stubbs NB, Bohlken RM. 2001. Body composition in 70-year-old adults responds to dietary beta-hydroxy-beta-methylbutyrate similarly to that of young adults. J Nutr. 131:2049–2052. doi:10.1093/jn/131.7.2049. PMID: 11435528.
   PubMed Web of Science ®Google Scholar
• WE S. 1961. Body composition from fluid spaces and density: analysis of methods. In: Brozek J and Henschel A (eds.). Techniques for measuring body composition. Washington (DC): National Academy of Sciences.
   Google Scholar
• Wu GY, Thompson JR. 1990. The effect of glutamine on protein turnover in chick skeletal muscle in vitro. Biochem J. 265:593–598. doi:10.1042/bj2650593. PMID: 2302190.
   PubMed Web of Science ®Google Scholar
• Xi P, Jiang Z, Zheng C, Lin Y, Wu G. 2011. Regulation of protein metabolism by glutamine: implications for nutrition and health. Front Biosci. 16:578–597. doi:10.2741/3707.
   Web of Science ®Google Scholar
• Yao K, Yin YL, Chu W, Liu Z, Deng D, Li T, Huang R, Zhang J, Tan B, Wang W, Wu G. 2008. 'Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs. J Nutr. 138:867–872. doi:10.1093/jn/138.5.867. PMID: 18424593.
   PubMed Web of Science ®Google Scholar
• Zanchi NE, Gerlinger-Romero F, Guimarães-Ferreira L, de Siqueira Filho MA, Felitti V, Lira FS, Seelaender M, Jr Lancha AH. 2010. HMB supplementation: clinical and athletic performance-related effects and mechanisms of action. Amino Acids. 40(4):1015–1025. doi:10.1007/s00726-010-0678-0.
   PubMed Web of Science ®Google Scholar