5-Hydroxymethylfurfural and Alpha-Ketoglutaric Acid as an Ergogenic Aid During Intensified Soccer Training: A Placebo Controlled Randomized Study

References

• Achten J, Jeukendrup AE. 2003. Heart rate monitoring: applications and limitations. Sports Med. 33(7):517–538.
   PubMed Web of Science ®Google Scholar
• Astorino TA, Robergs RA, Ghiasvand F, Marks D, Burns S. 2000. Incidence of the oxygen plateau at VO2max during exercise testing to volitional fatigue. J Exerc Physiol Online. 3(4):1–12.
   Google Scholar
• Billat LV, Koralsztein JP. 1996. Significance of the velocity at VO2max and time to exhaustion at this velocity. Sports Med. 22(2):90–108.
   PubMed Web of Science ®Google Scholar
• Christensen PM, Krustrup P, Gunnarsson TP, Kiilerich K, Nybo L, Bangsbo J. 2011. VO2 kinetics and performance in soccer players after intense training and inactivity. Med Sci Sports Exerc. 43(9):1716–1724. doi:10.1249/MSS.0b013e318211c01a
   PubMed Web of Science ®Google Scholar
• Cynober LA. 1999. The use of alpha-ketoglutarate salts in clinical nutrition and metabolic care. Curr Opin Clin Nutr Metab Care. 2(1):33–37.
   PubMedGoogle Scholar
• Dupont G, Akakpo K, Berthoin S. 2004. The effect of in-season, high-intensity interval training in soccer players. J Strength Cond Res. 18(3):584–589. doi:10.1519/1533-4287(2004)182.0.CO;2
   PubMed Web of Science ®Google Scholar
• Faiss R, Leger B, Vesin JM, Fournier PE, Eggel Y, Deriaz O, Millet GP. 2013. Significant Molecular and Systemic Adaptations after Repeated Sprint Training in Hypoxia. Plos One. 8(2):e56522. doi:10.1371/journal.pone.0056522
   PubMed Web of Science ®Google Scholar
• Faude O, Steffen A, Kellmann M, Meyer T. 2014. The effect of short-term interval training during the competitive season on physical fitness and signs of fatigue: a crossover trial in high-level youth football players. Int J Sports Physiol Perform. 9(6):936–944. doi:10.1123/ijspp.2013-0429
   PubMed Web of Science ®Google Scholar
• Fernandez-Fernandez J, Sanz-Rivas D, Sarabia JM, Moya M. 2015. Preseason Training: The Effects of a 17-Day High-Intensity Shock Microcycle in Elite Tennis Players. J Sports Sci Med. 14(4):783–791.
   PubMed Web of Science ®Google Scholar
• Gatterer H, Klarod K, Heinrich D, Schlemmer P, Dilitz S, Burtscher M. 2015. Effects of a 12-day maximal shuttle-run shock microcycle in hypoxia on soccer specific performance and oxidative stress. Appl Physiol Nutr Metab. 40(8):842–845. doi:10.1139/apnm-2014-0479
   PubMed Web of Science ®Google Scholar
• Gatterer H, Philippe M, Menz V, Mosbach F, Faulhaber M, Burtscher M. 2014. Shuttle-run sprint training in hypoxia for youth elite soccer players: a pilot study. J Sports Sci Med. 13(4):731–735.
   PubMed Web of Science ®Google Scholar
• Girard O, Racinais S, Kelly L, Millet GP, Brocherie F. 2011. Repeated sprinting on natural grass impairs vertical stiffness but does not alter plantar loading in soccer players. Eur J Appl Physiol. 111(10):2547–2555. doi:10.1007/s00421-011-1884-5
   PubMed Web of Science ®Google Scholar
• Hofmann P, Tschakert G. 2011. Special needs to prescribe exercise intensity for scientific studies. Cardiol Res Pract. 2011:209302. doi:10.4061/2011/209302
   Google Scholar
• Hopkins WG, Marshall SW, Batterham AM, Hanin J. 2009. Progressive statistics for studies in sports medicine and exercise science. Med Sci Sports Exerc. 41(1):3–13. doi:10.1249/MSS.0b013e31818cb278
   PubMed Web of Science ®Google Scholar
• Hopkins WG, Schabort EJ, Hawley JA. 2001. Reliability of power in physical performance tests. Sports Med. 31(3):211–234.
   PubMed Web of Science ®Google Scholar
• Issurin V. 2008. Block periodization versus traditional training theory: a review. J Sports Med Phys Fitness. 48(1):65–75.
   PubMed Web of Science ®Google Scholar
• Kadaja L, Eimre M, Paju K, Roosimaa M, Põdramägi T, Kaasik P, Pehme A, Orlova E, Mudist M, Peet N, et al. 2010. Impaired oxidative phosphorylation in overtrained rat myocardium. Exp Clin Cardiol. 15(4):e116–e127. 1
   PubMedGoogle Scholar
• Krustrup P, Mohr M, Nybo L, Jensen JM, Nielsen JJ, Bangsbo J. 2006. The Yo-Yo IR2 test: physiological response, reliability, and application to elite soccer. Med Sci Sports Exerc. 38(9):1666–1673. doi:10.1249/01.mss.0000227538.20799.08
   PubMed Web of Science ®Google Scholar
• Li YX, Li Y, Qian ZJ, Kim MM, Kim SK. 2009. In vitro antioxidant activity of 5-HMF isolated from marine red alga Laurencia undulata in free-radical-mediated oxidative systems. JMicrobiolBiotechnol. 1911–1319. (1327.
   Google Scholar
• Liu Y, Lange R, Langanky J, Hamma T, Yang B, Steinacker JM. 2012. Improved training tolerance by supplementation with α-Keto acids in untrained young adults: a randomized, double blind, placebo-controlled trial. J Int Soc Sports Nutr. 9(1):37. doi:10.1186/1550-2783-9-37
   PubMedGoogle Scholar
• Macpherson TW, Weston M. 2015. The effect of low-volume sprint interval training on the development and subsequent maintenance of aerobic fitness in soccer players. Int. J Sports Physiol Perform. 10(3):332–338. doi:10.1123/ijspp.2014-0075
   PubMed Web of Science ®Google Scholar
• Matzi V, Lindenmann J, Muench A, Greilberger J, Juan H, Wintersteiger R, Maier S, Smolle-Juettner FM. 2007. The impact of preoperative micronutrient supplementation in lung surgery. A prospective randomized trial of oral supplementation of combined alpha-ketoglutaric acid and 5-hydroxymethylfurfural. Eur J Cardiothorac Surg. 32(5):776–782. doi:10.1016/j.ejcts.2007.07.016
   PubMed Web of Science ®Google Scholar
• McGawley K, Juudas E, Kazior Z, Ström K, Blomstrand E, Hansson O, Holmberg HC. 2017. No Additional Benefits of Block- Over Evenly-Distributed High-Intensity Interval Training within a Polarized Microcycle. Front Physiol. 8413. doi:10.3389/fphys.2017.00413
   PubMed Web of Science ®Google Scholar
• Meeusen R, Duclos M, Foster C, Fry A, Gleeson M, Nieman D, Raglin J, Rietjens G, Steinacker J, Urhausen A, et al. 2013. Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine. Med Sci Sports Exerc. 45(1):186–205. doi:10.1249/MSS.0b013e318279a10a
   PubMed Web of Science ®Google Scholar
• Merry TL, Ristow M. 2016. Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?. J Physiol. 594(18):5135–5147. doi:10.1113/JP270654
   PubMed Web of Science ®Google Scholar
• Nakamura FY, Pereira LA, Rabelo FN, Ramirez-Campillo R, Loturco I. 2016. Faster Futsal Players Perceive Higher Training Loads and Present Greater Decreases in Sprinting Speed During the Preseason. J Strength Cond Res. 30(6):1553–1562. doi:10.1519/JSC.0000000000001257
   PubMed Web of Science ®Google Scholar
• Nicoll JX, Fry AC, Galpin AJ, Sterczala AJ, Thomason DB, Moore CA, Weiss LW, Chiu LZ. 2016. Changes in resting mitogen-activated protein kinases following resistance exercise overreaching and overtraining. Eur J Appl Physiol. 116(11-12):2401–2413. doi:10.1007/s00421-016-3492-x
   PubMed Web of Science ®Google Scholar
• Powers SK, Jackson MJ. 2008. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev. 88(4):1243–1276. doi:10.1152/physrev.00031.2007
   PubMed Web of Science ®Google Scholar
• Ramirez-Campillo R, Alvarez C, García-Pinillos F, Sanchez-Sanchez J, Yanci J, Castillo D, Loturco I, Chaabene H, Moran J, Izquierdo M. 2018. Optimal Reactive Strength Index: Is It an Accurate Variable to Optimize Plyometric Training Effects on Measures of Physical Fitness in Young Soccer Players? J Strength Cond Res. 32(4):885–893. doi:10.1519/JSC.0000000000002467
   PubMed Web of Science ®Google Scholar
• Rampinini E, Bishop D, Marcora SM, Ferrari Bravo D, Sassi R, Impellizzeri FM. 2007. Validity of simple field tests as indicators of match-related physical performance in top-level professional soccer players. Int J Sports Med. 28(3):228–235. doi:10.1055/s-2006-924340
   PubMed Web of Science ®Google Scholar
• Sanchez-Sanchez J, Sanchez M, Hernandez D, Ramirez-Campillo R, Martínez C, Nakamura FY. 2017. Fatigue In U12 Soccer-7 Players During Repeated One-Day Tournament Games - A Pilot Study. J Strength Cond Res. doi:10.1519/JSC.0000000000002141
   PubMed Web of Science ®Google Scholar
• Wahl P, Güldner M, Mester J. 2014. Effects and sustainability of a 13-day high-intensity shock microcycle in soccer. J Sports Sci Med. 13(2):259–265.
   PubMed Web of Science ®Google Scholar
• Wallner D, Simi H, Tschakert G, Hofmann P. 2014. Acute physiological response to aerobic short-interval training in trained runners. Int J Sports Physiol Perform. 9(4):661–666. doi:10.1123/ijspp.2013-0385
   PubMed Web of Science ®Google Scholar
• Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D. 2016. Alpha-Ketoglutarate: Physiological Functions and Applications. Biomol Ther (Seoul). 24(1):1–8. doi:10.4062/biomolther.2015.078
   PubMed Web of Science ®Google Scholar