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Articles

The Effect of a Polysaccharide-Based Multinutrient Dietary Supplementation Regimen on Infections and Immune Functioning in Multiple Sclerosis

, MD, , MD, , BS, , MD, , BS, , BS, , BSN, , MD & , PhD show all
Pages 184-199 | Received 02 Apr 2018, Accepted 28 Jun 2018, Published online: 04 Oct 2018

References

  • Albert M, Williamson D, Muscedere J, Lauzier F, Rotstein C, Kanji S, Jiang X, Hall M, Heyland D. 2014. Candida in the respiratory tract secretions of critically ill patients and the impact of antifungal treatment: A randomized placebo controlled pilot trial (Cantreat study). Intensive Care Med. 40(9):1313–1322.
  • Ali KH, Melillo A, Leonard S, Asthana D, Woolger J, Wolfson A, McDaniel HR, Lewis JE. 2012. An open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adults. Funct Foods Health Dis. 2(7):265–279.
  • Allizond V, Scutera S, Rossi S, Musso T, Crocilla C, Cavalla P, Trebini C, Marra ES, Cuffini AM, Banche G. 2015. Polymorphonuclear cell functional impairment in relapsing remitting multiple sclerosis patients: preliminary data. PLoS One. 10(6):e0131557.
  • Andreadou E, Kemanetzoglou E, Brokalaki C, Evangelopoulos ME, Kilidireas C, Rombos A, Stamboulis E. 2013. Demyelinating disease following anti-TNFA treatment: a causal or coincidental association? Report of four cases and review of the literature. Case Rep Neurol Med. 2013:671935.
  • Anthony RS, McKelvie ND, Craig JI, Parker AC. 1998. Fas antigen (cd95) expression in peripheral blood progenitor cells from patients with leukaemia and lymphoma. Leuk Lymphoma. 30(5-6):449–458.
  • Arnett HA, Mason J, Marino M, Suzuki K, Matsushima GK, Ting JP. 2001. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci. 4(11):1116–1122.
  • Asche CV, Singer ME, Jhaveri M, Chung H, Miller A. 2010. All-cause health care utilization and costs associated with newly diagnosed multiple sclerosis in the United States. J Manag Care Pharm. 16(9):703–712.
  • Bang MH, Van Riep T, Thinh NT, Song L. H, Dung TT, Van Truong L, Van Don L, Ky TD, Pan D, Shaheen M. 2010. Arabinoxylan rice bran (MGN-3) enhances the effects of interventional therapies for the treatment of hepatocellular carcinoma: a three-year randomized clinical trial. Anticancer Res. 30(12):5145–5151.
  • Beck J, Rondot P, Catinot L, Falcoff E, Kirchner H, Wietzerbin J. 1988. Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations? Acta Neurol Scand. 78(4):318–323.
  • Bertolotto A, Malucchi S, Capobianco M, Manzardo E, Guastamacchia G, Milano E, Audano L, Mutani R. 1999. Quantitative PCR reveals increased levels of tumor necrosis factor-alpha mRNA in peripheral blood mononuclear cells of multiple sclerosis patients during relapses. J Interferon Cytokine Res. 19(6):575–581.
  • Calder PC. 2011. Fatty acids and inflammation: the cutting edge between food and pharma. Eur J Pharmacol. 668 (Suppl 1):S50–S58.
  • Campbell JD, Ghushchyan V, Brett McQueen R, Cahoon-Metzger S, Livingston T, Vollmer T, Corboy J, Miravalle A, Schreiner T, Porter V, et al. 2014. Burden of multiple sclerosis on direct, indirect costs and quality of life: National US estimates. Mult Scler Relat Disord. 3(2):227–236.
  • Caughey GE, Mantzioris E, Gibson RA, Cleland LG, James MJ. 1996. The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr. 63(1):116–122.
  • Cholujova D, Jakubikova J, Czako B, Martisova M, Hunakova L, Duraj J, Mistrik M, Sedlak J. 2013. MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients. Cancer Immunol Immunother. 62(3):437–445.
  • Compston A, Coles A. 2008. Multiple sclerosis. Lancet. 372(9648):1502–1517.
  • Compston A, Zajicek J, Sussman J, Webb A, Hall G, Muir D, Shaw C, Wood A, Scolding N. 1997. Glial lineages and myelination in the central nervous system. J Anatomy. 190(2):161–200.
  • Cui S, Hassan RY, Heintz-Buschart A, Bilitewski U. 2016. Regulation of Candida albicans interaction with macrophages through the activation of hog pathway by genistein. Molecules. 21(2):162
  • Damal K, Stoker E, Foley JF. 2013. Optimizing therapeutics in the management of patients with multiple sclerosis: a review of drug efficacy, dosing, and mechanisms of action. Biologics. 7:247–258.
  • del Barco DG, Montero E, Coro-Antich RM, Brown E, Suarez-Alba J, Lopez L, Subiros N, Berlanga J. 2011. Coadministration of epidermal growth factor and growth hormone releasing peptide-6 improves clinical recovery in experimental autoimmune encephalitis. Restor Neurol Neurosci. 29(4):243–252.
  • Dykman KD, Dykman RA. 1998. Effect of nutritional supplements on attentional-deficit hyperactivity disorder. Integr Physiol Behav Sci. 33(1):49–60.
  • Finsen B, Antel J, Owens T. 2002. TNF alpha: Kill or cure for demyelinating disease? Mol Psychiatry. 7(8):820–821.
  • Gonzalez-Perez O, Romero-Rodriguez R, Soriano-Navarro M, Garcia-Verdugo JM, Alvarez-Buylla A. 2009. Epidermal growth factor induces the progeny of subventricular zone type b cells to migrate and differentiate into oligodendrocytes. Stem Cells. 27(8):2032–2043.
  • Goodin DS, Ebers GC, Cutter G, Cook SD, O'Donnell T, Reder AT, Kremenchutzky M, Oger J, Rametta M, Beckmann K, et al. 2012. Cause of death in MS: Long-term follow-up of a randomised cohort, 21 years after the start of the pivotal IFNbeta-1b study. BMJ Open. 2(6):e001972.
  • Heidary M, Rakhshi N, Pahlevan Kakhki M, Behmanesh M, Sanati MH, Sanadgol N, Kamaladini H, Nikravesh A. 2014. The analysis of correlation between IL-1B gene expression and genotyping in multiple sclerosis patients. J Neurol Sci. 343(1-2):41–45.
  • Hofman FM, Hinton DR, Johnson K, Merrill JE. 1989. Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med. 170(2):607–612.
  • Hollifield RD, Harbige LS, Pham-Dinh D, Sharief MK. 2003. Evidence for cytokine dysregulation in multiple sclerosis: peripheral blood mononuclear cell production of pro-inflammatory and anti-inflammatory cytokines during relapse and remission. Autoimmunity. 36(3):133–141.
  • Kampman MT, Steffensen LH, Mellgren SI, Jorgensen L. 2012. Effect of vitamin D3 supplementation on relapses, disease progression, and measures of function in persons with multiple sclerosis: exploratory outcomes from a double-blind randomised controlled trial. Mult Scler. 18(8):1144–1151.
  • Kurtzke JF. 1983. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 33(11):1444–1452.
  • Leithauser F, Dhein J, Mechtersheimer G, Koretz K, Bruderlein S, Henne C, Schmidt A, Debatin KM, Krammer PH, Moller P. 1993. Constitutive and induced expression of Apo-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab Invest. 69(4):415–429.
  • Leong EM, Semple SJ, Angley M, Siebert W, Petkov J, McKinnon RA. 2009. Complementary and alternative medicines and dietary interventions in multiple sclerosis: what is being used in South Australia and why? Complement Ther Med. 17(4):216–223.
  • Lewis JE, Atlas SE, Higuera OL, Fiallo A, Rasul A, Farooqi A, Kromo O, Lantigua LA, Tiozzo E, Woolger JM, et al. 2018. The effect of a hydrolyzed polysaccharide dietary supplement on biomarkers in adults with nonalcoholic fatty liver disease. Evid Based Complement Alternat Med. 2018:1751583
  • Lewis JE, McDaniel HR, Agronin ME, Loewenstein DA, Riveros J, Mestre R, Martinez M, Colina N, Abreu D, Konefal J, et al. 2013. The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer's disease. J Alzheimers Dis. 33(2):393–406.
  • Liao W, Lin JX, Leonard WJ. 2011. IL-2 family cytokines: new insights into the complex roles of il-2 as a broad regulator of t helper cell differentiation. Curr Opin Immunol. 23(5):598–604.
  • Livingston T, Fay M, Iyer R, Wells W, Pill MW. 2016. Quantifying differences in health care consumption for the management of multiple sclerosis within privately and publicly insured health care programs. J Manag Care Spec Pharm. 22(12):1385–1391.
  • Mahon BD, Gordon SA, Cruz J, Cosman F, Cantorna MT. 2003. Cytokine profile in patients with multiple sclerosis following vitamin d supplementation. J Neuroimmunol. 134(1-2):128–132.
  • Maimone D, Gregory S, Arnason BG, Reder AT. 1991. Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. J Neuroimmunol. 32(1):67–74.
  • Malek TR, Castro I. 2010. Interleukin-2 receptor signaling at the interface between tolerance and immunity. Immunity. 33(2):153–165.
  • McCarty MF. 1997. Glucosamine may retard atherogenesis by promoting endothelial production of heparan sulfate proteoglycans. Med Hypotheses. 48(3):245–251.
  • McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, et al. 2001. Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol. 50(1):121–127.
  • Miyawaki T, Uehara T, Nibu R, Tsuji T, Yachie A, Yonehara S, Taniguchi N. 1992. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood. J Immunol. 149(11):3753–3758.
  • Montgomery S, Hillert J, Bahmanyar S. 2013. Hospital admission due to infections in multiple sclerosis patients. Eur J Neurol. 20(8):1153–1160.
  • Nagafuji K, Shibuya T, Harada M, Mizuno S, Takenaka K, Miyamoto T, Okamura T, Gondo H, Niho Y. 1995. Functional expression of fas antigen (cd95) on hematopoietic progenitor cells. Blood. 86(3):883–889.
  • Nagata S, Golstein P. 1995. The fas death factor. Science. 267(5203):1449–1456.
  • Nelson RE, Xie Y, DuVall SL, Butler J, Kamauu AW, Knippenberg K, Schuerch M, Foskett N, LaFleur J. 2015. Multiple sclerosis and risk of infection-related hospitalization and death in us veterans. Int J MS Care. 17(5):221–230.
  • Nieuwkamp DJ, Murk JL, van Oosten BW, Cremers CH, Killestein J, Viveen MC, Van Hecke W, Frijlink DW, Wattjes MP, Consortium PMLiDMP. 2015. PML in a patient without severe lymphocytopenia receiving dimethyl fumarate. N Engl J Med. 372(15):1474–1476.
  • Oreja-Guevara C, Ramos-Cejudo J, Aroeira LS, Chamorro B, Diez-Tejedor E. 2012. TH1/TH2 cytokine profile in relapsing-remitting multiple sclerosis patients treated with glatiramer acetate or natalizumab. BMC Neurol. 12(1):95.
  • Owen-Schaub LB, Yonehara S, Crump WL, Grimm EA. 1992. DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by FAS antigen engagement. Cell Immunol. 140(1):197–205.
  • Perfetto SP, Ambrozak D, Nguyen R, Chattopadhyay P, Roederer M. 2006. Quality assurance for polychromatic flow cytometry. Nat Protoc. 1(3):1522–1530.
  • Petursdottir DH, Olafsdottir I, Hardardottir I. 2002. Dietary fish oil increases tumor necrosis factor secretion but decreases interleukin-10 secretion by murine peritoneal macrophages. J Nutr. 132(12):3740–3743.
  • Ramirez-Ramirez V, Macias-Islas MA, Ortiz GG, Pacheco-Moises F, Torres-Sanchez ED, Sorto-Gomez TE, Cruz-Ramos JA, Orozco-Avina G, Celis de la Rosa AJ. 2013. Efficacy of fish oil on serum of TNF α , IL-1 β , and IL-6 oxidative stress markers in multiple sclerosis treated with interferon beta-1b. Oxid Med Cell Longev. 2013:709493
  • Rezapour-Firouzi S, Arefhosseini SR, Mehdi F, Mehrangiz E-M, Baradaran B, Sadeghihokmabad E, Mostafaei S, Fazljou SMB, Torbati M-A, Sanaie S, Zamani F. 2013. Immunomodulatory and therapeutic effects of hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Complement Ther Med. 21(5):473–480.
  • Rosenkranz T, Novas M, Terborg C. 2015. PML in a patient with lymphocytopenia treated with dimethyl fumarate. N Engl J Med. 372(15):1476–1478.
  • Sachdeva N, Yoon HS, Oshima K, Garcia D, Goodkin K, Asthana D. 2007. Biochip array-based analysis of plasma cytokines in HIV patients with immunological and virological discordance. Scand J Immunol. 65(6):549–554.
  • Saheki K, Fujimori Y, Takemoto Y, Kakishita E. 2000. Increased expression of FAS (Apo-1, CD95) on CD34+ haematopoietic progenitor cells after allogeneic bone marrow transplantation. Br J Haematol. 109(2):447–452.
  • Scalabrino G, Galimberti D, Mutti E, Scalabrini D, Veber D, De Riz M, Bamonti F, Capello E, Mancardi GL, Scarpini E. 2010. Loss of epidermal growth factor regulation by cobalamin in multiple sclerosis. Brain Res. 1333:64–71.
  • Scalabrino G, Veber D, De Giuseppe R, Roncaroli F. 2015. Low levels of cobalamin, epidermal growth factor, and normal prions in multiple sclerosis spinal cord. Neuroscience. 298:293–301.
  • See DM, Cimoch P, Chou S, Chang J, Tilles J. 1998. The in vitro immunomodulatory effects of glyconutrients on peripheral blood mononuclear cells of patients with chronic fatigue syndrome. Integr Physiol Behav Sci. 33(3):280–287.
  • Sharief MK, Hentges R. 1991. Association between tumor necrosis factor-alpha and disease progression in patients with multiple sclerosis. N Engl J Med. 325(7):467–472.
  • Skurkovich S, Boiko A, Beliaeva I, Buglak A, Alekseeva T, Smirnova N, Kulakova O, Tchechonin V, Gurova O, Deomina T, et al. 2001. Randomized study of antibodies to IFN-G and TNF-A in secondary progressive multiple sclerosis. Mult Scler. 7(5):277–284.,.
  • Sugarman BJ, Aggarwal BB, Hass PE, Figari IS, Palladino MA, Jr, Shepard HM. 1985. Recombinant human tumor necrosis factor-alpha: Effects on proliferation of normal and transformed cells in vitro. Science. 230(4728):943–945.
  • Tejera-Alhambra M, Casrouge A, de Andres C, Seyfferth A, Ramos-Medina R, Alonso B, Vega J, Fernandez-Paredes L, Albert ML, Sanchez RS. 2015. Plasma biomarkers discriminate clinical forms of multiple sclerosis. PLoS One. 10(6):e0128952
  • Torkildsen O, Wergeland S, Bakke S, Beiske AG, Bjerve KS, Hovdal H, Midgard R, Lilleas F, Pedersen T, Bjornara B, et al. 2012. ω-3 fatty acid treatment in multiple sclerosis (OFAMS Study): a randomized, double-blind, placebo-controlled trial. Arch Neurol. 69(8):1044–1051. Omega
  • Valiathan R, Deeb K, Diamante M, Ashman M, Sachdeva N, Asthana D. 2014. Reference ranges of lymphocyte subsets in healthy adults and adolescents with special mention of t cell maturation subsets in adults of South Florida. Immunobiology. 219(7):487–496.
  • van Kester MS, Bouwes Bavinck JN, Quint KD. 2015. PML in patients treated with dimethyl fumarate. N Engl J Med. 373(6):583–584.
  • van Oosten BW, Killestein J, Barkhof F, Polman CH, Wattjes MP. 2013. PML in a patient treated with dimethyl fumarate from a compounding pharmacy. N Engl J Med. 368(17):1658–1659.
  • Vargas DL, Tyor WR. 2017. Update on disease-modifying therapies for multiple sclerosis. J Investig Med. 65(5):883–891.
  • Varki A, Cummings RD, Esko JD, Stanley P, Hart G, Aebi M, Darvill A, Kinoshita T, Packer NH, PJJ, et al. 2015. Essentials of glycobiology. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
  • Veldman FJ, Nair CH, Vorster HH, Vermaak WJ, Jerling JC, Oosthuizen W, Venter CS. 1999. Possible mechanisms through which dietary pectin influences fibrin network architecture in hypercholesterolaemic subjects. Thromb Res. 93(6):253–264.
  • Waters RS, Perry JS, Han S, Bielekova B, Gedeon T. 2018. The effects of interleukin-2 on immune response regulation. Math Med Biol. 35(1):79–119.
  • Winkelmann A, Loebermann M, Reisinger EC, Zettl UK. 2014. Multiple sclerosis treatment and infectious issues: Update 2013. Clin Exp Immunol. 175(3):425–438.

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