A Double-Blind, Cross-Over Study to Examine the Effects of Maritime Pine Extract on Exercise Performance and Postexercise Inflammation, Oxidative Stress, Muscle Soreness, and Damage

References

• Alessio HM, Goldfarb AH, Cao G. 1997. Exercise-induced oxidative stress before and after vitamin C supplementation. Int J Sport Nutr. 7(1):1–9.
   PubMedGoogle Scholar
• Bailey DM, Young IS, McEneny J, Lawrenson L, Kim J, Barden J, Richardson RS. 2004. Regulation of free radical outflow from an isolated muscle bed in exercising humans. Am J Physiol Heart Circ Physiol. 287(4):H1689–H1699. doi:10.1152/ajpheart.00148.2004.
   PubMed Web of Science ®Google Scholar
• Bellar D, Judge LW, Petersen J, Bellar A, Bryan CL. 2014. Exercise and academic performance among nursing and kinesiology students at US colleges. J Edu Health Promot . 3(1):9. doi:10.4103/2277-9531.127560.
   PubMedGoogle Scholar
• Carr A, Frei B. 2000. The role of natural antioxidants in preserving the biological activity of endothelium-derived nitric oxide. Free Radic. Biol. Med. 28(12):1806–1814. doi:10.1016/S0891-5849(00)00225-2.
   PubMed Web of Science ®Google Scholar
• Chen P, Song F, Lin L-Z. 2009. Chromatographic fingerprint analysis of Pycnogenol dietary supplements. J AOAC Int. 92:624–632.
   PubMed Web of Science ®Google Scholar
• Chevion M. 2000. Human studies related to protein oxidation: protein carbonyl content as a marker of damage. Free Radic Res. 33(Suppl):S99.
   PubMedGoogle Scholar
• Davies KJ, Quintanilha AT, Brooks GA, Packer L. 1982. Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun. 107(4):1198–1205.
   PubMed Web of Science ®Google Scholar
• Enseleit F, Sudano I, Périat D, Winnik S, Wolfrum M, Flammer AJ, Fröhlich GM, Kaiser P, Hirt A, Haile SR, et al. 2012. Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study. Eur Heart J. 33(13):1589–1597. doi:10.1093/eurheartj/ehr482.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick DF, Bing B, Rohdewald P. 1998. Endothelium-dependent vascular effects of Pycnogenol. J. Cardiovasc. Pharmacol. 32(4):509–515. doi:10.1097/00005344-199810000-00001.
   PubMed Web of Science ®Google Scholar
• Iravani S, Zolfaghari B. 2011. Pharmaceutical and nutraceutical effects of Pinus pinaster bark extract. Res Pharm Sci. 6(1):1–11.
   PubMedGoogle Scholar
• Knez WL, Jenkins DG, Coombes JS. 2007. Oxidative stress in half and full Ironman triathletes. Med Sci Sports Exerc. 29:283–288. doi:10.1249/01.mss.0000246999.09718.0c.
   Google Scholar
• Lee JOOHYUNG, Goldfarb ALLANH, Rescino MARKH, Hegde SUDHIR, Patrick STEVE, Apperson KATHY. 2002. Eccentric exercise effect on blood oxidative-stress markers and delayed onset of muscle soreness. Med Sci Sports Exerc. 34(3):443. doi:10.1097/00005768-200203000-00010.
   PubMed Web of Science ®Google Scholar
• Mach J, Midgley AW, Dank S, Grant RS, Bentley DJ. 2010. The effect of antioxidant supplementation on fatigue during exercise: potential role for NAD+(H). Nutrients. 2(3):319–329. doi:10.3390/nu2030319.
   PubMed Web of Science ®Google Scholar
• Marzatico F, Pansarasa O, Bertorelli L, Somenzini G, Della Valle G. 1997. Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly trained aerobic and sprint athletes. J. Sports Med Phys Fitness. 37:235–239.
   PubMed Web of Science ®Google Scholar
• Nikolaidis MG, Kyparos A, Hadziioannou M, Panou N, Samaras L, Jamurtas AZ, Kouretas D. 2007. Acute exercise markedly increases blood oxidative stress in boys and girls. Appl Physiol Nutr Metab. 32(2):197–205. doi:10.1139/h06-097.
   PubMed Web of Science ®Google Scholar
• Nishioka K, Hidaka T, Nakamura S, Umemura T, Jitsuiki D, Soga J, Goto C, Chayama K, Yoshizumi M, Higashi Y. 2007. Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans. Hypertens Res. 30(9):775–780. doi:10.1291/hypres.30.775.
   PubMed Web of Science ®Google Scholar
• Noda Y. 1997. Hydroxyl and superoxide anion radical scavenging activities of natural source antioxidants using the computerized JES-FR30 ESR spectrometer system. TBMB. 42:35–44. doi:10.1080/15216549700202411.
   Google Scholar
• Packer L, Rimbach G, Virgili F. 1999. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med. 27(5-6):704–724.
   PubMed Web of Science ®Google Scholar
• Pingitore A, Lima GPP, Mastorci F, Quinones A, Iervasi G, Vassalle C. 2015. Exercise and oxidative stress: potential effects of antioxidant dietary strategies in sports. Nutrition. 31(7-8):916–922. doi:10.1016/j.nut.2015.02.005.
   PubMed Web of Science ®Google Scholar
• Powers SK, Jackson MJ. 2008. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev. 4:1243–1276.
   Google Scholar
• Rohdewald P. 2002. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Cp . 40(04):158–168. doi:10.5414/CPP40158.
   Google Scholar
• Sivonová M, Waczulíková I, Kilanczyk E, Hrnciarová M, Bryszewska M, Klajnert B, Duracková Z. 2004. The effect of Pycnogenol on the erythrocyte membrane fluidity. Gen Physiol Biophys. 23(1):39–51.
   PubMed Web of Science ®Google Scholar
• Steinburg JG, Delliaux S, Jammes Y. 2006. Reliability of different blood indices to explore the oxidative stress in response to maximal cycling and static exercises. Clin Physiol Funct Imaging. 26:106–112. doi:10.1111/j.1475-097X.2006.00658.x.
   PubMed Web of Science ®Google Scholar
• Uhlenhut K, Högger P. 2012. Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol). Free Radic. Biol. Med. 53(2):305–313. doi:10.1016/j.freeradbiomed.2012.04.013.
   PubMed Web of Science ®Google Scholar
• Urso M, Clarkson PM. 2003. Oxidative stress, exercise and antioxidant supplementation. Toxicology. 189(1-2):41–54. doi:10.1016/S0300-483X(03)00151-3.
   PubMed Web of Science ®Google Scholar
• Vinciguerra G, Belcaro G, Bonanni E, Cesarone MR, Rotondi V, Ledda A, Hosoi M, Dugall M, Cacchio M, Cornelli U, et al. 2013. Evaluation of the effects of supplementation with Pycnogenol® on fitness in normal subjects with the Army Physical Fitness Test and in performances of athletes in the 100-minute triathlon. J Sports Med Phys Fitness. 53(6):644–654.
   PubMed Web of Science ®Google Scholar
• Vinciguerra G, Belcaro G, Cesarone MR, Rohdewald P, Stuard S, Ricci A, Di Renzo A, Hosoi M, Dugall M, Ledda A, et al. 2006. Cramps and muscular pain: prevention with Pycnogenol in normal subjects, venous patients, athletes, claudicants and in diabetic microangiopathy. Angiology. 57(3):331–339. doi:10.1177/000331970605700309.
   PubMed Web of Science ®Google Scholar
• Voss P, Horakova L, Jakstadt M, Kiekebusch D, Grune T. 2006. Ferritin oxidation and proteasomal degradation: protection by antioxidants. Free Radic. Res. 40(7):673–683. doi:10.1080/10715760500419357.
   PubMed Web of Science ®Google Scholar
• Waring WS, Convery A, Mishra V, Shenkin A, Webb DJ, Maxwell SRJ. 2003. Uric acid reduces exercise-induced oxidative stress in healthy adults. Clin Sci. 105(4):425–430. doi:10.1042/CS20030149.
   PubMed Web of Science ®Google Scholar