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Articles

The Novel Effects of a Hydrolyzed Polysaccharide Dietary Supplement on Immune, Hepatic, and Renal Function in Adults with HIV in a Randomized, Double-Blind, Placebo-Control Trial

, PhD, , , MD, , MD, , MD, , MBA, , BS, , MD, , BS, , MD, , MD, , PhD, , MD, , BS, , PhD, , MD & , PhD show all

References

  • Adleman LM, Wofsy D. 1993. T-cell homeostasis: Implications in HIV infection. J Acquir Immune Defic Syndr. 6(2):144–152.
  • Ali K, Melillo A, Leonard S, Asthana D, Woolger J, Wolfson A, McDaniel H, Lewis J. 2012. An open-label, randomized clinical trial to assess the immunomodulatory activity of a novel oligosaccharide compound in healthy adults. FFHD. 2(7):265–279. doi:10.31989/ffhd.v2i7.84.
  • Appay V, Sauce D. 2008. Immune activation and inflammation in HIV-1 infection: Causes and consequences. J Pathol. 214(2):231–241. doi:10.1002/path.2276.
  • Buggert M, Frederiksen J, Noyan K, Svard J, Barqasho B, Sonnerborg A, Lund O, Nowak P, Karlsson AC. 2014. Multiparametric bioinformatics distinguish the CD4/CD8 ratio as a suitable laboratory predictor of combined T cell pathogenesis in HIV infection. J Immunol. 192(5):2099–2108. doi:10.4049/jimmunol.1302596.
  • Caby F, Guihot A, Lambert-Niclot S, Guiguet M, Boutolleau D, Agher R, Valantin MA, Tubiana R, Calvez V, Marcelin AG, et al. 2016. Determinants of a low CD4/CD8 ratio in HIV-1-infected individuals despite long-term viral suppression. Clin Infect Dis. 62(10):1297–1303. doi:10.1093/cid/ciw076.
  • Caby F, Writing committee of the CD4+/CD8+ Ratio Working Group of the French Hospital Database on HIV (FHDH-ANRS CO4). 2017. CD4+/CD8+ ratio restoration in long-term treated HIV-1-infected individuals. AIDS. 31(12):1685–1695.
  • Centers for Disease Control and Prevention. 1992. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Morb Mortal Weekly Rep. 41(51):961–962.
  • Centers for Disease Control and Prevention. 2008. HIV prevalence estimates–United States, 2006. MMWR Morb Mortal Wkly Rep. 57(39):1073–1076.
  • Centers for Disease Control and Prevention. 2016. HIV surveillance report, 2015. [accessed May 12, 2017]. http://www.cdc.gov/hiv/library/reports/hiv-surveillance.html.
  • Cholujova D, Jakubikova J, Czako B, Martisova M, Hunakova L, Duraj J, Mistrik M, Sedlak J. 2013. MGN-3 arabinoxylan rice bran modulates innate immunity in multiple myeloma patients. Cancer Immunol Immunother. 62(3):437–445. doi:10.1007/s00262-012-1344-z.
  • De Biasi S, Bianchini E, Nasi M, Digaetano M, Gibellini L, Carnevale G, Borghi V, Guaraldi G, Pinti M, Mussini C, et al. 2016. Th1 and th17 proinflammatory profile characterizes invariant natural killer T cells in virologically suppressed HIV + patients with low CD4+/CD8+ ratio. AIDS. 30(17):2599–2610. doi:10.1097/QAD.0000000000001247.
  • Ghoneum M, Agrawal S. 2014. MGN3/biobran enhances generation of cytotoxic CD8+ T cells via upregulation of dec-205 expression on dendritic cells. Int J Immunopathol Pharmacol. 27(4):523–530. doi:10.1177/039463201402700408.
  • Ghoneum M, Matsuura M. 2004. Augmentation of macrophage phagocytosis by modified arabinoxylan rice bran (MGN-3/biobran). Int J Immunopathol Pharmacol. 17(3):283–292. doi:10.1177/039463200401700308.
  • Ghoneum M. 1998a. Anti-HIV activity in vitro of MGN-3, an activated arabinoxylane from rice bran. Biochem Biophys Res Commun. 243(1):25–29. doi:10.1006/bbrc.1997.8047.
  • Ghoneum M. 1998b. Enhancement of human natural killer cell activity by modified arabinoxylan from rice bran MGN-3. Int J Immunotherapy. 14(2):89–99.
  • Hazenberg MD, Otto SA, van Benthem BH, Roos MT, Coutinho RA, Lange JM, Hamann D, Prins M, Miedema F. 2003. Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS. 17(13):1881–1888. doi:10.1097/01.aids.0000076311.76477.6e.
  • Hema MN, Ferry T, Dupon M, Cuzin L, Verdon R, Thiebaut R, Protopopescu C, Leport C, Raffi F, Le Moing V. 2016. Low CD4/CD8 ratio is associated with non aids-defining cancers in patients on antiretroviral therapy: Anrs co8 (aproco/copilote) prospective cohort study. PLoS One. 11(8):e0161594. doi:10.1371/journal.pone.0161594.
  • Ivanov AV, Valuev-Elliston VT, Ivanova ON, Kochetkov SN, Starodubova ES, Bartosch B, Isaguliants MG. 2016. Oxidative stress during HIV infection: Mechanisms and consequences. Oxid Med Cell Longev. 2016:8910396. doi:10.1155/2016/8910396.
  • Kalebic T, Kinter A, Poli G, Anderson ME, Meister A, Fauci AS. 1991. Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and n-acetylcysteine. Proc Natl Acad Sci Usa. 88(3):986–990. doi:10.1073/pnas.88.3.986.
  • Krantz EM, Hullsiek KH, Okulicz JF, Weintrob AC, Agan BK, Crum-Cianflone NF, Ganesan A, Ferguson TM, Hale BR, Infectious Disease Clinical Research Program H. 2011. Elevated CD8 counts during haart are associated with HIV virologic treatment failure. J Acquir Immune Defic Syndr. 57(5):396–403. doi:10.1097/QAI.0b013e318221c62a.
  • Ku NS, Jiamsakul A, Ng OT, Yunihastuti E, Cuong DD, Lee MP, Sim BL, Phanuphak P, Wong WW, Kamarulzaman A, et al. 2016. Elevated CD8 T-cell counts and virological failure in HIV-infected patients after combination antiretroviral therapy. Medicine. 95(32):e4570. doi:10.1097/MD.0000000000004570.
  • Lewis JE, Atlas SE, Higuera OL, Fiallo A, Rasul A, Farooqi A, Kromo O, Lantigua LA, Tiozzo E, Woolger JM, et al. 2018. The effect of a hydrolyzed polysaccharide dietary supplement on biomarkers in adults with nonalcoholic fatty liver disease. Evid Based Complement Alternat Med. 2018:1751583. doi:10.1155/2018/1751583.
  • Merci NM, Emerence U, Augustin N, Habtu M, Julie I, Angelique T, Jessica B, Cynthia A, Penda AT. 2017. CD4+ cells recovery in HIV positive patients with severe immunosuppression at HAART initiation at centre medico-social corunum, kigali. Pan Afr Med J. 26:14. doi:10.11604/pamj.2017.26.14.10488.
  • Mussini C, Lorenzini P, Cozzi-Lepri A, Lapadula G, Marchetti G, Nicastri E, Cingolani A, Lichtner M, Antinori A, Gori A, et al. 2015. CD4/CD8 ratio normalisation and non-AIDS-related events in individuals with HIV who achieve viral load suppression with antiretroviral therapy: an observational cohort study. Lancet HIV. 2(3):e98–106. doi:10.1016/S2352-3018(15)00006-5.
  • Nanzigu S, Kiguba R, Kabanda J, Mukonzo JK, Waako P, Kityo C, Makumbi F. 2013. Poor immunological recovery among severely immunosuppressed antiretroviral therapy-naïve Ugandans. HIV AIDS (Auckl). 5:309–319. doi:10.2147/HIV.S50614.
  • Serrano-Villar S, Moreno S, Fuentes-Ferrer M, Sanchez-Marcos C, Avila M, Sainz T, de Villar NG, Fernandez-Cruz A, Estrada V. 2014. The CD4:CD8 ratio is associated with markers of age-associated disease in virally suppressed HIV-infected patients with immunological recovery. HIV Med. 15(1):40–49. doi:10.1111/hiv.12081.
  • Tazawa K, Namikawa H, Oida N, Masada M, Maeda H. 2000. Scavenging activity of modified arabinoxylane from rice bran (BioBran/MGN-3) with natural killer cell activity on free radicals. Biotherapy. 14:493–495.
  • Tinago W, Coghlan E, Macken A, McAndrews J, Doak B, Prior-Fuller C, Lambert JS, Sheehan GJ, Mallon PW; Mater Immunology Study G. 2014. Clinical, immunological and treatment-related factors associated with normalised CD4+/CD8+ T-cell ratio: Effect of naive and memory t-cell subsets. PLoS One. 9(5):e97011. doi:10.1371/journal.pone.0097011.
  • Zheng L, Taiwo B, Gandhi RT, Hunt PW, Collier AC, Flexner C, Bosch RJ. 2014. Factors associated with CD8+ T-cell activation in HIV-1-infected patients on long-term antiretroviral therapy. J Acquir Immune Defic Syndr. 67(2):153–160. doi:10.1097/QAI.0000000000000286.

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