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Articles

Effects of High-Dose, Short-Duration β-Alanine Supplementation on Cognitive Function, Mood, and Circulating Brain-Derived Neurotropic Factor (BDNF) in Recreationally-Active Males Before Simulated Military Operational Stress

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References

  • Banerjee S, Ghosh TK, Poddar MK. 2015. Carnosine reverses the aging-induced down regulation of brain regional serotonergic system. Mech Ageing Dev. 152:5–14.
  • Beedie CJ, Terry PC, Lane AM. 2000. The profile of mood states and athletic performance: two meta-analyses. J Appl Sport Psychol. 12(1):49–68.
  • Blancquaert L, Everaert I, Derave W. 2015. Beta-alanine supplementation, muscle carnosine and exercise performance. Curr Opin Clin Nutr Metab Care. 18(1):63–70.
  • Bleiberg J, Kane RL, Reeves DL, Garmoe WS, Halpern E. 2000. Factor analysis of computerized and traditional tests used in mild brain injury research. Clin Neuropsychol. 14(3):287–294.
  • Boldyrev A, Bulygina E, Leinsoo T, Petrushanko I, Tsubone S, Abe H. 2004. Protection of neuronal cells against reactive oxygen species by carnosine and related compounds. Comp Biochem Physiol B Biochem Mol Biol. 137(1):81–88.
  • Boldyrev A, Fedorova T, Stepanova M, Dobrotvorskaya I, Kozlova E, Boldanova N, Bagyeva G, Ivanova-Smolenskaya I, Illarioshkin S. 2008. Carnosine [corrected] increases efficiency of DOPA therapy of Parkinson’s disease: a pilot study. Rejuvenation Res. 11(4):821–827.
  • Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, et al. 2006. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314(5796):140–143.
  • Chengappa KN, Turkin SR, DeSanti S, Bowie CR, Brar JS, Schlicht PJ, Murphy SL, Hetrick ML, Bilder R, Fleet D. 2012. A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia. Schizophr Res. 142(1-3):145–152.
  • Chesnoy-Marchais D. 2016. Persistent GABAA/C responses to gabazine, taurine and beta-alanine in rat hypoglossal motoneurons. Neuroscience 330:191–204.
  • Church DD, Hoffman JR, Varanoske AN, Wang R, Baker KM, La Monica MB, Beyer KS, Dodd SJ, Oliveira LP, Harris RC, et al. 2017. Comparison of two beta-alanine dosing protocols on muscle carnosine elevations. J Am Coll Nutr. 36(8):608–616.
  • Cirulli F, Berry A, Chiarotti F, Alleva E. 2004. Intrahippocampal administration of BDNF in adult rats affects short-term behavioral plasticity in the Morris water maze and performance in the elevated plus-maze. Hippocampus 14(7):802–807.
  • Cohen J. 1969. Statistical power analysis for the behavioral sciences. New York (NY): Academic Press.
  • Dill DB, Costill DL. 1974. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol. 37(2):247–248.
  • Erickson KI, Prakash RS, Voss MW, Chaddock L, Heo S, McLaren M, Pence BD, Martin SA, Vieira VJ, Woods JA, et al. 2010. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. J Neurosci. 30(15):5368–5375.
  • Everaert I, Mooyaart A, Baguet A, Zutinic A, Baelde H, Achten E, Taes Y, De Heer E, Derave W. 2011. Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans. Amino Acids. 40(4):1221–1229.
  • Farmer CM, Vaughan CA, Garnett J, Weinick RM. 2015. Pre-deployment stress, mental health, and help-seeking behaviors among marines. Rand Health Q 5(1):23.
  • Faubert J, Sidebottom L. 2012. The NeuroTracker System: Its role for perceptual-cognitive training of athletes and its potential impact on injury reductions and concussion management in sports. J Clin Sport Psychol. 6:85–102.
  • Figurov A, Pozzo-Miller LD, Olafsson P, Wang T, Lu B. 1996. Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381(6584):706–709.
  • Fritzson P, Pihl A. 1957. The catabolism of C14-labeled uracil, dihydrouracil, and beta-ureidopropionic acid in the intact rat. J Biol Chem. 226(1):229–235.
  • Furst T, Massaro A, Miller C, Williams BT, LaMacchia ZM, Horvath PJ. 2018. beta-Alanine supplementation increased physical performance and improved executive function following endurance exercise in middle aged individuals. J Int Soc Sports Nutr. 15(1):32.
  • Gibbons TE, Pence BD, Petr G, Ossyra JM, Mach HC, Bhattacharya TK, Perez S, Martin SA, McCusker RH, Kelley KW, et al. 2014. Voluntary wheel running, but not a diet containing (-)-epigallocatechin-3-gallate and beta-alanine, improves learning, memory and hippocampal neurogenesis in aged mice. Behav Brain Res. 272:131–140.
  • Gross M, Boesch C, Bolliger CS, Norman B, Gustafsson T, Hoppeler H, Vogt M. 2014. Effects of beta-alanine supplementation and interval training on physiological determinants of severe exercise performance. Eur J Appl Physiol. 114(2):221–234.
  • Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JA. 2006. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids. 30(3):279–289.
  • Hayman M. 1942. Two minute clinical test for measurement of intellectual impairment in psychiatric disorders. Arch Neurpsych. 47(3):454–464.
  • Herculano B, Tamura M, Ohba A, Shimatani M, Kutsuna N, Hisatsune T. 2013. Beta-alanyl-L-histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer’s disease. J Alzheimers Dis. 33(4):983–997.
  • Hinton KE, Lahey BB, Villalta-Gil V, Boyd BD, Yvernault BC, Werts KB, Plassard AJ, Applegate B, Woodward ND, Landman BA, et al. 2018. Right fronto-subcortical white matter microstructure predicts cognitive control ability on the Go/No-go task in a community sample. Front Hum Neurosci. 12:127.
  • Hipkiss AR. 2010. Aging, proteotoxicity, mitochondria, glycation, NAD and carnosine: possible inter-relationships and resolution of the oxygen paradox. Front Aging Neurosci. 2:10.
  • Hipkiss AR, Worthington VC, Himsworth DT, Herwig W. 1998. Protective effects of carnosine against protein modification mediated by malondialdehyde and hypochlorite. Biochim Biophys Acta. 1380(1):46–54.
  • Hisatsune T, Kaneko J, Kurashige H, Cao Y, Satsu H, Totsuka M, Katakura Y, Imabayashi E, Matsuda H. 2015. Effect of anserine/carnosine supplementation on verbal episodic memory in elderly people. J Alzheimers Dis. 50(1):149–159.
  • Hobson RM, Saunders B, Ball G, Harris RC, Sale C. 2012. Effects of beta-alanine supplementation on exercise performance: a meta-analysis. Amino Acids. 43(1):25–37.
  • Hoffman JR, Gepner Y, Cohen H. 2019. Beta-alanine supplementation reduces anxiety and increases neurotrophin expression in both young and older rats. Nutr Res. 62:51–63.
  • Hoffman JR, Landau G, Stout JR, Dabora M, Moran DS, Sharvit N, Hoffman MW, Ben Moshe Y, McCormack WP, Hirschhorn G, et al. 2014. β-alanine supplementation improves tactical performance but not cognitive function in combat soldiers. J Int Soc Sports Nutr. 11(1):15.
  • Hoffman JR, Landau G, Stout JR, Hoffman MW, Shavit N, Rosen P, Moran DS, Fukuda DH, Shelef I, Carmom E, et al. 2015. β-Alanine ingestion increases muscle carnosine content and combat specific performance in soldiers. Amino Acids. 47(3):627–636.
  • Hoffman JR, Ostfeld I, Stout JR, Harris RC, Kaplan Z, Cohen H. 2015. β-Alanine supplemented diets enhance behavioral resilience to stress exposure in an animal model of PTSD. Amino Acids. 47(6):1247–1257.
  • Hoffman JR, Ratamess NA, Faigenbaum AD, Ross R, Kang J, Stout JR, Wise JA. 2008. Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players. Nutr Res. 28(1):31–35.
  • Hoffman JR, Rathmacher JA, Robinson J, Gepner Y, Cohen H. 2019. Effect of beta-alanine supplementation on carnosine and histidine content in the hippocampus of 14-month-old rats. Appl Physiol Nutr Metab. 44(10):1112–1115.
  • Hoffman JR, Zuckerman A, Ram O, Sadot O, Stout JR, Ostfeld I, Cohen H. 2017. Behavioral and inflammatory response in animals exposed to a low-pressure blast wave and supplemented with beta-alanine. Amino Acids. 49(5):871–886.
  • Jin CL, Yang LX, Wu XH, Li Q, Ding MP, Fan YY, Zhang WP, Luo JH, Chen Z. 2005. Effects of carnosine on amygdaloid-kindled seizures in Sprague-Dawley rats. Neuroscience 135(3):939–947.
  • Kane RL, Reeves DL. 1997. Computerized test batteries. In: Horton A, Wedding D, Webster J, editors. The neuropsychology handbook. New York (NY): Springer; p. 423–460.
  • Klein AB, Williamson R, Santini MA, Clemmensen C, Ettrup A, Rios M, Knudsen GM, Aznar S. 2011. Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharm Neuropsychopharmacol. 14(03):347–353.
  • Kohen R, Yamamoto Y, Cundy KC, Ames BN. 1988. Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain. Proc Natl Acad Sci USA. 85(9):3175–3179.
  • Logan GD, Schachar RJ, Tannock R. 1997. Impulsivity and inhibitory control. Psychol Sci. 8(1):60–64.
  • Lombardi C, Carubelli V, Lazzarini V, Vizzardi E, Bordonali T, Ciccarese C, Castrini AI, Dei Cas A, Nodari S, Metra M. 2015. Effects of oral administration of orodispersible levo-carnosine on quality of life and exercise performance in patients with chronic heart failure. Nutrition 31(1):72–78.
  • Mangine GT, Hoffman JR, Wells AJ, Gonzalez AM, Rogowski JP, Townsend JR, Jajtner AR, Beyer KS, Bohner JD, Pruna GJ, et al. 2014. Visual tracking speed is related to basketball-specific measures of performance in NBA players. J Strength Cond Res. 28(9):2406–2414.
  • Mariani E, Polidori MC, Cherubini A, Mecocci P. 2005. Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci. 827(1):65–75.
  • McNair DM, Lorr M, Droppleman LF. 1971. Manual for the profile of mood states (POMS). San Diego (CA): Educational and Industrial Testing Service.
  • Murakami T, Furuse M. 2010. The impact of taurine- and beta-alanine-supplemented diets on behavioral and neurochemical parameters in mice: antidepressant versus anxiolytic-like effects. Amino Acids. 39(2):427–434.
  • Rokicki J, Li L, Imabayashi E, Kaneko J, Hisatsune T, Matsuda H. 2015. Daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults. Front Aging Neurosci. 7:219.
  • Saunders B, Elliott-Sale K, Artioli GG, Swinton PA, Dolan E, Roschel H, Sale C, Gualano B. 2017. Beta-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis. Br J Sports Med. 51(8):658–669. +.
  • Solis MY, Cooper S, Hobson RM, Artioli GG, Otaduy MC, Roschel H, Robertson J, Martin D, Painelli VS, Harris RC, et al. 2015. Effects of beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory study. PLoS One. 10(4):e0123857.
  • Szczesniak D, Budzen S, Kopec W, Rymaszewska J. 2014. Anserine and carnosine supplementation in the elderly: effects on cognitive functioning and physical capacity. Arch Gerontol Geriatr. 59(2):485–490.
  • Thorne DR. 2006. Throughput: a simple performance index with desirable characteristics. Behav Res Methods. 38(4):569–573.
  • Tomonaga S, Yamane H, Onitsuka E, Yamada S, Sato M, Takahata Y, Morimatsu F, Furuse M. 2008. Carnosine-induced antidepressant-like activity in rats. Pharmacol Biochem Behav. 89(4):627–632.
  • Trombley PQ, Horning MS, Blakemore LJ. 2000. Interactions between carnosine and zinc and copper: implications for neuromodulation and neuroprotection. Biochemistry Mosc. 65(7):807–816.
  • van Paridon KN, Timmis MA, Nevison CM, Bristow M. 2017. The anticipatory stress response to sport competition; a systematic review with meta-analysis of cortisol reactivity. BMJ Open Sport Exerc Med. 3(1):e000261.
  • Varanoske AN, Wells AJ, Kozlowski GJ, Gepner Y, Frosti CL, Boffey D, Coker NA, Harat I, Hoffman JR. 2018. Effects of beta-alanine supplementation on physical performance, cognition, endocrine function, and inflammation during a 24 h simulated military operation. Physiol Rep. 6(24):e13938.
  • Wells AJ, Hoffman JR, Beyer KS, Jajtner AR, Gonzalez AM, Townsend JR, Mangine GT, Robinson EH, McCormack WP, Fragala MS, et al. 2014. Reliability of the dynavision (TM) D2 for assessing reaction time performance. J Sports Sci Med. 13(1):145–150.
  • Wetmore C, Ernfors P, Persson H, Olson L. 1990. Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp Neurol. 109(2):141–152.
  • Yamashita S, Sato M, Matsumoto T, Kadooka K, Hasegawa T, Fujimura T, Katakura Y. 2018. Mechanisms of carnosine-induced activation of neuronal cells. Biosci Biotechnol Biochem. 82(4):683–688.

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