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Research Articles

A Nutritional Blend Suppresses the Inflammatory Response from Bronchial Epithelial Cells Induced by SARS-CoV-2

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References

  • Poor HD. Pulmonary thrombosis and thromboembolism in COVID-19. Chest. 2021;S0012-3692(21)01126-0. doi:10.1016/j.chest.2021.06.016.PMID: 34153340.
  • de Roquetaillade C, Mansouri S, Brumpt C, Neuwirth M, Voicu S, Le Dorze M, Fontaine C, Barthelemy R, Gayat E, Megarbane B, et al. Comparison of circulating immune cells profiles and kinetics between coronavirus disease 2019 and bacterial sepsis. Crit Care Med. 2021. doi:10.1097/CCM.0000000000005088.PMID: 34001691.
  • Lange A, Lange J, Jaskuła E. Cytokine overproduction and immune system dysregulation in alloHSCT and COVID-19 patients. Front Immunol. 2021;12:658896. doi:10.3389/fimmu.2021.658896. PMID: 34149697; PMCID: PMC8206782.
  • Chua RL, Lukassen S, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, et al. COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis. Nat Biotechnol. 2020;38(8):970–9. doi:10.1038/s41587-020-0602-4. Epub 2020 Jun 26. PMID: 32591762.
  • Frey A, Lunding LP, Ehlers JC, Weckmann M, Zissler UM, Wegmann M. More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis. Front Immunol. 2020;11:761. doi:10.3389/fimmu.2020.00761.
  • Caricchio R, Abbate A, Gordeev I, Meng J, Hsue PY, Neogi T, Arduino R, Fomina D, Bogdanov R, Stepanenko T, CAN-COVID Investigators, et al. Effect of canakinumab vs placebo on survival without invasive mechanical ventilation in patients hospitalized with severe COVID-19: a randomized clinical trial. JAMA. 2021;326(3):230–9. doi:10.1001/jama.2021.9508.
  • Lambrecht BN, Hammad H. Allergens and the airway epithelium response: gateway to allergic sensitization. J Allergy Clin Immunol. 2014;134(3):499–507. doi:10.1016/j.jaci.2014.06.036.
  • Wohnhaas CT, Gindele JA, Kiechle T, Shen Y, Leparc GG, Stierstorfer B, Stahl H, Gantner F, Viollet C, Schymeinsky J, et al. Cigarette smoke specifically affects small airway ­epithelial cell populations and triggers the expansion of inflammatory and squamous differentiation associated basal cells. IJMS. 2021;22(14):7646. doi:10.3390/ijms22147646.
  • Stancil IT, Michalski JE, Davis-Hall D, Chu HW, Park JA, Magin CM, Yang IV, Smith BJ, Dobrinskikh E, Schwartz DA. Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional. Nat Commun. 2021;12(1):4566. doi:10.1038/s41467-021-24853-8.
  • Robinot R, Hubert M, de Melo GD, Lazarini F, Bruel T, Smith N, Levallois S, Larrous F, Fernandes J, Gellenoncourt S, et al. SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance. Nat Commun. 2021;12(1):4354. doi:10.1038/s41467-021-24521-x.
  • Lee HK, Jung O, Hennighausen L. JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells. Commun Biol. 2021;4(1):654. doi:10.1038/s42003-021-02167-1.
  • Garcia M, Santos-Dias A, Bachi ALL, Oliveira MC, Jr, Andrade-Souza AS, Ferreira SC, Aquino Jr, JCJ, Almeida FM, Rigonato-Oliveira NC, Oliveira APL, et al. Creatine supplementation impairs airway inflammation in an experimental model of asthma involving P2X7 receptor. Eur J Immunol. 2019;49(6):928–39. doi:10.1002/eji.201847657. Epub 2019 Apr 18.
  • Oliveira CR, Vieira RP. Anti-inflammatory activity of miodesin: modulation of inflammatory markers and epigenetic evidence. Oxid Med Cell Longev. 2020;2020:1–11. doi:10.1155/2020/6874260.
  • Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ, HLH Across Speciality Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395(10229):1033–4. Epub 2020 Mar 16. doi:10.1016/S0140-6736(20)30628-0.
  • Monteagudo LA, Boothby A, Gertner E. Continuous intravenous anakinra infusion to calm the cytokine storm in macrophage activation syndrome. ACR Open Rheumatol. 2020;2(5):276–82. doi:10.1002/acr2.11135.
  • Ullah MA, Rittchen S, Li J, Hasnain SZ, Phipps S. DP1 prostanoid receptor activation increases the severity of an acute lower respiratory viral infection in mice via TNF-α-induced immunopathology. Mucosal Immunol. 2021;14(4):963–10. doi:10.1038/s41385-021-00405-7.
  • Stravinskas Durigon T, MacKenzie B, Carneiro Oliveira M, Jr, Santos-Dias A, De Angelis K, Malfitano C, Kelly da Palma R, Moreno Guerra J, Damaceno-Rodrigues NR, Garcia Caldini E, et al. Aerobic exercise protects from pseudomonas aeruginosa-induced pneumonia in elderly mice. J Innate Immun. 2018;10(4):279–90. Epub 2018 May 29. doi:10.1159/000488953.
  • Lechowicz K, Drożdżal S, Machaj F, Rosik J, Szostak B, Zegan-Barańska M, Biernawska J, Dabrowski W, Rotter I, Kotfis K. COVID-19: The potential treatment of pulmonary fibrosis associated with SARS-CoV-2 infection. JCM. 2020;9(6):1917. doi:10.3390/jcm9061917.
  • Karina K, Christoffel LM, Novariani R, Rosadi I, Rosliana I, Rosidah S, Sobariah S, Fatkhurohman N, Puspitaningrum N, Hertati Y, et al. The effect of intravenous autologous activated platelet-rich plasma therapy on “Profibrotic Cytokine” IL-1beta levels in severe and critical COVID-19 patients: a preliminary study. Scientifica. 2021;2021:1–7. eCollection 2021. doi:10.1155/2021/9427978.
  • Borthwick LA. The IL-1 cytokine family and its role in inflammation and fibrosis in the lung. Semin Immunopathol. 2016;38(4):517–34. doi:10.1007/s00281-016-0559-z. Epub 2016 Mar 21.
  • Kohase M, May LT, Tamm I, Vilcek J, Sehgal PB. A cytokine network in human diploid fibroblasts: interactions of beta-interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1. Mol Cell Biol. 1987;7(1):273–80. doi:10.1128/mcb.7.1.273-280.1987.
  • Khaedir Y, Kartika R. Perspectives on targeting IL-6 as a potential therapeutic strategy for COVID-19. J Interferon Cytokine Res. 2021;41(2):37–43. doi:10.1089/jir.2020.0135.
  • Hollen CW, Henthorn J, Koziol JA, Burstein SA. Serum interleukin-6 levels in patients with thrombocytosis. Leuk Lymphoma. 1992;8(3):235–41. doi:10.3109/10428199209054910.
  • de la Cruz-Benito B, Rivas-Pollmar MI, Álvarez Román MT, Trelles-Martínez R, Martín-Salces M, Lázaro-Del Campo P, Ramírez-López A, García-Barcenilla S, Cebanu T, Acuña-Butta P, et al. Paradoxical effect of SARS-CoV-2 infection in patients with immune thrombocytopenia. Br J Haematol. 2021;192(6):973–7. doi:10.1111/bjh.17077. Epub 2020 Sep 10.
  • Vieira RP, Toledo ACd, Ferreira SC, Santos ABGd, Medeiros MCR, Hage M, Mauad T, Martins MdA, Dolhnikoff M, Carvalho CRFd Airway epithelium mediates the anti-inflammatory effects of exercise on asthma. Respir Physiol Neurobiol. 2011;175(3):383–9. doi:10.1016/j.resp.2011.01.002. Epub 2011 Jan 12.
  • Vieira RP, Claudino RC, Duarte AC, Santos AB, Perini A, Faria Neto HC, Mauad T, Martins MA, Dolhnikoff M, Carvalho CR. Aerobic exercise decreases chronic allergic lung inflammation and airway remodeling in mice. Am J Respir Crit Care Med. 2007;176(9):871–7. Epub 2007 Aug 9. doi:10.1164/rccm.200610-1567OC.
  • Toledo-Arruda AC, Vieira RP, Guarnier FA, Suehiro CL, Caleman-Neto A, Olivo CR, Arantes PMM, Almeida FM, Lopes F, Ramos EMC, et al. Time-course effects of aerobic physical training in the prevention of cigarette smoke-induced COPD. Physiol (1985). J Appl. 2017;123(3):674–83. Epub 2017 Jul 20. doi:10.1152/japplphysiol.00819.2016.
  • Rigonato-Oliveira NC, Mackenzie B, Bachi ALL, Oliveira MC, Jr, Santos-Dias A, Brandao-Rangel MAR, Delle H, Costa-Guimaraes T, Damaceno-Rodrigues NR, Dulley NR, et al. Aerobic exercise inhibits acute lung injury: from mouse to human evidence exercise reduced lung injury markers in mouse and in cells. Exerc Immunol Rev. 2018;24:36–44.
  • Kang S, Brown HM, Hwang S. Direct antiviral mechanisms of interferon-gamma. Immune Netw. 2018;18(5):e33. doi:10.4110/in.2018.18.e33.
  • Nathan CF, Murray HW, Wiebe ME, Rubin BY. Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med. 1983;158(3):670–89. doi:10.1084/jem.158.3.670.
  • Fan H, Hong B, Luo Y, Peng Q, Wang L, Jin X, Chen Y, Hu Y, Shi Y, Li T, et al. The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro. Signal Transduct Target Ther. 2020;5(1):275. doi:10.1038/s41392-020-00408-z. PMID: 33235188.
  • Campione E, Lanna C, Cosio T, Rosa L, Conte MP, Iacovelli F, Romeo A, Falconi M, Del Vecchio C, Franchin E, et al. Lactoferrin as antiviral treatment in COVID-19 management: preliminary evidence. IJERPH. 2021;18(20):10985. PMID: 34682731. doi:10.3390/ijerph182010985.
  • Ali AS, Hasan SS, Kow CS, Merchant HA. Lactoferrin reduces the risk of respiratory tract infections: a meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 2021;45:26–32. doi:10.1016/j.clnesp.2021.08.019. Epub 2021 Sep 3. PMID: 34620326.
  • Talukdar J, Bhadra B, Dattaroy T, Nagle V, Dasgupta S. Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19. Biomed Pharmacother. 2020;132:110886. doi:10.1016/j.biopha.2020.110886. Epub 2020 Oct 16. PMID: 33113418.
  • Zhang ZW, Xu XC, Liu T, Yuan S. Mitochondrion-permeable antioxidants to treat ros-burst-mediated acute diseases. Oxid Med Cell Longev. 2016;2016:6859523. doi:10.1155/2016/6859523. Epub 2015 Nov 16. PMID: 26649144.
  • Park JS, Chyun JH, Kim YK, Line LL, Chew BP. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr. Metab. 2010;7(18). doi:10.1186/1743-7075-7-18.
  • Chen H, Wang J, Li R, Lv C, Xu P, Wang Y, Song X, Zhang J. Astaxanthin attenuates pulmonary fibrosis through lncITPF and mitochondria-mediated signal pathways. J Cell Mol Med. 2020;24(17):10245–50. doi:10.1111/jcmm.15477. Epub 2020 Aug 19. PMID: 32813323
  • Giacomelli C, Piccarducci R, Marchetti L, Romei C, Martini C. Pulmonary fibrosis from molecular mechanisms to therapeutic interventions: lessons from post-COVID-19 patients. Biochem Pharmacol. 2021;193:114812. doi:10.1016/j.bcp.2021.114812. Online ahead of print. PMID: 34687672.
  • Chen S, Wu X, Duan J, Huang P, Li T, Yin Y, Yin J. Low-protein diets supplemented with glutamic acid or aspartic acid ameliorate intestinal damage in weaned piglets challenged with hydrogen peroxide. Anim Nutr. 2021;7(2):356–64. Epub 2021 Mar 10. PMID: 34258423. doi:10.1016/j.aninu.2020.12.005.
  • Asbaghi O, Ashtary-Larky D, Bagheri R, Moosavian SP, Nazarian B, Afrisham R, Kelishadi MR, Wong A, Dutheil F, Suzuki K, et al. Effects of folic acid supplementation on inflammatory markers: a grade-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Nutrients. 2021;13(7):2327. PMID: 34371837. doi:10.3390/nu13072327.
  • Ebaid H, Bashandy SAE, Abdel-Mageed AM, Al-Tamimi J, Hassan I, Alhazza IM. Folic acid and melatonin mitigate diabetic nephropathy in rats via inhibition of oxidative stress. Nutr Metab (Lond). 2020;17:6. doi:10.1186/s12986-019-0419-7. eCollection 2020. PMID: 31956332.
  • Candow DG, Vogt E, Johannsmeyer S, Forbes SC, Farthing JP. Strategic creatine supplementation and resistance training in healthy older adults. Appl Physiol Nutr Metab. 2015;40(7):689–94. Epub 2015 Feb 26. PMID: 25993883. doi:10.1139/apnm-2014-0498.
  • Piotrowicz K, Gąsowski J, Michel JP, Veronese N. Post-COVID-19 acute sarcopenia: physiopathology and management. Aging Clin Exp Res. 2021;33(10):2887–98. doi:10.1007/s40520-021-01942-8. Epub 2021 Jul 30. PMID: 34328636.
  • Nomura A, Zhang M, Sakamoto T, Ishii Y, Morishima Y, Mochizuki M, Kimura T, Uchida Y, Sekizawa K. Anti-inflammatory activity of creatine supplementation in endothelial cells in vitro. Br J Pharmacol. 2003;139(4):715–20. doi:10.1038/sj.bjp.0705316. PMID: 12812994.
  • Wood SM, Beckham C, Yosioka A, Darban H, Watson RR. Beta-carotene and selenium supplementation enhances immune response in aged humans. Integr Med. 2000;2(2–3):85–92. doi:10.1016/S1096-2190(00)00009-3.
  • Sun E, Xu H, Liu Q, Zhou J, Zuo P, Wang J. The mechanism for the effect of selenium supplementation on immunity. Biol Trace Elem Res. 1995;48(3):231–8. doi:10.1007/BF02789405.
  • Kieliszek M. Selenium. Adv Food Nutr Res. 2021;96:417–29. doi:10.1016/bs.afnr.2021.02.019.
  • Moffett JR, Namboodiri MA. Tryptophan and the immune response. Immunol Cell Biol. 2003;81(4):247–65. doi:10.1046/j.1440-1711.2003.t01-1-01177.x.
  • Sorgdrager FJH, Naudé PJW, Kema IP, Nollen EA, Deyn PP. Tryptophan metabolism in inflammaging: from biomarker to therapeutic target. Front Immunol. 2019;10:2565. doi:10.3389/fimmu.2019.02565.

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