410
Views
21
CrossRef citations to date
0
Altmetric
Original Articles

LC-ESI-MS/MS analysis of phosphodiesterase-5 inhibitors and their analogues in foods and dietary supplements in Korea

, , , , , , , & show all
Pages 1-8 | Received 26 Apr 2014, Accepted 18 Sep 2014, Published online: 18 Feb 2016

References

  • Alp M, Coşkun M, Göker H. 2013. Isolation and identification of a new sildenafil: propoxyphenyl sildenafil. J Pharm Biomed Anal. 72:155–158. doi:10.1016/j.jpba.2012.09.017
  • Balayssac S, Gilard V, Zedde C, Martino R, Malet-Martino M. 2012. Analysis of herbal dietary supplements for sexual performance enhancement: first characterization of propoxyphenyl-thiohydroxyhomosildenafil and identification of sildenafil, thiosildenafil, phentolamine and tetrahydropalmatine as adulterants. J Pharm Biomed Anal. 63:135–150. doi:10.1016/j.jpba.2012.01.035
  • Balayssac S, Trefi S, Gilard V, Malet-Martino M, Martino R, Delsuc M-A. 2009. 2D and 3D DOSY 1H NMR, a useful tool for analysis of complex mixtures: application to herbal drugs or dietary supplements for erectile dysfunction. J Pharm Biomed Anal. 50:602–612. doi:10.1016/j.jpba.2008.10.034
  • Han KM, Lee JH, Park H-J, Hwang I, Heo O-S, Kim WS. 2014. Isolation and identification of novel propoxyphenyl thiosildenafil found in natural health food product. Food Addit Contam Part A. 31:1–6. doi:10.1080/19440049.2013.855948
  • Kee C-L, Ge X, Koh H-L, Low M-Y. 2012. Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements. J Pharm Biomed Anal. 70:265–272. doi:10.1016/j.jpba.2012.07.008
  • Kim NS, Lee JH, Han KM, Kim HJ, Cho S, Han SY, Kim WS. 2013. Isolation and structural characterisation of a propoxyphenyl-linked thiohomosildenafil analogue found in a herbal product. Food Addit Contam Part A. 30:1693–1700. doi:10.1080/19440049.2013.823571
  • Kim S-H, Kim H-J, Son J, Jeon B-W, Jeong E-S, Cha E-J, Lee J. 2012. Simultaneous determination of synthetic phosphodiesterase-5- inhibitors in dietary supplements by liquid chromatography-high resolution/mass spectrometry. Mass Spectrom Lett. 3:50–53. doi:10.5478/MSL.2012.3.2.50
  • Korea Food and Drug Administration. 2011. Analysis of illegal compounds in food [Internet]. [cited 2013 Dec 12]. Available from: http://www.korea.kr/archive/expDocView.do?group=S&docId=30118
  • Lee H, Lee BJ. 2011. A novel approach to simultaneous screening and confirmation of regulated pharmaceutical compounds in dietary supplements by LC/MS/MS with an information-dependent acquisition method. Food Addit Contam Part A. 28:396–407. doi:10.1080/19440049.2011.551947
  • Lee E-S., Lee JH, Han KM, Kim JW, Hwang IS, Cho S, Han SY, Kim J. 2013. Simultaneous determination of 38 phospho-diestrase-5 inhibitors in illicit erectile dysfunction products by liquid chromatography -electrospray ionization-tandem mass spectrometry. J Pharm Biomed Anal. 83:171–178.
  • Lee JH, Kim NS, Han KM, Kim SH, Cho S, Kim WS. 2013. Monitoring by LC-MS/MS of 48 compounds of sildenafil, tadalafil, vardenafil and their analogues in illicit health food products in the Korean market advertised as enhancing male sexual performance. Food Addit Contam Part A. 30:1849–1857.
  • Park S, Lee JG, Roh SH, Kim G, Kwon CH, Park HR, Kwon KS, Kim D, Kwon SW. 2012. Determination of PDE-5 inhibitors and appetite suppressants in adulterated dietary supplements using LC/PDA and LC/MS. Food Addit Contam Part B. 5:29–32. doi:10.1080/19393210.2012.656706
  • Singh S, Handa T, Narayanam M, Sahu A, Junwal M, Shah RP. 2012. A critical review on the use of modern sophisticated hyphenated tools in the characterization of impurities and degradation products. J Pharm Biomed Anal. 69:148–173. doi:10.1016/j.jpba.2012.03.044
  • Singh S, Prasad B, Savaliya AA, Shah RP, Gohil VM, Kaur A. 2009. Strategies for characterizing sildenafil, vardenafil, tadalafil and their analogues in herbal dietary supplements, and detecting counterfeit products containing these drugs. Trends Anal Chem. 28:13–28. doi:10.1016/j.trac.2008.09.004
  • Trefi S, Gilard V, Balayssac S, Malet-Martino M, Martino R. 2009. The usefulness of 2D DOSY and 3D DOSY-COSY 1H NMR for mixture analysis: application to genuine and fake formulations of sildenafil (Viagra). Magn Reson Chem. 47:S163–S173. doi:10.1002/mrc.2490
  • Venhuis BJ, de Kaste D. 2012. Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks. J Pharm Biomed Anal. 69:196–208. doi:10.1016/j.jpba.2012.02.014
  • Zou P, Oh SSY, Hou P, Low MY, Koh HL. 2006. Simultaneous determination of synthetic phosphodiesterase-5-inhibitors found in a dietary supplement and pre-mixed bulk powders for dietary supplements using high-performance liquid chromatography with diode array detection and liquid chromatography-electrospray ionization tandem mass spectrometry. J Chromatogr A. 1104:113–112.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.