A Pilot Study Associating Urinary Concentrations of Phthalate Metabolites and Semen Quality

References

• ATSDR. (1995) Toxicological Profile for Diethyl Phthalate (DEP). Atlanta, GA: Agency for Toxic Substances and Disease Registry. Website: http://www.atsdr.cdc.gov/toxprofiles [accessed 1 July 2007]
   Google Scholar
• ATSDR. (2001) Toxicological Profile for Di-n-Butyl Phthalate. Atlanta, GA: Agency for Toxic Substances and Disease Registry. Website: http://www.atsdr.cdc.gov/toxprofiles [accessed 10 July 2007]
   Google Scholar
• Barlow N. J., Phillips S. L., Wallace D. G., Sar M., Gaido K. W., Foster P. D. M. Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate. Toxicol Sci 2003; 73: 431–451
   Google Scholar
• Barr D. B., Silva M. J., Kato K., Reidy J. A., Malek N. A., Hurtz D., Sadowski M., Needham L. L., Calafat A. M. Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers. Environ Health Perspect 2003; 111: 1148–1151
   Google Scholar
• Barr D. B., Wilder L. C., Caudill S. P., Gonzalez A. J., Needham L. L., Pirkle J. L. Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect 2005; 113: 192–200
   Google Scholar
• Blount B. C., Silva M. K., Caudill S. P., Needham L. L., Pirkle J. L., Sampson E. J., Lucier G. W., Jackson R. J., Brock J. W. Levels of seven urinary phthalate metabolites in a human reference population. Environ Health Perspect 2000; 108: 979–982
   Google Scholar
• Calafat A. M., Silva M. J., Reidy J. A., Gray L. E., Samandar E., Preau J. L., Jr., Herbert A. R., Needham L. L. Mono-(3-carboxypropyl) phthalate, a metabolite of di-n-octyl phthalate. J Toxicol Environ Health A 2006; 69: 215–227
   Google Scholar
• CDC. (2005) Third National Report on Human Exposure to Environmental Chemicals. Atlanta, GA: Centers for Disease Control and Prevention. Website: http://www.cdc.gov/exposurereport/pdf/thirdreport.pdf [accessed 12 December 2007]
   Google Scholar
• Duty S. M., Ackerman R. M., Calafat A. M., Hauser R. Personal care product use predicts urinary concentrations of some phthalate monoesters. Environ Health Perspect 2005; 113: 1530–1535
   Google Scholar
• Duty S. M., Silva M. J., Barr D. B., Brock J. W., Ryan L., Chen Z., Herrick R. F., Christiani D. C., Hauser R. Phthalate exposure and human semen parameters. Epidemiology 2003a; 14: 269–277
   Google Scholar
• Duty S. M., Singh N. P., Silva M. J., Barr D. B., Brock J. W., Ryan L., Herrick R. F., Christiani D. C., Hauser R. The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environ Health Perspect 2003b; 111: 1164–1169
   Google Scholar
• Food and Drug Administration. (2000) Indirect food additives: Adhesives and Components of coating: Adhesives. Code of Federal Regulations 21 CFR 175.105. Website: http://www.access.gpo.gov/nara/cfr/waisidx_00/21cfr175_00.html [accessed 22 August 2007].
   Google Scholar
• Foster P. M. Mode of action: impaired fetal Leydig cell function – effects on male reproductive development produced by certain phthalate esters. Crit Rev Toxicol 2005; 35: 713–719
   Google Scholar
• Fromme H., Lahrz T., Piloty M., Gebhart H., Oddoy A., Ruden H. Occurrence of phthalates and musk fragrances in indoor air and dust from apartments and kindergartens in Berlin (Germany). Indoor Air 2004; 14: 188–195
   Google Scholar
• Fujii S., Yabe K., Furukawa M., Hirata M., Kiguchi M., Ikka T. A two-generation reproductive toxicity study of diethyl phthalate (DEP) in rats. J Toxicol Sci 2005; 30: 97–116
   Google Scholar
• Gray L. E., Ostby J., Furr J., Price M., Veeramachaneni D. N. R., Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOT, alters sexual differentiation of the male rat. Toxicol Sci 2000; 58: 350–365
   Google Scholar
• Hauser R., Calafat A. M. Phthalates and human health. Occup Environ Med 2005; 62: 806–818
   Google Scholar
• Hauser R., Meeker J. D., Duty S., Silva M. J., Calafat A. Altered semen quality in relation to urinary concentrations of phthalate monoesters and oxidative metabolites. Epidemiol 2006; 17: 682–691
   Google Scholar
• Hauser R., Meeker J. D., Park S., Silva M. J., Calafat A. Temporal variability of urinary phthalate metabolites levels in men of reproductive age. Environ Health Perspect 2004; 112: 1734–1740
   Google Scholar
• Hoppin J. A., Brock J. W., Davis B. J., Daird D. D. Reproducibility of urinary metabolites in first morning urine samples. Environ Health Perspect 2002; 110: 515–518
   Google Scholar
• Higuchi T. T., Plamer J. S., Gray L. E., Jr., Veeramachaneni D. N. Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure. Toxicol Sci 2003; 72: 301–313
   Google Scholar
• Jones H. B., Garside D. A., Liu R., Roberts J. C. The influence of phthalate esters on Leydig cell structure and function in vitro and in vivo. Exp Molec Pathol 1993; 58: 179–193
   Google Scholar
• Jonsson B. A. G., Richtoff J., Rylander L., Giwercman A., Hagamar L. Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology 2005; 16: 487–493
   Google Scholar
• Kato K., Silva M. J., Needham L. L., Calafat A. M. Determination of 16 phthalate metabolites in urine using automated sample preparation and on-line preconcentration/high-performance liquid chromatography/tandem mass spectrometry. Anal Chem 2005; 77: 2985–2991
   Google Scholar
• Koch H. M., Rossback B., Drexler H., Angerer J. Internal exposure of the general population to DEHP and other phthalates – determination of secondary and primary phthalate monoesters metabolites in urine. Environ Res 2003; 93: 177–185
   Google Scholar
• Lehmann K. P., Phillips S., Sar M., Foster P. M., Gaido K. W. Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. Toxicol Sci 2004; 81: 60–68
   Google Scholar
• Li L.-H., Jeter W. F., Orth J. M. Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats. Toxicol Appl Pharmacol 1998; 153: 288–265
   Google Scholar
• Main K. M., Mortensen G. K., Kaleva M. M., Boisen K. A., Damgaard I. N., Chellakooty M., Schmidt I. M., Suomi A. M., Virtanen H. E., Petersen D. V., et al. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect 2006; 114: 270–276
   Google Scholar
• Mann A. H., Price S. C., Mitchell F. E., Grasso P., Hinton R. H., Bridges J. W. Comparison of the short-term effects of di(2-ethylhexyl) phthalate and di(n-octyl) phthalate in rats. Toxicol Appl Pharmacol 1985; 77: 116–132
   Google Scholar
• Murature D. A., Tang S. Y., Steinhardt G., Dougherty R. C. Phthalate-esters and semen quality parameters. Biomed Environ Mass Spectrom 1987; 14: 473–477
   Google Scholar
• Mylchreest E., Cattley R., Foster P. Male reproductive tract malformations in rats following gestational and lactational exposure to di-(n-butyl)-phthalate: an antiandrogenic mechanism?. Toxicol Sci 1998; 43: 47–60
   Google Scholar
• Nagao T., Ohta R., Marumo H., Shindo T., Yousimura S., Ono H. Effect of butyl benzyl phthalate in Sprague-Dawley rats after gavage administration: a two-generation reproductive study. Reprod Toxicol 2000; 14: 513–532
   Google Scholar
• NTP-CERHR. NTP-CEHHR Expert Panel Report on Butyl Benzyl Phthalate. NTP-CERHR_BBP-00. Research Triangle Park, NC: National Toxicological Program (2000) Website: http://cerhr.niehs.nih.gov/chemicals/dehp/DEHP-final.pdf [accessed 14 Aug 2007].
   Google Scholar
• NTP-CERHR. NTP-CEHHR Expert Panel Update on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. NTP-CERHR 08-08-05. Research Triangle Park, NC: National Toxicological Program (2005) Website: http://cerhr.niehs.nih.gov/news/dehp/DEHP-Update-Report-08-08-05.pdf [accessed 14 Aug 2007].
   Google Scholar
• Parks L. G., Ostby J. S., Lambright C. R., Abbott B. D., Klinefelter G. R., Barlow N. J., Gray L. E., Jr. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci 2000; 58: 339–349
   Google Scholar
• Peck C. C., Albro P. W. Toxic potential of the plasticizer Di (2-ethylhexyl) phtalate in the context of its disposition and metabolism in primates and man. Environ Health Perspect 2005; 45: 11–17
   Google Scholar
• Poon R., Lecavalier P., Mueller R., Valli V. E., Procter B. G., Chu I. Subchronic oral toxicity of di-n-octyl phthalate and di(2-ethylhexyl) phthalate and in the rat. Food Chem Toxicol 1997; 35: 225–239
   Google Scholar
• Rozati R., Reddy P. P., Reddanna P., Mujtaba R. Role of environmental estrogens in the deterioration of male factor fertility. Fertil Steril 2002; 78: 1187–1194
   Google Scholar
• Schisterman E. F., Whitcomb B. W., Louis G. M., Louis T. A. Lipid adjustment in the analysis of environmental contaminants and human health risks. Environ Health Perspect 2005; 113: 853–857
   Google Scholar
• Silva M. J., Barr D. B., Reidy J. A., Malek N. A., Hodge C. C., Caudill S. P. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999–2000. Environ Health Perspect 2004; 112: 331–338
   Google Scholar
• Swan S. H., Main K. M., Liu F., Stewart S. L., Kruse R. L., Calafat A. M., Mao C. S., Redmon J. B., Ternand C. L., Sullivan S., et al. Anogenital distance-a marker of fetal androgen action – is decreased in male infants following phthalate exposure during pregnancy. Environ Health Perspect 2005; 113: 1056–1061
   Google Scholar
• Teass, A. W., Biangini, R. E., DeBord, G., Hull, R. D.,1998. Application of biological monitoring methods. In: NIOSH Manual of Analytical Methods, 4th ed. Cincinnati: US Department of Heath and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, pp. 52–62.
   Google Scholar
• WHO. World Health Organization laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed. Cambridge University Press, New York 1999
   Google Scholar
• Wormuth M., Scheringer M., Vollenweider M., Hungerbuhler K. What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?. Risk Anal 2006; 26: 803–824
   Google Scholar
• Zavos P. M., Kaskar K., Correa J. R., Sikka S. C. Seminal characteristics and sexual behavior in men of different age groups: is there an aging effect?. Asian J Androl 2006; 8: 337–341
   Google Scholar