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Review Article

Impact of prenatal arsenic exposure on chronic adult diseases

, &
Pages 469-483 | Received 28 Feb 2018, Accepted 14 May 2018, Published online: 06 Jun 2018

References

  • Afridi HI, Kazi TG, Kazi N, Jamali MK, Arain MB, Jalbani N, Baig JA, Sarfraz RA. 2008. Evaluation of status of toxic metals in biological samples of diabetes mellitus patients. Diabetes Res Clin Pract. 80(2):280–288.
  • Ahmed S, Akhtar E, Roy A, von Ehrenstein OS, Vahter M, Wagatsuma Y, Raqib R. 2017. Arsenic exposure alters lung function and airway inflammation in children: a cohort study in rural Bangladesh. Environ Int. 101:108–116.
  • Anisimov VN, Ukraintseva SV, Yashin AI. 2005. Cancer in rodents: does it tell us about cancer in humans? Nat Rev Cancer. 5:807–819.
  • Argos M, Kalra T, Rathouz PJ, Chen Y, Pierce B, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, et al. 2010. Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study. Lancet. 376(9737):252–258.
  • Armienta MA, Rodríguez R, Cruz O. 1997. Arsenic content in hair of people exposed to natural arsenic polluted groundwater at Zimapán, México. Bull Environ Contam Toxicol. 59(4):583–589.
  • Balmain A, Harris CC. 2000. Carcinogenesis in mouse and human cells: parallels and paradoxes. Carcinogenesis. 21:371–377.
  • Barker DJ. 2007. The origins of the developmental origins theory. J Intern Med. 261(5):412–417.
  • Barker DJ, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS. 1993. Fetal nutrition and cardiovascular disease in adult life. Lancet. 341(8850):938–941.
  • Barker DJ, Osmond C. 1986. Diet and coronary heart disease in England and Wales during and after the second world war. J Epidemiol Community Health. 40:37–44.
  • Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ. 1989. Weight in infancy and death from ischaemic heart disease. Lancet. 2(8663):577–580.
  • Barouki R, Gluckman PD, Grandjean P, Hanson M, Heindel JJ. 2012. Developmental origins of non-communicable disease: implications for research and public health. Environ Health. 11(42):1–9.
  • Becker FF, Holton P, Ruchirawat M, Lapeyre JN. 1985. Perturbation of maintenance and de novo DNA methylation in vitro by UVB (280–340 nm)-induced pyrimidine photodimers. Proc Natl Acad Sci U S A. 82(18):6055–6059.
  • Benbrahim-Tallaa L, Waalkes MP. 2008. Inorganic arsenic and human prostate cancer. Environ Health Perspect. 116(2):158–164.
  • Bodin J, Stene LC, Nygaard UC. 2015. Can exposure to environmental chemicals increase the risk of diabetes type 1 development? BioMed Res Int. 1–19. doi: 10.1155/2015/208947
  • Boney CM, Verma A, Tucker R, Vohr BR. 2005. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 115(3):e290–296.
  • Brea A, Mosquera D, Martin E, Arizti A, Cordero JL, Ros E. 2005. Nonalcoholic fatty liver disease is associated with carotid atherosclerosis: a case-control study. Arterioscler Thromb Vasc Biol. 25(5):1045–1050.
  • Cave M, Falkner KC, Ray M, Joshi-Barve S, Brock G, Khan R, Bon Homme M, McClain CJ. 2010. Toxicant-associated steatohepatitis in vinyl chloride workers. Hepatology. 51(2):474–481.
  • Center for Drug Evaluation and Research (US). 2005. Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. Rockville (MD): U.S. Dept. of Health and Human Services, Food and Drug Administration.
  • Chandra M, Frith CH. 1992. Spontaneous neoplasms in aged CD-1 mice. Toxicol Lett. 61(1):67–74.
  • Chen Y, Graziano JH, Parvez F, Liu M, Slavkovich V, Kalra T, Argos M, Islam T, Ahmed A, Rakibuz-Zaman M, et al. 2011. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study. The BMJ. 342:d2431.
  • Chen Z, Myers R, Wei T, Bind E, Kassim P, Wang G, Ji Y, Hong X, Caruso D, Bartell T, et al. 2014. Placental transfer and concentrations of cadmium, mercury, lead, and selenium in mothers, newborns, and young children. J Expo Sci Environ Epidemiol. 24(5):537–544.
  • Cohen Hubal EA, de Wet T, Du Toit L, Firestone MP, Ruchirawat M, van Engelen J, Vickers C. 2014. Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: results of a World Health Organization review. Regul Toxicol Pharmacol. 69(1):113–124.
  • Cunningham ML, Irwin R, Boorman G. 2003. Tox/Path team takes on differential gene expression. Environ Health Perspect. 111(15):A814–A815.
  • Dauphiné DC, Ferreccio C, Guntur S, Yuan Y, Hammond SK, Balmes J, Smith AH, Steinmaus C. 2011. Lung function in adults following in utero and childhood exposure to arsenic in drinking water: preliminary findings. Int Arch Occup Environ Health. 84(6):591–600.
  • Dávila-Esqueda ME, Morales JMV, Jiménez-Capdeville ME, De la Cruz E, Falcón-Escobedo R, Chi-Ahumada E, Martin-Pérez S. 2011. Low-level subchronic arsenic exposure from prenatal developmental stages to adult life results in an impaired glucose homeostasis. Exp Clin Endocrinol Diabetes. 119(10):613–617.
  • Day P, James OF. 1998. Steatohepatitis: a tale of two “hits”? Gastroenterology. 114:842–845.
  • De BK, Majumdar D, Sen S, Guru S, Kundu S. 2004. Pulmonary involvement in chronic arsenic poisoning from drinking contaminated ground-water. J Assoc Physicians India. 52:395–400.
  • de Rooij SR, Painter RC, Phillips DI, Osmond C, Michels RP, Godsland IF, Bossuyt PM, Bleker OP, Roseboom TJ. 2006. Impaired insulin secretion after prenatal exposure to the Dutch famine. Diabetes Care. 29:1897–1901.
  • Del Razo LM, García-Vargas GG, Valenzuela OL, Castellanos EH, Sánchez-Peña LC, Currier JM, Drobná Z, Loomis D, Stýblo M. 2011. Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico. Environ Health. 10(1):73.
  • Demetrius L. 2005. Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans. EMBO Rep. 6:S39–S44.
  • Ditzel EJ, Nguyen T, Parker P, Camenisch TD. 2016. Effects of arsenic exposure during fetal development on energy metabolism and susceptibility to diet-induced fatty liver disease in male mice. Environ Health Perspect. 142(2):201–209.
  • Fängström B, Moore S, Nermell B, Kuenstl L, Goessler W, Grandér M, Kabir I, Palm B, Arifeen SE, Vahter M. 2008. Breast-feeding protects against arsenic exposure in Bangladeshi infants. Environ Health Perspect. 116(7):963–969.
  • Farzan SF, Karagas MR, Chen Y. 2013. In utero and early life arsenic exposure in relation to long-term health and disease. Toxicol Appl Pharmacol. 272(2):384–390.
  • Feinberg AP, Tycko B. 2004. The history of cancer epigenetics. Nat Rev Cancer. 4:143–153.
  • Foldspang A, Hansen JC. 1990. Dietary intake of methylmercury as a correlate of gestational length and birth weight among newborns in Greenland. Am J Epidemiol. 132(2):310–317.
  • Fry RC, Navasumrit P, Valiathan C, Svensson JP, Hogan BJ, Luo M, Bhattacharya S, Kandjanapa K, Soontararuks S, Nookabkaew S. 2007. Activation of inflammation/NF-κB signaling in infants born to arsenic-exposed mothers. PLoS Genet. 3(11):e207.
  • Gluckman PD, Hanson MA, Mitchell MD. 2010. Developmental origins of health and disease: reducing the burden of chronic disease in the next generation. Genome Med. 2(2):14.
  • Gonzalez-Cortes T, Recio-Vega R, Lantz RC, Chau BT. 2017. DNA methylation of extracellular matrix remodeling genes in children exposed to arsenic. Toxicol Appl Pharmacol. 15(329):140–147.
  • Grau-Perez M, Kuo CC, Gribble MO, Balakrishnan P, Jones Spratlen M, Vaidya D, KA F, Goessler W, Guallar E. 2017. Association of low-moderate arsenic exposure and arsenic metabolism with incident diabetes and insulin resistance in the Strong Heart Family Study. Environ Health Perspect. 125(12):127004.
  • Gribble MO, Howard BV, Umans JG, Shara NM, Francesconi KA, Goessler W, Crainiceanu CM, Silbergeld EK, Guallar E, Navas-Acien A. 2012. Arsenic exposure, diabetes prevalence, and diabetes control in the Strong Heart Study. Am J Epidemiol. 176(10):865–874.
  • Griskevicius V, Delton AW, Robertson TE, Tybur JM. 2011. Environmental contingency in life history strategies: the influence of mortality and socioeconomic status on reproductive timing. J Pers Soc Psychol. 100(2):241–254.
  • Guay C, Roggl E, Nesca V, Jacovetti C, Regazzi R. 2011. Diabetes mellitus, a microRNA-related disease? Transl Res. 157(4):253–264.
  • Heindel JJ, Balbus J, Birnbaum L, Brune-Drisse MN, Grandjean P, Gray K, Landrigan PJ, Sly PD, Suk W, Cory Slechta D. 2015. Developmental origins of health and disease: integrating environmental influences. Endocrinology. 156(10):416–3421.
  • Heindel JJ, Skallab LA, Jouberta BR, Dilwortha CH, Graya KA. 2017. Review of developmental origins of health and disease publications in environmental epidemiology. Reprod Toxicol. 68:34–48.
  • Huff J, Jacobson MF, Davis DL. 2008. The limits of two-year bioassay exposure regimens for identifying chemical carcinogens. Environ Health Perspect. 116(11):1439–1442.
  • Hulbert AJ. 2008. The links between membrane composition, metabolic rate and lifespan. Comp Biochem Physiol A Mol Integr Physiol. 150:196–203.
  • Hulbert AJ, Else PL. 2005. Membranes and the setting of energy demand. J Exp Biol. 208:1593–1599.
  • [IARC] International Agency for Research on Cancer (US). 1973. Monographs on the evaluation of carcinogenic risks to humans. Vol. 2, some inorganic and organometallic compounds. Lyons (FR).
  • [IARC] International Agency for Research on Cancer (US). 1980. Monographs on the evaluation of carcinogenic risks to humans. Vol. 23, some metals and metallic compounds. Lyons (FR).
  • [IARC] International Agency for Research on Cancer (US). 1987. Monographs on the evaluation of carcinogenic risks to humans: an updating of IARC monographs volumes 1–42. Lyons (FR).
  • [IARC] International Agency for Research on Cancer (US). 2004. Monographs on the evaluation of carcinogenic risks to humans: vol. 84, some drinking-water disinfectants and contaminants. Lyons (FR).
  • [IARC] International Agency for Research on Cancer (US). 2012. Monographs on the evaluation of carcinogenic risks to humans: vol. 100C, arsenic, metals, fibres, and dusts, Vol. 100C. Lyons (FR).
  • Islam MR, Attia J, Alauddin M, McEvoy M, McElduff P, Slater C, Islam MM, Akhter A, d’Este C, Peel R, et al. 2014. Availability of arsenic in human milk in women and its correlation with arsenic in urine of breastfed children living in arsenic contaminated areas in Bangladesh. Environ Health. 13(101):1–10.
  • Josyula AB, Poplin GS, Kurzius-Spencer M, McClellen HE, Kopplin MJ, Stürup S, Clark Lantz R, Burgess JL. 2006. Environmental arsenic exposure and sputum metalloproteinase concentrations. Environ Res. 102:283–290.
  • Jovanovic D, Rasic-Milutinovic Z, Paunovic K, Jakovljevic B, Plavsic S, Milosevic J. 2012. Low levels of arsenic in drinking water and type 2 diabetes in Middle Banat region, Serbia. Int J Hyg Environ Health. 216(1):50–55.
  • Kuo C-C, Moon K, Thayer KA, Navas-Acien A. 2013. Environmental chemicals and type 2 diabetes: an updated systematic review of the epidemiologic evidence. Curr Diab Rep. 13(6):831–849.
  • Lai MS, Hsueh YM, Chen CJ, Shyu MP, Chen SY, Kuo TL, Wu MM, Tai TY. 1994. Ingested inorganic arsenic and prevalence of diabetes mellitus. Am J Epidemiol. 139(5):484–492.
  • Lantz RC, Chau B, Sarihan P, Witten ML, Pivniouk VI, Chen GJ. 2009. In utero and postnatal exposure to arsenic alters pulmonary structure and function. Toxicol Appl Pharmacol. 235(1):105–113.
  • Lantz RC, Lynch BJ, Boitano S, Poplin GS, Littau S, Tsaprailis G, Burgess JL. 2007. Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic. Environ Health Perspect. 115(4):586–591.
  • Liaw J, Marshall G, Yuan Y, Ferreccio C, Steinmaus C, Smith AH. 2008. Increased childhood liver cancer mortality and arsenic in drinking water in Northern Chile. Cancer Epidemiol Biomarkers Prevent. 17(8):1982–1987.
  • Liu J, Xie Y, Ducharme DM, Shen J, Diwan BA, Merrick BA, Grissom SF, Tucker CJ, Paules RS, Tennant R, et al. 2006. Global gene expression associated with hepatocarcinogenesis in adult male mice induced by in utero arsenic exposure. Enviro Health Perspect. 114(3):404–411.
  • Loser E. 1980. A 2 year oral carcinogenicity study with cadmium on rats. Cancer Lett. 9(3):191–198.
  • Lu M, Wang H, Li X-F, Lu X, Cullen WR, Arnold LL, Cohen SM, Le XC. 2004. Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood. Chem Res Toxicol. 17:1733–1742.
  • Luo JL, Maeda S, Hsu LC, Yagita H, Karin M. 2004. Inhibition of NFkappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell. 6:297–305.
  • Makris KC, Christophi CA, Paisi M, Ettinger AS. 2012. A preliminary assessment of low level arsenic exposure and diabetes mellitus in Cyprus. BMC Public Health. 12:334.
  • Martinez VD, Vucic EA, Becker-Santos DD, Gil L, Lam WL. 2011. Arsenic exposures and the induction of human cancers. J Toxicol. doi: 10.1155/2011/431287.
  • Maull EA, Ahsan H, Edwards J, Longnecker MP, Navas-Acien A, Pi J, Silbergeld EK, Styblo M, Tseng CH, Thayer KA, et al. 2012. Evaluation of the association between arsenic and diabetes: a national toxicology program workshop review. Environ Health Perspect. 120(12):1658–1670.
  • Milton AH, Rahman M. 2002. Respiratory effects and arsenic contaminated well water in Bangladesh. Int J Environ Res Public Health. 12(2):175–179.
  • Moon SS. 2013. Additive effect of heavy metals on metabolic syndrome in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009–2010. Endocrine. 46(2):263–271.
  • Newbold NN, McLachlan JA. 1996. Transplacental hormonal carcinogenesis: diethylstilbestrol as an example. Prog Clin Bio Re. 394:131–147.
  • Newman WJ, Herbst AL, Ulfelder H, Poskanzer DC. 1971. Registry of clear-cell carcinoma of genital tract in young women. N Engl J Med. 285(7):407.
  • Ngalame NNO, Micciche AF, Feil ME, States JC. 2013. Delayed temporal increase of hepatic Hsp70 in ApoE knockout mice after prenatal arsenic exposure. Toxicol. Sci. 131(1):225–233.
  • Noble D. 2015. Conrad Waddington and the origin of epigenetics. J Exp Biol. 218:816–818.
  • Nohara K, Tateishi Y, Suzuki T, Okamura K, Murai H, Takumi S, Maekawa F, Nishimura N, Kobori M, Ito T. 2012. Late-onset increases in oxidative stress and other tumorigenic activities and tumors with a Ha-ras mutation in the liver of adult male C3H mice gestationally exposed to arsenic. Toxicol Sci. 129(2):293–304.
  • Olivas-Calderón E, Recio-Vega R, Gandolfi AJ, Lantz RC, González-Cortes T, Gonzalez-De Alba C, Froines JR, Espinosa-Fematt JA. 2015. Lung inflammation biomarkers and lung function in children chronically exposed to arsenic. Toxicol Appl Pharmacol. 287(2):161–167.
  • Osorio-Yáñez C, Ayllon-Vergara JC, Arreola-Mendoza L, Aguilar-Madrid G, Hernández-Castellanos E, Sánchez-Peña LC, Del Razo LM. 2015. Blood pressure, left ventricular geometry, and systolic function in children exposed to inorganic arsenic. Environ Health Perspect. 123(6):629–635.
  • Padilla MA, Elobeid M, Ruden DM, Allison DB. 2010. An examination of the association of selected toxic metals with total and central obesity indices: NHANES 99-02. Int J Environ Res Public Health. 7(9):3332–3347.
  • Painter RC, Roseboom TJ, Bleker OP. 2005. Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol. 20(3):345–352.
  • Paul S, Bhattacharjee P. 2016. Epigenetics and arsenic toxicity. In: States JC, Ed. Arsenic: exposure sources, health risks and mechanisms of toxicity (pp. 81–109). Hoboken (NJ): Wiley; p. 421–437.
  • Paules R. 2003. Phenotypic anchoring: linking cause and effect. Environ Health Perspect. 111(6):A338–A339.
  • Perlman RL. 2016. Mouse models of human disease: an evolutionary perspective. Evol Med Public Health. 170–176. doi:10.1093/emph/eow014.
  • Petrick JS, Blachere FM, Selmin O, Lantz RC. 2009. Inorganic arsenic as a developmental toxicant: in utero exposure and alterations in the developing rat lung. Mol Nutr Food Res. 53(5):583–591.
  • Rager JE, Bailey KA, Smeester L, Miller SK, Parker JS, Laine JE, Drobná Z, Currier J, Douillet C, Olshan AF. 2014. Prenatal arsenic exposure and the epigenome: altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood. Environ Mol Mutagen. 55(3):196–208.
  • Rahman M, Sohel N, Yunus M, Chowdhury ME, Hore SK, Zaman K, Bhuiya A, Streatfield PK. 2013. Increased childhood mortality and arsenic in drinking water in Matlab, Bangladesh: a population-based cohort study. PLoS ONE. 8(1):e55014.
  • Ramsey KA, Bosco A, McKenna KL, Carter KW, Elliot JG, Berry LJ, Sly PD, Larcombe AN, Zosky GR. 2013. In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice. Environ Health Perspect. 121(2):244–250.
  • Ravelli ACJ, Van Der Meulen JHP, Osmond C, Barker DJP, Bleker OP. 1999. Obesity at the age of 50 y in men and women exposed to famine prenatally. Am J Clin Nutr. 70:811–816.
  • Reagan-Shaw S, Nihal M, Ahmad N. 2008. Dose translation from animal to human studies revisited. FASEB J. 3:659–661.
  • Roseboom TJ, van der Meulen JH, Osmond C, Barker DJ, Ravelli AC, Schroeder-Tanka JM, van Montfrans GA, Michels RP, Bleker OP. 2000. Coronary heart disease after prenatal exposure to the Dutch famine, 1944–45. Heart. 84(6):595–598.
  • Rosenberg HG. 1973. Systemic arterial disease with myocardial infarction. report on two infants. Circulation. 47(2):270–275.
  • Rosenberg HG. 1974. Systemic arterial disease and chronic arsenicism in infants. Arch Pathol. 97(6):360–365.
  • Rudnai P, Börzsönyi M. 1980. Carcinogenic effect of arsenic trioxide in transplacental and neonatal treated CFLP mice. Natural Sci. 2:11–18.
  • Sanchez-Soria P, Broka D, Quach S, Hardwicj RN, Cherrington NJ, Camenisch TD. 2014. Fetal exposure to arsenic results in hyperglycemia, hypercholesterolemia, and nonalcoholic fatty liver disease in adult mice. J Toxicol Environ Health. 1(1):1–10.
  • Santra A, Das Gupta J, De BK, Roy B, Mazumder DN. 1999. Hepatic manifestations in chronic arsenic exposure. Indian J Gastroenterol. 18:152–155.
  • Schindhelm RK, Dekker JM, Nijpels G, Bouter LM, Stehouwer CD, Heine RJ, Diamant M. 2007. Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study. Atherosclerosis. 191:391–396.
  • Shen S, Li X-F, Cullen WR, Weinfeld M, Le XC. 2013. Arsenic binding to proteins. Chem Rev. 113(10):7769–7792.
  • Sikorski R, Paszkowski T, Szprengier-Juszkiewicz T. 1986. Mercury in neonatal scalp hair. Sci Total Environ. 57:105–110.
  • Smith AH, Goycolea M, Haque R, Biggs ML. 1998. Marked increase in bladder and lung cancer mortality in a region of northern Chile due to arsenic in drinking water. Am J Epidemiol. 147(7):660–669.
  • Smith AH, Marshall G, Liaw J, Yuan Y, Ferreccio C, Steinmaus C. 2012. Mortality in young adults following in utero and childhood exposure to arsenic in drinking water. Environ Health Perspect. 120(11):1527–1531.
  • Smith AH, Marshall G, Yuan Y, Ferreccio C, Liaw J, von Ehrenstein O, Steinmaus C, Bates MN, Selvin S. 2006. Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood. Environ Health Perspect. 114(8):1293–1296.
  • Sookoian S, Castaño GO, Burgueño AL, Rosselli MS, Gianotti TF, Mallardi P, Martino JS, Pirola CJ. 2010. Circulating levels and hepatic expression of molecular mediators of atherosclerosis in nonalcoholic fatty liver disease. Atherosclerosis. 209:585–591.
  • Srivastava S, D’Souza SE, Sen U, States JC. 2007. In utero arsenic exposure induces early onset of atherosclerosis in ApoE−/− mice. Reprod Toxicol. 23(3):449–456.
  • Srivastava S, Vladykovskaya EN, Haberzettl P, Sithu SD, D'Souza SE, States JC. 2009. Arsenic exacerbates atherosclerotic lesion formation and inflammation in ApoE–/–mice. Toxicol Appl Pharmacol. 241(1):90–100.
  • States JC. 2015. Disruption of mitotic progression by arsenite. Biol Trace Elem Res. 166(1):34–40.
  • States JC, Barchowsky A, Cartwright IL, Reichard JF, Futscher BW, Lantz RC. 2011. Arsenic toxicology: translating between experimental models and human pathology. Environ Health Perspect. 119(10):1356–1363.
  • States JC, Singh AV, Knudsen TB, Rouchka EC, Ngalame NO, Arteel GE, Piao Y, Ko MS. 2012. Prenatal arsenic exposure alters gene expression in the adult liver to a proinflammatory state contributing to accelerated Atherosclerosis. PLoS ONE. 7(6):e38713.
  • Steinmaus C, Ferreccio C, Acevedo J, Balmes JR, Liaw J, Troncoso P, Dauphiné DC, Nardone A, Smith AH. 2016. High risks of lung disease associated with early-life and moderate lifetime arsenic exposure in northern Chile. Toxicol Appl Pharmacol. 313:10–15.
  • Stranges S, Sieri S, Vinceti M, Grioni S, Guallar E, Laclaustra M, Muti P, Berrino F, Krogh V. 2010. A prospective study of dietary selenium intake and risk of type 2 diabetes. BMC Public Health. 10:564.
  • Takenaka S, Oldiges H, König H, Hochramer D, Oberdörster G. 1983. Carcinogenicity of cadmium chloride aerosols in W rats. J Natl Cancer Inst. 70(2):367–373.
  • Tan M, Schmidt RH, Beier JI, Watson WH, Zhong H, States JC, Arteel GE. 2011. Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice. Toxicol Appl Pharmacol. 257(3):356–364.
  • Thomas D. 2016. The chemistry and metabolism of arsenic. In: States JC, editor. Arsenic: exposure sources, health risks and mechanisms of toxicity. Hoboken (NJ): Wiley; p. 81–109.
  • Thomas DJ. 2013. The die is cast: arsenic exposure in early life and disease susceptibility. Chem Res Toxicol. 26(12):1778–1781.
  • Tokar EJ, Benbrahim-Tallaa L, Ward JM, Lunn R, Sams RL, Waalkes MP. 2010. Cancer in experimental animals exposed to arsenic and arsenic compounds. Crit Rev Toxicol. 40(10):912–927.
  • Tokar EJ, Diwan BA, Waalkes MP. 2012. Renal, hepatic, pulmonary and adrenal tumors induced by prenatal inorganic arsenic followed by dimethylarsinic acid in adulthood in CD1 mice. Toxicol Lett. 209(2):179–185.
  • Tokar EJ, Diwan BA, Ward JM, Delker DA, Waalkes MP. 2011. Carcinogenic effects of “wholelLife” exposure to inorganic arsenic in CD1 mice. Toxicol Sci. 119(1):73–83.
  • Tokar EJ, Xu Y, Waalkes MP. 2016. Cancer induced by exposure to arsenic in animals. In: States JC, editor. Arsenic: exposure sources, health risks and mechanisms of toxicity. Hoboken (NJ): Wiley; p. 441–452.
  • Vahter M. 2009. Effects of arsenic on maternal and fetal health. Annu Rev Nutr. 29:381–399.
  • Vahter M, Concha G. 2001. Role of metabolism in arsenic toxicity. Pharmacol Toxicol. 89(1):1–5.
  • Van Abeelen AFM, Elias SG, Bossuyt PMM, Grobbee DE, van der Schouw YT, Roseboom TJ, Uiterwaal CSPM. 2012. Famine exposure in the young and the risk of type 2 diabetes in adulthood. Diabetes. 61(9):2255–2260.
  • von Bibra H, Paulus W, St. John Sutton M. 2016. Cardiometabolic syndrome and increased risk of heart failure. Curr Heart Fail Rep. 13:219–229.
  • Waalkes MP, Liu J, Chen H, Xie Y, Achanzar WE, Zhou YS, Cheng ML, Diwan BA. 2004a. Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero. J Natl Cancer Inst. 96(6):466–474.
  • Waalkes MP, Liu J, Ward JM, Diwan BS. 2004b. Animal models for arsenic carcinogenesis: inorganic arsenic is a transplacental carcinogen in mice. Toxicol Appl Pharmacol. 198:377–384.
  • Waalkes MP, Qu W, Tokar EJ, Kissling GE, Dixon D. 2014. Lung tumors in mice induced by “whole life” inorganic arsenic exposure at human relevant doses. Arch Toxicol. 88(8):1619–1629.
  • Waalkes MP, Ward JM, Liu J, Diwan BS. 2003. Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice. Toxicol Appl Pharmacol. 186:7–17.
  • Wang G, Chen Z, Bartell T, Wang X. 2014. Early life origins of metabolic syndrome: the role of environmental toxicants. Curr Environ Health Rep. 1(1):78–89.
  • Wang SL, Chang FH, Liou SH, Wang HJ, Li WF, Hsieh DP. 2007. Inorganic arsenic exposure and its relation to metabolic syndrome in an industrial area of Taiwan. Environ Int. 33(6):805–811.
  • Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, et al. 2002. Initial sequencing and comparative analysis of the mouse genome. Nature. 420:520–562.
  • Wu MM, Kuo TL, Hwang YH, Chen CJ. 1989. Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases. Am J Epidemiol. 130(6):1123–1132.
  • Xie Y, Liu J, Benbrahim-Tallaa L, Ward JM, Logsdon D, Diwan BA, Waalkes MP. 2007. Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic. Toxicology. 236(1–2):7–15.
  • Yamamoto S, Konishi Y, Matsuda T, Murai T, Shibata MA, Matsui-Yuasa I, Otani S, Kuroda K, Endo G, Fukushima S. 1995. Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens. Cancer Res. 55:1271–1276.
  • Yuan Y, Marshall G, Ferreccio C, Steinmaus C, Selvin S, Liaw J, Bates MN, Smith AH. 2007. Acute myocardial infarction mortality in comparison with lung and bladder cancer mortality in arsenic-exposed region II of Chile from 1950 to 2000. Am J Epidemiol. 166(12):1381–1391.
  • Zaldivar R. 1980. A morbid condition involving cardio-vascular, broncho-pulmonary, digestive and neural lesions in children and young adults after dietary arsenic exposure. Zentralbl Bakteriol [B]. 170:44–56.
  • Zhao CQ, Young MR, Diwan BA, Coogan TP, Waalkes MP. 1997. Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc Natl Acad Sci USA. 94(20):10907–10912.

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