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Research Communication

Peroxisome Proliferator-Activated Receptors (PPARs) levels in spermatozoa of normozoospermic and asthenozoospermic men

, , , , , , , & ORCID Icon show all
Pages 409-419 | Received 31 May 2019, Accepted 04 Oct 2019, Published online: 01 Nov 2019

References

  • Abbott BD. 2009. Review of the expression of peroxisome proliferator-activated receptors alpha (PPARα), beta (PPARβ), and gamma (PPARγ) in rodent and human development. Reprod. Toxicol. 27(3–4):246–257.
  • Aitken R, Irvine S, Kelly R. 1986. Significance of intracellular calcium and cyclic adenosine 3ʹ, 5ʹ-monophosphate in the mechanisms by which prostaglandins influence human sperm function. J Reprod Fertil. 77(2):451–462.
  • Aitken R, Kelly R. 1985. Analysis of the direct effects of prostaglandins on human sperm function. J Reprod Fertil. 73(1):139–146.
  • Aksoy Y, Aksoy H, Altınkaynak K, Aydın HR, Özkan A. 2006. Sperm fatty acid composition in subfertile men. Prostaglandins Leukotrienes Essent. Fatty Acids. 75(2):75–79.
  • Aquila S, Bonofiglio D, Gentile M, Middea E, Gabriele S, Belmonte M, Catalano S, Pellegrino M, Andò S. 2006. Peroxisome proliferator‐activated receptor (PPAR) γ is expressed by human spermatozoa: its potential role on the sperm physiology. J Cell Physiol. 209(3):977–986.
  • Aquila S, Middea E, Catalano S, Marsico S, Lanzino M, Casaburi I, Barone I, Bruno R, Zupo S, Andò S. 2007. Human sperm express a functional androgen receptor: effects on PI3K/AKT pathway. Human Reprod. 22(10):2594–2605.
  • Aquila S, Sisci D, Gentile M, Middea E, Catalano S, Carpino A, Rago V, Andò S. 2004. Estrogen receptor (ER) α and ERβ are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway. J. Clin. Endocrinol. Metab. 89(3):1443–1451.
  • Attaman JA, Toth TL, Furtado J, Campos H, Hauser R, Chavarro JE. 2012. Dietary fat and semen quality among men attending a fertility clinic. Human Reprod. 27(5):1466–1474.
  • Barak Y, Liao D, He W, Ong ES, Nelson MC, Olefsky JM, Boland R, Evans RM. 2002. Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer. Proc. National Acad. Sci. 99(1):303–308.
  • Bionaz M, Chen S, Khan MJ, Loor JJ. 2013. Functional role of PPARs in ruminants: potential targets for fine-tuning metabolism during growth and lactation. PPAR Res. 2013:1–28.
  • Braissant O, Foufelle F, Scotto C, Dauça M, Wahli W. 1996. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha,-beta, and-gamma in the adult rat. Endocrinology. 137(1):354–366.
  • Cato AC, Nestl A, Mink S. 2002. Rapid actions of steroid receptors in cellular signaling pathways. Sci STKE. 2002(138):1–11.
  • Chavarro JE, Furtado J, Toth TL, Ford J, Keller M, Campos H, Hauser R. 2011. Trans–fatty acid levels in sperm are associated with sperm concentration among men from an infertility clinic. Fertil Steril. 95(5):1794–1797.
  • Chavarro JE, Mínguez-Alarcón L, Mendiola J, Cutillas-Tolín A, López-Espín JJ, Torres-Cantero AM. 2014. Trans fatty acid intake is inversely related to total sperm count in young healthy men. Human Reprod. 29(3):429–440.
  • Chawla A, Schwarz EJ, Dimaculangan DD, Lazar MA. 1994. Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology. 135(2):798–800.
  • Conquer JA, Martin JB, Tummon I, Watson L, Tekpetey F. 1999. Fatty acid analysis of blood serum, seminal plasma, and spermatozoa of normozoospermic vs. asthernozoospermic males. Lipids. 34(8):793–799.
  • Cooper TG, Noonan E, Von Eckardstein S, Auger J, Baker H, Behre HM, Haugen TB, Kruger T, Wang C, Mbizvo MT. 2010. World Health Organization reference values for human semen characteristics. Hum Reprod Update. 16(3):231–245.
  • Datta SR, Brunet A, Greenberg ME. 1999. Cellular survival: a play in three Akts. Genes Dev. 13(22):2905–2927.
  • De Amicis F, Guido C, Perrotta I, Avena P, Panza S, Andò S, Aquila S. 2011. Conventional progesterone receptors (PR) B and PRA are expressed in human spermatozoa and may be involved in the pathophysiology of varicocoele: a role for progesterone in metabolism. Int J Androl. 34(5pt1):430–445.
  • Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W. 1996. The PPARα–leukotriene B4 pathway to inflammation control. Nature. 384(6604):39.
  • Eslamian G, Amirjannati N, Rashidkhani B, Sadeghi M-R, Baghestani A-R, Hekmatdoost A. 2015. Dietary fatty acid intakes and asthenozoospermia: a case-control study. Fertil Steril. 103(1):190–198.
  • Eslamian G, Amirjannati N, Rashidkhani B, Sadeghi M-R, Hekmatdoost A. 2012. Intake of food groups and idiopathic asthenozoospermia: a case–control study. Human Reprod. 27(11):3328–3336.
  • Evans RM, Barish GD, Wang Y-X. 2004. PPARs and the complex journey to obesity. Nat Med. 10(4):355.
  • Grasa P, Coward K, Young C, Parrington J. 2008. The pattern of localization of the putative oocyte activation factor, phospholipase Cζ, in uncapacitated, capacitated, and ionophore-treated human spermatozoa. Human Reprod. 23(11):2513–2522.
  • Guido C, Perrotta I, Panza S, Middea E, Avena P, Santoro M, Marsico S, Imbrogno P, Andò S, Aquila S. 2011. Human sperm physiology: estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) influence sperm metabolism and may be involved in the pathophysiology of varicocele‐associated male infertility. J Cell Physiol. 226(12):3403–3412.
  • Howroyd P, Swanson C, Dunn C, Cattley RC, Corton JC. 2004. Decreased longevity and enhancement of age-dependent lesions in mice lacking the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). Toxicol Pathol. 32(5):591–599.
  • Huang J-C. 2008. The role of peroxisome proliferator-activated receptors in the development and physiology of gametes and preimplantation embryos. PPAR Res. 2008:1–7.
  • Issemann I, Green S. 1990. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature. 347(6294):645.
  • Jensen TK, Heitmann BL, Jensen MB, Halldorsson TI, Andersson A-M, Skakkebæk NE, Joensen UN, Lauritsen MP, Christiansen P, Dalgård C. 2013. High dietary intake of saturated fat is associated with reduced semen quality among 701 young Danish men from the general population. Am J Clin Nutr. 97(2):411–418.
  • Kadivar A, Heidari Khoei H, Hassanpour H, Ghanaei H, Golestanfar A, Mehraban H, Davoodian N, Dehghani Tafti R. 2016. Peroxisome proliferator-activated receptors (PPARα, PPARγ and PPARβ/δ) gene expression profile on ram spermatozoa and their relation to the sperm motility. Veterinary Research Forum. 7(1):27–34.
  • Karpe F, Ehrenborg EE. 2009. PPARδ in humans: genetic and pharmacological evidence for a significant metabolic function. Curr Opin Lipidol. 20(4):333–336.
  • Latini G, Scoditti E, Verrotti A, De Felice C, Massaro M. 2008. Peroxisome proliferator-activated receptors as mediators of phthalate-induced effects in the male and female reproductive tract: epidemiological and experimental evidence. PPAR Res. 2008:1–13.
  • Lefebvre P, Chinetti G, Fruchart J-C, Staels B. 2006. Sorting out the roles of PPARα in energy metabolism and vascular homeostasis. J Clin Invest. 116(3):571–580.
  • Lenzi A, Lombardo F, Gandini L, Dondero F. 1992. Metabolism and action of L-carnitine: its possible role in sperm tail function. Arch. Ital. Urol. Nefrol. Androl. 64(2):187–196.
  • Liu -L-L, Xian H, Cao J-C, Zhang C, Zhang Y-H, Chen -M-M, Qian Y, Jiang M. 2015. Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology. Asian J Androl. 17(6):942.
  • Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J, Peters JM, Kaya G, Gonzalez FJ, Zakany J. 2001. Impaired skin wound healing in peroxisome proliferator–activated receptor (PPAR) α and PPARβ mutant mice. J Cell Biol. 154(4):799–814.
  • Miki K. 2006. Energy metabolism and sperm function. Soc Reprod Fertil Suppl. 65:309–325.
  • Montagner A, Rando G, Degueurce G, Leuenberger N, Michalik L, Wahli W. 2011. New insights into the role of PPARs. Prostaglandins Leukotrienes Essent. Fatty Acids (PLEFA). 85(5):235–243.
  • Morrison JA, Glueck CJ, Wang P. 2008. Dietary trans fatty acid intake is associated with increased fetal loss. Fertil Steril. 90(2):385–390.
  • Moschos S, Chan JL, Mantzoros CS. 2002. Leptin and reproduction: a review. Fertil Steril. 77(3):433–444.
  • Nadra K, Anghel SI, Joye E, Tan NS, Basu-Modak S, Trono D, Wahli W, Desvergne B. 2006. Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor β/δ. Mol Cell Biol. 26(8):3266–3281.
  • Peters JM, Lee SS, Li W, Ward JM, Gavrilova O, Everett C, Reitman ML, Hudson LD, Gonzalez FJ. 2000. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor β (δ). Mol Cell Biol. 20(14):5119–5128.
  • Piomboni P, Focarelli R, Stendardi A, Ferramosca A, Zara V. 2012. The role of mitochondria in energy production for human sperm motility. Int J Androl. 35(2):109–124.
  • Qiu J-H, Li Y-W, Xie H-L, Li Q, Dong H-B, Sun M-J, Gao W-Q, Tan J-H. 2016. Effects of glucose metabolism pathways on sperm motility and oxidative status during long-term liquid storage of goat semen. Theriogenology. 86(3):839–849.
  • Reilly SM, Lee C-H. 2008. PPARδ as a therapeutic target in metabolic disease. FEBS Lett. 582(1):26–31.
  • Rondanino C, Ouchchane L, Chauffour C, Marceau G, Déchelotte P, Sion B, Pons-Rejraji H, Janny L, Volle DH, Lobaccaro J-MA. 2014. Levels of liver X receptors in testicular biopsies of patients with azoospermia. Fertil Steril. 102(2):361–371. e365.
  • Santoro M, Guido C, De Amicis F, Sisci D, Vizza D, Gervasi S, Carpino A, Aquila S. 2013. Sperm metabolism in pigs: a role for peroxisome proliferator-activated receptor gamma (PPARγ). J. Exp. Biol. 216(6):1085–1092.
  • Saravanan N, Haseeb A, Ehtesham NZ. 2005. Differential effects of dietary saturated and trans-fatty acids on expression of genes associated with insulin sensitivity in rat adipose tissue. Eur. J. Endocrinol. 153(1):159–165.
  • Shah C, Modi D, Sachdeva G, Gadkar S, D’souza S, Puri C. 2005. N‐terminal region of progesterone receptor B isoform in human spermatozoa. Int J Androl. 28(6):360–371.
  • Statistical Analysis System (SAS). 2013: SAS® Software, 17. Version 9.4. Cary, NC, USA.
  • Tavilani H, Doosti M, Nourmohammadi I, Mahjub H, Vaisiraygani A, Salimi S, Hosseinipanah SM. 2007. Lipid composition of spermatozoa in normozoospermic and asthenozoospermic males. Prostaglandins Leukot Essent Fatty Acids. 77(1):45–50.
  • Tontonoz P, Hu E, Spiegelman BM. 1994. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell. 79(7):1147–1156.
  • Vitti M, Di Emidio G, Di Carlo M, Carta G, Antonosante A, Artini PG, Cimini A, Tatone C, Benedetti E. 2016. Peroxisome proliferator-activated receptors in female reproduction and fertility. PPAR Res. 2016:1–12.
  • Wagner K-D, Wagner N. 2010. Peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) acts as regulator of metabolism linked to multiple cellular functions. Pharmacol Ther. 125(3):423–435.
  • World Health Organization (WHO). 2010. WHO Laboratory Manual for the Examination and Processing of Human Semen, 5th ed. World Health Organization, Geneva, Switzerland.
  • Yang J, Chen L, Zhang X, Zhou Y, Zhang D, Huo M, Guan Y. 2008. PPARs and female reproduction: evidence from genetically manipulated mice. PPAR Res. 2008:1–8.
  • Yang Q, Kurotani R, Yamada A, Kimura S, Gonzalez FJ. 2006a. PPARα activation during pregnancy severely impairs mammary lobuloalveolar development in mice. Endocrinology. 147(10):4772.
  • Yang X, Downes M, Ruth TY, Bookout AL, He W, Straume M, Mangelsdorf DJ, Evans RM. 2006b. Nuclear receptor expression links the circadian clock to metabolism. Cell. 126(4):801–810.
  • Yessoufou A, Hichami A, Besnard P, Moutairou K, Khan NA. 2006. Peroxisome proliferator-activated receptor α deficiency increases the risk of maternal abortion and neonatal mortality in murine pregnancy with or without diabetes mellitus: modulation of T cell differentiation. Endocrinology. 147(9):4410–4418.
  • Zalata AA, Christophe AB, Depuydt CE, Schoonjans F, Comhaire FH. 1998. The fatty acid composition of phospholipids of spermatozoa from infertile patients. Mol Hum Reprod. 4(2):111–118.

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