764
Views
0
CrossRef citations to date
0
Altmetric
RESEARCH COMMUNICATION

c-Fos is upregulated in the genital tubercle of DEHP-induced hypospadiac rats and the prepuce of patients with hypospadias

, , , , , , & show all
Pages 193-200 | Received 02 Feb 2020, Accepted 16 Nov 2020, Published online: 22 Feb 2021

References

  • An N, Peng J, He G, Fan X, Li F, Chen H. 2018. Involvement of activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) signaling pathway in proliferation of urethral plate fibroblasts in finasteride-induced rat hypospadias. Med Sci Monit. 24:8984–8992. eng. doi:10.12659/MSM.911271.
  • Araujo FC, Oliveira CA, Reis AB, Del Puerto HL, Martins AS, Reis FM. 2009. Expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and estrogen receptor beta in the human testis. Histol Histopathol. 24(12):1515–1522. doi:10.14670/HH-24.1515.
  • Ban S, Sata F, Kurahashi N, Kasai S, Moriya K, Kakizaki H, Nonomura K, Kishi R. 2008. Genetic polymorphisms of ESR1 and ESR2 that may influence estrogen activity and the risk of hypospadias. Hum Reprod (Oxford, England). 23(6):1466–1471. eng. doi:10.1093/humrep/den098.
  • Barrett CS, Millena AC, Khan SA. 2017. TGF-beta effects on prostate cancer cell migration and invasion require FosB. Prostate. 77(1):72–81. eng. doi:10.1002/pros.23250.
  • Crescioli C, Maggi M, Vannelli GB, Ferruzzi P, Granchi S, Mancina R, Muratori M, Forti G, Serio M, Luconi M. 2003. Expression of functional estrogen receptors in human fetal male external genitalia. J Clin Endocrinol Metab. 88(4):1815–1824. eng. doi:10.1210/jc.2002-021085.
  • Cunha GR, Sinclair A, Risbridger G, Hutson J, Baskin LS. 2015. Current understanding of hypospadias: relevance of animal models. Nat Rev Urol. 12(5):271–280.
  • Dahlman-Wright K, Qiao Y, Jonsson P, Gustafsson JA, Williams C, Zhao C. 2012. Interplay between AP-1 and estrogen receptor alpha in regulating gene expression and proliferation networks in breast cancer cells. Carcinogenesis. 33(9):1684–1691. eng. doi:10.1093/carcin/bgs223.
  • Dorman DC, Chiu W, Hales BF, Hauser R, Johnson KJ, Mantus E, Martel S, Robinson KA, Rooney AA, Rudel R. et al. 2018. Systematic reviews and meta-analyses of human and animal evidence of prenatal diethylhexyl phthalate exposure and changes in male anogenital distance. J Toxicol Environ Health B Crit Rev. 214:207–226. eng. doi:10.1080/10937404.2018.1505354.
  • Foster PM. 2006. Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters. Int J Androl. 29(1):140–147; discussion 181–145. doi:10.1111/j.1365-2605.2005.00563.x.
  • Govers LC, Phillips TR, Mattiske DM, Rashoo N, Black JR, Sinclair A, Baskin LS, Risbridger GP, Pask AJ. 2019. A critical role for estrogen signaling in penis development. Faseb J. 33:fj201802586RR. doi:10.1096/fj.201802586RR.
  • Gurbuz C, Demir S, Zemheri E, Canat L, Kilic M, Caskurlu T. 2010. Is activating transcription factor 3 up-regulated in patients with hypospadias? Korean J Urol. 51(8):561–564. doi:10.4111/kju.2010.51.8.561.
  • Hyder SM, Stancel GM, Loose-Mitchell DS. 1991. Presence of an estradiol response region in the mouse c-fos oncogene. Steroids. 56(10):498–504. eng. doi:10.1016/0039-128X(91)90114-B.
  • Karabulut R, Turkyilmaz Z, Sonmez K, Kumas G, Ergun S, Ergun M, Basaklar A. 2013. Twenty-four genes are upregulated in patients with hypospadias. Balkan J Med Genet. 16(2):39–44. eng. doi:10.2478/bjmg-2013-0030.
  • Khasin LG, Della Rosa J, Petersen N, Moeller J, Kriegsfeld LJ, Lishko PV. 2020. The impact of Di-2-Ethylhexyl phthalate on sperm fertility. Front Cell Dev Biol. 8:426. eng. doi:10.3389/fcell.2020.00426.
  • Kim KS, Torres CR Jr., Yucel S, Raimondo K, Cunha GR, Baskin LS. 2004. Induction of hypospadias in a murine model by maternal exposure to synthetic estrogens. Environ Res. 94(3):267–275. eng. doi:10.1016/S0013-9351(03)00085-9.
  • Kita DH, Meyer KB, Venturelli AC, Adams R, Machado DL, Morais RN, Swan SH, Gennings C, Martino-Andrade AJ. 2016. Manipulation of pre and postnatal androgen environments and anogenital distance in rats. Toxicology. 368–369:152–161. eng. doi:10.1016/j.tox.2016.08.021.
  • Li M, Qiu L, Lin T, He D, Hua Y, Yuan X, Liu X, Wei G. 2013. c-Jun N-terminal kinase is upregulated in patients with hypospadias. Urology. 81(1):178–183. eng. doi:10.1016/j.urology.2012.09.010.
  • Ma LM, Wang Z, Wang H, Li RS, Zhou J, Liu BC, Baskin LS. 2009. Estrogen effects on fetal penile and urethral development in organotypic mouse genital tubercle culture. J Urol. 182(5):2511–2517. eng. doi:10.1016/j.juro.2009.07.008.
  • Matsushita S, Suzuki K, Murashima A, Kajioka D, Acebedo AR, Miyagawa S, Haraguchi R, Ogino Y, Yamada G. 2018. Regulation of masculinization: androgen signalling for external genitalia development. Nat Rev Urol. 15(6):358–368. doi:10.1038/s41585-018-0008-y.
  • Piechaczyk M, Blanchard JM. 1994. c-fos proto-oncogene regulation and function. Crit Rev Oncol Hematol. 17(2):93–131. eng. doi:10.1016/1040-8428(94)90021-3.
  • Safe S, Kim K. 2008. Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. J Mol Endocrinol. 41(5):263–275. eng. doi:10.1677/JME-08-0103.
  • Snodgrass W, Macedo A, Hoebeke P, Mouriquand PD. 2011. Hypospadias dilemmas: a round table. J Pediatr Urol. 7(2):145–157. eng. doi:10.1016/j.jpurol.2010.11.009.
  • Strauss L, Mäkelä S, Joshi S, Huhtaniemi I, Santti R. 1998. Genistein exerts estrogen-like effects in male mouse reproductive tract. Mol Cell Endocrinol. 144(1-2):83–93. eng. doi:10.1016/s0303-7207(98)00152-x.
  • Suda N, Itoh T, Nakato R, Shirakawa D, Bando M, Katou Y, Kataoka K, Shirahige K, Tickle C, Tanaka M. 2014. Dimeric combinations of MafB, cFos and cJun control the apoptosis-survival balance in limb morphogenesis. Development. 141(14):2885–2894. eng. doi:10.1242/dev.099150.
  • Suzuki K, Numata T, Suzuki H, Raga DD, Ipulan LA, Yokoyama C, Matsushita S, Hamada M, Nakagata N, Nishinakamura R, et al. 2014. Sexually dimorphic expression of Mafb regulates masculinization of the embryonic urethral formation. Proc Natl Acad Sci USA. 111(46):16407–16412. doi:10.1073/pnas.1413273111.
  • Swan SH, Sathyanarayana S, Barrett ES, Janssen S, Liu F, Nguyen RH, Redmon JB. 2015. First trimester phthalate exposure and anogenital distance in newborns. Hum Reprod (Oxford, England). 30(4):963–972. eng. doi:10.1093/humrep/deu363.
  • Thorup J, Nordenskjold A, Hutson JM. 2014. Genetic and environmental origins of hypospadias. Curr Opin Endocrinol Diabetes Obes. 21(3):227–232. doi:10.1097/MED.0000000000000063.
  • Utsch B, Albers N, Ludwig M. 2004. Genetic and molecular aspects of hypospadias. Eur J Pediatr Surg [Et Al] = Zeitschrift Fur Kinderchirurgie. 14(5):297–302. eng. doi:10.1055/s-2004-821275.
  • van der Horst HJ, de Wall LL. 2017. Hypospadias, all there is to know. Eur J Pediatr. 176(4):435–441. doi:10.1007/s00431-017-2864-5.
  • Wang Y, Liu W, Yang Q, Yu M, Zhang Z. 2015. Di (2-ethylhexyl) phthalate exposure during pregnancy disturbs temporal sex determination regulation in mice offspring. Toxicology. 336:10–16. doi:10.1016/j.tox.2015.07.009.
  • Wang Z, Liu BC, Lin GT, Lin CS, Lue TF, Willingham E, Baskin LS. 2007. Up-regulation of estrogen responsive genes in hypospadias: microarray analysis. J Urol. 177(5):1939–1946. eng. doi:10.1016/j.juro.2007.01.014.
  • Weisz A, Rosales R. 1990. Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor. Nucleic Acids Res. 18(17):5097–5106. eng. doi:10.1093/nar/18.17.5097.
  • Zhang X, Zhang L, Yang H, Huang X, Otu H, Libermann TA, DeWolf WC, Khosravi-Far R, Olumi AF. 2007. c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells. Cancer Res. 67(19):9425–9434. eng. doi:10.1158/0008-5472.CAN-07-1310.
  • Zhou Y, Liu X, Huang F, Liu Y, Cao X, Shen L, Long C, He D, Lin T, Wei G. 2017. Epithelial-mesenchymal transformation and apoptosis in rat urethra development. Pediatr Res. 82(6):1073–1079. eng. doi:10.1038/pr.2017.185.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.