SARS-CoV-2 vs. human gametes, embryos and cryopreservation

References

• Adiga SK, Tholeti P, Uppangala S, Kalthur G, Gualtieri R, Talevi R. 2020. Fertility preservation during the COVID-19 pandemic: mitigating the viral contamination risk to reproductive cells in cryostorage. Reprod Biomed Online. 41(6):991–997. doi:10.1016/j.rbmo.2020.09.013.
   PubMed Web of Science ®Google Scholar
• Alam MH, Miyano T. 2020. Interaction between growing oocytes and granulosa cells in vitro. Reprod Med Biol. 19(1):13–23. doi:10.1002/rmb2.12292.
   PubMed Web of Science ®Google Scholar
• Alviggi C, Esteves SC, Orvieto R, Conforti A, La Marca A, Fischer R, Andersen CY, Bühler K, Sunkara SK, Polyzos NP, et al. 2020. POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) group 2020. COVID-19 and assisted reproductive technology services: repercussions for patients and proposal for individualized clinical management. Reprod Biol Endocrinol. 18(1):45. doi:10.1186/s12958-020-00605-z.
   PubMed Web of Science ®Google Scholar
• Ambagala A, Truong T, Cottam-Birt C, Berhane Y, Gerdts V, Karniychuk U, Safronetz D, Babiuk S. 2020. Susceptibility of Chicken Embryos, Sheep, Cattle, Pigs, and Chickens to Zika Virus Infection. Front Vet Sci. 7:23. doi:10.3389/fvets.2020.00023
   PubMed Web of Science ®Google Scholar
• Anifandis G, Messini CI, Daponte A, Messinis IE. 2020. COVID-19 and fertility: a virtual reality. Reprod Biomed Online. 41(2):157–159. doi:10.1016/j.rbmo.2020.05.001.
   PubMed Web of Science ®Google Scholar
• Anifandis G, Tempest H, Oliva R, Swanson G, Simopoulou M, Easley C, Primig M, Messini C, Turek P, Sutovsky P, et al. 2021. COVID-19 and human reproduction: a pandemic that packs a serious punch. Syst Biol Reprod Med. 67(1):3–23. doi:10.1080/19396368.2020.1855271
   PubMed Web of Science ®Google Scholar
• Arav A. 2020. A recommendation for IVF lab practice in light of the current COVID-19 pandemic. J Assist Reprod Genet. 37(7):1543. doi:10.1007/s10815-020-01841-3.
   PubMed Web of Science ®Google Scholar
• Barragan M, Guillén JJ, Martin-Palomino N, Rodriguez A, Vassena R. 2021. Undetectable viral RNA in oocytes from SARS-CoV-2 positive women. Hum Reprod. 36(2):390–394. doi:10.1093/humrep/deaa284.
   PubMed Web of Science ®Google Scholar
• Barreta MH, Gasperin BG, Ferreira R, Rovani M, Pereira GR, Bohrer RC, De Oliveira JF, Gonçalves PB. 2015. The components of the angiotensin-(1-7) system are differentially expressed during follicular wave in cattle. J Renin Angiotensin Aldosterone Syst. 16(2):275–283. doi:10.1177/1470320313491996.
   PubMed Web of Science ®Google Scholar
• Baud D, Greub G, Favre G, Gengler C, Jaton K, Dubruc E, Pomar L. 2020. Second-trimester miscarriage in a pregnant woman with SARS-CoV-2 infection. JAMA. 323(21):2198–2200. doi:10.1001/jama.2020.7233.
   PubMed Web of Science ®Google Scholar
• Berhane Y, Suderman M, Babiuk S, Pickering B. 2020. Susceptibility of turkeys, chickens and chicken embryos to SARS-CoV-2. Transbound Emerg Dis. Dec 29 . doi: 10.1111/tbed.13970.
   PubMed Web of Science ®Google Scholar
• Block LN, Aliota MT, Friedrich TC, Chotzko ML, Mean KD, Wiepz GJ, Golos TG, Schmidt JK. 2020. Embryotoxic impact of Zika virus in a rhesus macaque in vitro implantation model. Biol Reprod. 102(4):806‐16. doi:10.1093/biolre/ioz236.
   Web of Science ®Google Scholar
• Cardona Maya WD, Du Plessis SS, Velilla PA. 2016. Semen as virus reservoir? J Assist Reprod Genet. 33(9):1255–1256. doi:10.1007/s10815-016-0747-8.
   PubMed Web of Science ®Google Scholar
• Cardona Maya WD, Du Plessis SS, Velilla PA. 2020. SARS-CoV-2 and the testis: similarities to other viruses and routes of infection. Reprod Biomed Online. 40(6):763–764. doi:10.1016/j.rbmo.2020.04.009.
   PubMed Web of Science ®Google Scholar
• Chen W, Yuan P, Yang M, Yan Z, Kong S, Yan J, Liu X, Chen Y, Qiao J, Yan L. 2020. SARS-CoV-2 entry factors: ACE2 and TMPRSS2 are expressed in peri-implantation embryos and the maternal-fetal interface. Engineering (Beijing). 6(10):1162–1169. doi:10.1016/j.eng.2020.07.013.
   PubMedGoogle Scholar
• Corona G, Baldi E, Isidori AM, Paoli D, Pallotti F, De Santis L, Francavilla F, La Vignera S, Selice R, Caponecchia L, et al. 2020. SARS-CoV-2 infection, male fertility and sperm cryopreservation: a position statement of the Italian Society of Andrology and Sexual Medicine (SIAMS) (Società Italiana di Andrologia e Medicina della Sessualità). J Endocrinol Invest. 43(8):1153–1157. doi:10.1007/s40618-020-01290-w.
   PubMed Web of Science ®Google Scholar
• Dang D, Wang L, Zhang C, Li Z, Wu H. 2020. Potential effects of SARS-CoV-2 infection during pregnancy on fetuses and newborns are worthy of attention. J Obstet Gynaecol Res. 46(10):1951–1957. doi:10.1111/jog.14406.
   PubMed Web of Science ®Google Scholar
• De Toni L, Garolla A, Di Nisio A, Rocca MS, Foresta C. 2020. Caution in the management of SARS-CoV-2 infection in males. Andrology. 41(5):967–968. doi:10.1016/j.rbmo.2020.08.016.
   Google Scholar
• De Ziegler D, Pirtea P, Scott RT, Rienzi L, Poulain M, Pharm D, Jean Marc Ayoubi JM. 2020. ART during the SARS-CoV-2 pandemic: a new context, new challenges, and new recommendations. Fertil Steril (Fertility and Sterility Dialogue).
   Google Scholar
• Douglas GC, O’Bryan MK, Hedger MP, Lee DK, Yarski MA, Smith A, Lew RA. 2004. The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis. Endocrinology. 145(10):4703–4711. doi:10.1210/en.2004-0443.
   PubMed Web of Science ®Google Scholar
• Eisenberg ML. 2020. Coronavirus Disease 2019 (COVID-19) and men’s reproductive health. Fertil Steril. 113(6):1154. doi:10.1016/j.fertnstert.2020.04.039.
   PubMed Web of Science ®Google Scholar
• Essahib W, Verheyen G, Tournaye H, Van De Velde H. 2020. SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and blastocysts. J Assist Reprod Genet. 37(11):2657–2660. doi:10.1007/s10815-020-01952-x.
   PubMed Web of Science ®Google Scholar
• Esteves SC, Lombardo F, Garrido N, Alvarez J, Zini A, Colpi GM, Kirkman-Brown J, Lewis SE, Björndahl L, Majzoub A, et al. 2020. SARS-CoV-2 pandemic and repercussions for male infertility patients: a proposal for the individualized provision of andrological services. Andrology. 18(1):45. doi:10.1186/s12958-020-00605-z.
   Google Scholar
• Feldmann H. 2018. Virus in semen and the risk of sexual transmission. N Eng J Med. 378(15):1440–1441. doi:10.1056/NEJMe1803212.
   PubMed Web of Science ®Google Scholar
• Foresta C, Rocca MS, Di Nisio A. 2020. Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome. J Endocrinol Invest. 16:1–6. doi:10.1007/s40618-020-01383-6
   Google Scholar
• Fraietta R, Pasqualotto FF, Roque M, Taitson PF. 2020. SARS-COV-2 and male reproductive health. JBRA Assist Reprod. 24(3):347–350. doi:10.5935/1518-0557.20200047.
   PubMed Web of Science ®Google Scholar
• Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Manne K, Stalls V, Kopp MF, Henderson R, Edwards RJ, et al. 2020. D614G mutation alters SARS-CoV-2 spike conformation and enhances protease cleavage at the S1/S2 junction. Cell Rep. 108630. doi:10.1016/j.celrep.2020.108630
   PubMed Web of Science ®Google Scholar
• Gonzalez DC, Khodamoradi K, Pai R, Guarch K, Connelly ZM, Ibrahim E, Arora H, Ramasamy R. 2020. A systematic review on the investigation of SARS-CoV-2 in semen. Res Rep Urol. 12:615–621. doi:10.2147/RRU.S277679
   PubMed Web of Science ®Google Scholar
• Guruprasad L. 2021. Human SARS CoV-2 spike protein mutations. Proteins. 89(5):569–576. doi:10.1002/prot.26042.
   PubMed Web of Science ®Google Scholar
• Henarejos-Castillo I, Sebastian-Leon P, Devesa-Peiro A, Pellicer A, Diaz-Gimeno P. 2020. SARS-CoV-2 infection risk assessment in the endometrium: viral infection-related gene expression across the menstrual cycle. Fertil Steril. 114(2):223–232. doi:10.1016/j.fertnstert.2020.06.026.
   PubMed Web of Science ®Google Scholar
• Hickman C, Rogers S, Huang G, MacArthur S, Meseguer M, Nogueira D, Portela R, Rienzi L, Sharp T, Ye H. 2020. Managing the IVF laboratory during a pandemic: international perspectives from laboratory managers. Reprod Biomed Online. 41(2):141–150. doi:10.1016/j.rbmo.2020.05.006.
   PubMed Web of Science ®Google Scholar
• Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, et al. 2020. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 181(2):271–280.e8. doi:10.1016/j.cell.2020.02.052.
   PubMed Web of Science ®Google Scholar
• Holtmann N, Edimiris P, Andree M, Doehmen C, Baston-Buest D, Adams O, Kruessel J-S, Bielfeld A-P. 2020. Assessment of SARS-CoV-2 in human semen - a cohort study. Fertil Steril. 114(2):233–238. doi:10.1016/j.fertnstert.2020.05.028.
   PubMed Web of Science ®Google Scholar
• Honorato-Sampaio K, Pereira VM, Santos RA, Reis AM. 2012. Evidence that angiotensin-(1-7) is an intermediate of gonadotrophin-induced oocyte maturation in the rat preovulatory follicle. Exp Physiol. 97(5):642–650. 107:83-88. doi:10.1016/j.peptides.2018.08.007.
   PubMed Web of Science ®Google Scholar
• IFFS: COVID-19 task force statements. 2020. https://www.iffsreproduction.org/page/COVID-Statements.
   Google Scholar
• Iwata-Yoshikawa N, Okamura T, Shimizu Y, Hasegawa H, Takeda M, Nagata N. 2019. TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection. J Virol. 93(6):e01815–18. doi:10.1128/JVI.01815-18.
   PubMed Web of Science ®Google Scholar
• Kurscheidt FA, Mesquita CSS, Damke GMZF, Damke E, Carvalho ARBA, Suehiro TT, Teixeira JJV, Da Silva VRS, Souza RP, Consolaro MEL. 2019. Persistence and clinical relevance of Zika virus in the male genital tract. Nat Rev Urol. 16(4):211–230. doi:10.1038/s41585-019-0149-7.
   PubMed Web of Science ®Google Scholar
• La Marca A, Niederberger C, Pellicer A, Nelson SM. 2020. COVID-19: lessons from the Italian reproductive medical experience. Fertil Steril. 113(5):920–922. doi:10.1016/j.fertnstert.2020.03.021.
   PubMed Web of Science ®Google Scholar
• Larasati T, Noda T, Fujihara Y, Shimada K, Tobita T, Yu Z, Matzuk MM, Ikawa M. 2020. Tmprss12 is required for sperm motility and uterotubal junction migration in mice. Biol Reprod. 103(2):254–263. doi:10.1093/biolre/ioaa060.
   PubMed Web of Science ®Google Scholar
• Li D, Jin M, BaO P, Zhao W, Zhang S. 2020a. Clinical characteristics and results of semen tests among men with coronavirus disease 2019. JAMA. 3(5):e208292.
   Google Scholar
• Li G, Li W, Song B, Wu H, Tang D, Wang C, He X, Cao Y. 2020b. SARS-CoV-2 and the reproductive system: assessment of risk and recommendations for infection control in reproductive departments. Syst Biol Reprod Med. 66(6):343–346. doi:10.1080/19396368.2020.1817627.
   PubMed Web of Science ®Google Scholar
• Li R, Yin T, Fang F, Li Q, Chen J, Wang Y, Hao Y, Wu G, Duan P, Wang Y, et al. 2020c. Potential risks of SARS-CoV-2 infection on reproductive health. Reprod Biomed Online. 41(1):89–95. doi:10.1016/j.rbmo.2020.04.018.
   PubMed Web of Science ®Google Scholar
• Li Y, Li H, Zhou L. 2020d. EZH2-mediated H3K27me3 inhibits ACE2 expression. Biochem Biophys Res Commun. 526(4):947–952. doi:10.1016/j.bbrc.2020.04.010.
   PubMed Web of Science ®Google Scholar
• Lin Z, Fang Q, Mai J, Zhou L, Qian Y, Cai T, Chen Z, Wang P, Lin B 2020. The nucleocapsid protein of SARS-CoV-2 abolished pluripotency in human induced pluripotent stem cells. bioRxiv 2020–2023.
   Google Scholar
• Liu Y, Yan LM, Wan L, Xiang TX, Le A, Liu JM, Peiris M, Poon LLM, Zhang W. 2020. Viral dynamics in mild and severe cases of COVID-19. Lancet Infect Dis. 20(6):656–657. doi:10.1016/S1473-3099(20)30232-2.
   PubMed Web of Science ®Google Scholar
• Lü M, Qiu L, Jia G, Guo R, Leng Q. 2020. Single-cell expression profiles of ACE2 and TMPRSS2 reveals potential vertical transmission and fetus infection of SARS-CoV-2. Aging (Albany NY). 12(20):19880–19897. doi:10.18632/aging.104015.
   PubMedGoogle Scholar
• Lukassen S, Chua RL, Trefzer T, Kahn NC, Schneider MA, Muley T, Winter H, Meister M, Veith C, Boots AW, et al. 2020. SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. EMBO J. 39(10):e105114. doi:10.15252/embj.20105114.
   PubMed Web of Science ®Google Scholar
• Ma L, Xie W, Li D, Shi L, Mao Y, Xiong Y, Zhang Y, Zhang M 2020. Effect of SARS-CoV-2 infection upon male gonadal function: a single center-based study. medRxiv.2020.2003.2021.20037267.
   Google Scholar
• Maggiulli R, Giancani A, Fabozzi G, Dovere L, Tacconi L, Amendola MG, Cimadomo D, Ubaldi FM, Rienzi L. 2020. Assessment and management of the risk of SARS-CoV-2 infection in an IVF laboratory. Reprod Biomed Online. 41(3):385–394. doi:10.1016/j.rbmo.2020.06.017.
   PubMed Web of Science ®Google Scholar
• Maleki BH, Tartibian B. 2021. COVID-19 and male reproductive function: a prospective, longitudinal cohort study. Reproduction. 161(3):319–331. doi:10.1530/REP-20-0382.
   PubMed Web of Science ®Google Scholar
• Massarotti C, Garolla A, Maccarini E, Scaruffi P, Stigliani S, Anserini P, Foresta C. 2021. SARS-CoV-2 in the semen: where does it come from? Andrology. 9(1):39–41. doi:10.1111/andr.12839.
   PubMed Web of Science ®Google Scholar
• Merino O, Aguagüiña WE, Esponda P, Risopatrón J, Isachenko E, Isachenko V, Sánchez R. 2015. Protective effect of butylated hydroxytoluene on sperm function in human spermatozoa cryopreserved by vitrification technique. Andrologia. 47(2):186–193. doi:10.1111/and.12246.
   PubMed Web of Science ®Google Scholar
• Merrill DR, Wade CD, Fahnestock P, Baker RO 2018. Long-term and short-term stability of viruses depend on storage temperature and preservation method. Beiresources poster.
   Google Scholar
• Monteleone PA, Nakano M, Lazar V, Gomes AP, Martin H, Bonetti TC. 2020. A review of initial data on pregnancy during the COVID-19 outbreak: implications for assisted reproductive treatments. JBRA Assist Reprod. 24(2):219–225. doi:10.5935/1518-0557.20200030.
   PubMed Web of Science ®Google Scholar
• Pal R, Banerjee M. 2020. COVID-19 and the endocrine system: exploring the unexplored. J Endocrinol Invest. 43(7):1027–1031. doi:10.1007/s40618-020-01276-8.
   PubMed Web of Science ®Google Scholar
• Pan F, Xiao X, Guo J, Song Y, Li H, Patel DP, Spivak AM, Alukal JP, Zhang X, Xiong C, et al. 2020. No evidence of SARS-CoV-2 in semen of males recovering from COVID-19. Fertil Steril. 13(6):1135–1139. doi:10.1016/j.fertnstert.2020.04.024.
   Google Scholar
• Pan PP, Zhan QT, Le F, Zheng YM, Jin F. 2013. Angiotensin-converting enzymes play a dominant role in fertility. Int J Mol Sci. 14(10):21071–21086. doi:10.3390/ijms141021071.
   PubMed Web of Science ®Google Scholar
• Paoli D, Pallotti F, Turriziani O, Mazzuti L, Antonelli G, Lenzi A, Lombardo F. 2021. SARS-CoV-2 presence in seminal fluid: myth or reality. Andrology. 9(1):23–26. doi:10.1111/andr.12825.
   PubMed Web of Science ®Google Scholar
• Parmegiani L, Accorsi A, Bernardi S, Arnone A, Cognigni GE, Filicori MA. 2012. Reliable procedure for decontamination before thawing of human specimens cryostored in liquid nitrogen: three washes with sterile liquid nitrogen (SLN2). Fertil Steril. 98(4):870–875. doi:10.1016/j.fertnstert.2012.06.028.
   PubMed Web of Science ®Google Scholar
• Perry MJ, Arrington S, Neumann LM, Carrell D, Mores CN. 2020. It is currently unknown whether SARS-CoV-2 is viable in semen or whether COVID-19 damages spermatozoa. Andrology. 9(1):30–32. doi:10.1111/andr.12831.
   PubMed Web of Science ®Google Scholar
• Qian G, Yang N, Ma AHY, Wang L, Li G, Chen X, Chen X. 2020. A COVID-19 Transmission within a family cluster by presymptomatic infectors in China. Clin Infect Dis. 71(15):861–862. doi:10.1093/cid/ciaa316.
   PubMed Web of Science ®Google Scholar
• Rajput SK, Logsdon DM, Kile B, Engelhorn HJ, Goheen B, Khan S, Swain J, McCormick S, Schoolcraft WB, Yuan Y, et al. 2020. Human eggs, zygotes, and embryos express the receptor ACE2 and protease TMPRSS2 protein necessary for SARS-CoV-2 infection. F S Sci. 10.1016/j.xfss.2020.12.005.
   PubMedGoogle Scholar
• Reis FM, Bouissou DR, Pereira VM, Camargos AF, Dos Reis AM, Santos RA. 2011. Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary. Fertil Steril. 95(1):176–181. doi:10.1016/j.fertnstert.2010.06.060.
   PubMed Web of Science ®Google Scholar
• Requena A, Cruz M, Vergara V, Prados N, Galliano D, Pellicer A. 2020. A picture of the covid-19 impact on IVIRMA fertility treatment clinics in Spain and Italy. Reprod BioMed Online. 41(1):1–5. doi:10.1016/j.rbmo.2020.04.015.
   PubMed Web of Science ®Google Scholar
• Ruan Y, Hu B, Liu Z, Liu K, Jiang H, Li H, Li R, Luan Y, Liu X, Yu G, et al. 2021. No detection of SARS-CoV-2 from urine, expressed prostatic secretions, and semen in 74 recovered COVID-19 male patients: a perspective and urogenital evaluation. Andrology. 9(1):99–106. doi:10.1111/andr.12939.
   PubMed Web of Science ®Google Scholar
• Santos RA, Ferreira AJ, Verano-Braga T, Bader M. 2013. Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system. J Endocrinol. 216(2):R1–R17. doi:10.1530/JOE-12-0341.
   PubMed Web of Science ®Google Scholar
• Scarica C, Parmegiani L, Rienzi L, Anastasi A, Cimadomo D, Klinger FG, Licata E, Sosa Fernandez L, De Santis L. 2021. SARS-CoV-2 persistence at subzero temperatures. J Assist Reprod Genet. 5:1–3. doi:10.1007/s10815-021-02094-4
   Google Scholar
• Schulz M, Risopatrón J, Uribe P, Isachenko E, Isachenko V, Sánchez R. 2020. Human sperm vitrification: a scientific report. Andrology. 8(6):1642–1650. doi:10.1111/andr.12847.
   PubMed Web of Science ®Google Scholar
• Song C, Wang Y, Li W, Hu B, Chen G, Xia P, Wang W, Li C, Diao F, Hu Z, et al. 2020. Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients. Biol Reprod. 103(1):4–6. doi:10.1093/biolre/ioaa050.
   PubMed Web of Science ®Google Scholar
• Souza MD, Nakagawa H, Taitson PF, Cordts EB, Antunes RA. 2020. Management of ART and COVID-19: infertility in times of pan- demic. What now? JBRA Assist Reprod. 24(3):231–232. doi:10.5935/1518-0557.20200031.
   PubMed Web of Science ®Google Scholar
• Stanley KE, Thomas E, Leaver M, Wells D. 2020. Coronavirus disease (COVID-19) and fertility: viral host entry protein expression in male and female reproductive tissues. Fertil Steril. 114(1):33–43. doi:10.1016/j.fertnstert.2020.05.001.
   PubMed Web of Science ®Google Scholar
• Tan L, Lacko LA, Zhou T, Tomoiaga D, Hurtado R, Zhang T, Sevilla A, Zhong A, Mason CE, Noggle S, et al. 2019. Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells. Nat Commun. 10(1):4155. doi:10.1038/s41467-019-12063-2.
   PubMedGoogle Scholar
• Temiz MZ, Dincer MM, Hacibey I, Yazar RO, Celik C, Kucuk SH, Alkurt G, Doganay L, Yuruk E, Muslumanoglu AY. 2020. Investigation of SARS-CoV-2 in semen samples and the effects of COVID-19 on male sexual health by using semen analysis and serum male hormone profile: a cross-sectional, pilot study. Andrologia. e13912. doi:10.1111/and.13912
   PubMed Web of Science ®Google Scholar
• Tesarik J. 2020. After corona: there is life after the pandemic. Reprod BioMed Online. 40(6):760–762. doi:10.1016/j.rbmo.2020.04.002.
   PubMed Web of Science ®Google Scholar
• Veiga A, Gianaroli L, Ory S, Horton M 2021. Joint IFFS/ESHRE statement on COVID-19 vaccination for pregnant women and those considering pregnancy.
   Google Scholar
• Veiga A, Gianaroli L, Ory S, Horton M, Feinberg E, Penzias A. 2020. Assisted reproduction and COVID-19: a joint statement of ASRM, ESHRE and IFFS. Hum Reprod Open. 2020(3):hoaa033. doi:10.1093/hropen/hoaa033.
   PubMedGoogle Scholar
• Verma S, Saksena S, Sadri-Ardekani H. 2020. ACE2 receptor expression in testes: implications in COVID-19 pathogenesis. Biol Reprod. 40(6):760–762. doi:10.1016/j.rbmo.2020.04.002.
   Google Scholar
• Virant-Klun I, Strle F. 2021. Human oocytes express both ACE2 and BSG genes and corresponding proteins: is SARS-CoV-2 infection possible? Stem Cell Rev Rep. 5:1–7. doi:10.1007/s12015-020-10101-x
   Google Scholar
• Wadman M. 2020. COVID-19 unlikely to cause birth defects, but doctors await fall births. Science. 369(6504):607. doi:10.1126/science.369.6504.607.
   PubMed Web of Science ®Google Scholar
• Wang M, Liu X, Chang G, Chen Y, An G, Yan L, Gao S, Xu Y, Cui Y, Dong J, et al. 2018. Single-cell RNA sequencing analysis reveals sequential cell fate transition during human spermatogenesis. Cell Stem Cell. 23(4):599–614.e4. doi:10.1016/j.stem.2018.08.007.
   PubMed Web of Science ®Google Scholar
• Wang Z, Xu X. 2020. scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, leydig and sertoli cells. Cells. 9(4):920. doi:10.3390/cells9040920.
   PubMed Web of Science ®Google Scholar
• Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS. 2020. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 367(6483):1260–1263. doi:10.1126/science.abb2507.
   PubMed Web of Science ®Google Scholar
• Yakass MB, Woodward B. 2020. COVID-19: should we continue to cryopreserve sperm during the pandemic? Reprod BioMed Online. 40(6):905. doi:10.1016/j.rbmo.2020.04.004.
   PubMed Web of Science ®Google Scholar
• Yan L, Yang M, Guo H, Yang L, Wu J, Li R, Liu P, Lian Y, Zheng X, Yan J, et al. 2013. Single-cell RNA-Seq profiling of human pre-implantation embryos and embryonic stem cells. Nat Struct Mol Biol. 20(9):1131–1139. doi:10.1038/nsmb.2660.
   PubMed Web of Science ®Google Scholar
• Younis JS, Abassi Z, Skorecki K. 2020. Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection. Am J Physiol Endocrinol Metab. 318(6):E878–E880. doi:10.1152/ajpendo.00183.2020.
   PubMed Web of Science ®Google Scholar
• Zhang P, Heyman T, Greechan M, Dygulska B, Al Sayyed F, Narula P, Lederman S. 2021. Maternal, neonatal and placental characteristics of SARS-CoV-2 positive mothers. J Matern Fetal Neonatal Med. 28:1–9. doi:10.1080/14767058.2021.1892637
   Google Scholar