Cbl ubiquitin ligases mediate the inhibition of natural killer cell activity

References

• Vivier E, Nunes JA, Vely F. Natural killer cell signaling pathways. Science 2004; 306:1517-9; PMID:15567854; http://dx.doi.org/10.1126/science.1103478
   PubMed Web of Science ®Google Scholar
• Caraux A, Kim N, Bell SE, Zompi S, Ranson T, Lesjean-Pottier S, et al. Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. Blood 2006; 107:994-1002; PMID:16204312; http://dx.doi.org/10.1182/blood-2005-06-2428
   PubMed Web of Science ®Google Scholar
• Upshaw JL, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ. The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors. J Immunol 2005; 175:213-8; PMID:15972651; http://dx.doi.org/10.4049/jimmunol.175.1.213
   PubMed Web of Science ®Google Scholar
• Tassi I, Presti R, Kim S, Yokoyama WM, Gilfillan S, Colonna M. Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors. J Immunol 2005; 175:749-54; PMID:16002670; http://dx.doi.org/10.4049/jimmunol.175.2.749
   PubMed Web of Science ®Google Scholar
• Balagopalan L, Coussens NP, Sherman E, Samelson LE, Sommers CL. The LAT story: a tale of cooperativity, coordination, and choreography. Cold Spring Harb Perspect Biol 2010; 2:a005512; PMID:20610546; http://dx.doi.org/10.1101/cshperspect.a005512
   PubMedGoogle Scholar
• Clapham DE. Calcium signaling. Cell 2007; 131:1047-58; PMID:18083096; http://dx.doi.org/10.1016/j.cell.2007.11.028
   PubMed Web of Science ®Google Scholar
• Joseph N, Reicher B, Barda-Saad M. The calcium feedback loop and T cell activation: how cytoskeleton networks control intracellular calcium flux. Biochimica et biophysica acta 2014; 1838:557-68; PMID:23860253; http://dx.doi.org/10.1016/j.bbamem.2013.07.009
   PubMed Web of Science ®Google Scholar
• Braiman A, Barda-Saad M, Sommers CL, Samelson LE. Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains. Embo J 2006; 25:774-84; PMID:16467851; http://dx.doi.org/10.1038/sj.emboj.7600978
   PubMed Web of Science ®Google Scholar
• Zhang W, Trible RP, Zhu M, Liu SK, McGlade CJ, Samelson LE. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. J Biol Che 2000; 275:23355-61; PMID:10811803; http://dx.doi.org/10.1074/jbc.M000404200
   PubMedGoogle Scholar
• Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 1998; 92:83-92; PMID:9489702; http://dx.doi.org/10.1016/S0092-8674(00)80901-0
   PubMed Web of Science ®Google Scholar
• Matalon O, Fried S, Ben-Shmuel A, Pauker MH, Joseph N, Keizer D, Piterburg M, Barda-Saad M. Dephosphorylation of the adaptor LAT and phospholipase C-gamma by SHP-1 inhibits natural killer cell cytotoxicity. Sci Signal 2016; 9:ra54; PMID:27221712
   PubMed Web of Science ®Google Scholar
• Long EO. Negative signaling by inhibitory receptors: the NK cell paradigm. Immunol Rev 2008; 224:70-84; PMID:18759921; http://dx.doi.org/10.1111/j.1600-065X.2008.00660.x
   PubMed Web of Science ®Google Scholar
• Lanier LL. Up on the tightrope: natural killer cell activation and inhibition. Nat Immunol 2008; 9:495-502; PMID:18425106; http://dx.doi.org/10.1038/ni1581
   PubMed Web of Science ®Google Scholar
• Lanier LL. NK cell recognition. Annu Rev Immunol 2005; 23:225-74; PMID:15771571; http://dx.doi.org/10.1146/annurev.immunol.23.021704.115526
   PubMed Web of Science ®Google Scholar
• Eissmann P, Davis DM. Inhibitory and regulatory immune synapses. Curr Topic Microbiol Immunol 2010; 340:63-79; PMID:19960309
   PubMed Web of Science ®Google Scholar
• Stebbins CC, Watzl C, Billadeau DD, Leibson PJ, Burshtyn DN, Long EO. Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol Cell Biol 2003; 23:6291-9; PMID:12917349; http://dx.doi.org/10.1128/MCB.23.17.6291-6299.2003
   PubMed Web of Science ®Google Scholar
• Ciechanover A. Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 2005; 6:79-87; PMID:15688069; http://dx.doi.org/10.1038/nrm1552
   PubMed Web of Science ®Google Scholar
• Reicher B, Joseph N, David A, Pauker MH, Perl O, Barda-Saad M. Ubiquitylation-dependent negative regulation of WASp is essential for actin-cytoskeleton dynamics. Mol Cell Biol 2012; 15:3153-63; http://dx.doi.org/10.1128/MCB.00161-12
   Web of Science ®Google Scholar
• Joseph N, Reicher B, David A, Matalon O, Barda-Saad M. Ubiquitylation-dependent downregulation of Nck regulates its functional activity. FEBS letters 2014; 588:3808-15; PMID:25218436; http://dx.doi.org/10.1016/j.febslet.2014.08.033
   PubMed Web of Science ®Google Scholar
• Matalon O, Reicher B, Barda-Saad M. Wiskott-Aldrich syndrome protein–dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes. Immunol Rev 2013; 256:10-29; PMID:24117810; http://dx.doi.org/10.1111/imr.12112
   PubMed Web of Science ®Google Scholar
• Paolini R, Molfetta R, Piccoli M, Frati L, Santoni A. Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement. Proc Natl Acad Sci U S A 2001; 98:9611-6; PMID:11493682; http://dx.doi.org/10.1073/pnas.161298098
   PubMed Web of Science ®Google Scholar
• Balagopalan L, Barr VA, Sommers CL, Barda-Saad M, Goyal A, Isakowitz MS, et al. c-Cbl-mediated regulation of LAT-nucleated signaling complexes. Mol Cell Biol 2007; 27:8622-36; PMID:17938199; http://dx.doi.org/10.1128/MCB.00467-07
   PubMed Web of Science ®Google Scholar
• Huang F, Gu H. Negative regulation of lymphocyte development and function by the Cbl family of proteins. Immunol Rev 2008; 224:229-38; PMID:18759930; http://dx.doi.org/10.1111/j.1600-065X.2008.00655.x
   PubMed Web of Science ®Google Scholar