Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins

References

• Mohieldin AM, Pala R, Sherpa RT, et al. Proteomic identification reveals the role of ciliary extracellular-like vesicle in cardiovascular function. Adv Sci (Weinh). 2020;7(16):1903140. PMID: 32832346. PMC7435257.
   PubMedGoogle Scholar
• Mohieldin AM, Pala R, Beuttler R, et al. Ciliary extracellular vesicles are distinct from the cytosolic extracellular vesicles. J Extracell Vesicles. 2021;10(6):e12086. PMID: 33936569. PMC8077156.
   PubMed Web of Science ®Google Scholar
• Edvardson S, Shaag A, Zenvirt S, et al. Joubert syndrome 2 (JBTS2) in Ashkenazi Jews is associated with a TMEM216 mutation. Am J Hum Genet. 2010;86(1):93–97. PMID: 20036350. PMC2801745.
   PubMed Web of Science ®Google Scholar
• Farrer MJ, et al. DCTN1 mutations in Perry syndrome. Nat Genet. 2009;41:163–165. PMID: 19136952. PMC2813485.
   PubMed Web of Science ®Google Scholar
• Ferland RJ, et al. Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert syndrome. Nat Genet. 2004;36(9):1008–1013. PMID: 15322546.
   PubMed Web of Science ®Google Scholar
• Masters CL, Bateman R, Blennow K, et al. Alzheimer’s disease. Nat Rev Dis Primers. 2015;1(1):15056. PMID: 27188934.
   PubMedGoogle Scholar
• Karunakaran KB, Chaparala S, Lo CW, et al. Cilia interactome with predicted protein-protein interactions reveals connections to Alzheimer’s disease, aging and other neuropsychiatric processes. Sci Rep. 2020;10(1):15629. PMID: 32973177. PMC7515907.
   PubMed Web of Science ®Google Scholar
• Bennouna-Greene V, Kremer S, Stoetzel C, et al. Hippocampal dysgenesis and variable neuropsychiatric phenotypes in patients with Bardet-Biedl syndrome underline complex CNS impact of primary cilia. Clin Genet. 2011;80(6):523–531. PMID: 21517826.
   PubMed Web of Science ®Google Scholar
• Baker K, Northam GB, Chong WK, et al. Neocortical and hippocampal volume loss in a human ciliopathy: a quantitative MRI study in Bardet-Biedl syndrome. Am J Med Genet A. 2011;155A(1):1–8. PMID: 21204204.
   PubMed Web of Science ®Google Scholar
• Einstein EB, Patterson Ca, Hon BJ, et al. Somatostatin signaling in neuronal cilia is critical for object recognition memory. J Neurosci. 2010;30(12):4306–4314. PMID: 20335466. PMC3842454.
   PubMed Web of Science ®Google Scholar
• Rodriguez JJ, Jones VC, Tabuchi M, et al. Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer’s disease. PLoS One. 2008;3(8):e2935. PMID: 18698410. PMC2492828.
   PubMed Web of Science ®Google Scholar
• Burgos-Ramos E, Hervás-Aguilar A, Aguado-Llera D, et al. Somatostatin and Alzheimer’s disease. Mol Cell Endocrinol. 2008;286(1–2):104–111. PMID: 18359553.
   PubMed Web of Science ®Google Scholar
• Peng C, Trojanowski JQ, Lee VM. Protein transmission in neurodegenerative disease. Nat Rev Neurol. 2020;16(4):199–212. PMID: 32203399.
   PubMed Web of Science ®Google Scholar
• D’Anca M, et al. Exosome determinants of physiological aging and age-related neurodegenerative diseases. Front Aging Neurosci. 2019;11:232. PMID: 31555123. PMC6722391.
   PubMed Web of Science ®Google Scholar
• Vorobyeva AG, Saunders AJ. Amyloid-beta interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure. Cilia. 2018;7(5). PMID: 30140428.PMC6098584. DOI:https://doi.org/10.1186/s13630-018-0059-y.
   Google Scholar
• Hu L, Wang B, Zhang Y. Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer’s disease by regulating cilia function. Alzheimers Res Ther. 2017;9(76). PMID: 28931427. PMC5607612. DOI:https://doi.org/10.1186/s13195-017-0304-4.
   Google Scholar
• Hamlett ED, Ledreux A, Potter H, et al. Exosomal biomarkers in down syndrome and Alzheimer’s disease. Free Radic Biol Med. 2018;114:110–121. PMID: 28882786. PMC6135098.
   PubMed Web of Science ®Google Scholar
• Ma W, Wu M, Zhou S, et al. Reduced smoothened level rescues Abeta-induced memory deficits and neuronal inflammation in animal models of Alzheimer’s disease. J Genet Genomics. 2018;45(5):237–246. PMID: 29807798.
   PubMed Web of Science ®Google Scholar
• He P, Staufenbiel M, Li R, et al. Deficiency of patched 1-induced Gli1 signal transduction results in astrogenesis in Swedish mutated APP transgenic mice. Hum Mol Genet. 2014;23(24):6512–6527. PMID: 25027328. PMC4296204.
   PubMed Web of Science ®Google Scholar
• Huangfu D, Liu A, Rakeman AS, et al. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003;426(6962):83–87. PMID: 14603322.
   PubMed Web of Science ®Google Scholar
• Li XL, Wang P, Xie Y. Protease nexin-1 protects against Alzheimer’s disease by regulating the sonic hedgehog signaling pathway. Int J Neurosci. 2021;131(11):1087–1096. PMID: 32449865.
   PubMed Web of Science ®Google Scholar
• Yang T, et al. CD151 promotes Colorectal Cancer progression by a crosstalk involving CEACAM6, LGR5 and Wnt signaling via TGFbeta1. Int J Biol Sci. 2021;17(3):848–860. PMID: 33767593. PMC7975690.
   PubMed Web of Science ®Google Scholar
• Zhong S, Yan Q, Ge J, et al. Identification of driver genes and key pathways of ependymoma. Turk Neurosurg. 2018; PMID: 30649797. DOI:https://doi.org/10.5137/1019-5149.JTN.21876-17.5.
   Google Scholar
• Liu K, Wang X, Zou C, et al. Defective CFTR promotes intestinal proliferation via inhibition of the hedgehog pathway during cystic fibrosis. Cancer Lett. 2019;446:15–24. PMID: 30639531.
   PubMed Web of Science ®Google Scholar
• Dai J, Lin K, Huang Y, et al. Identification of critically carcinogenesis-related genes in basal cell carcinoma. Onco Targets Ther. 2018;11:6957–6967. PMID: 30410353. PMC6199216.
   PubMed Web of Science ®Google Scholar
• Sampaolo S, et al. Identification of the first dominant mutation of LAMA5 gene causing a complex multisystem syndrome due to dysfunction of the extracellular matrix. J Med Genet. 2017;54(10):710–720. PMID: 28735299.
   PubMed Web of Science ®Google Scholar
• Lu Y, Li J, Cheng J, et al. Genes targeted by the Hedgehog-signaling pathway can be regulated by Estrogen related receptor beta. BMC Mol Biol. 2015;16(1):19. PMID: 26597826. PMC4657266.
   PubMedGoogle Scholar
• Gopinath S, Malla R, Alapati K, et al. Cathepsin B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression. Carcinogenesis. 2013;34(3):550–559. PMID: 23222817. PMC3581601.
   PubMed Web of Science ®Google Scholar
• Mille F, et al. The Patched dependence receptor triggers apoptosis through a DRALcaspase-9 complex. Nat Cell Biol. 2009;11(6):739–746. PMID: 19465923. PMC2844407.
   PubMed Web of Science ®Google Scholar
• Schmidt K, Hughes C, Chudek JA, et al. Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb. Mol Cell Biol. 2009;29(10):2716–2729. PMID: 19273610. PMC2682028.
   PubMed Web of Science ®Google Scholar
• Alhassen W, Chen S, Vawter M, et al. Patterns of cilia gene dysregulations in major psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2021;109:110255. PMID: 33508383. DOI:https://doi.org/10.1016/j.pnpbp.2021.110255.
   PubMed Web of Science ®Google Scholar