Modelling the chronic non-cancer effects of mixtures of migrants using Cramer classes and quantitative models of uncertainty

References

• AFC. 2005 Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Material in Contact with Food (AFC) on a request from the Commission related to di-butylphthalate (DBP) for use in food-contact materials Question No. EFSA-Q-2003-192 Adopted on 23 June 2005 by written procedure. EFSA J P. 242
   Google Scholar
• Agency for Toxic Substances and Disease Registry (ATSDR) . 2004 . Guidance manual for the assessment of joint toxic actions of chemical mixtures , Atlanta, GA : US Department of Health and Human Services, Public Health Service .
   Google Scholar
• Baird , SJS . 1996 . Noncancer risk assessment: a probabilistic alternative to current practice . Hum Ecol Risk Assess , 2 ( 1 ) : 79 – 102 .
   Web of Science ®Google Scholar
• Barlow , S . 2005 . Threshold of toxicological concern (TTC) – A tool for assessing substances of unknown toxicity present at low levels in the diet , Washington, DC : International Life Sciences Institute .
   Google Scholar
• Bokkers , BG and Slob , W . 2005 . A comparison of ratio distributions based on the NOAEL and the benchmark approach for subchronic-to-chronic extrapolation . Toxicol Sci , 85 ( 2 ) : 1033 – 1040 .
   PubMed Web of Science ®Google Scholar
• Bokkers , BG and Slob , W . 2007 . Deriving a data-based interspecies assessment factor using the NOAEL and the benchmark dose approach . Crit Rev Toxicol , 37 ( 5 ) : 355 – 373 .
   PubMed Web of Science ®Google Scholar
• Bosgra , S , Pos , PMJ , Vermeire , TG , Luit , RJ and Slob , W . 2005 . Probabilistic risk characterization: an example with di(2-ethylhexyl) phthalate . Regul Toxicol Pharmacol , 43 ( 1 ) : 104 – 113 .
   PubMed Web of Science ®Google Scholar
• Bradley , E and Coulier , L . 2007 . An investigation into the reaction and breakdown products from starting substances used to produce food contact plastics , York, , UK : Central Science Laboratory .
   Google Scholar
• Brand , KP , Catalano , PJ , Hammitt , JK , Rhomberg , L and Evans , JS . 2001 . Limitations to empirical extrapolation studies: the case of BMD ratios . Risk Anal , 21 ( 4 ) : 625 – 640 .
   PubMed Web of Science ®Google Scholar
• Brand , KP , Rhomberg , L and Evans , JS . 1999 . Estimating noncancer uncertainty factors: are ratios NOAELs informative? . Risk Anal , 19 ( 2 ) : 295 – 308 .
   PubMed Web of Science ®Google Scholar
• Carlson-Lynch , H , Cohen , JT , Graham , JD , Shlyakhter , AI and Evans , JS . 1999 . Application of quantitative information on the uncertainty in the RfD to noncarcinogenic risk assessments . Hum Ecol Risk Assess , 5 ( 3 ) : 527 – 546 .
   Web of Science ®Google Scholar
• Cramer , GM , Ford , RA and Hall , RL . 1978 . Estimation of toxic hazard – a decision tree approach . Food Cosmet Toxicol , 16 ( 3 ) : 255 – 276 .
   PubMedGoogle Scholar
• European Chemicals Agency (ECHA) . 2008 . Characterisation of dose [concentration]–response for human health. In: Guidance on information requirements and chemical safety assessment , Helsinki, , Finland : ECHA .
   Google Scholar
• FAO/WHO 1997. Joint FAO/WHO Expert Committee on Food Additives 2-ETHYL-1-HEXANOL FAS 40-JECFA 49/189. Available from: http://www.inchem.org/documents/jecfa/jeceval/jec763.htm
   Google Scholar
• Gaylor , DW and Kodell , RL . 2000 . Percentiles of the product of uncertainty factors for establishing probabilistic reference doses . Risk Anal , 20 ( 2 ) : 245 – 250 .
   PubMed Web of Science ®Google Scholar
• Interdepartmental Group on Health Risks from Chemicals (IGHRC) . 2009 . Chemical mixtures: A framework for assessing risks (CR14) , Cranfield, , UK : Institute of Environment and Health, Cranfield University .
   Google Scholar
• Kalberlah , F , Fost , U and Schneider , K . 2002 . Time extrapolation and interspecies extrapolation for locally acting substances in case of limited toxicological data . Ann Occupat Hyg , 46 ( 2 ) : 175 – 185 .
   PubMed Web of Science ®Google Scholar
• Kalberlah , F , Schneider , K and Schuhmacher-Wolz , U . 2003 . Uncertainty in toxicological risk assessment for non-carcinogenic health effects . Regul Toxicol Pharmacol , 37 ( 1 ) : 92 – 104 .
   PubMed Web of Science ®Google Scholar
• Kodell , RL and Chen , JJ . 2007 . On the use of hierarchical probabilistic models for characterizing and managing uncertainty in risk/safety assessment . Risk Anal , 27 ( 2 ) : 433 – 437 .
   PubMedGoogle Scholar
• Könemann , WH and Pieters , MN . 1996 . Confusion of concepts in mixture toxicology . Food Chem Toxicol , 34 ( 11–12 ) : 1025 – 1031 .
   PubMedGoogle Scholar
• Kroes , R , Renwick , AG , Cheeseman , M , Kleiner , J , Mangelsdorf , I , Piersma , A , Schilter , B , Schlatter , J , van Schothorst , F , Vos , JG and Wurtzen , G . 2004 . Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet . Food Chem Toxicol , 42 ( 1 ) : 65 – 83 .
   PubMed Web of Science ®Google Scholar
• Munro , IC , Ford , RA , Kennepohl , E and Sprenger , JG . 1996 . Correlation of structural class with no-observed-effect levels: a proposal for establishing a threshold of concern . Food Chem Toxicol , 34 ( 9 ) : 829 – 867 .
   PubMed Web of Science ®Google Scholar
• Price , PS , Keenan , RE , Swartout , JC , Gillis , CA and Dourson , MC . 1995 . A Monte Carlo based approach for modeling noncarcinogenic dose response rates , Paper presented at : Society for Risk Analysis Annual Meeting, 3–5 December 1995; Honolulu, HI, USA .
   Google Scholar
• Price , PS , Keenan , RE , Swartout , JC , Gillis , CA , Carlson-Lynch , H and Dourson , ML . 1997 . An approach for modeling noncancer dose responses with an emphasis on uncertainty . Risk Anal , 17 ( 4 ) : 427 – 437 .
   PubMed Web of Science ®Google Scholar
• Price , PS , Keenan , RE and Swartout , JC . 2008 . Characterizing interspecies uncertainty using data from studies of anti-neoplastic agents in animals and humans . Toxicol Appl Pharmacol , 233 ( 1 ) : 64 – 70 .
   PubMed Web of Science ®Google Scholar
• Rhomberg , LR and Wolff , SK . 1998 . Empirical scaling of single oral lethal doses across mammalian species based on a large database . Risk Anal , 18 ( 6 ) : 741 – 753 .
   PubMed Web of Science ®Google Scholar
• Schneider , K , Schuhmacher-Wolz , U , Hassauer , M , Darschnik , S , Elmhäuser , E and Mosbach-Schulz , O . 2006 . A probabilistic effect assessment model for hazardous substances at the workplace . Regul Toxicol Pharmacol , 44 ( 2 ) : 172 – 181 .
   PubMed Web of Science ®Google Scholar
• Schneider , K , Oltmanns , J and Hassauer , M . 2004 . Allometric principles for interspecies extrapolation in toxicological risk assessment – empirical investigations . Regul Toxicol Pharmacol , 39 ( 3 ) : 334 – 347 .
   PubMed Web of Science ®Google Scholar
• Skjevrak , I , Brede , C , Steffensen , I , Mikalsen , A , Alexander , J , Fjeldal , P and Herikstad , H . 2005 . Non-targeted multi-component analytical surveillance of plastic food-contact materials: Identification of substances not included in EU positive lists and their risk assessment . Food Addit Contam , 22 ( 10 ) : 1012 – 1022 .
   PubMed Web of Science ®Google Scholar
• Slob , W and Pieters , MN . 1997 . A probabilistic approach for deriving acceptable human intake limits and human health risks from toxicological studies: General framework , Bilthoven, , the Netherlands : RIVM. . Report Number 620110005
   Google Scholar
• Slob , W and Pieters , MN . 1998 . A probabilistic approach for deriving acceptable human intake limits and human health risks from toxicological studies: General framework . Risk Anal , 18 ( 6 ) : 787 – 798 .
   PubMed Web of Science ®Google Scholar
• Swartout , JC , Price , PS , Dourson , DL , Carlson-Lynch , H and Keenan , RE . 1998 . A probabilistic framework for the reference dose (probabilistic RfD) . Risk Anal , 18 ( 3 ) : 271 – 282 .
   PubMed Web of Science ®Google Scholar
• US Environmental Protection Agency (USEPA). 1988. US EPA Integrated Risk Information System “Phthalic Anhydride”. Available from: http://www.epa.gov/ncea/iris/subst/0308.htm
   Google Scholar
• US Environmental Protection Agency (USEPA). 1993. Reference dose (RfD): Description and use in health risk assessments: Background Document 1A [Internet]. Washington (DC): USEPA, Office of Research and Development, National Center for Environmental Assessment; [cited 2008 Dec 1]. Available from: http://www.epa.gov/IRIS/rfd.htm/
   Google Scholar
• US Environmental Protection AgencyAgency (USEPA). 2000. Supplementary guidance for conducting health risk assessment of chemical mixtures. In: Risk assessment forum. Washington (DC): USEPA, Office of Research and Development. EPA Number 630/R-00-002
   Google Scholar
• US Environmental Protection Agency (USEPA). 2007. Concepts, methods and data sources for cumulative health risk assessment of multiple chemicals, exposures and effects: A resource document. Cincinnati (OH): USEPA, Office of Research and Development, National Center for Environmental Assessment. EPA Number 600/R-06/013F
   Google Scholar
• Van der Voet , H and Slob , W . 2007 . Integration of probabilistic exposure assessment and probabilistic hazard characterization . Risk Anal , 27 ( 2 ) : 351 – 371 .
   PubMed Web of Science ®Google Scholar
• Vermeire , T , Stevenson , H , Pieters , MN , Rennen , M , Slob , W and Hakkert , BC . 1999 . Assessment factors for human health risk assessment: a discussion paper . Crit Rev Toxicol , 29 ( 5 ) : 439 – 490 .
   PubMed Web of Science ®Google Scholar
• Vermeire , T , Pieters , MN , Rennen , M and Bos , P . 2001 . Probabilistic assessment factors for human health risk assessment: A practical guide , Bilthoven, , the Netherlands : RIVM. . TNO Report Number V3489
   Google Scholar