Carry-over of pyrrolizidine alkaloids from feed to milk in dairy cows

References

• Aguiar , R and Wink , M . 2005 . Do naïve ruminants degrade alkaloids in the rumen? . J Chem Ecol , 31 : 761 – 787 .
   PubMedGoogle Scholar
• Boppré , M , Colegate , SM , Edgar , JA and Fischer , OW . 2008 . Hepatotoxic pyrrolizidine alkaloids in pollen and drying-related implications for commercial processing of bee pollen . J Agric Food Chem , 56 : 5662 – 5672 .
   PubMed Web of Science ®Google Scholar
• Bull , LB , Culvenor , CCJ and Dick , AT . 1968 . “ The pyrrolizidine alkaloids ” . In Frontiers of biology , Edited by: Neuberger , A and Tatum , EL . 206 – 215 . Amsterdam, , the Netherlands : North-Holland .
   Google Scholar
• Candrian , U , Zweifel , U , Lüthy , J and Schlatter , C . 1991 . Transfer of orally administered [3H]seneciphylline into cow's milk . J Agric Food Chem , 39 : 930 – 933 .
   Web of Science ®Google Scholar
• Chou , MW , Wang , YP , Yan , J , Yang , YC , Beger , RD , Williams , LD , Doerge , DR and Fu , PP . 2003 . Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine . Toxicol Lett , 145 : 239 – 247 .
   PubMed Web of Science ®Google Scholar
• Chu , PS and Segall , HJ . 1991 . Species difference in the urinary excretion of isatinecic acid from the pyrrolizidine alkaloid retrorsine . Comp Biochem Physiol , 100C : 683 – 686 .
   Google Scholar
• CliniTox Giftpflanzen. 2009. Senecio jacobaea. Available from: http://www.vetpharm.uzh.ch/giftdb/pflanzen/0038_vet.htm; [cited 2010 Feb 10]
   Google Scholar
• Crews , C , Berthiller , F and Krska , R . 2010 . Update on analytical methods for toxic pyrrolizidine alkaloids . Anal Bioanal Chem , 396 : 327 – 338 .
   PubMed Web of Science ®Google Scholar
• Crews , C , Startin , JR and Clarke , PA . 1997 . Determination of pyrrolizidine alkaloids in honey from selected sites by solid phase extraction and HPLC-MS . Food Addit Contam , 14 : 419 – 428 .
   PubMedGoogle Scholar
• Deinzer , ML , Arbogast , BL , Buhler , DR and Cheeke , PR . 1982 . Gas chromatographic determination of pyrrolizidine alkaloids in goat's milk . Anal Chem , 54 : 1811 – 1814 .
   Web of Science ®Google Scholar
• Dickinson , JO , Cooke , MP , King , RR and Mohamed , PA . 1976 . Milk transfer of pyrrolizidine alkaloids in cattle . J Am Vet Med Assoc , 169 : 1192 – 1196 .
   PubMed Web of Science ®Google Scholar
• Edgar , JA , Roeder , E and Molyneux , RJ . 2002 . Honey from plants containing pyrrolizidine alkaloids: A potential threat to health . J Agric Food Chem , 50 : 2719 – 2730 .
   PubMed Web of Science ®Google Scholar
• Estep , JE , Lamé , MW and Segall , HJ . 1990 . Excretion and blood radioactivity levels following [14C]senecionine administration in the rat . Toxicology , 64 : 179 – 189 .
   PubMed Web of Science ®Google Scholar
• European Food Safety Authority (EFSA) . 2007 . Opinion of the Scientific panel on contaminants in the food chain on a request from the European Commission related to pyrrolizidine alkaloids as undesirable substances in animal feed . EFSA J , 447 : 1 – 51 .
   Google Scholar
• Fearn , T and Thompson , M . 2001 . A new test for ‘sufficient homogeneity’ . Analyst , 126 : 1414 – 1417 .
   PubMed Web of Science ®Google Scholar
• Fu , PP , Xia , Q , Lin , G and Chou , MW . 2004 . Pyrrolizidine alkaloids – genotoxicity, metabolism, enzymes, metabolic activation, and mechanisms . Drug Metab Rev , 36 : 1 – 55 .
   PubMed Web of Science ®Google Scholar
• Hartmann , T and Toppel , G . 1986 . Senecionine N-oxide, the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris . Phytochemistry , 26 : 1639 – 1643 .
   Google Scholar
• Hartmann , T and Witte , L . 1995 . “ Chemistry, biology and chemoecology of the pyrrolizidine alkaloids ” . In Chemical and biological perspectives , Edited by: Pelletier , SW . Vol. 9 , 155 – 233 . Oxford, , UK : Pergamon .
   Google Scholar
• He , YQ , Yang , L , Liu , HX , Zhang , JW , Liu , Y , Fong , A , Xiong , AZ , Lu , YL , Yang , L Wang , CH . 2010 . Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids . Chem Res Toxicol , 23 : 591 – 599 .
   PubMed Web of Science ®Google Scholar
• Joosten , L , Mulder , PPJ , Klinkhamer , PGL and van Veen , JA . 2009 . Soil-borne microorganisms and soil-type affect pyrrolizidine alkaloids in Jacobaea vulgaris . Plant Soil , 325 : 133 – 143 .
   Google Scholar
• Joosten , L , Mulder , PPJ , Vrieling , K , van Veen , JA and Klinkhamer , PGL . 2010 . The analysis of pyrrolizidine alkaloids in Jacobaea vulgaris; a comparison of extraction and detection methods . Phytochem Anal , 21 : 197 – 204 .
   PubMed Web of Science ®Google Scholar
• Lanigan , GW . 1970 . Metabolism of pyrrolizidine alkaloids in ovine rumen. 2. Some factors affecting rate of alkaloid breakdown by rumen fluid in-vitro . Aust J Agric Res , 21 : 633 – 639 .
   Google Scholar
• Lindigkeit , R , Biller , A , Buch , M , Schiebel , HM , Boppré , M and Hartmann , T . 1997 . The two faces of pyrrolizidine alkaloids: the role of the tertiary amine and its N-oxide in chemical defense of insect with acquired plant toxins . Eur J Biochem , 245 : 626 – 636 .
   PubMedGoogle Scholar
• Mattocks , AR . 1971 . Hepatotoxic effects due to pyrrolizidine alkaloid N-oxides . Xenobiotica , 1 : 563 – 565 .
   PubMedGoogle Scholar
• Molyneux , RJ and James , LF . 1990 . Pyrrolizidine alkaloids in milk: thresholds of intoxication . Vet Hum Toxicol , 32 : 94 – 103 .
   PubMedGoogle Scholar
• Mulder , PPJ , Beumer , B and Oosterink , E . de Jong J. 2010. Dutch survey on pyrrolizidine alkaloids in animal forage. Report No. 2009.518. Wageningen (the Netherlands): RIKILT. Available from: http://edepot.wur.nl/135952/
   Google Scholar
• Oosterink , E and Mulder , PPJ . 2008 . Standard operation procedure RSV A1070 Grass forage – confirmation of pyrrolizidine alkaloids by LC-MS/MS , Wageningen, , The Netherlands : RIKILT [in Dutch] .
   Google Scholar
• Panariti , E , Xinxo , A and Leksani , D . 1997 . Transfer of 14C-seneciphylline into sheep milk following multiple oral intakes . Deutsche Tierärtzl Wochenschr , 104 : 85 – 124 .
   Google Scholar
• van den Top H, Schothorst R. 2007. Standard operation procedure for the determination of pyrrolizidine alkaloids in milk by LC-MS/MS, ARO/527. Bilthoven (the Netherlands): RIVM-ARO [in Dutch]
   Google Scholar
• van der Zee M. 2005. Advies inzake pyrrolyzidine alkaloïden in kruidenpreparaten , FO . advies dd. 27-04-2005. Bilthoven (the Netherlands): Centrum voor Stoffen en Integrale Risicoschatting, RIVM
   Google Scholar
• Xiong , A , Li , Y , Yang , L , Gao , J , He , Y , Wang , C and Wang , Z . 2009 . Simultaneous determination of sencionine, adonifoline and their metabolites in rat serum by UPLC-ESIMS and its application in pharmacokinetic studies . J Pharm Biomed Anal , 50 : 1070 – 1074 .
   PubMedGoogle Scholar
• Xiong , A , Yang , L , He , Y , Zhang , F , Wang , J , Han , H , Wang , C , Bligh , SWA and Wang , Z . 2009 . Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry . Rapid Commun Mass Spectrom , 23 : 3907 – 3916 .
   PubMedGoogle Scholar