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Original Articles

Evaluation of LC-high-resolution FT-Orbitrap MS for the quantification of selected mycotoxins and the simultaneous screening of fungal metabolites in food

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Pages 1457-1468 | Received 22 Apr 2011, Accepted 20 Jun 2011, Published online: 22 Aug 2011

References

  • Bennet , JW and Klich , M . 2003 . Mycotoxins . Clin Microbial Rev , 16 : 497 – 516 .
  • Berger , U , Oehme , M and Kuhn , F . 1999 . Quantitative determination and structure elucidation of type A- and B-trichothecenes by HPLC/ion trap multiple mass spectrometry . J Agric Food Chem , 47 : 4240 – 4245 .
  • Blokland , MH , Zoontjes , PW , Sterk , SS , Stephany , RW , Zweigenbaum , J and van Ginkel , LA . 2008 . Confirmatory analysis of trenbolone using accurate mass measurement with LC/TOF-MS . Anal Chim Acta , 618 : 86 – 93 .
  • Delaforge , M , Andre , F , Jaouen , M , Dolgos , H , Benech , H , Gomis , JM , Noel , JP , Cavelier , F , Verduci , J Aubagnac , JL . 1997 . Metabolism of tentoxin by hepatic cytochrome P-450 3 A isozymes . Eur J Biochem , 250 : 150 – 157 .
  • European Commission. 2002. 2002/657/EC. Commission decision of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Off J Eur Commun. L221:8–36
  • European Commission. 2006. Commission regulation (EC) No. 1881/2006 setting maximum levels for certain contaminants in foodstuffs. Off J Eur Union. L364:5–24
  • European Commission. 2007. Commission regulation (EC) No. 1126/2007 of 28 September 2007 amending Regulation (EC) No 1881/2006 setting maximum levels for certain contaminants in foodstuffs as regards Fusarium toxins in maize and maize products. Off J Eur Union. L255:14–17
  • European Commission. 2009. Method validation and quality control procedures for pesticide residues analysis in food and feed (Document No. SANCO/10684/2009); [cited 2011 June 9]. Available from: http://ec.europa.eu/food/plant/protection/resources/qualcontrol_en.pdf/
  • Harris , DC . 2006 . Quantitative chemical analysis , 7th , Houndmills, , UK : Palgrave Macmillan .
  • Herebian , D , Zühlke , S , Lamshöft , M and Spiteller , M . 2009 . Multi-mycotoxin analysis in complex biological matrices using LC-ESI/MS: experimental study using triple stage quadrupole and LTQ-Orbitrap . J Sep Sci , 32 : 939 – 948 .
  • Kaufmann , A . 2009 . Validation of multiresidue methods for veterinary drug residues; related problems and possible solutions . Anal Chim Acta , 637 : 144 – 155 .
  • Kaufmann , A , Butcher , P , Maden , K , Walker , S and Widmer , M . 2011 . Development of an improved high-resolution mass spectrometry based multi-residue method for veterinary drugs in various food matrices . Anal Chim Acta. , 700 : 86 – 94 .
  • Keller , BO , Sui , J , Young , AB and Whittal , RM . 2008 . Interferences and contaminants encountered in modern mass spectrometry . Anal Chim Acta , 627 : 71 – 81 .
  • Kellmann , M , Muenster , H , Zomer , P and Mol , H . 2009 . Full-scan MS in comprehensive qualitative and quantitative residue analysis in food and feed matrices: how much resolving power is required? . J Am Soc Mass Spectrom , 20 : 1464 – 1476 .
  • Krauss , M , Singer , H and Hollender , J . 2010 . LC-high-resolution MS in environmental analysis: from target screening to the identification of unknowns . Anal Bioanal Chem , 397 : 943 – 951 .
  • Linsinger , T . 2010. Comparison of a measurement result with the certified value. European Reference Materials’ Application Note 1 (European Commission); [cited 2011 March 25]. Available from: http://www.erm-crm.org/ERM_products/application_notes/Pages/index.aspx/
  • Mol , HGJ , Plaza-Bolaños , P , Zomer , P , de Rijk , TC , Stolker , AAM and Mulder , PJP . 2008 . Toward a generic extraction method for simultaneous determination of pesticides, mycotoxins, plant toxins, and veterinary drugs in feed and food matrixes . Anal Chem , 80 : 9450 – 9459 .
  • Nielen , MWF , van Engelen , MC , Zuiderent , R and Ramaker , R . 2007 . Screening and confirmation criteria for hormone residue analysis using liquid chromatography accurate mass time-of-flight, Fourier transform ion cyclotron resonance and Orbitrap mass spectrometry techniques . Anal Chim Acta , 586 : 122 – 129 .
  • Nielsen , KF and Smedsgaard , J . 2003 . Fungal metabolite screening: database of 474 mycotoxins and fungal metabolites for dereplication by standardized liquid chromatography-UV-mass spectrometry methodology . J Chromatogr A , 1002 : 111 – 136 .
  • Sulyok , M , Berthiller , F , Krska , R and Schuhmacher , R . 2006 . Development and validation of a liquid chromatography/tandem mass spectrometric method for the determination of 39 mycotoxins in wheat and maize . Rapid Commun Mass Spectrom , 20 : 2649 – 2659 .
  • Sulyok , M , Krska , R and Schuhmacher , R . 2007 . A liquid chromatography/tandem mass spectrometric multi-mycotoxin method for the quantification of 87 analytes and its application to semi-quantitative screening of moldy food samples . Anal Bioanal Chem , 389 : 1505 – 1523 .
  • van der Heeft , E , Bolck , YJC , Beumer , B , Nijrolder , AWJM , Stolker , AAM and Nielen , MWF . 2009 . Full-scan accurate mass selectivity of ultra-performance liquid chromatography combined with time-of-flight and Orbitrap mass spectrometry in hormone and veterinary drug residue analysis . J Am Soc Mass Spectrom , 20 : 451 – 463 .
  • van Egmond , HP , Schothorst , RC and Jonker , MA . 2007 . Regulations relating to mycotoxins in food . Anal Bioanal Chem , 389 : 147 – 157 .
  • Vishwanath , V , Sulyok , M , Labuda , R , Bicker , W and Krska , R . 2009 . Simultaneous determination of 186 fungal and bacterial metabolites in indoor matrices by liquid chromatography/tandem mass spectrometry . Anal Bioanal Chem , 395 : 1355 – 1372 .
  • Wegscheider , W , Rohrer , C and Neubäck , R . 1999. Validata (Excel-Makro zur Methodenvalidierung), version 3.02.48
  • Xu , Y , Heilier , JF , Madalinski , G , Genin , E , Ezan , E , Tabet , JC and Junot , C . 2010 . Evaluation of accurate mass and relative isotopic abundance measurements in the LTQ-Orbitrap Mass Spectrometer for further metabolomics database building . Anal Chem , 82 : 5490 – 5501 .
  • Zachariasova , M , Lacina , O , Malachova , A , Kostelanska , M , Poustka , J , Godula , M and Hajslova , J . 2010a . Novel approaches in analysis of Fusarium mycotoxins in cereals employing ultra performance liquid chromatography coupled with high-resolution mass spectrometry . Anal Chim Acta , 662 : 51 – 61 .
  • Zachariasova , M , Cajka , T , Godula , M , Malachova , A , Veprikova , Z and Hajslova , J . 2010b . Analysis of multiple mycotoxins in beer employing (ultra)-high-resolution mass spectrometry . Rapid Commun Mass Spectrom , 24 : 3357 – 3367 .
  • Zhang , NR , Yu , S , Tiller , P , Yeh , S , Mahan , E and Emary , WB . 2009 . Quantitation of small molecules using high-resolution accurate mass spectrometers-a different approach for analysis of biological samples . Rapid Commun Mass Spectrom , 23 : 1085 – 1094 .

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