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Original Articles

Endogenous steroid profiling by gas chromatography-tandem mass spectrometry and multivariate statistics for the detection of natural hormone abuse in cattle

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Pages 1030-1045 | Received 07 Dec 2011, Accepted 11 Mar 2012, Published online: 24 Apr 2012

References

  • Angeletti , R , Contiero , L , Gallina , G and Montesissa , C . 2006 . The urinary ratio of testosterone to epitetosterone: a good marker of illegal treatment also in cattle? . Vet Res Comm , 30 : 127 – 131 .
  • Anizan , S , Bichon , E , Di Nardo , D , Monteau , F , Cesbron , N , Antignac , JP and Le Bizec , B . 2011 . Screening of 4-androstenedione misuse in cattle by LC-MS/MS profiling of glucuronide and sulfate steroids in urine . Talanta , 86 : 186 – 194 .
  • Anizan , S , Di Nardo , D , Bichon , E , Monteau , F , Cesbron , N , Antignac , J and Le Bizec , B . 2011 . Targeted phase II metabolites profiling as new screening strategy to investigate natural steroid abuse in animal breeding . Anal Chim Acta , 700 ( 1–2 ) : 105 – 113 .
  • Aqai , P , Stolker , A and Lasaroms , J . 2009 . Effect of sample pre-treatment on the determination of steroid esters in hair of bovine calves . J Chromatogr A , 1216 ( 46 ) : 8233 – 8239 .
  • Blokland , M , van Rossum , H , Sterk , S , van Ginkel , L and Stephany , R . 2007 . Development of a method which discriminates between endogenous and exogenous [beta]-boldenone . Anal Chim Acta , 586 ( 1–2 ) : 147 – 153 .
  • Buisson , C , Hebestreit , M , Weigert , AP , Heinrich , K , Fry , H , Flenker , U , Banneke , S , Prevost , S , Andre , F Schaenzer , W . 2005 . Application of stable carbon isotope analysis to the detection of 17beta-estradiol administration to cattle . J Chromatogr A , 1093 ( 1–2 ) : 69 – 80 .
  • Costain , R , Fesser , A , McKenzie , D , Mizuno , M and MacNeil , J . 2008 . Identification of hormone esters in injection site in muscle tissues by LC/MS/MS . Food Addit Contam A , 25 ( 12 ) : 1520 – 1529 .
  • Donike , M , Bärwald , K-R , Klostermann , K , Schänzer , W and Zimmermann , J . 1983 . “ Nachweis von exogenem Testosteron ” . In Sport, Leistung und Gesundheit , Edited by: Heck , H , Hollmann , W , Liesen , H and Rost , R . 293 – 298 . Köln : Deutscher Ärzte .
  • European Commission . 1996 . Directive 96/22/EC of 29 April 1996 concerning the prohibition on the use in stock farming of certain substances having a hormonal or thyrostatic action and of -agonists, and repealing Directives 81/602 . Off J Eur Comm , 88 ( 146 ) : 3 – 9 .
  • European Commission . 2002 . 2002/657/EC . Council Decision 2002/657/EC. Off J Eur Comm , 221 : 8
  • Fritsche , S and Steinhart , H . 1998 . Differences in natural steroid hormone patterns of beef from bulls and steers . J Anim Sci , 76 ( 6 ) : 1621 – 1625 .
  • Hebestreit , M , Flenker , U , Buisson , C , Andre , F , Le Bizec , B , Fry , H , Lang , M , Weigert , AP , Heinrich , K Hird , S . 2006 . Application of stable carbon isotope analysis to the detection of testosterone administration to cattle . J Agric Food Chem , 54 ( 8 ) : 2850 – 2858 .
  • Hemmerbach , P , Esbensen , K , Norli , HR , Birkeland , KI and Westad , F . 1994 . Chemometric evaluation of urinary steroid profiles in doping control , In : Donike M, Geyer H, Gotzmann A, Mareck-Engelke U, Rauth S, editors. . Recent Advances in Doping Analysis (1). Proceedings of the 11th Cologne Workshop on Dope Analysis; 1993 Mar 7–12; Cologne (Germany): Sport & Buch Strauß
  • International Organization for Standardization (ISO). 1994. ISO 5725-2 (1994): Accuracy (trueness and precision) of measurement methods and results – Part 2: Basic method for the determination of repeatability and reproducibility of a standard measurement method. Geneva (Switzerland): ISO
  • Le Bizec BL, Antignac JP, Preiss-Weigert A, Prevost S, Andre F. 2006. A multidimensional statistic approach applied to a large data set of natural steroid concentrations in bovine muscle arid bidney samples, to determine suspicion criteria of natural hormone misuse in cattle. Paper presented at: 5th International Symposium on Hormone and Veterinary Drug Residue Analysis; Antwerp, Belgium
  • Mareck , U , Geyer , H , Opfermann , G , Thevis , M and Schanzer , W . 2008 . Factors influencing the steroid profile in doping control analysis . J Mass Spectrom , 43 ( 7 ) : 877 – 891 .
  • Miller , J and Miller , J . 2005 . Statistics and chemometrics for analytical chemistry , Harlow : Prentice-Hall .
  • Mooney , MH , Situ , C , Cacciatore , G , Hutchinson , T , Elliott , C and Bergwerff , AA . 2008 . Plasma biomarker profiling in the detection of growth promoter use in calves . Biomarkers , 13 ( 3 ) : 246 – 256 .
  • Nielen , MWF , Lasaroms , JJP , Essers , ML , Sanders , MB , Heskamp , HH , Bovee , TF , van Rhijn , JH and Groot , MJ . 2007 . The ultimate veal calf reference experiment: hormone residue analysis data obtained by gas and liquid chromatography tandem mass spectrometry . Anal Chim Acta , 586 ( 1–2 ) : 30 – 34 .
  • Nielen , MWF , Lasaroms , JJP , Mulder , PPJ , van Hende , JM , van Rhijn , JHA and Groot , MJ . 2006 . Multi residue screening of intact testosterone esters and boldenone undecylenate in bovine hair using liquid chromatography electrospray tandem mass spectrometry . J Chromatogr B Anal Technol Biomed Life Sci , 830 ( 1 ) : 126 – 134 .
  • Nielen , MWF , Vissers , JPC , Fuchs , REM , Velde , JW and Lommen , A . 2001 . Screening for anabolic steroids and related compounds in illegal cocktails by liquid chromatography/time of flight mass spectrometry and liquid chromatography/quadrupole time of flight tandem mass spectrometry with accurate mass measurement . Rapid Comm Mass Spectrom , 15 ( 17 ) : 1577 – 1585 .
  • Pinel , G , Rambaud , L , Monteau , F , Elliot , C and Le Bizec , B . 2010 . Estranediols profiling in calves’ urine after 17 [beta]-nandrolone laureate ester administration . J Steroid Biochem Mol Biol , 121 ( 3–5 ) : 626 – 632 .
  • Regal , P , Vázquez , B , Franco , C , Cepeda , A and Fente , C . 2009 . Quantitative LC-MS/MS method for the sensitive and simultaneous determination of natural hormones in bovine serum . J Chromatogr B Anal Technol Biomed Life Sci , 877 ( 24 ) : 2457 – 2464 .
  • Rijk , JC , Lommen , A , Essers , ML , Groot , MJ , van Hende , JM , Doeswijk , TG and Nielen , MWF . 2009 . Metabolomics approach to anabolic steroid urine profiling of bovines treated with prohormones . Anal Chem , 81 ( 16 ) : 6879 – 6888 .
  • Scarth , J , Akre , C , van Ginkel , L , Le Bizec , B , De Brabander , H , Korth , W , Points , J , Teale , P and Kay , J . 2009 . Presence and metabolism of endogenous androgenic–anabolic steroid hormones in meat-producing animals: a review . Food Addit Contam Part A Chem Anal Control Expo Risk Assess , 26 ( 5 ) : 640 – 671 .
  • Scarth , J , Clarke , A , Hands , J , Teale , P , Macarthur , R and Kay , J . 2010 . Validation of a quantitative multi-residue urinary assay for the detection of androgen, oestrogen and progestagen abuse in the bovine . Chromatographia , 71 ( 3 ) : 241 – 252 .
  • Scarth , J , Clarke , A , Teale , P , Mill , A , Macarthur , R and Kay , J . 2011 . Detection of endogenous steroid abuse in cattle: results from population studies in the UK . Food Addit Contam A Chem Anal Control Expo Risk Assess , 28 ( 1 ) : 44 – 61 .
  • Scarth , JP , Clarke , A , Hands , J , Teale , P , Mill , AC , Macarthur , R and Kay , J . De Brabander H. 2010. Validation of an analytical biomarker approach for the detection of nandrolone abuse in the porcine. Chromatographia. 72:1–9
  • Sterk , S , van Tricht , F , van Soeren-Kieft , A , Herbold , H , Stephany , R and van Ginkel , L . 1998 . Bank of reference samples of blank urine from livestock . Fresenius’ J Anal Chem , 360 ( 3 ) : 454 – 455 .
  • Stolker , AAM , Groot , M , Lasaroms , JJP , Nijrolder , AWJM , Blokland , M , Riedmaier , I , Becker , C , Meyer , HHD and Nielen , MWF . 2009 . Detectability of testosterone esters and estradiol benzoate in bovine hair and plasma following pour-on treatment . Anal Bioanalyt Chem , 395 ( 4 ) : 1075 – 1087 .
  • Tricht , EF , Blokland , MH and Sterk , SS . van Ginkel LA. 2008. Quantitative analysis of natural hormones in serum and urine samples from cattle. Proceedings of the Euroresidues VI Conference. Federation of European Chemical Societies, Egmond aan Zee, The Netherlands
  • Van Renterghem , P , van Eenoo , P , Geyer , H , Schanzer , W and Delbeke , FT . 2010 . Reference ranges for urinary concentrations and ratios of endogenous steroids, which can be used as markers for steroid misuse, in a Caucasian population of athletes . Steroids , 75 ( 2 ) : 154 – 163 .
  • Van Renterghem , P , van Eenoo , P , Sottas , P , Saugy , M and Delbeke , F . 2010 . Subject-based steroid profiling and the determination of novel biomarkers for DHT and DHEA misuse in sports . Drug Test Anal , 2 ( 11–12 ) : 582 – 588 .
  • Weeth , H , Witton , R and Speth , C . 1969 . Prediction of bovine urine specific gravity and total solids by refractometry . J Anim Sci , 28 ( 1 ) : 66 – 69 .

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