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Original Articles

High-performance liquid chromatographic analysis of biogenic amines in pharmaceutical products containing Citrus aurantium

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Pages 634-642 | Received 16 Dec 2012, Accepted 27 Jan 2013, Published online: 10 Apr 2013

References

  • Andrade AS, Schmitt GC, Rossato LG, Russowsky D, Limberger RP. 2009. Gas chromatographic method for analysis of p-synephrine in Citrus aurantium L products. Chromatographia. 69:225–229.
  • Arbo MD, Larentis ER, Linck VM, Aboy AL, Pimentel AL, Henriques AT, Dallegrave E, Garcia SC, Leal MB, Limberger RP. 2008. Concentrations of p-synephrine in fruits and leaves of Citrus species (Rutaceae) and the acute toxicity testing of Citrus aurantium extract and p-synephrine. Food Chem Toxicol. 46:2770–2775.
  • Arbo MD, Schmitt GC, Limberger MF, Charão MF, Moro AM, Ribeiro GL, Dallegrave E, Garcia SC, Leal MB, Limberger RP. 2009. Subchronic toxicity of Citrus aurantium L. (Rutaceae) extract and p-synephrine in mice. Regul Toxicol Pharmac. 54:114–117.
  • Avula B, Khan IA. 2004. Separation and determination of ephedrine enantiomers and synephrine by high performancecapillary electrophoresis in dietary supplements. Chromatographia. 59:71–77.
  • Avula B, Upparapalli SK, Khan IA. 2005. Enantiomeric Separation of Adrenergic Amines in Citrus Species, Related Genera and Dietary Supplements by Capillary Electrophoresis. Chromatographia. 62:151–157.
  • Avula B, Upparapalli SK, Navarrete A, Khan IA. 2005. Simultaneous quantification of adrenergic amines and flavonoids in C. aurantium, various Citrus species, and dietary supplements by liquid chromatography. J AOAC Int. 88:1593–1606.
  • Carvalho LM, Martini M, Moreira APL, Lima APS, Correia D, Falcão T, Garcia SC, Bairros AV, Nascimento PC, Bohrer D. 2011. Presence of synthetic pharmaceuticals as adulterants in slimming phytotherapeutic formulations and their analytical determination. Forensic Sci Int. 204:6–12.
  • Fugh-Berman A, Myers A. 2004. Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research. Experim Biol Med. 229:698–704.
  • Ganzera M, Lanser C, Stuppner H. 2005. Simultaneous determination of Ephedra sinica and Citrus aurantium var. amara alkaloids by ion-pair chromatography. Talanta. 66:889–894.
  • Gatti R, Lotti C, Morigi R, Andreani A. 2012. Determination of octopamine and tyramine traces in dietary supplements and phytoextracts by high performance liquid chromatography after derivatization with 2,5-dimethyl-1H-pyrrole-3,4-dicarbaldehyde. J Chrom A. 1220:92–100.
  • Gay ML, Niemann RA, Musser SM. 2006. An isotopically labeled internal standard liquid chromatography-Tandem mass spectrometry method for determination of ephedrine alkaloids and synephrine in dietary supplements. J Agric Food Chem. 54:285–291.
  • Haller CA, Jacob P, Benowitz NL. 2004. Enhanced stimulant and metabolic effects of combined ephedrine and caffeine. Cl Pharmacol Therap. 75:259–273.
  • Hashimoto K, Yasuda T, Ohsawa K. 1992. Determination of synephrine from Chinese medicinal drugs originating from citrus. J. Chromatogr. 623:386–389.
  • He X, Lian L, Lin L, Bernart MW. 1997. High-performance liquid chromatography–electrospray mass spectrometry in phytochemical analysis of sour orange (Citrus aurantium L). J Chromatogr A. 791:127–134.
  • Health Canada – Natural Health Products Directorate. 2011. Synephrine, octopamine and caffeine health risk assessment report [Internet]. [cited 2013 Jan 22]. Available from: http://www.nutratechinc.com/advz/Studies2011/Safety/S1%20Health%20Canada%200511.pdf
  • Helrich K. 1990. Official Methods of Analytical Chemists of Association of Official Analytical Chemistssource. 15th ed. Washington (DC): AOAC.
  • International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Steering Committee. 1996. Validation of analytical procedures: methodology [Internet]. Geneva, Switzerland: ICH. [cited 2013 Mar 13]. Available from: http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q2_R1/Step4/Q2_R1__Guideline.pdf
  • Italia. 2002. Circolare n.3, 18 luglio. Applicazione della procedura di notifica di etichetta di cui all’art. 7 del Decreto legislativo n.111/1992, ai prodotti a base di piante e derivati aventi finalità salutistiche. Gazzetta Ufficiale n. 188, 12 agosto 2002. [Internet]; Available from: http://www.frascati.enea.it/spp/legislazione/Igiene_alimenti/MS_C_3_02.pdf
  • Kusu F, Li XD, Takamura K. 1992. Determination of synephrine and N-methyltyramine in Zhishi and Zhike (immature citrus fruits) by high-performance liquid chromatography with electrochemical detection. Chem Pharm Bull. 40:3284–3286.
  • Kusu F, Matsumoto K, Arai K, Takamura K. 1996. Determination ofsynephrine enantiomers in food and conjugated synephrine in urine by high-performance liquid chromatography with electrochemical detection. Anal Biochem. 235:191–194.
  • Kusu F, Matsumoto K, Takamura K. 1995. Direct speciation and determination of synephrine enantiomers by high-performance liquid chromatography with electrochemical detection. Chem Pharm Bull. 43:1158–1161.
  • Marchei E, Pichini S, Pacifici R, Pellegrini M, Zuccaro P. 2006. A rapid and simple procedure for determination of synephrine in dietary supplements by gas chromatography-mass spectrometry. J Pharm Biomed Anal. 41:1468–1472.
  • Mattioli L, Cangi F, Maidecchi A, Ghiara C, Tubaro M, Traldi P. 2005. A rapid liquid chromatography electrospray ionization mass spectrometryn method for evaluation of synephrine incitrus aurantium L. samples. J Agric Food Chem. 53:9860–9866.
  • Niemann RA, Gay ML. 2003. Determination of ephedrine alkaloids and synephrine in dietary supplements by column-switching cation exchange high-performance liquid chromatography with scanning-wavelength ultraviolet and fluorescence detection. J Agric Food Chem. 51:5630–5638.
  • Pellati F, Benvenutti S. 2007. Chromatographic and electrophoretic methods for the analysis of phenetylamine alkaloids in Citrus aurantium. J Chrom A. 1161:71–88.
  • Pellati F, Benvenuti S, Melegari M, Firenzuoli F. 2002. Determination of adrenergic agonists from extracts and herbal products of Citrus aurantium L. var. amara by LC. J. Pharm Biomed Anal. 29:1113–1119.
  • Peng Y, Liu F, Ye J. 2006. Quantitative and qualitative analysis of flavonoid markers in Frucus aurantii of different geographical origin by capillary electrophoresis with electrochemical detection. J Chromatogr B. 830:224–230.
  • Roman MC, Betz JM, Hildreth J. 2007. Determination of synephrine in bitter orange raw materials, extracts, and dietary supplements by liquid chromatography with ultraviolet detection: single-laboratory validation. J AOAC Int. 90:68–81.
  • Rossato LG, Costa VM, Limberger RP, Bastos ML, Remião F. 2011. Synephrine: from trace concentrations to massive consumption in weight-loss. Food Chem Toxicol. 49:8–16.
  • Santana J, Sharpless KE, Nelson BC. 2008. Liquid chromatographic methods for the determination of para-synephrine and meta-synephrine positional isomers in bitterorange-containing dietary supplements. Food Chem. 109:675–682.
  • Schaneberg BT, Khan IA. 2004. Quantitative and qualitative HPLC analysis of thermogenic weight loss products. Pharmazie. 59:819–823.
  • Schmitt GC, Arbo MD, Lorensi AL, Maciel ES, Krahn CL, Mariotti KC, Dallegrave E, Leal MB, Limberger RP. 2012. Toxicological effects of a mixture used in weight loss products: p-synephrine associated with ephedrine, salicin, and caffeine. Int J Toxic. 31:184–191.
  • Slezak T, Francis PS, Anastos N, Barnett NW. 2007. Determination of synephrine in weight-loss products using high performance liquid chromatography with acidic potassium permanganate chemiluminescence detection. Anal Chim Acta. 593:98–102.
  • Stavric B. 1988. Methylxanthines: toxicity to humans caffeine. Food Chem Toxicol. 26:645–662.
  • Tang F, Tao L, Luo X, Ding L, Guo M, Nie L, Yao S. 2006. Determination of octopamine, synephrine and tyramine in Citrus herbs by ionic liquid improved “green” chromatography. J. Chromatogr. A. 1125:182–188.
  • Uckoo RM, Jayaprakasha GK, Nelson SD, Patil BS. 2011. Rapid simultaneous determination of amines and organic acids in citrus using high-performance liquid chromatography. Talanta. 83:948–954.
  • The United States Pharmacopoeia Convention. 2011. 35th ed. Rockville: United States Pharmacopeial Convention; p. 2622–2625.

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