Effect of quercetin on the toxicokinetics of ochratoxin A in rats

References

• Adler M, Müller K, Rached E, Dekant W, Mally A. 2009. Modulation of key regulators of mitosis linked to chromosomal instability is an early event in Ochratoxin A carcinogenicity. Carcinogenesis. 30:711–719.
   PubMed Web of Science ®Google Scholar
• Aherne SA, O’Brien NM. 2002. Dietary flavonols: chemistry, food content, and metabolism. Nutrition. 18:75–81.
   PubMed Web of Science ®Google Scholar
• Berger V, Gabriel AF, Sergent T, Trouet A, Larondelle Y, Schneider YJ. 2002. Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2). Toxicol Lett. 140–141:465–476.
   Web of Science ®Google Scholar
• Blank R, Rolfs JP, Südekum KH, Frohlich AA, Marquardt RR, Wolffram S. 2003. Effects of chronic ingestion of ochratoxin A on blood levels and excretion of the mycotoxin in sheep. J Agric Food Chem. 51:6899–6905.
   PubMed Web of Science ®Google Scholar
• Bock KW, Eckle T, Ouzzine M, Fournel-Gigleux S. 2000. Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 Cells. Biochem Pharmacol. 59:467–470.
   PubMed Web of Science ®Google Scholar
• Castegnaro M, Mohr U, Pfohl-Leszkowicz A, Estève J, Steinmann J, Tillmann T, Michelon J, Bartsch H. 1998. Sex- and strain-specific induction of renal tumors by Ochratoxin A in rats correlates with DNA adduction. Int J Cancer. 77:70–75.
   PubMed Web of Science ®Google Scholar
• Cooray HC, Jansvilisri T, van Veen HW, Hladky SB, Barrand MA. 2004. Interaction of the breast cancer resistance protein with plant polyphenols. Biochem Biophys Res Commun. 317:269–275.
   PubMed Web of Science ®Google Scholar
• Creppy EE, Kern D, Steyn PS, Vlegaar R, Röschenthaler R, Dirheimer G. 1983. Comparative study of the effect of ochratoxin A analogues on yeast aminoacyl-tRNA synthesis and on the growth and protein synthesis of hepatoma cells. Toxicol Lett. 19:217–224.
   PubMed Web of Science ®Google Scholar
• Di Giacomo C, Acquaviva R, Piva A, Sorrenti V, Vanella L, Piva G, Casadei G, La Fauci L, Ritieni A, Bognanno M, et al. 2007. Protective effect of cyanidin 3-O-β-d-glucoside on ochratoxin A-mediated damage in the rat. Brit J Nutr. 98:937–943.
   PubMed Web of Science ®Google Scholar
• Doster RC, Sinnhuber RO. 1972. Comparative rates of hydrolysis of Ochratoxins A and B in vitro. Food Cosmet Toxicol. 10:389–394.
   PubMedGoogle Scholar
• Ebert B, Seidel A, Lampen A. 2007. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci. 96:227–236.
   PubMed Web of Science ®Google Scholar
• Ferrufino-Guardia EV, Tangni EK, Larondelle Y, Ponchaut S. 2000. Transfer of ochratoxin A during lactation: exposure of sucling via milk of rabbit does fed a naturally contamined feed. Food Addit Contam. 17:167–175.
   PubMed Web of Science ®Google Scholar
• Galtier P. 1978. Contribution of pharmacokinetic studies to mycotoxicology – Ochratoxin A. Vet Sci Commun. 1:349–358.
   Web of Science ®Google Scholar
• Gekle M, Oberleithner H, Silbernagl S. 1993. Ochratoxin A impairs “postproximal” nephron function in vivo and blocks plasma membrane anion conductance in Madin-Darby canine kidney cells in vitro. Pflügers Arch. 425:401–408.
   PubMed Web of Science ®Google Scholar
• Harwing J, Kuiper-Goodman T, Scott PM. 1983. Microbial food toxicant: ochratoxins. In: Rechcigl M, editor. Handbook of foodborne diseases of biological origin. Boca Raton, FL: CRC Press; p. 192–238.
   Google Scholar
• Kumagai S, Aibara K. 1982. Intestinal absorption and secretion of ochratoxin A in the rat. Toxicol Appl Pharmacol. 64: 94–102.
   PubMed Web of Science ®Google Scholar
• Leier I, Hummel-Eisenbeiss J, Cui Y, Keppler D. 2000. ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 57:1636–1642.
   PubMed Web of Science ®Google Scholar
• Madhyastha MS, Marquardt RR, Frohlich AA. 1992. Hydrolysis of ochratoxin A by the micorbial activity of digesta in the gastrointestinal tracts of rats. Arch Environ Contam Toxicol. 23:468–472.
   PubMed Web of Science ®Google Scholar
• Mally A, Völkel W, Amberg A, Kurz M, Wanek P, Eder E, Hard G, Dekant W. 2005. Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats. Chem Res Toxicol. 18:1242–1252.
   PubMed Web of Science ®Google Scholar
• Mantle PG. 2008. Interpretation of the pharmacokinetics of ochratoxin A in blood plasma of rats, during and after acute or chronic ingestion. Food Chem Toxicol. 46:1808–1816.
   PubMed Web of Science ®Google Scholar
• Meki AMA, Hussein AAA. 2001. Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney. Comp Biochem Physiol C. 130:305–313.
   PubMed Web of Science ®Google Scholar
• Middleton Jr E, Kandaswami C, Theoharides T. 2000. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 52:673–751.
   PubMed Web of Science ®Google Scholar
• National Toxicology Program. 1989. Technical report on the toxicology and carcinogenesis studies of ochratoxin A (CAS No. 303-47-9) in F344 rats (Gavage Studies), NIH Publication No. 89–2813. Research Triangle Park, NC: US Department of Health and Human Services, National Institutes of Health.
   Google Scholar
• O’Leary KA, Day AJ, Needs PW, Mellon FA, O’Brien NM, Williamson G. 2003. Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism. Biochem Pharmacol. 65:479–491.
   PubMed Web of Science ®Google Scholar
• Omar RF, Hasinoff BB, Mejilla F, Rahimtula AD. 1990. Mechanism of ochratixin A stimulated lipid peroxidation. Biochem Pharmacol. 40:1183–1191.
   PubMed Web of Science ®Google Scholar
• Peraica M, Domijan A-M, Miletić-Medved M, Fuchs R. 2008. The involvement of mycotoxins in the development of endemic nephropathy. Wien Klin Wochenschr. 120:402–407.
   PubMed Web of Science ®Google Scholar
• Schrickx J, Lektarau Y, Fink-Gremmels J. 2006. Ochratoxin A secretion by ATP dependent membrane transporters in Caco-2 cells. Arch Toxicol. 80:243–249.
   PubMed Web of Science ®Google Scholar
• Sergent T, Garsou S, Schaut A, De Saeger S, Pussemier L, Van Peteghem C, Larondelle Y, Schneider YJ. 2005. Differential modulation of ochratoxin A absorption across Caco-2 cells by dietary polyphenols, used at realistic intestinal concentrations. Toxicol Lett. 159:60–70.
   PubMed Web of Science ®Google Scholar
• Soyoz M, Özçelik N, Kilinç I, Altuntaş I. 2004. The effects of ochratoxin A on lipid peroxidation and antioxidant enzymes: a protective role of melatonin. Cell Biol Toxicol. 20:213–219.
   PubMed Web of Science ®Google Scholar
• Stoev SD, Paskalev M, MacDonald S, Mantle PG. 2002. Experimental one year ochratoxin A toxicosis in pigs. Exp Toxicol Pathol. 53:481–487.
   PubMed Web of Science ®Google Scholar
• van der Merwe KJ, Steyn PS, Fourie L. 1965. Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh. Nature. 205:7083–7088.
   Web of Science ®Google Scholar
• Walgren RA, Karnaky Jr KJ, Lindenmayer GE, Walle T. 2000. Efflux of dietary flavonoid quercetin 4’-β-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2. J Pharmacol Exp Ther. 294:830–836.
   PubMed Web of Science ®Google Scholar
• Xiao H, Marquardt RR, Frohlich AA, Yang ZL. 1995. Synthesis and structural elucidation of analogs of ochratoxin A. J Agric Food Chem. 43:524–530.
   Web of Science ®Google Scholar
• Zepnik H, Völkel W, Dekant W. 2003. Toxicokinetics of the mycotoxin ochratoxin A in F344 rats after oral administration. Toxicol Appl Pharmacol. 192:36–44.
   PubMed Web of Science ®Google Scholar
• Zhang S, Yang X, Morris ME. 2004. Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol. 65:1208–1216.
   PubMed Web of Science ®Google Scholar