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Original Articles

Novel in vitro systems for prediction of veterinary drug residues in ovine milk and dairy products

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Pages 1026-1037 | Received 03 Dec 2013, Accepted 21 Mar 2014, Published online: 09 May 2014

References

  • Allen JD, Brinkhuis RF, van Deemter L, Wijnholds J, Schinkel AH. 2000. Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance. Cancer Res. 60:5761–5766.
  • Allen JD, van Loevezijn A, Lakhai JM, van der Valk M, van Tellingen O, Reid G, Schellens JH, Koomen GJ, Schinkel AH. 2002. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Mol Cancer Ther. 1:417–425.
  • Antignac JP, Cariou R, Le Bizec B, André F. 2004. New data regarding phytoestrogens content in bovine milk. Food Chem. 87:275–281.
  • Bardsley WG. 2001. SIMFIT. Simulation, fitting, statistics and plotting. Version 5.4. Reference Manual. Manchester: University of Manchester.
  • Barrera B, González-Lobato L, Otero JA, Real R, Prieto JG, Álvarez AI, Merino G. 2013. Effects of triclabendazole on secretion of danofloxacin and moxidectin into the milk of sheep: role of triclabendazole metabolites as inhibitors of the ruminant ABCG2 transporter. Vet J. 198:429–436.
  • De Liguoro M, Longo F, Brambilla G, Cinquina A, Bocca A, Lucisano A. 1996. Distribution of the anthelmintic drug albendazole and its major metabolites in ovine milk and milk products after a single oral dose. J Dairy Res. 63:533–542.
  • Desuzinges-Mandon E, Arnaud O, Martinez L, Huche F, Di Pietro A, Falson P. 2010. Abcg2 transports and transfers heme to albumin through its large extracellular loop. J Biol Chem. 285:33123–33133.
  • Dorne JL, Fink-Gremmels J. 2013. Human and animal health risk assessments of chemicals in the food chain: comparative aspects and future perspectives. Toxicol Appl Pharmacol. 270:187–195.
  • Escudero E, Cárceles CM, Fernandez-Varon E, Marin P, Benchaoui H. 2007. Pharmacokinetics of danofloxacin 18% in lactating sheep and goats. J Vet Pharmacol Ther. 30:572–577.
  • European Commission. 2009. Commission Decision 2010/37/EC, December 22, 2009. Pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Off J Eur Comm. L 15.
  • Fink-Gremmels J. 2008. Mycotoxins in cattle feeds and carry-over to dairy milk: a review. Food Addit Contam: Part A. 25:172–180.
  • Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, et al. 2010. Membrane transporters in drug development. Nat Rev Drug Discov. 9:215–236.
  • Hegedűs C, Szakács G, Homolya L, Orbán TI, Telbisz Á, Jani M, Sarkadi B. 2009. Ins and outs of the ABCG2 multidrug transporter: an update on in vitro functional assays. Adv Drug Deliv Rev. 61:47–56.
  • Herrera-Herrera AV, Hernández-Borges J, Rodríguez-Delgado MA. 2009. Fluoroquinolone antibiotic determination in bovine, ovine and caprine milk using solid-phase extraction and high-performance liquid chromatography-fluorescence detection with ionic liquids as mobile phase additives. J Chromatogr A. 1216:7281–7287.
  • Imperiale F, Farias C, Pis A, Sallovitz JM, Lifschitz A, Lanusse C. 2009. Thermal stability of antiparasitic macrocyclic lactones milk residues during industrial processing. Food Addit Contam: Part A. 26:57–62.
  • Imperiale F, Ortiz P, Cabrera M, Farias C, Sallovitz JM, Iezzi S, Pérez J, Alvarez L, Lanusse C. 2011. Residual concentrations of the flukicidal compound triclabendazole in dairy cows’ milk and cheese. Food Addit Contam: Part A. 28:438–445.
  • Imperiale F, Sallovitz J, Lifschitz A, Lanusse C. 2002. Determination of ivermectin and moxidecin residues in bovine milk and examination of the effects of these residues on acid fermentation of milk. Food Addit Contam. 19:810–818.
  • Jani M, Makai I, Kis E, Szabó P, Nagy T, Krajcsi P, Lespine A. 2011. Ivermectin interacts with human abcg2. J Pharm Sci. 100:94–97.
  • Jonker JW, Merino G, Musters S, van Herwaarden AE, Bolscher E, Wagenaar E, Mesman E, Dale TC, Schinkel AH. 2005. The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nat Med. 11:127–129.
  • Jonker JW, Smit JW, Brinkhuis RF, Maliepaard M, Beijnen JH, Schellens JH, Schinkel AH. 2000. Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan. J Natl Cancer Inst. 92:1651–1656.
  • Kinsella TM, Nolan GP. 1996. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum Gene Ther. 7:1405–1413.
  • Lespine A, Martin S, Dupuy J, Roulet A, Pineau T, Orlowski S, Alvinerie M. 2007. Interaction of macrocyclic lactones with p-glycoprotein: structure-affinity relationship. Eur J Pharm Sci. 30:84–94.
  • Li Y, Paxton JW. 2013. The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs. Expert Opin Drug Metab Toxicol. 9:267–285.
  • Marazuela MD, Moreno-Bondi MC. 2004. Multiresidue determination of fluoroquinolones in milk by column liquid chromatography with fluorescence and ultraviolet absorbance detection. J Chromatogr A. 1034:25–32.
  • Marín P, Fernández-Varón E, Escudero E, Cárceles CM. 2007. Pharmacokinetics after intravenous, intramuscular and subcutaneous administration of difloxacin in sheep. Res Vet Sci. 83:234–238.
  • McManaman JL, Neville MC. 2003. Mammary physiology and milk secretion. Adv Drug Deliv Rev. 55:629–641.
  • Mealey KL. 2012. ABCG2 transporter: therapeutic and physiologic implications in veterinary species. J Vet Pharmacol Ther. 35:105–112.
  • Merino G, Alvarez AI, Pulido MM, Molina AJ, Schinkel AH, Prieto JG. 2006. Breast Cancer Resistance Protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability pharmacokinetics and milk secretion. Drug Metab Dispos. 34:690–695.
  • Merino G, Jonker JW, Wagenaar E, van Herwaarden AE, Schinkel AH. 2005. The Breast Cancer Resistance Protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion and milk secretion of the antibiotic nitrofurantoin. Mol Pharmacol. 67:1758–1764.
  • Michiels F, van der Kammen RA, Janssen L, Nolan G, Collard JG. 2000. Expression of Rho GTPases using retroviral vectors. Methods Enzymol. 325:295–302.
  • Muenster U, Grieshop B, Ickenroth K, Gnoth MJ. 2008. Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions. Pharm Res. 25:2320–2326.
  • Nagel OG, Beltrán MC, Molina MP, Althaus RL. 2012. Novel microbiological system for antibiotic detection in ovine milk. Small Ruminant Res. 102:26–31.
  • Oliver SP, Murinda SE, Jayarao BM. 2011. Impact of antibiotic use in adult dairy cows on antimicrobial resistance of veterinary and human pathogens: a comprehensive review. Foodborne Pathogens Dis. 8:337–355.
  • Otero JA, Real R, de la Fuente A, Prieto JG, Marques M, Alvarez AI, Merino G. 2013. The bovine ATP-binding cassette transporter ABCG2 Tyr581Ser single-nucleotide polymorphism increases milk secretion of the fluoroquinolone Danofloxacin. Drug Metab Dispos. 41:546–549.
  • Pavek P, Merino G, Wagenaar E, Bolscher E, Novotna M, Jonker JW, Schinkel AH. 2005. Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine. J Pharmacol Exp Ther. 312:144–152.
  • Perez M, Otero JA, Barrera B, Prieto JG, Merino G, Alvarez AI. 2013. Inhibition of ABCG2/BCRP transporter by soy isoflavones genistein and daidzein: effect on plasma and milk levels of danofloxacin in sheep. Vet J. 196:203–208.
  • Pérez M, Real R, Mendoza G, Merino G, Prieto JG, Alvarez AI. 2009. Milk secretion of nitrofurantoin, as a specific bcrp/abcg2 substrate, in assaf sheep: modulation by isoflavones. J Vet Pharmacol Ther. 32:498–502.
  • Pulido MM, Molina AJ, Merino G, Mendoza G, Prieto JG, Alvarez AI. 2006. Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): influence of flavonoids and role in milk secretion in sheep. J Vet Pharmacol Ther. 29:279–287.
  • Real R, Egido E, Pérez M, González-Lobato L, Barrera B, Prieto JG, Álvarez AI, Merino G. 2011. Involvement of breast cancer resistance protein (BCRP/ABCG2) in the secretion of danofloxacin into milk: interaction with ivermectin. J Vet Pharmacol Ther. 34:313–321.
  • Real R, González-Lobato L, Baro MF, Valbuena S, de la Fuente A, Prieto JG, Alvarez AI, Marques MM, Merino G. 2011. Analysis of the effect of the bovine adenosine triphosphate-binding cassette transporter G2 single nucleotide polymorphism Y581S on transcellular transport of veterinary drugs using new cell culture models. J Anim Sci. 89:4325–4338.
  • Schnepf R, Zolk O. 2013. Effect of the ATP-binding cassette transporter ABCG2 on pharmacokinetics: experimental findings and clinical implications. Expert Opin Drug Metab Toxicol. 9:287–306.
  • Schrickx JA, Fink-Gremmels J. 2008. Implications of ABC transporters on the disposition of typical veterinary medicinal products. Eur J Pharmacol. 585:510–519.
  • Sidhu PK, Landoni MF, Aliabadi FS, Lees P. 2010. PK-PD integration and modeling of marbofloxacin in sheep. Res Vet Sci. 88:134–141.
  • Tang SC, Lagas JS, Lankheet NA, Poller B, Hillebrand MJ, Rosing H, Beijnen JH, Schinkel AH. 2012. Brain accumulation of sunitinib is restricted by p-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration. Int J Cancer. 130:223–233.
  • Urpi-Sarda M, Morand C, Besson C, Kraft G, Viala D, Scalbert A, Besle JM, Manach C. 2008. Tissue distribution of isoflavones in ewes after consumption of red clover silage. Arch Biochem Biophys. 476:205–210.
  • van Herwaarden AE, Schinkel AH. 2006. The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins. Trends Pharmacol Sci. 27:10–16.
  • van Herwaarden AE, Wagenaar E, Karnekamp B, Merino G, Jonker JW, Schinkel AH. 2006. Breast cancer resistance protein (bcrp1/abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin b1, iq and trp-p-1 but also mediates their secretion into breast milk. Carcinogenesis. 27:123–130.
  • Wassermann L, Halwachs S, Baumann D, Schaefer I, Seibel P, Honscha W. 2013. Assessment of ABCG2-mediated transport of xenobiotics across the blood-milk barrier of dairy animals using a new MDCKII in vitro model. Arch Toxicol. 87:1671–1682.
  • Wassermann L, Halwachs S, Lindner S, Honscha KU, Honscha W. 2013. Determination of functional ABCG2 activity and assessment of drug-ABCG2 interactions in dairy animals using a novel MDCKII in vitro model. J Pharm Sci. 102:772–784.
  • Wu HJ, Luo J, Wu N, Matand K, Zhang LJ, Han XF, Yang BJ. 2008. Cloning, sequence and functional analysis of goat atp-binding cassette transporter g2 (ABCG2). Mol Biotechnol. 39:21–27.
  • Yue W, Abe K, Brouwer KL. 2009. Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion. Mol Pharm. 6:134–143.

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