2,244
Views
147
CrossRef citations to date
0
Altmetric
Original Articles

Determination of pyrrolizidine alkaloids in tea, herbal drugs and honey

, , , , , , , & show all
Pages 1886-1895 | Received 27 Jun 2014, Accepted 07 Sep 2014, Published online: 09 Oct 2014

References

  • Asres K, Sporer F, Wink M. 2004. Patterns of pyrrolizidine alkaloids in 12 Ethiopian Crotalaria species. Biochem Syst Ecol. 32:915–930.
  • BFR 2011. Scientific opinion [Internet]. [cited 2014 Jun 26]. Available from: http://www.bfr.bund.de/cm/349/chemical-analysis-and-toxicity-of-pyrrolizidine-alkaloids-and-assessment-of-the-health-risks-posed-by-their-occurence-in-honey.pdf
  • BFR 2013. Scientific opinion [Internet]. [cited 2014 Jun 26]. Available from: http://www.bfr.bund.de/cm/349/pyrrolizidine-alkaloids-in-herbal-teas-and-teas.pdf
  • Boppré M, Colegate SM, Edgar JA. 2005. Pyrrolizidine alkaloids of Echium vulgare honey found in pure pollen. J Agric Food Chem. 53:594–600.
  • Chung WG, Buhler DR. 1994. The effect of spironolactone treatment on the cytochrome P450-mediated metabolism of the pyrrolizidine alkaloid senecionine by hepatic microsomes from rats and guinea-pigs. Toxicol Appl Pharmacol. 127:314–319.
  • COT. 2008. Statement on pyrrolizidine alkaloids in food [Internet]. Food Standard Agency. [cited 2014 Jun 26]. Available from: http://cot.food.gov.uk/sites/default/files/cot/cotstatementpa200806.pdf
  • Culvenor CCJ, Clarke M, Edgar JA, Frahn JL, Jago MV, Peterson JE, Smith LW. 1980. Structure and toxicity of the alkaloids of Russian comfrey (Symphytum X Uplandicum Nyman), a medicinal herb and item of human diet. Experientia. 36:377–379.
  • Culvenor CCJ, Edgar JA, Smith LW. 1981. Pyrrolizidine alkaloids in honey from Echium-plantagineum L. J Agric Food Chem. 29:958–960.
  • Deinzer ML, Thomson PA, Burgett DM, Isaacson DL. 1977. Pyrrolizidine alkaloids: their occurrence in honey from tansy ragwort (Senecio jacobaea L.). Science. 195:497–499.
  • Dübecke A, Beckh G, Lüllmann C. 2011. Pyrrolizidine alkaloids in honey and bee pollen. Food Addit Contam: Part A. 28:348–358.
  • EFSA. 2011. Panel on Contaminants in the Food Chain (CONTAM); Scientific Opinion on Pyrrolizidine alkaloids in food and feed. EFSA J. 9:2406:134 pp.
  • EUROPEAN PHARMACOPOEIA 6.0. 2008. 01/2008:1433 Herbal Drugs
  • Fu PP, Xia QS, Lin G, Chou MW. 2004. Pyrrolizidine alkaloids - Genotoxicity, metabolism enzymes, metabolic activation, and mechanisms. Drug Metab Rev. 36:1–55.
  • Hartmann T, Witte L. 1995. Pyrrolizidine alkaloids: chemical, biological and chemoecological aspects. In: Pelletier SW, editor. Alkaloids: chemical and biological perspectives, Vol. 9. Oxford: Pergamon Press; p. 155–233.
  • Hoogenboom LAP, Mulder PPJ, Zeilmaker MJ, van den Top HJ, Remmelink GJ, Brandon EFA, Klijnstra M, Meijer GAL, Schothorst R, Van Egmond HP. 2011. Carry-over of pyrrolizidine alkaloids from feed to milk in dairy cows. Food Addit Contam: Part A. 28:359–372.
  • Huxtable RJ. 1980. Herbal teas and toxins - novel aspects of pyrrolizidine poisoning in the United-States. Perspect Biol Med. 24:1–14.
  • Johnson AE, Molyneux RJ, Merrill GB. 1985. Chemistry of toxic range plants - Variation in pyrrolizidine alkaloid content of Senecio, Amsinckia, and Crotalaria Species. J Agric Food Chem. 33:50–55.
  • Kakar F, Akbarian Z, Leslie T, Mustafa M, Watson J, van Egmond H, Omar M, Mofleh J. 2010. An outbreak of hepatic veno-occlusive disease in Western Afghanistan associated with exposure to wheat flour contaminated with pyrrolizidine alkaloids. J Toxicol. 313280:1–7.
  • Kempf M, Beuerle T, Bühringer M, Denner M, Trost D, von der Ohe K, Vijaya BR, Schreier, P. 2008. Pyrrolizidine alkaloids in honey: risk analysis by gas chromatography-mass spectrometry. Mol Nutr Food Res. 52:1193–1200.
  • Kempf M, Wittig M, Schönfeld K, Cramer L, Schreier P, Beuerle T. 2011. Pyrrolizidine alkaloids in food: downstream contamination in the food chain caused by honey and pollen. Food Addit Contam: Part A. 28:325–331.
  • Mattocks AR, Driver HE, Barbour RH, Robins DJ. 1986. Metabolism and toxicity of synthetic analogues of macrocyclic diester pyrrolizidine alkaloids. Chem Biol Interact. 58:95–108.
  • Mohabbat O, Shafiq Younos M, Merzad AA, Srivastava RN, Sediq GG, Aram GN. 1976. An outbreak of hepatic veno-occlusive disease in North-Western Afghanistan. Lancet. 308:269–271.
  • Molyneux RJ, Johnson AE, Roitman JN, Benson ME. 1979. Chemistry of toxic range plants - Determination of pyrrolizidine alkaloid content and composition in Senecio species by nuclear magnetic-resonance spectroscopy. J Agric Food Chem. 27:494–499.
  • Smith LW, Culvenor CCJ. 1981. Plant sources of hepatotoxic pyrrolizidine alkaloids. J Nat Product. 44:129–152.
  • Stillman AE, Huxtable R, Consroe P, Kohnen P, Smith S. 1977. Hepatic veno-occlusive disease due to pyrrolizidine (Senecio) poisoning in Arizona. Gastroenterology. 73:349–352.
  • These A, Bodi D, Ronczka S, Lahrssen-Wiederholt M, Preiss-Weigert A. 2013. Structural screening by multiple reaction monitoring as a new approach for tandem mass spectrometry: presented for the determination of pyrrolizidine alkaloids in plants. Anal Bioanal Chem. 405:9375–9383.
  • Wiedenfeld H, Edgar J. 2011. Toxicity of pyrrolizidine alkaloids to humans and ruminants. Phytochem Rev. 10:137–151.
  • Wiedenfeld H, Rroeder E, Bouaul T, Edgar J. 2008. Pyrrolizidine alkaloids – structure and toxicity. Goettingen, Germany: Bonn University Press.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.