References
- BfR, Scientific Opinion. 2010. Cases of poisoning through grayanotoxins in rhododendron honey originating from the Turkish Black Sea Region [Internet]. [cited 2010 Sep 3]. Available from: http://www.bfr.bund.de/cm/349/cases_of_poisoning_through_grayanotoxins_in_rhododendron_honey_originating_from_the_turkish_black_sea_region.pdf
- Burke JW, Doskotch RW. 1990. High-Field H-1-NMR and C-13-NMR assignments of grayanotoxins I, IV, and XIV isolated from Kalmia-Angustifolia. J Nat Prod. 53:131–137.
- Carey FM, Lewis JJ, Macgregor JL, Martinsmith M. 1959. Pharmacological and chemical observations on some toxic nectars. J Pharm Pharmacol. 11:T269–T274.
- Deguchi T, Sakai Y. 1967. Sustained after-depolarization in grayanotoxin-treated muscle cell membrane. J Physiol Soc Jpn. 29:172–173.
- El-Naggar SF, Doskotch RW, Odell TM, Girard L. 1980. Antifeedant diterpenes for the gypsy moth larvae from Kalmia latifolia: isolation and characterization of ten grayanoids. J Nat Prod. 43:617–631.
- Fukuda H, Kudo Y, Ono H, Yasue M, Sakakibara J, Kato T. 1974. Structure-activity relationship of Lyoniol-A and related compounds in association with the excitatory effect on muscle spindle afferents. Chem Pharm Bull. 22:884–888.
- Gunduz A, Turedi S, Russell RM, Ayaz FA. 2008. Clinical review of grayanotoxin-mad honey poisoning past and present. Clin Toxicol. 46:437–442.
- Gunduz A, Turedi S, Uzun H, Topbas M. 2006. Mad honey poisoning. Am J Emerg Med. 24:595–598.
- Hikino H, Ohta T, Ogura M, Ohizumi Y, Konno C, Takemoto T. 1976. Structure-activity relationship of ericaceous toxins on acute toxicity in mice. Toxicol Appl Pharmacol. 35:303–310.
- Holstege DM, Puschner B, Le T. 2001. Determination of grayanotoxins in biological samples by LC-MS/MS. J Agric Food Chem. 49:1648–1651.
- Jansen SA, Kleerekooper I, Hofman ZLM, Kappen IFPM, Stary-Weinzinger A, Van Der Heyden MAG. 2012. Grayanotoxin poisoning: ‘Mad honey disease’ and beyond. Cardiovasc Toxicol. 12:208–215.
- Kaplan M, Olgun EO, Karaoglu O. 2014. Determination of grayanotoxins in honey by liquid chromatography tandem mass spectrometry using dilute-and-shoot sample preparation approach. J Agric Food Chem. 62:5485–5491.
- Kinghorn AD, Jawad FH, Doorenbos NJ. 1978. Structure-activity relationship of grayanotoxin derivatives using a tetrodotoxin-antagonized spasmodic response of brine shrimp larvae (Artemia-Salina). Toxicon. 16:227–234.
- Klocke JA, Mei-Ying H, Shin-Foon C, Kubo I. 1991. Grayanoid diterpene insect antifeedants and insecticides from Rhododendron molle. Phytochemistry. 30:1797–1800.
- Koca I, Koca AF. 2007. Poisoning by mad honey: a brief review. Food Chem Toxicol. 45:1315–1318.
- Kron KA, Judd WS, Stevens PF, Crayn DM, Anderberg AA, Gadek PA, Quinn CJ, Luteyn JL. 2002. Phylogenetic classification of Ericaceae: molecular and morphological evidence. Bot Rev. 68:335–423.
- Li Y, Liu Y-B, Yu S-S. 2013. Grayanoids from the Ericaceae family: structures, biological activities and mechanism of action. Phytochem Rev. 12:305–325.
- Narahashi T, Seyama I. 1974. Mechanism of nerve membrane depolarization caused by grayanotoxin I. J Physiol. 242:471–487.
- Narayanan P, Röhrl M, Zechmeister K, Hoppe W. 1970. Crystal and molecular structure of grayanotoxin - I, C22H36O7. Tetrahedron Lett. 11:3943–3944.
- Nishikawa Y, Fukumoto K, Tetsumi T, Katai M, Meguri H. 1989. Effects of grayanotoxin-III on liver-function and renal-function in rats. Yakugaku Zasshi-J Pharm Soc Jpn. 109:340–343.
- Onat F, Yegen BC, Lawrence R, Oktay A, Oktay S. 1991. Site of action of grayanotoxins in mad honey in rats. J Appl Toxicol. 11:199–201.
- Qiang Y, Zhou B, Gao K. 2011. Chemical constituents of plants from the genus rhododendron. Chem Biodivers. 8:792–815.
- Sakakibara J, Shirai N, Kaiya T, Nakata H. 1979. Grayanotoxin-XVIII and grayanoside B, a new a-nor-b-homo-ent-kaurene and its glucoside from Leucothoe grayana. Phytochemistry. 18:135–137.
- Scott PM, Coldwell BB, Wiberg GS. 1971. Grayanotoxins - occurrence and analysis in honey and a comparison of toxicities in mice. Food Cosmet Toxicol. 9:179–184.
- Sütlüpmar N, Mat A, Satganoglu Y. 1993. Poisoning by toxic honey in Turkey. Arch Toxicol. 67:148–150.
- Tallent WH, Riethof ML, Horning EC. 1957. Studies on the occurrence and structure of Acetylandromedol (Andromedotoxin). J Am Chem Soc. 79:4548–4554.
- Teuscher E, Lindequist U. 1994. Biogene Gifte. Stuttgart: Gustav Fischer Verlag.
- These A, Bodi D, Ronczka S, Lahrssen-Wiederholt M, Preiss-Weigert A. 2013. Structural screening by multiple reaction monitoring as a new approach for tandem mass spectrometry: presented for the determination of pyrrolizidine alkaloids in plants. Anal Bioanal Chem. 405:9375–9383.
- Wang L-Q, Ding B-Y, Qin G-W, Lin G, Kin-Fai C. 1998. Grayanoids from Pieris formosa. Phytochemistry. 49:2045–2048.
- White Jr JW, Riethof ML. 1959. The composition of honey. III. Detection of acetylandromedol in toxic honeys. Arch Biochem Biophys. 79:165–167.
- Wood HB, Stromberg VL, Keresztesy JC, Horning EC. 1954. Andromedotoxin - a potent hypotensive agent from rhododendron-maximum. J Am Chem Soc. 76:5689–5692.
- Zhang HP, Wang LQ, Qin GW. 2005. Grayanane diterpenoids from the leaves of Craiobiodendron yunnanense. Bioorg Med Chem. 13:5289–5298.
- Zhang WD, Jin HZ, Chen G, Li XF, Yan SK, Zhang L, Shen YH, Yang M. 2008. A new grayanane diterpenoid from Rhododendron decorum. Fitoterapia. 79:602–604.