Study of the natural occurrence of T-2 and HT-2 toxins and their glucosyl derivatives from field barley to malt by high-resolution Orbitrap mass spectrometry

References

• Berthiller F, Crews C, Dall’Asta C, De Saeger S, Haesaert G, Karlovsky P, Oswald IP, Seefelder W, Speijers G, Stroka J. 2013. Masked mycotoxins: a review. Mol Nutr Food Res. 57:165–186.
   PubMed Web of Science ®Google Scholar
• Berthiller F, Dall’Asta C, Corradini R, Marchelli R, Sulyok M, Krska R, Adam G, Schuhmacher R. 2009. Occurrence of deoxynivalenol and its 3-betaglucoside in wheat and maize. Food Addit Contam. 26:507–511.
   Web of Science ®Google Scholar
• Berthiller F, Dall’Asta C, Schuhmacher R, Lemmens M, Adam G, Krska R. 2005. Masked mycotoxins: determination of a deoxynivalenol glucoside in artificially and naturally contaminated wheat by liquid chromatography−tandem mass spectrometry. J Agric Food Chem. 53:3421–3425.
   PubMed Web of Science ®Google Scholar
• Beyer M, Ferse I, Mulac D, Würthwein E-U, Humpf H-U. 2009. Structural elucidation of T-2 toxin thermal degradation products and investigations toward their occurrence in retail food. J Agric Food Chem. 57:1867–1875.
   PubMed Web of Science ®Google Scholar
• Bottalico A, Perrone G. 2002. Toxigenic Fusarium species and mycotoxins associated with head blight in small-grain cereals in Europe. Eur J Plant Pathol. 108:611–624.
   Web of Science ®Google Scholar
• Busman M, Poling SM, Maragos CM. 2011. Observation of T-2 toxin and HT-2 toxin glucosides from Fusarium sporotrichioides by liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS). Toxins. 3:1554–1568.
   PubMed Web of Science ®Google Scholar
• Dall’Erta A, Cirlini M, Dall’Asta M, Del Rio D, Galaverna G, Dall’Asta C. 2013. Masked mycotoxins are efficiently hydrolyzed by human colonic microbiota releasing their aglycones. Chem Res Toxicol. 25:305–312.
   Web of Science ®Google Scholar
• De Boevre M, Di Mavungu JD, Maene P, Audenaert K, Deforce D, Haesaert G, Eeckhout M, Callebaut A, Berthiller F, Van Peteghem C, et al. 2012. Development and validation of an LC-MS/MS method for the simultaneous determination of deoxynivalenol, zearalenone, T-2-toxin and some masked metabolites in different cereals and cereal-derived food. Food Addit Contam. 29:819–835.
   PubMed Web of Science ®Google Scholar
• Delogu G, Terzi V, Rossi V, Cigolini M, Scudellari D. 2005. Micotossine nei cereali, pronto un nuovo metodo per ridurre i rischi. Agricoltura. 7:121–123.
   Google Scholar
• Desmarchelier A, Seefelder W. 2011. Survey of deoxynivalenol and deoxynivalenol-3- glucoside in cereal-based products by liquid chromatography electrospray ionization tandem mass spectrometry. World Mycotox J. 4:29–35.
   Web of Science ®Google Scholar
• EFSA Panel on Contaminants in the Food Chain (CONTAM). 2011. Scientific Opinion on the risk for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed. EFSA J. 9:2481.
   Google Scholar
• European Commission. 2013. Commission Recommendation (EC) 165/2013 of 17 March 2013 on the presence of T-2 toxin and HT-2 toxin in cereals and cereal products. Off J Eur Union. L91:12.
   Google Scholar
• Lancova K, Hajslova J, Kostelanska M, Kohoutkova J, Nedelnik J, Moravcova H, Vanova M. 2008. Fate of trichothecene mycotoxins during the processing: milling and baking. Food Addit Contam A. 25:650–659.
   Web of Science ®Google Scholar
• Lancova K, Hajslova J, Poustka J, Krplova A, Zachariasova M, Dostalek P, Sachambula L. 2008. Transfer of Fusarium mycotoxins and ‘masked’ deoxynivalenol (deoxynivalenol-3-glucoside) from field barley through malt to beer. Food Addit Contam A. 25:732–744.
   Web of Science ®Google Scholar
• Lattanzio VMT, Ciasca B, Haidukowski M, Infantino A, Visconti A, Pascale M. 2013. Mycotoxin profile of Fusarium langsethiae isolated from wheat in Italy: production of type-A trichothecenes and relevant glucosyl derivatives. J Mass Specrom. 48:1291–1298.
   PubMed Web of Science ®Google Scholar
• Lattanzio VMT, Visconti A, Haidukowski M, Pascale M. 2012. Identification and characterization of new Fusarium masked mycotoxins, T-2 and HT-2 glycosyl derivatives, in naturally contaminated wheat and oats by liquid chromatography - high resolution mass spectrometry. J Mass Spectrom. 47:466–475.
   PubMed Web of Science ®Google Scholar
• Leonard KJ, Bushnell WR, editors. 2003. Fusarium head blight of wheat and barley [Internet]. APS Press. [cited 2015 May 25]. Available from: http://www.apsnet.org/apsstore/shopapspress/Pages/4302X.aspx
   Google Scholar
• Maragos CM, Kurtzman CP, Busman M, Price N, McCormick S. 2013. Development and evaluation of monoclonal antibodiesfor the glucoside of T-2 toxin (T2-Glc). Toxins. 5:1299–1313.
   PubMed Web of Science ®Google Scholar
• McCormick SP, Kato T, Maragos CM, Busman M, Lattanzio VMT, Galaverna G, Dall-Asta C, Crich D, Price NP, Kurtzman CP. 2015. Anomericity of T-2 toxin-glucoside: masked mycotoxin in cereal crops. J Agric Food Chem. 63:731–738.
   PubMed Web of Science ®Google Scholar
• McCormick SP, Price NP, Kurtzman CP. 2012. Glucosylation and other biotransformations of T-2 toxin by yeasts of the Trichomonascus clade. Appl Environ Microbiol. 78:8694–8702.
   PubMed Web of Science ®Google Scholar
• Morcia C, Tumino G, Ghizzoni R, Badeck F, Lattanzio VMT, Pascale M, Terzi V. Forthcoming 2015. Occurrence of Fusarium langsethiae and T-2 and HT-2 toxins in Italian malting barley. Int J Food Microbiol.
   PubMed Web of Science ®Google Scholar
• Nagl V, Schwarz H, Krska R, Moll WD, Knasmüller S, Ritzmann M, Adam G, Berthiller F. 2012. Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats. Toxicol Lett. 213:367–373.
   PubMed Web of Science ®Google Scholar
• Nakagawa H, Sakamoto S, Sago Y, Kushiro M, Nagashima H. 2013. Detection of masked mycotoxins derived from type-A trichothecenes in corn by high-resolution LC-Orbitrap mass spectrometer. Food Addit Contam. 30:1407–1414.
   PubMed Web of Science ®Google Scholar
• Nakagawa H, Sakamoto S, Sago Y, Nagashima H. 2013. Detection of type A trichothecene di-glucosides produced in corn by high-resolution liquid chromatography-orbitrap mass spectrometry. Toxins. 5:590–604.
   PubMedGoogle Scholar
• Nielsen LK, Cook DJ, Edwards SG, Ray RV. 2014. The prevalence and impact of Fusarium head blight pathogens and mycotoxins on malting barley quality in UK. Int J Food Microbiol. 179:38–49.
   PubMed Web of Science ®Google Scholar
• Pascale M, Haidukowski M, Lattanzio VMT, Silvestri M, Ranieri R, Visconti A. 2011. Distribution of T-2 and HT-2 toxins in milling fractions of durum wheat. J Food Protect. 10:1700–1707.
   Web of Science ®Google Scholar
• Sasanya JJ, Hall C, Wolf-Hall C. 2008. Analysis of deoxynivalenol, masked deoxynivalenol, and Fusarium graminearum pigment in wheat samples, using liquid chromatography–UV–mass spectrometry. J Food Protect. 71:1205–1213.
   PubMed Web of Science ®Google Scholar
• Schwake-Anduschus C, Langenkämper G, Unbehend G, Dietrich R, Märtlbauer E, Münzing K. 2010. Occurrence of Fusarium T-2 and HT-2 toxins in oats from cultivar studies in Germany anddegradation of the toxins during grain cleaning treatment and food processing. Food Addit Contam A. 27:1253–1260.
   Web of Science ®Google Scholar
• Schwarz PB, Casper HH, Beattie S. 1995. Fate and development of naturally occurring Fusarium mycotoxins during malting and brewing. J Am Soc Brew Chem. 53:121–127.
   Web of Science ®Google Scholar
• Scudamore KA, Baillie H, Patel S, Edwards SG. 2007. Occurrence and fate of Fusarium mycotoxins during commercial processing of oats in the UK. Food Addit Contam. 24:1374–1385.
   PubMed Web of Science ®Google Scholar
• Scudamore KA, Patel S, Edwards SG. 2009. HT-2 toxin and T-2 toxin in commercial cereal processing in the United Kingdom, 2004–2007. World Mycotoxin J. 2:357–365.
   Web of Science ®Google Scholar
• Slaiding I. 2009. T-2, HT-2 and deoxynivalenol (DON) in malting barley and malt. 6th EC Forum on Fusarium toxins; 2009 Feb 9–10; Brussels.
   Google Scholar
• Terzi V, Tumino G, Stanca AM, Morcia C. 2014. Reducing the incidence of cereal head infection and mycotoxins in small grain cereal species. J Cereal Sci. 59:284–293.
   Web of Science ®Google Scholar
• van der Fels-Klerx HJ 2010. Occurrence data of trichothecene mycotoxins T-2 toxin and HT-2 toxin in food and feed. Scientific/Technical report EFSA-Q-2010-00949 [Internet]. [cited 2015 May 22]. Available from: http://www.efsa.europa.eu/it/search/doc/66e.pdf
   Google Scholar
• Veprikova Z, Vaclavikova M, Lacina O, Dzuman Z, Zachariasova M, Hajslova J. 2012. Occurrence of mono- and di-glycosylated conjugates of T-2 and HT-2 toxins in naturally contaminated cereals. World Mycotoxin J. 5:231–240.
   Web of Science ®Google Scholar
• Yoshinari T, Sakuda S, Furihata K, Furusawa H, Ohnishi T, Sugita-Konishi Y, Ishizaki N, Terajima J. 2014. Structural determination of a nivalenol glucoside and development of an analytical method for the simultaneous determination of nivalenol and deoxynivalenol, and their glucosides, in wheat. J Agric Food Chem. 62:1174–1180.
   PubMed Web of Science ®Google Scholar