Why semicarbazide (SEM) is not an appropriate marker for the usage of nitrofurazone on agricultural animals

References

• Abernethy G, Higgs K. 2013. Lactose semicarbazone as a marker for semicarbazide adulteration in Milk. J Chrom A. 1295:152–155.
   PubMed Web of Science ®Google Scholar
• Abernethy GA. 2015. Generation of semicarbazide from natural azine development in foods, followed by reaction with urea compounds. Food Addit Contam: Part A. 32:1416–1430.
   PubMed Web of Science ®Google Scholar
• Becalski A, Bpy L, Lewis D, Seaman S. 2006. Semicarbazide in Canadian bakery products. Food Addit Contam: Part A. 23:107–109.
   PubMed Web of Science ®Google Scholar
• Becalski A, Bpy L, Lewis D, Seaman SW. 2004. Semicarbazide formation in azodicarbonamide-treated flour: a model study. J Agric Food Chem. 52:5730–5734.
   PubMed Web of Science ®Google Scholar
• Bendall JG. 2009. Semicarbazide is non-specific as a marker metabolite to reveal nitrofurazone abuse as it can form under Hofmann conditions. Food Addit Contam: Part A. 26:47–56.
   Web of Science ®Google Scholar
• Commission of the European Communities. 1995. Commission Regulation 1442/95 amending Annexes I, II, III and IV of council regulation EEC n° 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin. OJ L. 143:28.
   Google Scholar
• Commission of the European Communities. 2002. Commission Decision 2002/657/EC implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. OJ L. 221:8.
   Google Scholar
• Commission of the European Communities. 2005. Commission Decision 2005/34/EC laying down harmonized standards for the testing for certain residues in products of animal origin imported from third countries. OJ L. 1:6.
   Google Scholar
• Cooper KM, Le J, Kane C, Kennedy DG. 2008. Kinetics of semicarbazide and nitrofurazone in chicken eggs and egg powders. Food Addit Contam: Part A. 25:684–692.
   Web of Science ®Google Scholar
• Crews C. 2012. Potential natural sources of semicarbazide in honey [Internet]. Report for the Food Standards Agency in Scotland. Project code FS241065, 3rd July 2012. York: The Food and Environment Research Agency Sand Hutton. Available from: www.defra.gov.uk/fera
   Google Scholar
• de la Calle MB, Anklam E. 2005. Semicarbazide: occurrence in food products and state-of-the-art in analytical methods used for its determination. Anal Bioanal Chem. 382:968–977.
   PubMed Web of Science ®Google Scholar
• EFSA. 2005. Scientific panel on food additives, flavourings, processing aids and materials in contact with food on a request from the commission related to semicarbazide in food question number EFSA-2003-235. EFSA Journal [Internet]. [cited Jul 15];219:1–36. Available from: http://www.efsa.europa.eu/en/efsajournal/doc/219.pdf
   Google Scholar
• EFSA. 2015. Scientific Panel on Contaminants in the Food Chain (CONTAM). Scientific Opinion on nitrofurans and their metabolites in food. EFSA Journal. [Internet]. [cited Jul 15];13:4140. Available from: http://www.efsa.europa.eu/en/efsajournal/pub/4140.htm?utm_source=feed&utm_medium=rss&utm_campaign=ej
   Google Scholar
• FDA Code of Federal Regulations Title 21, Section 172.806 Azodicarbonamide [Internet]. [cited Jul 15]. Available from: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=172.806
   Google Scholar
• Gatermann R, Hoenicke K, Mandix M. 2004. Formation of semicarbazide (SEM) from natural compounds in food by heat treatment. Czech J Food Sci. 22:353–354.
   Google Scholar
• Health Canada, Food and Drug Regulations, List of permitted food additives, List of Bleaching, Maturing or dough conditioning agents [Internet]. [cited 2015 Jul]. Available from: http://www.hc-sc.gc.ca/fn-an/securit/addit/list/2-bleach-blanch-eng.php
   Google Scholar
• Heberer T, Lahrssen-Wiederholt M, Schafft H, Abraham K, Pzyrembel H, Henning KJ, Schauzu M, Braeunig J, Goetz M, Niemann L, et al. 2007. Zero tolerances in food and animal feed–are there any scientific alternatives? A European point of view on an international controversy. Toxicol Letters. 175:118–135.
   PubMed Web of Science ®Google Scholar
• Hoenicke K, Gatermann R, Hartig L, Mandix M, Otte S. 2004. Formation of semicarbazide (SEM) in food by hypochlorite treatment: is SEM a specific marker for nitrofurazone abuse? Food Addit Contam: Part A. 21:526–537.
   PubMed Web of Science ®Google Scholar
• [IARC] International Agency for Research on Cancer. 1987. Monographs on the evaluation of the carcinogenic risk to humans: overall evaluations of carcinogenicity: an updating of IARC monographs volumes 1 to 42. Supplement 7. Lyon: International Agency for Research on Cancer; p. 71.
   Google Scholar
• [IDF] International Dairy Federation. 2015 Jul. IDF, Factsheet. Why semicarbazide is not a suitable marker for nitrofurazone in dairy products [Internet]. [cited Jul 15]. Available from: http://www.fil-idf.org/Public/LinksPage.php?ID=40415
   Google Scholar
• Khong SP, Gremaud E, Richoz J, Delatour T, Guy PA, Stadler RH, Mottier P. 2004. Analysis of matrix-bound nitrofuran residues in worldwide-originated honeys by isotope dilution high-performance liquid chromatography-tandem mass spectrometry. J Agric Food Chem. 52:5309–5315.
   PubMed Web of Science ®Google Scholar
• Kuhn TW. 2014. Contaminants from natural and food processing sources. Paper presented at: The International Symposium on Food Safety and Quality; 2014 Nov 12; Vienna.
   Google Scholar
• McCracken R, Hanna B, Ennis D, Cantley L, Faulkner D, Kennedy DG. 2013. The occurrence of semicarbazide in the meat and shell of Bangladeshi fresh-water shrimp. Food Chem. 136:1562–1567.
   PubMed Web of Science ®Google Scholar
• Mottier P, Khong S-P, Gremaud E, Richoz J, Delatour T, Goldmann T, Guy PA. 2005. Quantitative determination of four nitrofuran metabolites in meat by isotope dilution liquid chromatography–electrospray ionisation–tandem mass spectrometry. J Chrom A. 1067:85–91.
   PubMed Web of Science ®Google Scholar
• Nestmann ER, Lynch BS, Musa-Veloso K, Goodfellow GH, Cheng E, Haighton LA, Lee-Brotherton VM. 2005. Safety assessment and risk-benefit analysis of the use of azodicarbonamide in baby food jar closure technology: putting trace levels of semicarbazide exposure into perspective – a review. Food Addit Contam: Part A. 22:875–891.
   PubMed Web of Science ®Google Scholar
• New Zealand Ministry for Primary Industries. 2015. National Programme for the monitoring and surveillance of chemical residues and contaminants in milk - Plan for 1 July 2013 to 30 June 2014 [Internet]. [cited Jul 15]. Available from: http://foodsafety.govt.nz/industry/sectors/dairy/monitoring-testing/nccp/documents.htm
   Google Scholar
• Noonan GO, Warner CR, Hsu W, Begley TH, Perfetti GA, Diachenko GW. 2005. The determination of semicarbazide (N-aminourea) in commercial bread products by liquid chromatography-mass spectrometry. J Agric Food Chem. 53:4680–4685.
   PubMed Web of Science ®Google Scholar
• Phongvivat S. 2004. Nitrofurans Case Study: Thailand’s experience. Joint FAO/WHO Technical Workshop on Residues of Veterinary Drugs without ADI/MRL - Bangkok, 24–26 August 2004 [Internet]. [cited 2015 Apr 20]. Available from: http://www.fao.org/3/a-y5723e/y5723e0u.htm
   Google Scholar
• Points JD, Burns D, Walker MJ. 2015. Forensic issues in the analysis of trace nitrofuran veterinary residues in food of animal origin. Food Control. 50:92–103.
   Web of Science ®Google Scholar
• Radovnikovic A, Conroy E-R, Gibney M, O’Mahony J, Danaher M. 2013. Residue analyses and exposure assessment of the Irish population to nitrofuran metabolites from different food commodities in 2009–2010. Food Addit Contam: Part A. 30:1858–1869.
   PubMed Web of Science ®Google Scholar
• Rothgery EF. 1984. Patent US 4482738A, process for preparing semicarbazide. HCl.
   Google Scholar
• Saari L, Peltonen K. 2004. Novel source of semicarbazide: levels of semicarbazide in cooked crayfish samples determined by LC/MS/MS. Food Addit Contam: Part A. 21:825–832.
   PubMedGoogle Scholar
• Samsonova JV, Douglas AJ, Cooper KM, Kennedy DG, Elliott CT. 2008. The identification of potential alternative biomarkers of nitrofurazone abuse in animal derived food products. Food Chem Toxicol. 46:1548–1554.
   PubMed Web of Science ®Google Scholar
• Stadler RH, Mottier P, Guy P, Gremaud E, Varga N, Lalljie S, Whitaker R, Kintscher J, Dudler V, Read WA, et al. 2004. Semicarbazide is a minor thermal decomposition product of azodicarbonamide used in the gaskets of certain food jars. Analyst. 129:276–281.
   PubMed Web of Science ®Google Scholar
• Takahashi M, Yoshida M, Inoue K, Morikawa T, Nishikawa A, Ogawa K. 2014. Chronic toxicity and carcinogenicity of semicarbazide hydrochloride in Wistar Hannover GALAS rats. Food Chem Toxicol. 73:84–94.
   PubMed Web of Science ®Google Scholar
• Tian W-R, Sang Y-X, Wang X-H. 2014. Semicarbazide - from state-of-the-art analytical methods and exposure to toxicity: a review. Food Addit Contam: Part A. 31:1850–1860.
   PubMed Web of Science ®Google Scholar
• Van Poucke C, Detavernier C, Wille M, Kwakman J, Sorgeloos P, Van Peteghem C. 2011. Investigation into the possible natural occurence of semicarbazide in Macrobrachium rosenbergii prawns. J Agric Food Chem. 59:2107–2112.
   PubMed Web of Science ®Google Scholar
• Vass M, Hruska K, Franek M. 2008. Nitrofuran antibiotics: a review on the application, prohibition and residual analysis. Veterinarni Medicina. 53:469–500.
   Web of Science ®Google Scholar
• Xing Y-N, Ni H-G, Chen Z-Y. 2012. Semicarbazide in selected bird’s nest products. J Food Prot. 75:1654–1659.
   PubMed Web of Science ®Google Scholar
• Xu YJ, Sun YZ, Song XK, Tian X, Gong XH, Zhang XZ, Zhang LM. 2010. Survey of semicarbazide contamination in coastal waters adjacent to the chaohe river estuary. Oceanologia Et Limnologia Sinica. 41:1–5.
   Google Scholar