Advanced search
Publication Cover
Food Additives & Contaminants: Part A Volume 33, 2016 - Issue 2
Submit an article Journal homepage
248
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

Separation and identification of a novel tadalafil analogue adulterant in a dietary supplement

Yen-Chun HuangDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan (ROC)View further author information
,
Hui-Chun LeeDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan (ROC)Correspondence[email protected]
View further author information
,
Yun-Lian LinDivision of Chinese Medicinal Chemistry, National Research Institute of Chinese Medicine, Taipei, Taiwan (ROC)View further author information
,
Chia-Ying LiDepartment of Applied Chemistry, National Pingtung University, Pingtung City, Taiwan (ROC)View further author information
,
Chia-Fen TsaiDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan (ROC)View further author information
&
Hwei-Fang ChengDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan (ROC)View further author information
Pages 179-185 | Received 14 Sep 2015, Accepted 24 Nov 2015, Published online: 24 Dec 2015

References

  • Abdel-Aziz AA-M, Asiri YA, El-Azab AS, Al-Omar MA, Kunieda T. 2011. Tadalafil. In: Brittain HG, editor. Profiles of drug substances, excipients, and related methodology. Amsterdam: Elsevier Inc.; p. 287–329.
  • Daugan A, Grondin P, Ruault C, de Gouville A-C, Le M, Coste H, Linget JM, Kirilovsky J, Hyafil F, Labaudinière R. 2003. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. J Med Chem. 46:4533–4542.
  • Häberlia A, Girarda P, Low M-Y, Ge X. 2010. Isolation and structure elucidation of an interaction product of aminotadalafil found in an illegal health food product. J Pharm Biomed Anal. 53:24–28.
  • Hasegawa T, Saijo M, Ishii T, Nagata T, Haishima Y, Kawahara N, Goda Y. 2008. Structural elucidation of a tadalafil analogue found in a dietary supplement. J Food Hyg Soc Jpn (Shokuhin Eiseigaku Zasshi). 49:311–315.
  • Kern SE, Nickum EA, Flurer RA, Toomey VM, Litzau JJ. 2015. Isolation and structural characterization of a new tadalafil analog (2-hydroxyethylnortadalafil) found in a dietary supplement. J Pharm Biomed Anal. 103:99–103.
  • Lai K-C, Liu Y-C, Tseng M-C, Lin J-H. 2006. Isolation and identification of a sildenafil analogue illegally added in dietary supplements. J Food Drug Anal. 14:19–23.
  • Lai K-C, Liu Y-C, Tseng M-C, Lin Y-L, Lin J-H. 2007a. Isolation and identification of a vardenafil analogue in a functional food marketed for penile erectile dysfunction. J Food Drug Anal. 15:133–138.
  • Lai K-C, Liu Y-C, Tseng M-C, Lin Y-L, Lin J-H. 2007b. Isolation and identification of a vardenafil analogue in a dietary supplement. J Food Drug Anal. 15:220–227.
  • Lebel P, Gagnon J, Furtos A, Waldron KC. 2014. A rapid, quantitative liquid chromatography-mass spectrometry screening method for 71 active and 11 natural erectile dysfunction ingredients present in potentially adulterated or counterfeit products. J Chromatogr A. 1343:143–151.
  • Liao Y-C, Lai K-C, Lee H-C, Liu Y-C, Lin Y-L, Shin Y-C. 2013. Isolation and identification of new sildenafil analogues from dietary supplements. J Food Drug Anal. 21:40–49.
  • Lin M-C, Liu Y-C, Lin J-H. 2006. Identification of a sildenafil analogue adulterated in two herbal food supplements. J Food Drug Anal. 14:260–264.
  • Lin M-C, Liu Y-C, Lin Y-L, Lin J-H. 2008. Isolation and identification of a novel sildenafil analogue adulterated in dietary supplements. J Food Drug Anal. 16:15–20.
  • Lin M-C, Liu Y-C, Lin Y-L, Lin J-H. 2009. Identification of a tadalafil analogue adulterated in a dietary supplement. J Food Drug Anal. 17:451–458.
  • Rosen RC, Kostis JB. 2003. Overview of phosphodiesterase 5 inhibition in erectile dysfunction. Am J Cardiol. 92:9–18.
  • Toomey VM, Litzau JJ, Flurer CL. 2012. Isolation and structural characterization of two tadalafil analogs found in dietary supplements. J Pharm Biomed Anal. 59:50–57.
  • Venhuis BJ, de Kaste D. 2012. Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks. J Pharm Biomed Anal. 69:196–208.
  • Zhang G, Yu Y, Wu X, Li J. 2014. Separation and structural elucidation of a new tadalafil analogue diethylaminopretadalafil included as an adulterant in a dietary supplement. J Pharm Biomed Anal. 94:210–214.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.