Simultaneous determination of aditoprim and its three major metabolites in pigs, broilers and carp tissues, and its application in tissue distribution and depletion studies

References

• Alvinerie M, Sutra JF, Eeckhoutte C, Galtier P, van ‘t Klooster GA, van Miert AS. 1993. Determination of aditoprim and its oxidative metabolites in plasma and microsomal incubation mixtures by high-performance liquid chromatography. J Chromatogr. 612:115–121.
   PubMed Web of Science ®Google Scholar
• Ascalone V, Jordan JC, Ludwig BM. 1986. Determination of aditoprim, a new dihydrofolate reductase inhibitor, in the plasma of cows and pigs. J Chromatogr. 383:111–118.
   PubMed Web of Science ®Google Scholar
• Bellmann R. 2014. Pharmacokinetic and pharmacodynamic aspects in antibiotic treatment. Med Klin Intensivmed Notfmed. 109:162–166.
   PubMed Web of Science ®Google Scholar
• [CVMP] Committee for Veterinary Medicinal Products. 2013. Revised reflection paper on injection site residues: considerations for risk assessment and residue surveillance; [cited 2015.Dec 3]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2013/10/WC500152656.pdf.
   Google Scholar
• Damte D, Jeong HJ, Lee SJ, Cho BH, Kim JC, Park SC. 2012. Evaluation of linear regression statistical approaches for withdrawal time estimation of veterinary drugs. Food Chem Toxicol. 50:773–778.
   PubMed Web of Science ®Google Scholar
• Economou A, Petraki O, Tsipi D, Botitsi E. 2012. Development of a liquid chromatography–tandem mass spectrometry method for the determination of sulfonamides, trimethoprim and dapsone in honey and validation according to Commission Decision2002/657/EC for banned compounds. Talanta. 15:32–41.
   Web of Science ®Google Scholar
• EMEA. 1997a. Trimethoprim. Summary Report (2) (EMEA/MRL/255/97-FINAL); [cited 2015 Dec 3]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500015681.pdf.
   Google Scholar
• EMEA. 1997b. Baquiloprim. Summary Report (2) (EMEA/MRL/199/97-FINAL); [cited 2015 Dec 3]. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500010884.pdf.
   Google Scholar
• Engeli J, Riond JL, Wanner M. 1993. Research note: pharmacokinetics of aditoprim in turkeys after intravenous and oral administration. Poult Sci. 72:979–983.
   PubMed Web of Science ®Google Scholar
• FAO/WHO. 2010. Request for data on dietary intake (consumption) of standard and non-standard animal tissues and food of animal origin; [cited 2015 Dec 3]. Available from: http://www.who.int/foodsafety/chem/JECFA75.pdf.
   Google Scholar
• Felton T, Troke PF, Hope WW. 2014. Tissue penetration of antifungal agents. Clin Microbiol Rev. 27:68–88.
   PubMed Web of Science ®Google Scholar
• Garwacki S, Lewicki J, Wiechetek M, Grys S, Rutkowski J, Zaremba M. 1996. A study of the pharmacokinetics and tissue residues of an oral trimethoprim/sulphadiazineformulation in healthy pigs. J Vet Pharmacol Ther. 19:423–430.
   PubMed Web of Science ®Google Scholar
• Gehring R, Baynes RE, Wang J, Craigmill AL, Rivierea JE. 2004. A web-based decision support system to estimate extended withdrawal intervals. Comput Electron Agric. 44:145–151.
   Web of Science ®Google Scholar
• Gros M, Petrović M, Barceló D. 2006. Multi-residue analytical methods using LC-tandem MS for the determination of pharmaceuticals in environmental and wastewater samples: a review. Anal Bioanal Chem. 386:941–952.
   PubMed Web of Science ®Google Scholar
• Haenni K, Jordan J-C, Ludwig B, Rehm WF. 1987. Pharmacokinetics of aditoprim, a dihydrofolate reductase inhibitor, in sheep. J Vet Pharmacol Ther. 10:169–171.
   PubMed Web of Science ®Google Scholar
• Hawser S, Lociuro S, Islam K. 2006. Dihydrofolate reductase inhibitors as antibacterialagents. Biochem Pharmacol. 71:941–948.
   PubMed Web of Science ®Google Scholar
• Huovinen P. 2001. Resistance to trimethoprim-sulfamethoxazole. Clin Infect Dis. 32:1608–1614.
   PubMed Web of Science ®Google Scholar
• Iqbal MP, Ashfaq MK, Niazi SK, Mahboobali M, Khawaja KN. 1994. Pharmacokinetics of aditoprim and trimethoprim in buffalo calves. Biopharm Drug Dispos. 15:173–177.
   PubMed Web of Science ®Google Scholar
• Iqbal MP, Niazi SK, Mehboobali N, Zaidi AA. 1995. Disposition kinetics of aditoprim in two monkeys in comparison to other mammalian species. Biopharm Drug Dispos. 16:713–718.
   PubMed Web of Science ®Google Scholar
• JECFA. 2003. 62nd meeting of FAO/WHO joint expert committee on food additives; [cited 2015 Dec 3]. Available from: http://www.fao.org/fileadmin/user_upload/agns/zip/tool_1.1551.zip.
   Google Scholar
• Jordan JC, Klatt P, Ludwig B. 1987. Pharmacokinetics of aditoprim, a new long-acting dihydrofolate reductase inhibitor, in heifers. Zentralbl Veterinarmed A. 34:33–41.
   PubMedGoogle Scholar
• Knoppert NW, Nijmeijer SM, van Duin CT, Korstanje C, van Gogh H, van Miert AS. 1988. Some pharmacokinetic data of aditoprim and trimethoprim in healthy and tick-borne fever infected dwarf goats. J Vet Pharmacol Ther. 11:135–144.
   PubMed Web of Science ®Google Scholar
• Lohuis JA, Sutter HM, Graser T, Ludwig B, van Miert AS, Rehm WF, Schneider B, Wanner M, van Werven T. 1992. Effects of endotoxin-induced mastitis on the pharmacokinetic properties of aditoprim in dairy cows. Am J Vet Res. 53:2311–2314.
   PubMed Web of Science ®Google Scholar
• Ludwig B. 1989. Use of pharmacokinetics when dealing with the drug residue problem in food-producing animals. Dtsch Tierarztl Wochenschr. 96:243–248.
   PubMedGoogle Scholar
• Luo H, Zhang L, Xue F, Li Y, Wang X, Fei C, Zhang C. 2014. Simultaneous determination of trimethoprim and diaveridine in tissues of chicken, porcine, and fish by hydrophilic interaction liquid chromatography-tandem mass spectrometry. Food Anal Method. 7:308–317.
   Web of Science ®Google Scholar
• Mengelers MJ, Kleter GA, Hoogenboom LA, Kuiper HA, Van Miert AS. 1997. The biotransformation of sulfadimethoxine, sulfadimidine, sulfamethoxazole, trimethoprim and aditoprim by primary cultures of pig hepatocytes. J Vet Pharmacol Therap. 20:24–32.
   PubMed Web of Science ®Google Scholar
• Mengelers MJ, van Klingeren B, van Miert AS. 1990. In vitro susceptibility of some porcine respiratory tract pathogens to aditoprim, trimethoprim, sulfadimethoxine, sulfamethoxazole, and combinations of these agents. Am J Vet Res. 51:1860–1864.
   PubMed Web of Science ®Google Scholar
• Riond JL, Muller P, Wanner M. 1992. The influence of age on the pharmacokinetics of aditoprim in pigs after intravenous and oral administration. Vet Res Commun. 16:355–364.
   PubMed Web of Science ®Google Scholar
• Riond JL, Riviere JE. 1990. Allometric analysis of doxycycline pharmacokinetic parameters. J Vet Pharmacol Ther. 13:404–407.
   PubMed Web of Science ®Google Scholar
• Roberts MC. 2002. Resistance to tetracycline, macrolide-lincosamide-streptogramin, trimethoprim, and sulfonamide drug classes. Mol Biotechnol. 20:261–283.
   PubMed Web of Science ®Google Scholar
• Sköld O. 2001. Resistance to trimethoprim and sulfonamides. Vet Res. 32:261–273.
   PubMed Web of Science ®Google Scholar
• Stephan-Güldner M. 1993. Preclinical toxicology and safety pharmacology of brodimoprim in comparison to trimethoprim and analogs. J Chemother. 5:400–410.
   PubMed Web of Science ®Google Scholar
• Sutter H-M, Ludwig B, Bremer KD, Jordan J-C, Rehm WF, Wanner M. 1991. Pharmacokinetics of aditoprim in dogs after intravenous and oral administration: a preliminary study. J Small Anim Pract. 32:517–520.
   Web of Science ®Google Scholar
• Sutter HM, Riond JL, Wanner M. 1993. Comparative pharmacokinetics of aditoprim in milk-fed and conventionally fed calves of different ages. Res Vet Sci. 54:86–93.
   PubMed Web of Science ®Google Scholar
• Then RL, Keller M. 1988. Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor. Zentralbl Veterinarmed B. 35:114–120.
   PubMedGoogle Scholar
• Toutain PL, Ferran A, Bousquet-Mélou A. 2010. Species differences in pharmacokinetics and pharmacodynamics. Handb Exp Pharmacol. 199:19–48.
   PubMedGoogle Scholar
• van Miert AS. 1994. The sulfonamide-diaminopyrimidine story. J Vet Pharmacol Ther. 17:309–316.
   PubMed Web of Science ®Google Scholar
• VICH. 2015a. VICH GL48(R) (MRK): studies to evaluate the metabolism and residue kinetics of veterinary drugs in food-producing animals: marker residue depletion studies to establish product withdrawal periods; [cited 2015.Dec 3]. Available from: http://www.vichsec.org/guidelines/pharmaceuticals/pharma-safety/metabolism-and-residue-kinetics.html.
   Google Scholar
• VICH. 2015b. VICH GL49(R) (MRK): studies to evaluate the metabolism and residue kinetics of veterinary drugs in food-producing animals: validation of analytical methods used in residue depletion studies; [cited 2015.Dec 3]. Available from: http://www.vichsec.org/guidelines/pharmaceuticals/pharma-safety/metabolism-and-residue-kinetics.html.
   Google Scholar
• von Fellenberg RL, Jordan JC, Ludwig B, Rehm WF. 1990. Plasma disposition and tolerance of aditoprim in horses after single intravenous injection. Zentralbl Veterinarmed A. 37:253–258.
   PubMedGoogle Scholar
• Wang H, Yuan B, Zeng Z, He L, Ding H, Guo C, Kong X, Wang W, Huang X. 2014. Identification and elucidation of the structure of in vivo metabolites of diaveridine in chicken. J Chromatogr B Analyt Technol Biomed Life Sci. 965:91–99.
   PubMed Web of Science ®Google Scholar
• Wang L, Huang L, Pan Y, Kuča K, Klímová B, Wu Q, Xie S, Ahmad I, Chen D, Tao Y, et al. 2016. Metabolism and disposition of aditoprim in swine, broilers, carp and rats. Sci Rep. doi:10.1038/srep20370
   PubMed Web of Science ®Google Scholar
• Wang X, Tan Z, Cheng G, Awais I, Huang L, Chen D, Pan Y, Liu Z, Yuan Z. 2015. Two-generation reproduction and teratology studies of feeding aditoprim in Wistar rats. J Appl Toxicol. 35:1531–1538.
   PubMed Web of Science ®Google Scholar
• Wang X, Tan Z, Pan Y, Ihsan A, Liu Q, Huang L, Cheng G, Chen D, Tao Y, Liu Z, Yuan Z. 2015. Safety assessment of aditoprim acute, subchronic toxicity and mutagenicity studies. J Appl Toxicol. 35:1415–1426.
   PubMed Web of Science ®Google Scholar
• White G, Daluge SM, Sigel CW, Ferone R, Wilson HR. 1993. Baquiloprim, a new antifolate antibacterial: in vitro activity and pharmacokinetic properties in cattle. Res Vet Sci. 54:372–378.
   PubMed Web of Science ®Google Scholar
• WHO. 2010. Principles and methods for the risk assessment of chemicals in food; [cited 2015.Dec 3]. Available from: http://apps.who.int/iris/bitstream/10665/44065/9/WHO_EHC_240_9_eng_Chapter6.pdf?ua=1.
   Google Scholar
• Wolfe GW, Quander R, Kiorpes A, Hall B, Palmer T, Ball D. 1993. Sub-chronic toxicity studies of aditoprim in beagle dogs. Toxicologist. 13:313.
   Google Scholar