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Original Articles

Physiologically based pharmacokinetic model for quinocetone in pigs and extrapolation to mequindox

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Pages 192-210 | Received 20 Jul 2016, Accepted 30 Oct 2016, Published online: 21 Dec 2016

References

  • American Veterinary Medical Association (AMVA). 2001. Panel on euthanasia 2000 report of the AVMA panel on euthanasia. J Am Vet Med Assoc. 218:669–696.
  • Brocklebank JR, Namdari R, Law FC. 1997. An oxytetracycline-residue depletion study to assess the physiologically based pharmokinetic (PBPK) model in farmed Atlantic salmon. Can Vet J. 38:645–646.
  • Buur JL, Baynes RE, Craigmill AL. 2005. Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues. Am J Vet Res. 66:1686–1693.
  • Buur JL, Baynes RE, Riviere JE. 2008. Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model. Regul Toxicol Pharmacol. 51:324–331.
  • Buur JL, Baynes RE, Smith G. 2006. Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine. Antimicrob Agents Chemother. 50:2344–2351.
  • Chiesa OA, Bredow J, Nochetto C, Smith M, Heller D, Moulton K, Thomas MH. 2006a. Use of tissue-fluid correlations to estimate gentamicin residues in kidney tissue of Holstein steers. J Vet Pharmacol Ther. 29:99–106.
  • Chiesa OA, Bredow J, Smith M, Heller D, Condon R, Thomas MH. 2006b. Bovine kidney tissue/biological fluid correlation for penicillin. J Vet Pharmacol Ther. 29:299–306.
  • Clewell HJ, Gentry PR, Covington TR, Sarangapani R, Teeguarden JG. 2004. Evaluation of the potential impact if age- and gender-species pharmacokinetic differences on tissue dosimetry. Toxicol Sci. 79:381–393.
  • Corley RA, Bartels MJ, Carney EW, Weitz KK, Thrall KD. 2005. Development of a physiologically based pharmacokinetic model for ethylene glycol and its metabolite, glycolic acid, in rats and humans. Toxicol Sci. 85:476–490.
  • Corley RA, Gordon SM, Wallace LA. 2000. Physiologically based pharmacokinetic modeling of the temperature-dependent dermal absorption of chloroform by humans following bath water exposures. Toxicol Sci. 53:13–23.
  • Cortright KA, Wetzlich SE, Craigmill AL. 2009. A PBPK model for midazolam in four avian species. J Vet Pharmacol Ther. 32:552–565.
  • Craigmill AL. 2003. A physiologically based pharmacokinetic model for oxytetracycline residues in sheep. J Vet Pharmacol Ther. 26:55–63.
  • Duddy J, Hayden TL, Bourne DW. 1984. Physiological model for distribution of sulfathiazole in swine. J Pharm Sci. 73:1525–1528.
  • Grass GM, Sinko PJ. 2002. Physiologically-based pharmacokinetic model for oxytetracycline. Adv Drug Deliv Rev. 54:433–451.
  • Huang LL, Lin ZM, Zhou X. 2015a. Estimation of residue depletion of cyadox and its marker residue in edible tissues of pigs using physiologically based pharmacokinetic modeling. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 32:2002–2017.
  • Huang LL, Yin FJ, Pan YH, Chen DM, Li J, Wan D, Liu ZL, Yuan ZH. 2015b. Metabolism, distribution, and elimination of mequindox in pigs, chickens, and rats. J Agric Food Chem. 63:9839–9849.
  • Huang XJ, Ihsan A, Wang X, Dai MH, Wang YL, Su SJ, Xue XJ, Yuan ZH. 2009. Longterm dose dependent response of mequindox aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats. Toxicol Lett. 191:167–173.
  • Ihsan A, Wang X, Huang XJ, Liu Y, Liu Q, Zhou W, Yuan ZH. 2010. Acute and subchronic toxicological evaluation of mequindox in Wistar rats. Regul Toxicol Pharmacol. 57:307–314.
  • Ihsan A, Wang X, Liu ZY, Huang XJ, Liu Y, Yu H, Zhang HF, Li TT, Yang CH, Yuan ZH. 2011. Longterm mequindox treatment induced endocrine and reproductive toxicity via oxidative stress in male Wistar rats. Toxicol Appl Pharmacol. 252:281–288.
  • Ihsan A, Wang X, Tu HG, Zhang W, Dai MH, Peng DP, Wang YL, Huang LL, Chen DM, Mannan SZ, et al. 2013b. Genotoxicity evaluation of mequindox in different shortterm tests. Food Chem Toxicol. 51:330–336.
  • Ihsan A, Wang X, Zhang W, Tu HG, Wang YL, Huang LL, Yuan ZH. 2013a. Genotoxicity of quinocetone, cyadox and olaquindox in vitro and in vivo. Food Chem Toxicol. 59:207–214.
  • James MG, Peter V, Emad EH, Dennis RG. 1993. Targeting anticancer drugs to the brain: physiologically pharmacokinetic model of oxantrazole following intraarterial administration to rat glioma-2 bearing rats. J Pharmacokinet Biopharm. 21:575–592.
  • Law FC. 1992. A physiologically based pharmacokinetic model of oxytetracycline for salmonids. J Vet Pharmacol Ther. 8:33–43.
  • Leavens TL, Tell LA, Clothier KA. 2012. Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats. J Vet Pharmacol Ther. 35:121–131.
  • Leavens TL, Tell LA, Kissell LW. 2014. Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus). Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 31:1506–1521.
  • Li J, Huang LL, Pan YH, Liu ZY, Chen DM, Wang X, Tao YF, Liu ZL, Yuan ZH. 2014b. Tissue depletion of quinocetone and its five major metabolites in pigs, broilers, and carp fed quinocetone premix. J Agric Food Chem. 62:10348–10356.
  • Li J, Huang LL, Wang X, Pan YH, Liu ZY, Chen DM, Tao YF, Wu QH, Yuan ZH. 2014a. Metabolic disposition and excretion of quinocetone in rats, pigs, broilers, and carp. Food Chem Toxicol. 69:109–119.
  • Li JY, Zhou XZ, Li JS, Zhao RC, Miao XL, Zhang JY. 2005. The pharmacokinetics of quinocetone in pigs. Zhongguo Shou Yao Zazhi. 39:1–3.
  • Liu Y, Huang LL, Wang YL, Yang B, Ishan A, Fang K, Peng DP, Liu ZL, Dai MH, Yuan ZH. 2010. Tissue depletion and concentration correlations between edible tissues and biological fluids of 3-amino-2-oxazolidinone in pigs fed with a furazolidone medicated feed. J Agric Food Chem. 58:6774–6779.
  • Liu YM. 2011. Pharmacokinetics and residual depletion of mequindox and its main metabolites in swine. Guangzhou: South China Agricultural University.
  • Liu ZY, Huang LL, Chen DM, Dai MH, Tao YF, Wang YL, Yuan ZH. 2010. Application of electrospray ionization hybrid ion trap/time-of-flight mass spectrometry in the rapid characterization of quinocetone metabolites formed in vitro. Anal Bioanal Chem. 396:1259–1271.
  • Mercer HD, Baggot JD, Sams RA. 1977. Application of pharmacokinetic methods to the drug residue profile. Environ Health Toxicol. 2:787–801.
  • Nestorov I. 2003. Whole body pharmacokinetic models. Clin Pharmacokinet. 42:883–908.
  • Riviere JE. 2011. Comparative pharmacokinetics: principles, techniques, and applications. 2nd ed. Ames (IA): Wiley-Blackwell.
  • Teeguarden JG, Waechter JM, Clewell HJ, Covington RR, Barton HA. 2005. Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding, and uterine tissue dose metrics of bisphenol A: a physiologically based pharmacokinetic approach. Toxicol Sci. 85:823–838.
  • Upton RN. 2008. Organ weights and blood flows of sheep and pig for physiological pharmacokinetic modeling. J Pharmacol Toxicol Methods. 58:198–205.
  • Wang X, Zhang W, Wang YL, Peng DP, Ihsan A, Huang XJ, Yuan ZH. 2010. Acute and sub-chronic oral toxicological evaluations of quinocetone in Wistar rats. Regul Toxicol Pharmacol. 58:421–427.
  • Wang YY, Fang BF, Fan WD, Wang L. 2012. Pharmacokinetics of quinocetone and its major metabolites in swines. Zhongguo Xu Mu Shou Yi. 39:213–216.
  • World Health Organization (WHO). 2010. Characterization and application of physiologically based pharmacokinetic models in risk assessment. Geneva: World Health Organization; p. 21–37.
  • Xu LG, Zhao W, Li JQ, Huang J, Liao YQ. 2003. The treatment of mequindox on swine dysentery. Zhongguo Shou Yi Za Zhi. 39:278.
  • Xu N, Huang LL, Liu ZY, Pan YH, Wang X, Yuan ZH. 2011. Metabolism of cyadox by the intestinal mucosa microsomes and gut flora of swine, and identification of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 25:2333–2344.
  • Yang B, Huang LL, Fang K, Yuan ZH. 2013a. A physiologically based pharmacokinetic model for the prediction of the depletion of methyl-3-quinoxaline-2-carboxylic acid, the marker residue of olaquindox, in the edible tissues of pigs. J Vet Pharmacol Ther. 37:66–82.
  • Yang B, Huang LL, Wang YL, Liu Y, Tao YF, Chen DM, Liu ZL, Fang K, Chen YP, Yuan ZH. 2010. Residue depletion and tissue-plasma correlation of methyl-3-quinoxaline-2-carboxylic acid after dietary administration of olaquindox in pigs. J Agric Food Chem. 58:937–942.
  • Yang F, Huang XH, Li GH. 2013b. Estimating tulathromycin withdrawal time in pigs using a physiologically based pharmacokinetics model. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30:1255–1263.
  • Yang F, Liu HW, Li M. 2012a. Use of a Monte Carlo analysis within a physiologically based pharmacokinetic model to predict doxycycline residue withdrawal time in edible tissues in swine. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 29:73–81.
  • Yang F, Sun N, Liu YM. 2014b. Estimating danofloxacin withdrawal time in broiler chickens based on physiologically based pharmacokinetics modeling. J Vet Pharmacol Ther. 38:174–182.
  • Yang F, Sun N, Sun YX. 2012b. A physiologically based pharmacokinetics model for florfenicol in crucian carp and oral-to-intramuscular extrapolation. J Vet Pharmacol Ther. 36:192–200.
  • Yang F, Yang YR, Wang L. 2014c. Estimating marbofloxacin withdrawal time in broiler chickens using a population physiologically based pharmacokinetics model. J Vet Pharmacol Ther. 38:1–10.
  • Yang W, Fu J, Xiao X, Yan H, Bao W, Wang D, Hao LP, Liu LG. 2013c. Quinocetone triggers oxidative stress and induces cytotoxicity and genotoxicity in human peripheral lymphocytes of both genders. J Sci Food Agric. 93:1317–1325.
  • Yang X, Zhou YF, Yu Y. 2014a. A physiologically based pharmacokinetic model for quinoxaline-2-carboxylic acid in rats, extrapolation to pigs. J Vet Pharmacol Ther. 38:55–64.
  • Young JF, Wosilait WD, Lueche RH. 2001. Analysis of methylmercury disposition in humans utilizing a PBPK model and animal pharmacokinetic data. J Toxicol Environ Health A. 63:19–52.
  • Yu M, Xu MJ, Liu Y, Yang W, Rong Y, Liu LG. 2013. Nrf2/ARE is the potential pathway to protect Sprague-Dawley rats against oxidative stress induced by quinocetone. Regul Toxicol Pharmacol. 66:279–285.
  • Yuan LG, Luo XY, Zhu LX. 2011. A physiologically based pharmacokinetic model for valnemulin in rats and extrapolation to pigs. J Vet Pharmacol Ther. 34:224–231.
  • Zhang HH, Wang X, Huang LL, Pan YH, Yuan ZH. 2015. Deoxidation rates play a critical role in DNA damage mediated by important synthetic drugs, quinoxaline 1, 4-dioxides. Chem Res Toxicol. 28:470–481.
  • Zhong JL, Wang L, Zhao N, Yu HM, Jia HQ, Lu XX, Wu ZY, Ding HZ. 2012. Study on residue depletion of quinocetone and its major metabolites in swine. Hua Nan Nong Ye Da Xue Xue Bao. 33:248–252.
  • Zhou X. 2012. Physiologically based pharmacokinetic model for the marker residue of cyadox in pigs. Wuhan: Huazhong Agricultural University.

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