604
Views
24
CrossRef citations to date
0
Altmetric
Original Articles

Assessment of aflatoxin exposure among young children in Ethiopia using urinary biomarkers

, , , , &
Pages 1606-1616 | Received 26 Apr 2017, Accepted 19 Jun 2017, Published online: 10 Jul 2017

References

  • Abia WA, Warth B, Sulyok M, Krska R, Tchana A, Njobeh PB, Turner PC, Kouanfack C, Eyongetah M, Dutton M, et al. 2013. Bio-monitoring of mycotoxin exposure in Cameroon using a urinary multi-biomarker approach. Food Chem Toxicol. 62:927–934.
  • Adejumo O, Atanda O, Raiola A, Somorin Y, Bandyopadhyay R, Ritieni A. 2013. Correlation between aflatoxin M 1 content of breast milk, dietary exposure to aflatoxin B 1 and socioeconomic status of lactating mothers in Ogun State, Nigeria. Food Chem Toxicol. 56:171–177.
  • Ali N, Hossain K, Blaszkewicz M, Rahman M, Mohanto NC, Alim A, Degen GH. 2016. Occurrence of aflatoxin M1 in urines from rural and urban adult cohorts in Bangladesh. Arch Toxicol. 90:1749-1755.
  • Arcella D, Leclercq C. 2004. Modelling exposure to mycotoxins. New York, Cambridge, England: Mycotoxins in Food, Detection and Control. CRC Press, Woodhead Publishing Ltd; p. 32–48.
  • Atasever M, Yildirim Y, Atasever M, Tastekin A. 2014. Assessment of aflatoxin M1 in maternal breast milk in Eastern Turkey. Food Chem Toxicol. 66:147–149.
  • Beyene AA, Woldegiorgis AZ, Adish AA, de Saeger S, Tolossa AL. 2016. Assessment of mothers’ knowledge and practice towards aflatoxin contamination in complementary foods in Ethiopia: from pre-harvest to household. World Mycotoxin J. 9:535–544.
  • Boonen J, Malysheva SV, Taevernier L, di Mavungu JD, de Saeger S, de Spiegeleer B. 2012. Human skin penetration of selected model mycotoxins. Toxicology. 301:21–32.
  • Cardwell KF, Henry SH. 2004. Risk of exposure to and mitigation of effect of aflatoxin on human health: a west african example. J Toxicol-Toxin Rev. 23:217-247.
  • [CSA] Central Statistical Agency. 2014. Ethiopia mini demographic and health survey 2014. Ethiopia: Addis Ababa.
  • Ediage EN, di Mavungu JD, Song S, Sioen I, De Saeger S. 2013. Multimycotoxin analysis in urines to assess infant exposure: a case study in Cameroon. Environ Int. 57:50–59.
  • Ediage EN, di Mavungu JD, Song S, Wu A, van Peteghem C, de Saeger S. 2012. A direct assessment of mycotoxin biomarkers in human urine samples by liquid chromatography tandem mass spectrometry. Anal Chim Acta. 741:58–69.
  • EU Commission. 2002. Commission Decision EC 2002/657 of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. Off Journal Eur Communities. L221:8-36.
  • EU Commission. 2006. Commission Regulation (EC) No 401/2006. Laying down the methods of sampling and analysis for the official control of the levels of mycotoxins in foodstuffs. Off Journal Eur Communities. L:70:12.
  • Ezekiel CN, Warth B, Ogara IM, Abia WA, Ezekiel VC, Atehnkeng J, Sulyok M, Turner PC, Tayo GO, Krska R, et al. 2014. Mycotoxin exposure in rural residents in northern Nigeria: a pilot study using multi-urinary biomarkers. Environ Int. 66:138–145.
  • Gong Y, Hounsa A, Egal S, Turner PC, Sutcliffe AE, Hall AJ, Cardwell K, Wild CP. 2004. Postweaning exposure to aflatoxin results in impaired child growth: A longitudinal study in Benin, West Africa. Environ Health Perspect. 112:1334–1338.
  • Gong YY, Cardwell K, Hounsa A, Egal S, Turner PC, Hall AJ, Wild CP. 2002. Dietary aflatoxin exposure and impaired growth in young children from Benin and Togo: cross sectional study. Bmj. 325:20–21.
  • Gong YY, Watson S, Routledge MN. 2016. Aflatoxin exposure and associated human health effects, a review of epidemiological studies. Food Saf. 4:14–27.
  • Hatem NL, Hassab HM, Al-Rahman EMA, El-Deeb SA, Ahmed RLES. 2005. Prevalence of aflatoxins in blood and urine of Egyptian infants with protein–energy malnutrition. Food Nutr Bull. 26:49–56.
  • [IARC] International Agency for Research on Cancer. 2016. New IARC report urges action against widespread mycotoxin contamination in developing countries. Lyon: IARC, Press release N0 242.
  • Iha MH, Barbosa CB, Heck AR, Trucksess MW. 2014. Aflatoxin M1 and ochratoxin A in human milk in Ribeirão Preto-SP, Brazil. Food Con. 40:310–313.
  • Jolly PE, Akinyemiju TF, Jha M, Aban I, Gonzalez-Falero A, Joseph D. 2015. Temporal variation and association of aflatoxin B1 albumin-adduct levels with socio-economic and food consumption factors in HIV positive adults. Toxins. 7:5129–5140.
  • Kirk GD, Turner PC, Gong Y, Lesi OA, Mendy M, Goedert JJ, Hall AJ, Whittle H, Hainaut P, Montesano R, et al. 2005. Hepatocellular carcinoma and polymorphisms in carcinogen-metabolizing and DNA repair enzymes in a population with aflatoxin exposure and hepatitis B virus endemicity. Cancer Epidemiol Biomarkers Prev. 14:373–379.
  • Kuiper-Goodman T. 1999. Approaches to the risk analysis of mycotoxins in the food supply. Food Nutr Agric. 23:10-16.
  • Makri A, Goveia M, Balbus J, Parkin R. 2004. Children’s susceptibility to chemicals: a review by developmental stage. J Toxicol Environ Health B. 7:417–435.
  • Mykkanen H, Zhu H, Salminen E, Juvonen RO, Ling W, Ma J, Polychronaki N, Kemilainen H, Mykkanen O, Salminen S, et al. 2005. Fecal and urinary excretion of aflatoxin B1 metabolites (AFQ1, AFM1 and AFB‐N7‐guanine) in young Chinese males. Int J Cancer. 115:879–884.
  • Omer RE, Kuijsten A, Kadaru AM, Kok FJ, Idris MO, El Khidir IM, Van’t Veer P. 2004. Population-attributable risk of dietary aflatoxins and hepatitis B virus infection with respect to hepatocellular carcinoma. Nutr Cancer. 48:15–21.
  • Piekkola S, Turner PC, Abdel-Hamid M, Ezzat S, El-Daly M, El-Kafrawy S, Savchenko E, Poussa T, Woo JCS, Mykkanen H, et al. 2012. Characterisation of aflatoxin and deoxynivalenol exposure among pregnant Egyptian women. Food Addit Contam Part A. 29:962–971.
  • Polychronaki N, Turner PC, Mykkänen H, Gong Y, Amra H, Abdel-Wahhab M, El-Nezami H. 2006. Determinants of aflatoxin M1 in breast milk in a selected group of Egyptian mothers. Food Addit Contam. 23:700–708.
  • Polychronaki N, West RM, Turner PC, Amra H, Abdel-Wahhab M, Mykkänen H, El-Nezami H. 2007. A longitudinal assessment of aflatoxin M1 excretion in breast milk of selected Egyptian mothers. Food Chem Toxicol. 45:1210–1215.
  • Polychronaki N, Wild CP, Mykkänen H, Amra H, Abdel-Wahhab M, Sylla A, Diallo M, El-Nezami H, Turner PC. 2008. Urinary biomarkers of aflatoxin exposure in young children from Egypt and Guinea. Food Chem Toxicol. 46:519–526.
  • Schleicher RL, McCoy LF, Powers CD, Sternberg MR, Pfeiffer CM. 2013. Serum concentrations of an aflatoxin-albumin adduct in the National Health and Nutrition Examination Survey (NHANES) 1999–2000. Clinica Chimica Acta. 423:46–50.
  • Schwartzbord JR, Leroy JL, Severe L, Brown DL. 2016. Urinary aflatoxin M1 in Port-au-Prince and a rural community in northeast Haiti. Food Addit Contam Part A. 33:1036–1042.
  • Sharma RA, Farmer PB. 2004. Biological relevance of adduct detection to the chemoprevention of cancer. Clin Cancer Res. 10:4901–4912.
  • Shephard GS, Burger HM, Gambacorta L, Gong YY, Krska R, Rheeder JP, Warth B. 2013. Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa. Food Chem Toxicol. 62:217–225.
  • Song S, Ediage EN, Wu A, De Saeger S. 2013. Development and application of salting-out assisted liquid/liquid extraction for multi-mycotoxin biomarkers analysis in pig urine with high performance liquid chromatography/tandem mass spectrometry. J Chromatogr A. 1292:111–120.
  • Tang L, Tang M, Xu L, Luo H, Huang T, Yu J, Zhang L, Gao W, Cox SB, Wang J-S. 2008. Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention. Carcinogenesis. 29:411–417.
  • Terry MB, Susser E. 2001. Commentary: the impact of fetal and infant exposures along the life course. Int J Epidemiol. 30:95–96.
  • Turner PC. 2013. The molecular epidemiology of chronic aflatoxin driven impaired child growth. Scientifica. 2013:1-21.
  • Turner PC, Collinson AC, Cheung YB, Gong Y, Hall AJ, Prentice AM, Wild CP. 2007. Aflatoxin exposure in utero causes growth faltering in Gambian infants. Int J Epidemiol. 36:1119–1125.
  • Turner PC, Flannery B, Isitt C, Ali M, Pestka J. 2012. The role of biomarkers in evaluating human health concerns from fungal contaminants in food. Nutr Res Rev. 25:162–179.
  • Turner PC, Mendy M, Whittle H, Fortuin M, Hall AJ, Wild CP. 2000. Hepatitis B infection and aflatoxin biomarker levels in Gambian children. Trop Med Int Health. 5:837–841.
  • Turner PC, Moore SE, Hall AJ, Prentice AM, Wild CP. 2003. Modification of immune function through exposure to dietary aflatoxin in Gambian children. Environ Health Perspect. 111:217–220.
  • Wang J, Huang T, Su J, Liang F, Wei Z, Liang Y, Luo H, Kuang S, Qian G, Sun G, et al. 2001. Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People’s Republic of China. Cancer Epidemiol Biomarkers Prev. 10:143–146.
  • Watson S, Chen G, Sylla A, Routledge MN, Gong YY. 2016. Dietary exposure to aflatoxin and micronutrient status among young children from Guinea. Mol Nutr Food Res. 60:511–518.
  • WHO. 2006. WHO child growth standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age. Geneva, Switzerland: Methods and development department.
  • Wild CP, Gong PP. 2010. Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis. 31:71–82.
  • Wild CP, Miller JD, Groopman JD. 2015. Mycotoxin control in low- and middle-income countries. Lyon, France: International Agency for Research on Cancer (IARC Working Group Report No. 9.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.