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Food Additives & Contaminants: Part A Volume 35, 2018 - Issue 7
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Articles

Identification of a new type tadalafil analogue in a supplement product

Yen-Chun HuangChemical Lab, Super Laboratory Company Limited, New Taipei City, Taiwan (R.O.C)View further author information
,
Hui-Chun LeeDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan(R.O.C)Correspondence[email protected]
View further author information
,
Yun-Lian LinDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, Taiwan (R.O.C)View further author information
,
Chia-Fen TsaiDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan(R.O.C)View further author information
&
Hwei-Fang ChengDivision of Research and Analysis, Taiwan Food and Drug Administration, Taipei City, Taiwan(R.O.C)View further author information
Pages 1233-1237 | Received 11 Jan 2018, Accepted 13 Mar 2018, Published online: 30 May 2018

References

  • Abdel-Aziz AA-M, Asiri YA, El-Azab AS, Al-Omar MA, Kunieda T. 2011. Tadalafil. In: Brittain HG, editor. Profiles of drug substances, excipients, and related methodology. Amsterdam: Elsevier Inc.; p. 287–329.
  • Hasegawa T, Saijo M, Ishii T, Nagata T, Haishima Y, Kawahara N, Goda Y. 2008. Structural elucidation of a tadalafil analogue found in a dietary supplement. J Food Hyg Soc Jpn (Shokuhin Eiseigaku Zasshi). 49:311–315.
  • Huang Y-C, Lee H-C, Lin Y-L, Li C-Y, Tsai C-F, Cheng H-F. 2016a. Separation and identification of a novel tadalafil analogue adulterant in a dietary supplement. Food Addit Contam Part A. 33:179–185.
  • Huang Y-C, Lee H-C, Lin Y-L, Li C-Y, Tsai C-F, Cheng H-F. 2016b. Identification of a new tadalafil analogue, dipropylaminopretadalafil, in a dietary supplement food addit. Contam Part A. 33:953–958.
  • Kee C-L, Ge X, Gilard V, Malet-Martino M, Low M-Y. 2017. A review of synthetic phosphodiesterase type 5 inhibitors (PDE-5i) found as adulterants in dietary supplements. J Pharm Biomed Anal. 87:176–190.
  • Lin M-C, Liu Y-C, Lin Y-L, Lin J-H. 2009. Identification of a tadalafil analogue adulterated in a dietary supplement. J Food Drug Anal. 17:451–458.
  • [TFDA] Taiwan Food and Drug Administration. 2012. Method of test for adulterants in Chinese medicine and foods (no. TFDAO0015.01). [accessed 2012 Nov 23]. http://www.fda.gov.tw/upload/133/Content/2012112316074585170.pdf.
  • Zou P, Hou P, Low MY, Koh HL. 2006. Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product. Food Addit Contam. 23:446–451.

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