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Articles

A U.S. population dietary exposure assessment for 4-methylimidazole (4-MEI) from foods containing caramel colour and from formation of 4-MEI through the thermal treatment of food

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Pages 1890-1910 | Received 30 Apr 2018, Accepted 25 Jul 2018, Published online: 21 Aug 2018

References

  • [IPCS] International Programme on Chemical Safety. 2009. Environmental health criteria 240: principles and methods for the risk assessment of chemicals in food. Geneva: World Health Organization. p. 6–19 to 6–20. Chapter 6: Dietary Exposure Assessment of Chemicals in Food, Handling non-detects or non-quantified results.
  • Casal S, Fernandes JO, Oliveira MBPP, Ferreira MA. 2002. Gas chromatographic – mass spectrometric quantification of 4-(5-)-methylimidazole in roasted coffee after ion-pair extraction. J Chrom A. 976:285–291.
  • Choi SJ, Jung MY. 2017. Simple and fast sample preparation followed by gas chromatography-tandem mass spectrometry (GC-MS/MS) for the analysis of 2- and 4-methylimidazole in cola and dark beer. J Food Sci. 82:1044–1052.
  • Consumer Reports. 2014a. Consumer reports: caramel color: the health risk that may be in your soda. Last updated February 10, 2014. accessed 2018 Mar 13. https://www.consumerreports.org/cro/news/2014/01/caramel-color-the-health-risk-that-may-be-in-your-soda/index.htm
  • Consumer Reports. 2014b. Consumer reports: caramel color in pancake syrup may pose a health risk. Last updated April 28, 2014. accessed 2018 Mar 13. https://www.consumerreports.org/cro/news/2014/03/caramel-coloring-in-pancake-syrup/index.htm
  • Consumers Union. 2014. Citizen petition from consumers union et al. See docket number FDA-2014-P-1650-0001. www.regulations.gov.
  • [CSPI] Center for Science in the Public Interest. 2011. Citizen petition from center for science in the public interest (CSPI). See docket number FDA-2011-P-0407-0001. www.regulations.gov.
  • Cunha SC, Senra L, Cruz R, Casal S, Fernandes JO. 2016. 4-Methylimidazole in soluble coffee and coffee substitutes. Food Control. 63:15–20.
  • [EFSA] European Food Safety Authority. 2011. Scientific opinion on the re-evaluation of caramel colours (E150a,b,c,d) as food additives, EFSA panel on food additives and nutrient sources added to food (ANS). EFSA J. 9(3):2004.
  • European Commission. 2012 Mar 22. Commission regulation (EU) No. 231/2012 of 9 march 2012 laying down specifications for food additives listed in annexes II and III to regulation (EC) No 1333/2008 of the European Parliament and of the Council. Off J Eur Union. L 83:32–34.
  • United States Pharmacopeial Convention. 2016. Food chemicals codex, tenth edition. Monograph for caramel. Washington (DC).
  • Fierens T, Van Holderbeke M, Cornelis C, Jacobs G, Sioen I, De Maeyer M, Vinkx C, Vanermen G. 2018. Caramel colour and process contaminants in foods and beverages: part II - Occurrence data and exposure assessment of 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole (THI) and 4-methylimidazole (4-MEI) in Belgium. Food Chem. 255:372–379.
  • Hengel M, Shibamoto T. 2013. Carcinogenic 4 (5)-methylimidazolefound in beverages, sauces, and caramel colors: chemical properties, analysis, and biological activities. J Agric Food Chem. 61:780−789.
  • Jacobs G, Voorspoels S, Vloemans P, Fierens T, Van Holderbeke M, Cornelis C, Sioen I, De Maeyer M, Vinkx C, Vanermen G. 2018. Caramel colour and process by-products in foods and beverages: part I – Development of a UPLC-MS/MS isotope dilution method for determination of 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole (THI), 4-methylimidazole (4-MEI) and 2-methylimidazol (2-MEI). Food Chem. 255:348–356.
  • [JECFA] Joint FAO/WHO Expert Committee on Food Additives. 2011. Compendium of food additive specifications. FAO JECFA monographs 11. Monograph for caramel colours. Rome: Food and Agriculture Organization of the United Nations.
  • Lambe J, Kearney J, Leclercq C, Zunft HFJ, De Henauw S, Lamberg Allardt CJE, Dunne A, Gibney MJ. 2000. The influence of survey duration on estimates of food intakes and its relevance for public health nutrition and food safety issues. Eur J Clin Nutr. 54:166–173.
  • Lee S, Lee KG. 2016. Analysis and risk assessment of 4 (5)-methylimidazolein brown colored foods and beverages. Food Add Contam. 9:59–65.
  • Moon JK, Shibamoto T. 2011. Formation of carcinogenic 4 (5)-methylimidazolein maillard reaction systems. J Agric Food Chem. 59:615–618.
  • Mottier P, Mujahid C, Tarres A, Bressaire T, Stadler R. 2017. Process-induced formation of imidazoles in selected foods. Food Chem. 228:381–387.
  • [NTP] National Toxicology Program. 2007. National toxicology program (NTP, 2007). Toxicology and carcinogenesis studies of 4-methylimidazole (CAS No. 822-36-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). National toxicology program. Technical Report Series No. 535. NIH Publication No. 07-4471. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, 2007. https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr535.pdf.
  • Petruci J, Pereira E, Cardoso A. 2013. Determination of 2-methylimidazole and 4-methylimidazole in caramel colors by capillary electrophoresis. J Agric Food Chem. 61:2263–2267.
  • Schlee C, Markova M, Schrank J, Laplagne F, Schneider R, Lachenmeier DW. 2013. Determination of 2-methylimidazole, 4-methylimidazole and 2-acetyl-4-(1,2,3,4-tetrahydroxybutyl)imidazole in caramel colours and cola using LC/MS/MS. J Chom B. 927:223–226.
  • Smith TJS, Wolfson JA, Jiao D, Crupain MJ, Rangan U, Sapkota A, Bleich SN, Nachman KE. 2015. Caramel color in soft drinks and exposure to 4-methylimidazole: a quantitative risk assessment. PLOS One. doi:10.1371/journal.pone.0118138
  • Tzatzarakis M, Vakonaki E, Moti S, Alegakis A, Tsitsimpikou C, Tsakiris I, Goumenou M, Nosyrev AE, Rizoa AK, Tsatsakis AM. 2017. Quantification of 4-Methylimidazole in soft drinks, sauces and vinegars of Greek market using two liquid chromatography techniques. Food Chem Tox. 107:565–571.
  • Vollmuth T. 2018. Caramel color safety – an update. Food Chem Tox. 111:578–596.
  • Yamaguchi H, Masuda T. 2011. Determination of 4 (5)-methylimidazolein soy sauce and other foods by LC-MS/MS after solid-phase extraction. J Agric Food Chem. 59:9770–9775.

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