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Food Additives & Contaminants: Part A Volume 38, 2021 - Issue 7
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Articles

Development and validation of liquid chromatography-tandem mass spectrometry method for screening six selective androgen receptor modulators in dietary supplements

Ji Hyun Leea Center for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, Republic of KoreaView further author information
,
Ji Hye Hana Center for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, Republic of KoreaView further author information
,
Eun-Ju Junga Center for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, Republic of KoreaView further author information
,
Hari Krishna Nallapanenib College of Pharmacy, Kangwon National University, Chuncheon-si, Republic of KoreaView further author information
,
Nam Sook Kima Center for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, Republic of KoreaView further author information
,
Hyungil Kima Center for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, Republic of KoreaView further author information
,
Jongkook Leeb College of Pharmacy, Kangwon National University, Chuncheon-si, Republic of KoreaView further author information
&
Sun Young Baeka Center for Advanced Analysis, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, Republic of KoreaCorrespondence[email protected]
View further author information
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Pages 1075-1086 | Received 01 Feb 2021, Accepted 15 Mar 2021, Published online: 01 May 2021

References

  • Cox HD, Eichner D. 2017. Detection of LGD–4033 and its metabolites in athlete urine samples. Drug Test Anal. 9(1):127–134. doi:10.1002/dta.1986.
  • Da Fonseca GWP, Dworatzek E, Ebner N, Von Haehling S. 2020. Selective androgen receptor modulators (SARMs) as pharmacological treatment for muscle wasting in ongoing clinical trials. Expert Opin Investig Drugs. 8(29):881–891. doi:10.1080/13543784.2020.1777275.
  • Dalton JT, Mukherjee A, Zhu Z, Kirkovsky L, Miller DD. 2014. Discovery of nonsteroidal androgens. Biochem Biophys Res Commun. 244(1):1–4. doi:10.1006/bbrc.1998.8209.
  • Dmitrieva EV, Temerdashev AZ, Azaryan AA, Gashimova EM. 2018. Determination of andarine (S–4), a selective androgen receptor modulator, and ibutamoren (MK–677), a nonpeptide growth hormone secretagogue, in urine by ultra–high performance liquid chromatography with tandem mass–spectrometric detection. J Anal Chem. 73(7):674–678. doi:10.1134/S1061934818070031.
  • Gadaj A, Ventura E, Healy J, Botrè F, Sterk SS, Buckley T, Mooney MH. 2020. Enhanced UHPLC–MS/MS screening of selective androgen receptor modulators following urine hydrolysis. MethodsX. 7:100926. doi:10.1016/j.mex.2020.100926.
  • Grata E, Perrenoud LT, Saugy M, Baume N. 2011. SARM–S4 and metabolites detection in sports drug testing: a case report. Forensic Sci Int. 213:104–108. doi:10.1016/j.forsciint.2011.07.014.
  • International conference on harmonization, Harmonized Tripartite Guideline. 2005. Validation of analytical procedures: text and methodology Q2(R1). London, United States: European Medicines Agency (EIMA).
  • Kanno Y, Kusakabe T, Saito N, Kikkawa S, Takahashi K, Azumaya I, Nemoto K, Kato K. 2020. Improved synthesis and determination of the biologically active diastereomer of YK11. Molbank. 2020(2):M1125. doi:10.3390/M1125.
  • Kintz P, Ameline A, Gheddar L, Raul JS. 2019. LGD–4033, S–4 and MK–2866 – testing for SARMs in hair: about 2 doping cases. Toxicol anal Clin. 31:56–63. doi:10.1016/j.toxac.2018.12.001.
  • Leaney AE, Beck P, Biddle S, Brown P, Grace PB, Hudson SC, Mawson DH. 2020. Analysis of supplements available to UK consumers purporting to contain selective androgen receptor modulators. Drug Test Anal. 13(1):122–127. doi:10.1002/dta.2908.
  • Moschou IC, Dasenaki ME, Thomaidis NS. 2019. Ionization study and simultaneous determination of avermectins and milbemycines in fish tissue by LC-ESI-MS/MS. J Chromatogr B. 1104:134–140. doi:10.1016/j.jchromb.2018.11.017.
  • Narayanan R, Coss CC, Dalton JT. 2018. Development of selective androgen receptor modulators (SARMs). Mol Cell Endocrinol. 465(15):134–142. doi:10.1016/j.mce.2017.06.013.
  • Negro–Vilar A. 1999. Selective androgen receptor modulator (SARMs): a novel approach to androgen therapy for the new millennium. J Clin Endocrinol Metab. 84(10):3459–3462. doi:10.1210/jcem.84.10.6122.
  • Sobolevsky T, Dikunets M, Sukhanova I, Virus E, Rodchenkov G. 2012. Detection of PPARδ agonists GW1516 and GW0742 and their metabolites in human urine. Drug Test Anal. 4(10):754–760. doi:10.1002/dta.1413.
  • Starcevic B, Ahrens BD, Butch AW. 2013. Detection of the selective androgen receptor modulator S–4 (Andarine) in a doping control sample. Drug Test Anal. 5(5):377–379. doi:10.1002/dta.1466.
  • Thevis M, Beuck S, Thomas A, Kortner B, Kohler M, Rodchenkov G, Schänzer W. 2009. Doping control analysis of emerging drugs in human plasma – identification of GW501516, S–107, JTV–519, and S–40503. Rapid Commun Mass Spectrom. 23:1139–1146. doi:10.1002/rcm.3987.
  • Thevis M, Piper T, Dib J, Lagojda A, Kühne D, Packschies L, Geyer H, Schänzer W. 2017. Mass spectrometric characterization of the selective androgen receptor modulator (SARM) YK–11 for doping control purposes. Rapid Commun Mass Spectrom. 31(14):1175–1183. doi:10.1002/rcm.7886.
  • Van Wagoner RM, Eichner A, Bhasin S, Deuster PA, Eichner D. 2017. Chemical composition and labeling of substances marketed as selective androgen receptor modulators and sold via the internet. JAMA. 318(20):2004–2010. doi:10.1001/jama.2017.17069.
  • World Anti-Doping Agency. 2008. The World Anti-Doping Code. The 2008 prohibited list, International Standard. Montreal, Canada.
  • World Anti-Doping Agency. 2018. The World Anti-Doping Code. The 2018 prohibited list, International Standard. Montreal, Canada.
  • World Anti-Doping Agency. 2019. The World Anti-Doping Code. The 2019 prohibited list, International Standard. Montreal, Canada.
  • Zhang X, Sui Z. 2013. Deciphering the selective androgen receptor modulators paradigm. Expert Opin Drug Discov. 8(2):191–218. doi:10.1517/17460441.2013.741582.

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