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Articles

Quantitative analysis and carcinogenic/non-carcinogenic risk assessment of aflatoxin M1 in milk-based baby food and infant formula milk – a case study in Iran

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Pages 1604-1618 | Received 08 Apr 2022, Accepted 22 Jun 2022, Published online: 20 Jul 2022

References

  • Abd Alla A, Neamat-Allah A, Aly SE. 2000. Situation of mycotoxins in milk, dairy products and human milk in Egypt. Mycotoxin Res. 16(2):91–100.
  • Akhtar S, Shahzad MA, Yoo SH, Ismail A, Hameed A, Ismail T, Riaz M. 2017. Determination of aflatoxin M1 and heavy metals in infant formula milk brands available in Pakistani markets. Korean J Food Sci Anim Resour. 37(1):79–86. doi:10.5851/kosfa.2017.37.1.79
  • Alonso V, Monge M, Larriestra A, Dalcero A, Cavaglieri L, Chiacchiera S. 2010. Naturally occurring aflatoxin M1 in raw milk from farm cooling tanks in Argentina. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 27(3):373–379. doi:10.1080/19440040903403362
  • Alvito PC, Sizoo EA, Almeida CM, Van Egmond HP. 2010. Occurrence of aflatoxins and ochratoxin A in baby foods in Portugal. Food Anal Methods. 3(1):22–30. doi:10.1007/s12161-008-9064-x
  • Awaisheh SS, Rahahleh RJ, Algroom RM, Al-Bakheit AA, Al-Khazaleh JF, Al-Dababseh BA. 2019. Contamination level and exposure assessment to Aflatoxin M1 in Jordanian infant milk formulas. Ital J Food Saf. 8:8263.
  • Baker P, Smith J, Salmon L, Friel S, Kent G, Iellamo A, Dadhich JP, Renfrew MJ. 2016. Global trends and patterns of commercial milk-based formula sales: is an unprecedented infant and young child feeding transition underway. Public Health Nutr. 19(14):2540–2550. doi:10.1017/S1368980016001117
  • Bakirci I. 2001. A study on the occurrence of aflatoxin M1 in milk and milk products produced in Van province of Turkey. Food Control. 12(1):47–51. doi:10.1016/S0956-7135(00)00020-7
  • Baydar T, Erkekoglu P, Sipahi H, Sahin G. 2007. Aflatoxin B1, M1 and ochratoxin a levels in infant formulae and baby foods marketed in Ankara, Turkey. J Food Drug Anal. 15:89–92.
  • Cano-Sancho G, Marin S, Ramos AJ, Peris-Vicente J, Sanchis V. 2010. Occurrence of aflatoxin M1 and exposure assessment in Catalonia (Spain). Rev Iberoam Micol. 27(3):130–135. doi:10.1016/j.riam.2010.05.003
  • Commission Regulation (EC). 2006. Laying down the methods of sampling and analysis for the official control of the levels of mycotoxins in foodstuffs No 401/2006. Official Journal of the European Union (OJEU). [accessed 23 February 2006]. https://eur-lex.europa.eu/legalcontent/EN/TXT/PDF/?uri=CELEX:32006R0401&from=EN/.
  • European Food Safety Authority (EFSA) Scientific Committee. 2005. Opinion of the scientific committee on a request from EFSA related to A harmonised approach for risk assessment of substances which are both genotoxic and carcinogenic. EFSA J. 282:1–31.
  • Elaridi J, Dimassi H, Hassan H. 2019. Aflatoxin M1 and ochratoxin A in baby formulae marketed in Lebanon: occurrence and safety evaluation. Food Control. 106:106680. doi:10.1016/j.foodcont.2019.06.006
  • El-Tras WF, El-Kady NN, Tayel AA. 2011. Infants exposure to aflatoxin M1 as a novel foodborne zoonosis. Food Chem Toxicol. 49(11):2816–2819. doi:10.1016/j.fct.2011.08.008
  • Er B, Demirhan B, Yentür G. 2014. Investigation of aflatoxin M1 levels in infant follow-on milks and infant formulas sold in the markets of Ankara, Turkey. J Dairy Sci. 97(6):3328–3331.
  • Fakhri Y, Ghorbani R, Taghavi M, Keramati H, Amanidaz N, Moradi B, Nazari SH, Shariatifar N, Khaneghah AM. 2019. Concentration and prevalence of aflatoxin M1 in human breast milk in Iran: systematic review, meta-analysis, and carcinogenic risk assessment: a review. J Food Prot. 82(5):785–795. doi:10.4315/0362-028X.JFP-18-367
  • Food and Drug Administration (FDA), Compliance Policy Guide (CPG). 2005. CPG Sec. 527.400 whole milk, low fat milk, skim milk-aflatoxin M1. FDA. [accessed 20 October 2019]. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/cpg-sec-527400-wholemilk-lowfat-milk-skim-milk-aflatoxin-m1/.
  • García-Moraleja A, Font G, Mañes J, Ferrer E. 2015. Analysis of mycotoxins in coffee and risk assessment in Spanish adolescents and adults. Food Chem Toxicol. 86:225–233. doi:10.1016/j.fct.2015.10.014
  • Ghaffarian Bahraman A, Mohammadi S, Jafari A, Ghani-Dehkordid J, Arabnezhad MR, Rahmdel S, Hosseini Teshnizi S. 2020. Occurrence of aflatoxin M1 in milks of five animal species in Iran: a systematic review and meta-analysis. Food Rev Int. 36(7):692–712. doi:10.1080/87559129.2019.1669164
  • Ghanem I, Orfi M. 2009. Aflatoxin M1 in raw, pasteurized and powdered milk available in the Syrian market. Food Control. 20(6):603–605. doi:10.1016/j.foodcont.2008.08.018
  • Guo LY, Zheng N, Zhang YD, Du RH, Zheng BQ, Wang JQ. 2016. A survey of seasonal variations of aflatoxin M1 in raw milk in Tangshan region of China during 2012–2014. Food Control. 69:30–35. doi:10.1016/j.foodcont.2016.03.017
  • Heshmati A, Milani JM. 2010. Contamination of UHT milk by aflatoxin M1 in Iran. Food Control. 21(1):19–22. doi:10.1016/j.foodcont.2009.03.013
  • Hooshfar S, Khosrokhavar R, Yazdanpanah H, Eslamizad S, Kobarfard F, Nazari F, Kokaraki V, Kokkinakis M, Goumenou M, Tsitsimpikou C, et al. 2020. Health risk assessment of aflatoxin M1 in infant formula milk in IR Iran. Food Chem Toxicol. 142:111455. doi:10.1016/j.fct.2020.111455
  • Ishikawa AT, Takabayashi-Yamashita CR, Ono E, Bagatin AK, Rigobello FF, Kawamura O, Hirooka EY, Itano EN. 2016. Exposure assessment of infants to aflatoxin M1 through consumption of breast milk and infant powdered milk in Brazil. Toxins. 8(9):246. doi:10.3390/toxins8090246
  • The Institute of Standards and Industrial Research of Iran (ISIRI). 2020. Food and feed- maximum tolerated level of mycotoxins. ISIRI.No. 5925. p. 11. http://standard.isiri.gov.ir/StandardView.aspx?Id=53664.
  • The Institute of Standards and Industrial Research of Iran (ISIRI). 2002. Maximum tolerated limits of mycotoxins in foods and feeds. ISIRI. No. A1-5925. p. 1. http://standard.isiri.gov.ir/StandardView.aspx?Id=12991.
  • Joint Food and Agriculture Organization of the United Nations (FAO). 2017. World Health Organization, WHO Expert Committee on Food Additives. Evaluation of certain contaminants in food: eighty-third report of the Joint FAO/WHO Expert Committee on Food Additives. Geneva, Switzerland: World Health Organization.
  • Juan C, Raiola A, Mañes J, Ritieni A. 2014. Presence of mycotoxin in commercial infant formulas and baby foods from Italian market. Food Control. 39:227–236. doi:10.1016/j.foodcont.2013.10.036
  • Kabak B. 2012. Aflatoxin M1 and ochratoxin A in baby formulae in Turkey: occurrence and safety evaluation. Food Control. 26(1):182–187. doi:10.1016/j.foodcont.2012.01.032
  • Kamkar A. 2008. Detection of aflatoxin M1 in powdered milk samples by ELISA. Pajouhesh Sazandegi. 21:174–180.
  • Kanungo L, Bhand S. 2014. A survey of Aflatoxin M1 in some commercial milk samples and infant formula milk samples in Goa, India. Food Agric Immunol. 25(4):467–476. doi:10.1080/09540105.2013.837031
  • Khaneghahi Abyaneh H, Bahonar A, Noori N, Yazdanpanah H, Shojaee AliAbadi MH. 2020. Shojaee AliAbadi MH. 2020. The overall and variations of Aflatoxin M1 contamination of milk in Iran: a systematic review and meta-analysis study. Food Chem. 310:125848. doi:10.1016/j.foodchem.2019.125848
  • Kuiper-Goodman T. 1990. Uncertainties in the risk assessment of three mycotoxins: aflatoxin, ochratoxin, and zearalenone. Can J Physiol Pharmacol. 68(7):1017–1024. − doi:10.1139/y90-155
  • Li S, Min L, Wang G, Li D, Zheng N, Wang J. 2018. Occurrence of aflatoxin M1 in raw milk from manufacturers of infant milk powder in China. Int J Environ Res Public Health. 15(5):879. doi:10.3390/ijerph15050879
  • Londoño VA, Boasso AC, de Paula MC, Garcia LP, Scussel VM, Resnik S, Pacín A. 2013. Aflatoxin M1 survey on randomly collected milk powder commercialized in Argentina and Brazil. Food Control. 34(2):752–755. doi:10.1016/j.foodcont.2013.06.030
  • Maki CR, Haney S, Wang M, Ward SH, Bailey RH. 2017. Calcium montmorillonite clay for the reduction of atoxin residues in milk and dairy products. Dairy and Vet Sci J. 2(3):555587.
  • Maki CR, Haney S, Wang M, Ward SH, Rude BJ, Bailey RH, Harvey RB, Phillips TD. 2017. Calcium montmorillonite clay for the reduction of aflatoxin residues in milk and dairy products. J Dairy Vet Sci. 2(3):555587.
  • Meucci V, Razzuoli E, Soldani G, Massart F. 2010. Mycotoxin detection in infant formula milks in Italy. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 27(1):64–71. doi:10.1080/02652030903207201
  • Noori N, Karim G, Raeesian M, Khaneghahi AH, Bahonar A, Akhondzadeh BA, Ghadami F. 2013. Antibiotic residues and aflatoxin M1 contamination in milk powder used in Tehran dairy factories. Iran. Iran J Vet Med. 7:221–226.
  • Omar SS. 2016. Aflatoxin M1 levels in raw milk, pasteurised milk and infant formula. Ital J Food Saf. 5:158–160.
  • Oveisi MR, Jannat B, Sadeghi N, Hajimahmoodi M, Nikzad A. 2007. Presence of aflatoxin M1 in milk and infant milk products in Tehran, Iran. Food Control. 18(10):1216–1218. doi:10.1016/j.foodcont.2006.07.021
  • Pardakhti A, Maleki S. 2019. Risk assessment of Aflatoxin M1 contamination of milk in Iran. Int J Environ Res. 13(2):265–271. doi:10.1007/s41742-019-00172-1
  • Pirsaheb M, Fattahi N, Rahimi R, Sharafi K, Ghaffari HR. 2017. Evaluation of abamectin, diazinon and chlorpyrifos pesticide residues in apple product of Mahabad region gardens: Iran in 2014. Food Chem. 231:148–155. doi:10.1016/j.foodchem.2017.03.120
  • Pirsaheb M, Hadei M, Sharafi K. 2021. Human health risk assessment by Monte Carlo simulation method for heavy metals of commonly consumed cereals in Iran-Uncertainty and sensitivity analysis. J Food Compost Anal. 96:103697. doi:10.1016/j.jfca.2020.103697
  • Pour SH, Mahmoudi S, Masoumi S, Rezaie S, Barac A, Ranjbaran M, Oliya S, Mehravar F, Sasani E, Noorbakhsh F, et al. 2020. Aflatoxin M1 contamination level in Iranian milk and dairy products: a systematic review and meta-analysis. World Mycotoxin J. 13(1):67–82. doi:10.3920/WMJ2019.2485
  • Quevedo-Garza PA, Amador-Espejo GG, Salas-García R, Ramos-Peña EG, Trujillo AJ. 2020. Aflatoxin M1 determination in infant formulae distributed in Monterrey, Mexico. Toxins. 12(2):100. doi:10.3390/toxins12020100
  • Rastogi S, Dwivedi PD, Khanna SK, Das M. 2004. Detection of aflatoxin M1 contamination in milk and infant milk products from Indian markets by ELISA. Food Control. 15(4):287–290. doi:10.1016/S0956-7135(03)00078-1
  • Rostami-Javanroudi S, Moradi M, Sharafi K, Fattahi N. 2021. Novel hydrophobic deep eutectic solvent for vortex-assisted liquid phase microextraction of common acaricides in fruit juice followed by HPLCUV determination. RSC Adv. 11(48):30102–30108. doi:10.1039/d1ra04781g
  • Ruangwises N, Saipan P, Ruangwises S. 2011. Estimated daily intake of AFM1 in Thailand. In: Guevara-Gonzalez R, editor. Aflatoxins– biochemistry and molecular biology. Rijeka, Croatia: In Tech; p. 439–446.
  • Scaglioni PT, Becker-Algeri T, Drunkler D, Badiale-Furlong E. 2014. Aflatoxin B1 and M1 in milk. Anal Chim Acta. 829:68–74. doi:10.1016/j.aca.2014.04.036
  • Sharafi K, Karami Matin B, Omer AK, Mansouri B, Soleimani H, Fattahi N, Sharafi H, Kiani A. 2022. A worldwide systematic literature review for aflatoxin M1 in infant formula milk: human health risk assessment by Monte Carlo simulation. Food Control. 134:108681. doi:10.1016/j.foodcont.2021.108681
  • Shuib NS, Saad B. 2022. In-syringe dispersive micro-solid phase extraction method for the HPLC-fluorescence determination of aflatoxins in milk. Food Control. 132:108510. doi:10.1016/j.foodcont.2021.108510
  • Tola M, Kebede B. 2016. Occurrence, importance and control of mycotoxins: a review. Cogent Food Agric. 2:1–12.
  • Tsakiris IN, Tzatzarakis MN, Alegakis AK, Vlachou MI, Renieri EA, Tsatsakis AM. 2013. Risk assessment scenarios of children’s exposure to aflatoxin M1 residues in different milk types from the Greek market. Food Chem Toxicol. 56:261–265. doi:10.1016/j.fct.2013.02.024
  • Udovicki B, Djekic I, Kalogianni EP, Rajkovic A. 2019. Exposure assessment and risk characterization of Aflatoxin M1 intake through consumption of milk and yoghurt by student population in Serbia and Greece. Toxins. 11(4):205. doi:10.3390/toxins11040205
  • US Food and Drug Administration (USFDA). 2001. Guidance for industry: bioanalytical method validation.

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