Advanced search
Publication Cover
Food Additives & Contaminants: Part A Volume 40, 2023 - Issue 4
Submit an article Journal homepage
195
Views
0
CrossRef citations to date
0
Altmetric
Articles

Analysis of N-nitrosamines and N-nitrosatable substances from baby bottle rubber teats by liquid chromatography tandem mass spectrometry

Joung Boon Hwanga National Institute of Food and Drug Safety Evaluation, Food Additives and Packaging Division, Cheongju, South KoreaView further author information
,
Jung Eun Leea National Institute of Food and Drug Safety Evaluation, Food Additives and Packaging Division, Cheongju, South KoreaView further author information
,
Eunbi Kima National Institute of Food and Drug Safety Evaluation, Food Additives and Packaging Division, Cheongju, South KoreaView further author information
,
Kwon Yong Eomb Korea Food and Drug Administration-Advanced Analysis Team, Cheongju, South KoreaView further author information
,
Hyun-Ah Kima National Institute of Food and Drug Safety Evaluation, Food Additives and Packaging Division, Cheongju, South KoreaView further author information
&
Soonho Leea National Institute of Food and Drug Safety Evaluation, Food Additives and Packaging Division, Cheongju, South KoreaCorrespondence[email protected]
View further author information
Pages 518-527 | Received 27 Dec 2022, Accepted 28 Feb 2023, Published online: 27 Mar 2023

References

  • American Society for Testing and Materials (ASTM). 2011. Standard specification for volatile N-nitrosamine levels in rubber nipples on pacifiers. F1313-1390.
  • Barnes JM, Magee PN. 1954. Some toxic properties of dimethylnitrosamine. Br J Ind Med. 11(3):167–174.
  • European Committee for Standardization (CEN). 1999. Child use and care articles – method for determining the release of N-nitrosamines and N-nitrosatable substances from elastomer or rubber teats and soothers. EN 12868.
  • European Committee for Standardization (CEN). 2002. Child use and care articles soother for babies and young children part 3: chemical requirements and tests. EN 1400–3.
  • European Committee for Standardization (CEN). 2016. Safety of toys – part 12: N-Nitrosamines and N-nitrosatable substances. EN 71–12.
  • European Committee for Standardization (CEN). 2017. Child use and care articles – method for determining the release of N-nitrosamines and N-nitrosatable substances from elastomer or rubber teats and soothers. EN 12868:2017–4.
  • European Commission (EC). 1993. European Communities Commission Directive 93/11/EEC Concerning the release of the N-nitrosamines and N-nitrosatable substances from elastomer or rubber teats and soothers.
  • European Food Safety Authority (EFSA). 2009. Guidelines for performance criteria and validation procedures of analytical methods used in controls of food contact materials. EUR24105EN-1st ed. http://publications.jrc.ec.europa.eu/respository/handle/JRC53034.
  • Food and Drug Administration (FDA). 2005. Volatile N-nitrosamines in rubber baby bottle nipples. Food and Drug Administration Compliancy Policy Guide (2005). Sec: 500.450.
  • Food and Drug Administration (FDA). 2020. Liquid chromatography-high resolution mass spectrometry (LC-ESI-HRMS) method for the determination of MNP in rifampin and CPNP in rifapentine drug substance and drug product. https://www.fda.gov/media/142092/download.
  • Feng D, Liu L, Zhao L, Zhou Q, Tan T. 2012. Evaluation of simulant migration of volatile nitrosamines from latex gloves and balloons by HS-SPME-GC-MS. J Chromatogr Sci. 50(8):733–738. doi:10.1093/chromsci/bms057
  • Gold LS, Manley NB, Slone TH, Garfinkel GB, Rohrbach L, Ames BN. 1993. The fifth plot of the carcinogenic potency database: results of animal bioassays published in the general literature through 1988 and by the National Toxicology Program through 1989. Environ Health Perspect. 100:65–168. doi:10.1289/ehp.9310065
  • International Agency for Research on Cancer (IARC). 1978. IARC Summary & Evaluations. N-nitromethylethylamine. Vol. 17. p. 221. https://www.inchem.org/documents/iarc/vol17/nitrosomethylethylamine.htm.
  • Jiao J, Douglas GR, Gingerich JD, Soper LM. 1997. Analysis of tissue-specific lacZ mutations induced by N-nitrosodibenzylamine in transgenic mice. Carcinogenesis. 18(11):2239–2245. doi:10.1093/carcin/18.11.2239
  • Ministry of Food and Drug Safety (MFDS). 2021. Standards and specifications for food utensils, containers and packages. https://www.mfds.go.kr/eng/brd/m_15/view.do?seq=72435&srchFr=&srchTo=&srchWor=&srchTp=&itm_seq_1=0&itm_seq_2=0&multi_itm_seq=0&company_cd=&company_ m=&page=1.
  • Mutsuga M, Yamaguchi M, Kawamura Y. 2013. Analysis of N-nitrosamine migration from rubber teats and soothers. AJAC. 04(06):277–285. doi:10.4236/ajac.2013.46035
  • Napalkov NP, Alexandrov VA. 1968. On the effects of blastomogenic substances on the organism during embryogenesis. Z Krebsforsch. 71(1):32–50. doi:10.1007/BF00524500
  • Park SJ, Jeong MJ, Park SR, Choi JC, Choi H, Kim MK. 2018. Release of N-nitrosamines and N-nitrosatable substances from baby bottle teats and rubber kitchen tools in Korea. Food Sci Biotechnol. 27(5):1519–1524. doi:10.1007/s10068-018-0373-6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.