384
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

A New Bayesian Dose-Finding Design for Drug Combination Trials

&
Pages 384-389 | Received 01 Nov 2015, Accepted 01 Oct 2017, Published online: 30 Jan 2018

References

  • Babb, J., Rogatko, A., and Zacks, S. (1998), “Cancer Phase I Clinical Trials: Efficient Dose Escalation With Overdose Control,” Statistics in Medicine, 17, 1103–1120.
  • Bozic, I., Reiter, J. G., Allen, B., Antal, T., Chatterjee, K., Shah, P., Sup Moon, Y., Yaqubie, A., Kelly, N., Le, D. T., et al. (2013), “Evolutionary Dynamics of Cancer in Response to Targeted Combination Therapy,” eLife, 2, e00747.
  • Ferguson, J., Arozarena, I., Ehrhardt, M., and Wellbrock, C. (2013), “Combination of MEK and SRC Inhibition Suppresses Melanoma Cell Growth and Invasion,” Oncogene, 32, 86–96.
  • Gasparini, M., Bailey, S., and Neuenschwander, B. (2010), “Bayesian Dose Finding in Oncology for Drug Combinations by Copula Regression,” Journal of the Royal Statistical Society, Series C, 59, 543–544.
  • Huo, L., Yuan, Y., and Yin, G. (2012), “Bayesian Dose Finding for Combined Drugs With Discerete and Continuous Doses,” Bayesian Analysis, 7, 235–252.
  • Jin, I. H., Huo, L., Yin, G., and Yuan, Y. (2015), “Phase I Trial Design for Drug Combinations With Bayesian Model Averaging,” Pharmaceutical Statistics, 14, 108–119.
  • Lokich, J. (2001), “Phase I Clinical Trial of Weekly Combined Topotecan and Irinotecan,” American Journal of Clinical Oncology, 24, 336–340.
  • Mandrekar, S. J., Cui, Y., and Sargent, D. J. (2007), “An Adaptive Phase I Design for Identifying a Biologically Optimal Dose for Dual Agent Drug Combinations,” Statistics in Medicine, 26, 2317–2330.
  • Podolsky, S. H., and Greene, J. A. (2011), “Combination Drugs Hype, Harm, and Hope,” The New England Journal of Medicine, 365, 488–491.
  • Riviere, M. K., Dubois, F., and Zohar, S. (2015), “Competing Designs for Drug Combination in Phase I Dose-Finding Clinical Trials,” Statistics in Medicine, 34, 1–12.
  • Riviere, M. K., and Jourdan, J. H. (2015), dfcomb: Phase I/II Adaptive Dose-Finding Design for Combination Studies, R package version 2.0-2.
  • Riviere, M. K., Yuan, Y., Dubois, F., and Zohar, S. (2014), “A Bayesian Dose-Finding Design for Drug Combination Clinical Trials Based on the Logistic Model,” Pharmaceutical Statistics, 13, 247–257.
  • Shi, Y., and Yin, G. (2013), “Escalation With Overdose Control for Phase I Drug-Combination Trials,” Statistics in Medicine, 32, 4400–4412.
  • Thall, P. F., Millikan, R. E., Mueller, P., and Lee, S. J. (2003), “Dose-Finding With Two Agents in Phase I Oncology Trials,” Biometrics, 59, 487–496.
  • Tighiouart, M., Piantadosi, S., and Rogatko, A. (2014), “Dose Finding With Drug Combinations in Cancer Phase I Clinical Trials Using Conditional Escalation With Overdose Control,” Statistics in Medicine, 33, 3815–3829.
  • Tighiouart, M., and Rogatko, A. (2012), “Number of Patients Per Cohort and Sample Size Considerations Using Dose Escalation With Overdose Control,” Journal of Probability and Statistics, 2012, ID 692725.
  • Wages, N. A., Conaway, M. R., and O’Quigley, J. (2011), “Continual Reassessment Method for Partial Ordering,” Biometrics, 67, 1555–1563.
  • Wang, K., and Ivanova, A. (2005), “Two-Dimensional Dose Finding in Discrete Dose Space,” Biometrics, 61, 217–222.
  • Yin, G., and Yuan, Y. (2009a), “Bayesian Dose-Finding in Oncology for Drug Combinations by Copula Regression,” Journal of the Royal Statistical Society, Series C, 58, 211–224.
  • ——— (2009b), “A Latent Contingency Table Approach to Dose Finding for Combinations of Two Agents,” Biometrics, 65, 866–875.
  • Yuan, Y., and Yin, G. (2008), “Sequential Continual Reassessment Method for Two-Dimensional Dose Finding,” Statistics in Medicine, 30, 5664–5678.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.