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Statistics in Biopharmaceutical Research Volume 12, 2020 - Issue 4
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Letter to the Editor

The Hazards of Period Specific and Weighted Hazard Ratios

Jonathan W. BartlettDepartment of Mathematical Sciences, University of Bath, Bath, UK; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-7117-0195
ORCID Icon,
Tim P. MorrisMRC Clinical Trials Unit at UCL, London, UK;
,
Mats J. StensrudDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; ;Department of Biostatistics, Oslo Centre for Biostatistics and Epidemiology, University of Oslo, Oslo, Norway;
,
Rhian M. DanielDivision of Population Medicine, Cardiff University, Cardiff, UK;
,
Stijn K. VansteelandtDepartment of Applied Mathematics, Computer Science and Statistics, Ghent University, Gent, Belgium; ;Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK;
&
Carl-Fredrik BurmanData Science & AI, AstraZeneca R&D Gothenburg, Goteborg, Sweden
Pages 518-519 | Received 20 Mar 2020, Accepted 03 Apr 2020, Published online: 23 Jun 2020

References

  • Aalen, O. O., Borgan, O., and Gjessing, H. (2008), “Unobserved Heterogeneity: The Odd Effects of Frailty” (Chapter 6), in Survival and Event History Analysis: A Process Point of View, New York: Springer Science & Business Media, pp. 231–270.
  • Aalen, O. O., Cook, R. J., and Røysland, K. (2015), “Does Cox Analysis of a Randomized Survival Study Yield a Causal Treatment Effect?,” Lifetime Data Analysis, 21, 579–593. DOI: 10.1007/s10985-015-9335-y.
  • Hernán, M. A. (2010), “The Hazards of Hazard Ratios,” Epidemiology, 21, 13–15.
  • Hernán, M. A., and Robins, J. M. (2020), Causal Inference: What If, Boca Raton, FL: Chapman & Hall/CRC.
  • ICH E9 (R1) (2019), “ICH E9 (R1) Addendum on Estimands and Sensitivity Analysis in Clinical Trials to the Guideline on Statistical Principles for Clinical Trials,” available at https://database.ich.org/sites/default/files/E9-R1_Step4_Guideline_2019_1203.pdf.
  • Lin, R. S., and León, L. F. (2017), “Estimation of Treatment Effects in Weighted Log-Rank Tests,” Contemporary Clinical Trials Communications, 8, 147–155. DOI: 10.1016/j.conctc.2017.09.004.
  • Lin, R. S., Lin, J., Roychoudhury, S., Anderson, K. M., Hu, T., Huang, B., Leon, L. F., Liao, J. J., Liu, R., Luo, X., and Mukhopadhyay, P. (2019), “Alternative Analysis Methods for Time to Event Endpoints Under Non-Proportional Hazards: A Comparative Analysis,” Statistics in Biopharmaceutical Research, 12, 187–198, DOI: 10.1080/19466315.2019.1697738.
  • Magirr, D., and Burman, C. F. (2019), “Modestly Weighted Logrank Tests,” Statistics in Medicine, 38, 3782–3790. DOI: 10.1002/sim.8186.
  • Martinussen, T., Vansteelandt, S., and Andersen, P. K. (2018), “Subtleties in the Interpretation of Hazard Ratios,” arXiv no. 1810.09192.
  • Stensrud, M. J., Aalen, J. M., Aalen, O. O., and Valberg, M. (2019), “Limitations of Hazard Ratios in Clinical Trials,” European Heart Journal, 40, 1378–1383. DOI: 10.1093/eurheartj/ehy770.

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